Detailed information for compound 336075

Basic information

Technical information
  • TDR Targets ID: 336075
  • Name: diethyl (2R)-2-[[2-(2-acetyloxyethyl)-8-morph olin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quin olin-4-yl]amino]butanedioate
  • MW: 620.628 | Formula: C27H32N4O11S
  • H donors: 1 H acceptors: 8 LogP: 1.21 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C[C@H](C(=O)OCC)Nc1nc2ccc(cc2c2c1C(=O)N(C2=O)CCOC(=O)C)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C27H32N4O11S/c1-4-40-21(33)15-20(27(36)41-5-2)29-24-23-22(25(34)31(26(23)35)10-13-42-16(3)32)18-14-17(6-7-19(18)28-24)43(37,38)30-8-11-39-12-9-30/h6-7,14,20H,4-5,8-13,15H2,1-3H3,(H,28,29)/t20-/m1/s1
  • InChiKey: LBKKUCOWOUOPJT-HXUWFJFHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • diethyl (2R)-2-[[2-(2-acetoxyethyl)-8-morpholinosulfonyl-1,3-dioxo-pyrrolo[3,4-c]quinolin-4-yl]amino]butanedioate
  • (2R)-2-[[2-(2-acetoxyethyl)-8-morpholinosulfonyl-1,3-dioxo-4-pyrrolo[3,4-c]quinolinyl]amino]butanedioic acid diethyl ester
  • diethyl (2R)-2-[[2-(2-acetyloxyethyl)-8-morpholin-4-ylsulfonyl-1,3-dioxo-pyrrolo[3,4-c]quinolin-4-yl]amino]butanedioate
  • (2R)-2-[[2-(2-acetoxyethyl)-1,3-diketo-8-morpholinosulfonyl-pyrrolo[3,4-c]quinolin-4-yl]amino]succinic acid diethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0675 0.2236 0.2236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.012 0.0252
Loa Loa (eye worm) hypothetical protein 0.2945 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0296 0.1126
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0056 0.012 0.0252
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0011 0.0018
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0296 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0766 0.2549 0.536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.3251 0.6837
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.0332 0.0693
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0327 0.1045 0.2197
Mycobacterium ulcerans lipase LipD 0.0108 0.0296 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0054 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0296 0.0623
Loa Loa (eye worm) glutathione reductase 0.0047 0.0089 0.0089
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0103 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Echinococcus multilocularis cathepsin L cysteine protease 0.1412 0.4755 0.4755
Plasmodium falciparum serine repeat antigen 5 0.0327 0.1045 0.2192
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0048 0.01
Giardia lamblia Cathepsin B precursor 0.0327 0.1045 0.2733
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0038 0.0038
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0082 0.0209 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0083 0.0174
Toxoplasma gondii cathepsin B 0.1137 0.3814 0.802
Loa Loa (eye worm) hypothetical protein 0.0078 0.0194 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0194 0.0194
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0054 0.0114
Mycobacterium ulcerans hypothetical protein 0.0108 0.0296 1
Plasmodium vivax importin-beta 2, putative 0.003 0.003 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1045 0.2197
Brugia malayi cathepsin F-like cysteine proteinase 0.044 0.1432 0.1432
Plasmodium vivax metacaspase 1, putative 0.0032 0.0038 0.0073
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0089 0.0181
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0038 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0244 0.0244
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.003 0.0063
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0766 0.2549 0.2549
Plasmodium falciparum serine repeat antigen 7 0.0327 0.1045 0.2192
Schistosoma mansoni cathepsin S (C01 family) 0.0327 0.1045 0.1045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0972 0.3251 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0077
Trypanosoma cruzi cruzipain precursor, putative 0.044 0.1432 0.1432
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0048 0.0048
Trypanosoma brucei glucosidase, putative 0.0035 0.0048 0.01
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0338 0.0338
Trypanosoma cruzi cysteine peptidase, putative 0.1412 0.4755 0.4755
Giardia lamblia Hypothetical protein 0.0327 0.1045 0.2733
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0327 0.1045 0.2733
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0059 0.0129 0.0331
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1137 0.3814 0.3814
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0194 0.0194
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.0071 0.0071
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0054 0.0054
Echinococcus multilocularis cysteine protease 0.1412 0.4755 0.4755
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0058 0.0116
Schistosoma mansoni alpha-glucosidase 0.0136 0.0392 0.0392
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0048 0.01
Plasmodium falciparum cysteine proteinase falcipain 3 0.1412 0.4755 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1137 0.3814 0.8022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0038 0.0073
Echinococcus multilocularis cathepsin L 0.0766 0.2549 0.2549
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.0332 0.0699
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0296 0.1126
Schistosoma mansoni cathepsin F (C01 family) 0.0972 0.3251 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0083 0.0174
