Detailed information for compound 335917

Basic information

Technical information
  • TDR Targets ID: 335917
  • Name: [phosphono-(3-propan-2-ylanilino)methyl]phosp honic acid
  • MW: 309.193 | Formula: C10H17NO6P2
  • H donors: 5 H acceptors: 6 LogP: -0.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cccc(c1)NC(P(=O)(O)O)P(=O)(O)O)C
  • InChi: 1S/C10H17NO6P2/c1-7(2)8-4-3-5-9(6-8)11-10(18(12,13)14)19(15,16)17/h3-7,10-11H,1-2H3,(H2,12,13,14)(H2,15,16,17)
  • InChiKey: SMQMMNCKAYAHJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(3-isopropylanilino)-phosphono-methyl]phosphonic acid
  • [(3-isopropylanilino)-phosphonomethyl]phosphonic acid
  • [phosphono-[(3-propan-2-ylphenyl)amino]methyl]phosphonic acid
  • [[(3-isopropylphenyl)amino]-phosphono-methyl]phosphonic acid
  • [[(3-isopropylphenyl)amino]-phosphonomethyl]phosphonic acid
  • AIDS-257694
  • AIDS257694
  • Phosphonic acid, [[(5-isopropylphenyl)amino]methylene]bis-
  • AIDS-231627
  • AIDS231627
  • Phosphonic acid, [[[3-(1-methylethyl)phenyl]amino]methylene]bis-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 Starlite/ChEMBL References
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1, putative References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 Get druggable targets OG5_128905 All targets in OG5_128905
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium berghei inorganic pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium knowlesi vacuolar-type H+-translocating inorganic pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma congolense vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium yoelii V-type H(+)-translocating pyrophosphatase Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania mexicana vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1 Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei gambiense vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium knowlesi V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania braziliensis vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium yoelii vacuolar-type H+ pumping pyrophosphatase-related Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania infantum vacuolar-type proton translocating pyrophosphatase 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Leishmania donovani Pyrophosphate-energized vacuolar membrane proton pump 1, putative Get druggable targets OG5_128905 All targets in OG5_128905
Neospora caninum hypothetical protein Get druggable targets OG5_128905 All targets in OG5_128905
Plasmodium berghei V-type H(+)-translocating pyrophosphatase, putative Get druggable targets OG5_128905 All targets in OG5_128905
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor 0.0239 0.2908 1
Onchocerca volvulus 0.0021 0.0168 0.0285
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0287 0.0287
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0086 0.0086
Onchocerca volvulus 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0021 0.0168 0.0579
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0287 0.0287
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0287 0.0705
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0168 0.0168
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0619 0.2128
Echinococcus multilocularis g-protein coupled receptor 0.0239 0.2908 0.2908
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0086 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0126 0.0156
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0328 0.0853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni nuclear receptor 0.0014 0.0088 0.0088
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0408 0.7836
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0502 0.0372
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni nuclear receptor 0.0014 0.0088 0.0088
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1865 0.1865
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0328 0.6206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0287 0.0986
Schistosoma mansoni rab6-interacting 0.0021 0.0168 0.0168
Schistosoma mansoni lipoxygenase 0.0058 0.0633 0.0633
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Echinococcus multilocularis neuropeptide receptor A26 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0033 0.0328 0.0853
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0239 0.2908 0.2908
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2908 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0239 0.2908 0.2908
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0287 0.0986
Echinococcus granulosus neuropeptide s receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0452 1
Loa Loa (eye worm) ctsf protein 0.0033 0.0328 0.1129
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0088 0.0302
Loa Loa (eye worm) cysteine protease 0.0033 0.0328 0.1129
Plasmodium vivax unspecified product 0.0017 0.0126 0.0156
Brugia malayi Cathepsin L-like precursor 0.0022 0.019 0.0654
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0287 0.0986
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0126 0.0432
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.019 0.0654
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Echinococcus granulosus sex peptide receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Echinococcus multilocularis neuropeptide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0049 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Schistosoma mansoni hypothetical protein 0.0805 1 1
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0287 0.0705
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1162 0.2255
Schistosoma mansoni hypothetical protein 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus ankyrin repeat protein 0.0166 0.1991 0.1991
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0287 0.0986
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1921 0.1921
Brugia malayi nuclear receptor RXR 0.0016 0.0109 0.0376
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0088 0.0088
Schistosoma mansoni loxhd1 0.0021 0.0168 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi nuclear receptor NHR-88 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni hypothetical protein 0.0153 0.1825 0.1825
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Brugia malayi Cathepsin L-like precursor 0.0011 0.0049 0.0167
Entamoeba histolytica cysteine protease, putative 0.0033 0.0328 0.6206
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0287 0.0986
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0405 0.4988 1
Schistosoma mansoni cpg binding protein 0.0057 0.0619 0.0619
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) fibroinase 0.0033 0.0328 0.1129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus 0.0021 0.0168 0.0285
Brugia malayi AKH receptor 0.0239 0.2908 1
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0126 0.0126
Echinococcus granulosus g protein coupled receptor 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Echinococcus granulosus allatostatin A receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Brugia malayi hypothetical protein 0.0016 0.0109 0.0376
Brugia malayi G-protein coupled receptor 0.0239 0.2908 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.022
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0126 0.0156
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1365 0.2666
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0088 0.0088
Schistosoma mansoni myosin xvIII 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0239 0.2908 1
Brugia malayi neuropeptide F receptor 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1503 0.2946
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0287 0.0986
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni polycystin 1-related 0.0021 0.0168 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis G-protein coupled receptor, putative 0.0239 0.2908 0.2908
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni alpha-1 adrenergic receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Brugia malayi nuclear receptor NHR-88 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Echinococcus granulosus RUN 0.0021 0.0168 0.0168
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0064 0.5
Brugia malayi RE15519p 0.0239 0.2908 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0031
Brugia malayi GnHR receptor homolog 0.0239 0.2908 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Brugia malayi ORL1-like opioid receptor 0.0239 0.2908 1
Brugia malayi sulfakinin receptor protein 0.0239 0.2908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0126 0.0126
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0502 0.0502
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0088 0.0302
Echinococcus granulosus neuropeptide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus orexin receptor type 2 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0126 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0057 0.0619 0.1882
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.013 0.013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.022
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0452 1
Echinococcus granulosus cpg binding protein 0.006 0.0659 0.0659
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0287 0.0287
Brugia malayi G protein-coupled receptor 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0287 0.0986
Echinococcus multilocularis sex peptide receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis allatostatin A receptor 0.0239 0.2908 0.2908
Echinococcus granulosus neuropeptide receptor A26 0.0239 0.2908 0.2908
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0126 0.1274
Echinococcus multilocularis transient receptor potential cation channel 0.0166 0.1994 0.1994
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0049 0.0167
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi ecdysone receptor 0.0014 0.0088 0.0302
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Echinococcus multilocularis orexin receptor type 2 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0287 0.0287
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.1846 0.1846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Schistosoma mansoni hypothetical protein 0.0124 0.1469 0.1469
Brugia malayi Dopamine receptor protein 2 0.0239 0.2908 1
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0021 0.0168 0.0579
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0408 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0328 0.0328
Echinococcus granulosus FTZ F1 alpha 0.003 0.0287 0.0287
Brugia malayi larval opioid receptor 0.0239 0.2908 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0452 0.0672
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1302 0.2089
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1469 0.1469
Brugia malayi hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.013 0.013
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0239 0.2908 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0328 0.6206
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0405 0.4988 1
Echinococcus granulosus transient receptor potential cation channel 0.0166 0.1991 0.1991
Schistosoma mansoni biogenic amine receptor 0.0239 0.2908 0.2908
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) melatonin receptor type 1A 0.0239 0.2908 1
Brugia malayi Dopamine receptor 0.0239 0.2908 1
Echinococcus multilocularis cpg binding protein 0.006 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0239 0.2908 0.2908
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0408 0.1404
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0088 0.0302
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0287 0.0986
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus 0.0033 0.0328 0.0853
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Plasmodium vivax vivapain-3 0.0017 0.0126 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0287 0.0986
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0328 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0328 0.0853
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.2908 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Loa Loa (eye worm) hypothetical protein 0.004 0.0408 0.1404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0287 0.0986
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0287 0.0287
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0502 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0126 0.1274
Echinococcus granulosus cysteine protease 0.0017 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0016 0.0109 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0287 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0408 0.7836
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus multilocularis g protein coupled receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.022
Echinococcus granulosus cathepsin L 0.0017 0.0126 0.0126
Echinococcus multilocularis dro:myosuppressin receptor 0.0239 0.2908 0.2908
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0287 0.0287
Echinococcus granulosus cathepsin l1 0.0022 0.019 0.019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0408 0.0408
Loa Loa (eye worm) TYRA-2 protein 0.0239 0.2908 1
Echinococcus multilocularis cysteine protease 0.0033 0.0328 0.0328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0405 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0109 0.0109
Schistosoma mansoni adenoreceptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.019 0.2771
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0408 0.7836
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0239 0.2908 0.2908
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0328 0.0567
Brugia malayi CXXC zinc finger family protein 0.0057 0.0619 0.2128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0408 0.8655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0088 0.0302
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0239 0.2908 0.2908
Echinococcus granulosus cathepsin l1 0.0033 0.0328 0.0328
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Brugia malayi hypothetical protein 0.0239 0.2908 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0502 0.0917
Schistosoma mansoni cathepsin s 0.0011 0.0049 0.0049
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.2908 0.2908
Echinococcus granulosus hypothetical protein 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0239 0.2908 1
Echinococcus multilocularis RUN 0.0021 0.0168 0.0168
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0239 0.2908 0.2908
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Echinococcus multilocularis fmrfamide receptor 0.0239 0.2908 0.2908
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0328 0.1129
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0633 0.0633
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0239 0.2908 0.2908
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0408 0.0408
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0088 0.0302
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0633 0.0633
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.2908 0.2908
Trypanosoma brucei RNA helicase, putative 0.0153 0.1825 0.3577
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1413 0.1413
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0287 0.0705
Echinococcus multilocularis neuropeptide FF receptor 2 0.0239 0.2908 0.2908
Echinococcus multilocularis ankyrin repeat protein 0.0166 0.1991 0.1991
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0328 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0239 0.2908 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0287 0.0986
Brugia malayi cathepsin L-like precursor 0.0022 0.019 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0088 0.0088
Echinococcus granulosus somatostatin receptor 0.0239 0.2908 0.2908
Schistosoma mansoni growth hormone secretagogue receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0287 0.0986
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0239 0.2908 0.2908
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0168 0.0088
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0405 0.4988 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0109 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0328 0.0328
Echinococcus granulosus G protein coupled receptor 139 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0287 0.0287
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0287 0.0287
Schistosoma mansoni histamine h1 receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0049 0.0167
Onchocerca volvulus 0.0239 0.2908 1
Schistosoma mansoni coup transcription factor 0.003 0.0287 0.0287
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0239 0.2908 1
Brugia malayi neuropeptide F receptor 0.0239 0.2908 1
Brugia malayi Doublecortin family protein 0.0021 0.0168 0.0579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0166 0.1991 0.1991
Brugia malayi nuclear hormone receptor 0.0014 0.0088 0.0302
Onchocerca volvulus 0.0239 0.2908 1
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0405 0.4988 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0287 0.0287
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0126 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Echinococcus granulosus 7TM GPCR rhodopsin 0.0239 0.2908 0.2908
Brugia malayi G-protein coupled receptor 0.0239 0.2908 1
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0405 0.4988 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0064 0.022
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0328 0.0853
Echinococcus granulosus alpha 1A adrenergic receptor 0.0239 0.2908 0.2908
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0239 0.2908 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0088 0.0302
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus g-protein coupled receptor 0.0239 0.2908 0.2908
Brugia malayi steroid hormone receptor 0.003 0.0287 0.0986
Schistosoma mansoni zinc finger protein 0.0014 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0287 0.0287
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0328 0.0328
Brugia malayi putative neuropeptide receptor NPR1 0.0239 0.2908 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.019 0.1975
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0126 0.0156
Loa Loa (eye worm) acetyltransferase 0.016 0.1921 0.6606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2908 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0405 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0579
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0405 0.4988 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0287 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis neuropeptide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni amine GPCR 0.0239 0.2908 0.2908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0408 0.0408
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0328 0.0417
Onchocerca volvulus 0.0033 0.0328 0.0853
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1921 0.1921
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0168 0.0243
Onchocerca volvulus Neuropeptide F receptor homolog 0.0239 0.2908 1
Onchocerca volvulus 0.0022 0.019 0.0363
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0405 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0408 0.0408
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0287 0.0986
Loa Loa (eye worm) histone methyltransferase 0.0017 0.013 0.0445
Schistosoma mansoni cpg binding protein 0.006 0.0659 0.0659
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0408 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Brugia malayi conserved hypotetical protein 0.0014 0.0088 0.0302
Echinococcus multilocularis dnaJ subfamily B 0.0805 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0579
Brugia malayi Melatonin receptor type 1A 0.0239 0.2908 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0239 0.2908 0.2908
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0287 0.0986
Brugia malayi hypothetical protein 0.0239 0.2908 1
Brugia malayi nuclear receptor RXR 0.0014 0.0088 0.0302
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0127 0.0436
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1921 0.6606
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.2908 0.2908
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0239 0.2908 1
Echinococcus multilocularis G protein coupled receptor 139 0.0239 0.2908 0.2908
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.2908 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0086 0.0086
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0086 0.0086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0328 0.1129
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0328 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0287 0.0986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0126 0.0126
Echinococcus multilocularis somatostatin receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Schistosoma mansoni hypothetical protein 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Brugia malayi Tachykinin-like peptides receptor 99D 0.0239 0.2908 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0168 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0287 0.0986
Plasmodium vivax vivapain-1 0.0017 0.0126 0.0156
Schistosoma mansoni opsin-like receptor 0.0239 0.2908 0.2908
Schistosoma mansoni rab6-interacting 0.0021 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0376
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0502 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis serotonin receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0408 0.0408
Onchocerca volvulus 0.0239 0.2908 1
Plasmodium vivax vivapain-2 0.0033 0.0328 0.0567
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0239 0.2908 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0239 0.2908 0.2908
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0088 0.0088
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0239 0.2908 0.2908
Echinococcus multilocularis serotonin receptor 0.0239 0.2908 0.2908
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0088 0.0088
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0088 0.0088
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Brugia malayi hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0408 0.0408
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0287 0.0287
Brugia malayi hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1503 0.2924
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.2908 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0287 0.0986
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0328 0.0417
Onchocerca volvulus 0.0239 0.2908 1
Echinococcus granulosus dro:myosuppressin receptor 0.0239 0.2908 0.2908
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.2908 0.2908
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.019 0.019
Brugia malayi hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0239 0.2908 0.2908
Schistosoma mansoni cpg binding protein 0.006 0.0659 0.0659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0088 0.0088
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0168 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Brugia malayi nuclear receptor NHR-67 0.0014 0.0088 0.0302
Schistosoma mansoni neuropeptide f receptor 76f 0.0239 0.2908 0.2908
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0287 0.0287
Brugia malayi Cathepsin L-like precursor 0.0022 0.019 0.0654
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0405 0.4988 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0328 0.0328
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0287 0.0287
Brugia malayi G protein-coupled receptor F59B2.13 0.0239 0.2908 1
Brugia malayi Serotonin receptor 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0239 0.2908 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.2908 0.2908
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0239 0.2908 0.2908
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.07
Plasmodium vivax vivapain-2 0.0033 0.0328 0.0567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0126 0.0126
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0287 0.0287
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0287 0.0287
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.2908 1
Brugia malayi Dopamine receptor protein 1 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0328 0.598
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1469 0.1469
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.2908 0.2908
Echinococcus granulosus peptide allatostatin:somatostatin 0.0239 0.2908 0.2908
Schistosoma mansoni nuclear hormone receptor 0.003 0.0287 0.0287
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0287 0.0287
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0109 0.0109
Onchocerca volvulus 0.0033 0.0328 0.0853
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0287 0.0986
Onchocerca volvulus 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0328 0.1129
Brugia malayi hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis fmrfamide receptor 0.0239 0.2908 0.2908
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1846 0.1846
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0328 0.598
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0168 0.0168
Brugia malayi Cathepsin L-like precursor 0.0033 0.0328 0.1129
Echinococcus multilocularis cysteine protease 0.0033 0.0328 0.0328
Brugia malayi tailless protein 0.0014 0.0088 0.0302
Echinococcus granulosus serotonin receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.2908 0.2908
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0239 0.2908 0.2908
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.2908 0.2908
Onchocerca volvulus 0.003 0.0287 0.0705
Onchocerca volvulus 0.0239 0.2908 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.0729
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.2908 0.2908
Brugia malayi Serotonin receptor 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.1503 0.2946
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1846 0.1846
Echinococcus multilocularis cathepsin L 0.0017 0.0126 0.0126
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0502 0.0372
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Brugia malayi nuclear hormone receptor 0.003 0.0287 0.0986
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0986
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.2908 0.2908
Loa Loa (eye worm) DR-78 0.0014 0.0088 0.0302
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0109 0.0376
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0287 0.0986
Brugia malayi hypothetical protein 0.0239 0.2908 1
Schistosoma mansoni lipoxygenase 0.0021 0.0168 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Onchocerca volvulus 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0127 0.1503 0.2924
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0408 0.0729
Loa Loa (eye worm) hypothetical protein 0.0022 0.019 0.0654
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus granulosus neuropeptide FF receptor 2 0.0239 0.2908 0.2908
Echinococcus multilocularis neuropeptide s receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0126 0.0432
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0328 0.0328
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0239 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Leishmania major cathepsin L-like protease 0.0033 0.0328 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0287 0.0986
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.2908 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0287 0.0986
Schistosoma mansoni neuropeptide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.2908 0.2908
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0088 0.0088
Onchocerca volvulus 0.0033 0.0328 0.0853
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0239 0.2908 1
Brugia malayi ecdysteroid receptor 0.003 0.0287 0.0986
Echinococcus granulosus fmrfamide receptor 0.0239 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0287 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.019 0.2771

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 771 uM Dose of the compound to inhibit the growth of human KB carcinoma cell line ChEMBL. 16162013
ED50 (functional) = 771 uM Dose of the compound to inhibit the growth of human KB carcinoma cell line ChEMBL. 16162013
IC50 (binding) = 9.7 uM Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli ChEMBL. 16162013
IC50 (binding) = 9.7 uM Inhibition of recombinant trypanosoma brucei soluble vacuolar pyrophosphatase expressed in escherichia coli ChEMBL. 16162013
IC50 (functional) = 160.4 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
IC50 (functional) = 160.4 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate ChEMBL. 17149863
IZ (functional) = 8 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 8 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 9 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
IZ (functional) = 9 mm Antibacterial activity against Escherichia coli pTMV19 ChEMBL. 17149863
TI (functional) = 79 Ratio of ED50 against KB cell line to that of IC50 of TbVSP1 ChEMBL. 16162013
TI (functional) = 79 Ratio of ED50 against KB cell line to that of IC50 of TbVSP1 ChEMBL. 16162013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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