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0048 0.0094
Giardia lamblia Cathepsin B precursor 0.0327 0.1045 0.2733
Echinococcus granulosus cathepsin l cysteine peptidase 0.1412 0.4755 0.4755
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0752 0.0752
Onchocerca volvulus Cathepsin L homolog 0.1412 0.4755 1
Echinococcus multilocularis cysteine protease 0.1412 0.4755 0.4755
Echinococcus granulosus importin subunit beta 1 0.003 0.003 0.003
Plasmodium falciparum importin beta, putative 0.003 0.003 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0296 0.0296
Plasmodium falciparum metacaspase 1 0.0032 0.0038 0.0073
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1045 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1137 0.3814 0.8022
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0056 0.012 0.012
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Toxoplasma gondii ABC1 family protein 0.0108 0.0296 0.0617
Brugia malayi Papain family cysteine protease containing protein 0.0766 0.2549 0.2549
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Onchocerca volvulus 0.1412 0.4755 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0327 0.1045 0.2192
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0766 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0129 0.0368 0.0368
Trypanosoma cruzi target of rapamycin kinase 3 0.0045 0.0083 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Echinococcus granulosus cathepsin L cysteine protease 0.0766 0.2549 0.2549
Plasmodium vivax vivapain-2 0.1412 0.4755 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0048 0.01
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0103 0.0217
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0011 0.0018
Giardia lamblia Cathepsin L-like protease 0.0327 0.1045 0.2733
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Onchocerca volvulus 0.0108 0.0296 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Brugia malayi Papain family cysteine protease containing protein 0.1412 0.4755 0.4755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0047 0.0099
Loa Loa (eye worm) hypothetical protein 0.0972 0.3251 0.3251
Toxoplasma gondii thioredoxin reductase 0.0047 0.0089 0.0181
Plasmodium falciparum cysteine proteinase falcipain 1 0.0766 0.2549 0.5357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0038 0.0079
Trypanosoma brucei oligopeptidase b 0.0051 0.0103 0.0217
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0089 0.0089
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0296 0.0296
Loa Loa (eye worm) inositol-1 0.0038 0.0058 0.0058
Echinococcus multilocularis geminin 0.0675 0.2236 0.2236
Onchocerca volvulus 0.0327 0.1045 0.2135
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0296 0.0296
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.012 0.012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1045 0.1045
Trypanosoma cruzi oligopeptidase b 0.0051 0.0103 0.0103
Loa Loa (eye worm) ctsf protein 0.1412 0.4755 0.4755
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0296 0.1126
Trichomonas vaginalis esterase, putative 0.0108 0.0296 0.0623
Plasmodium falciparum metacaspase-like protein 0.0032 0.0038 0.0073
Schistosoma mansoni ran 0.0022 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Plasmodium vivax unspecified product 0.0327 0.1045 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0766 0.2549 0.536
Loa Loa (eye worm) hypothetical protein 0.0048 0.0093 0.0093
Entamoeba histolytica cysteine proteinase 1, putative 0.0766 0.2549 0.5357
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0093 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0296 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1045 0.1045
Giardia lamblia Cysteine protease 0.0327 0.1045 0.2733
Trypanosoma cruzi cysteine peptidase, putative 0.1412 0.4755 0.4755
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0327 0.1045 0.2192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0688 0.228 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0011 0.0022
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.0332 0.0699
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0071 0.0143
Trypanosoma cruzi cysteine peptidase, putative 0.1412 0.4755 0.4755
Schistosoma mansoni cathepsin B (C01 family) 0.0327 0.1045 0.1045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0056 0.012 0.0246
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0103 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0038 0.0038
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0003 0.0003
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.0368 0.0701
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0327 0.1045 0.2192
Schistosoma mansoni cathepsin F (C01 family) 0.1412 0.4755 0.4755
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1412 0.4755 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0327 0.1045 0.2192
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0296 0.0296
Toxoplasma gondii prolyl endopeptidase 0.0129 0.0368 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0057 0.0119
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0327 0.1045 0.2192
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1045 0.1045
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0327 0.1045 0.1045
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1045 0.2192
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1412 0.4755 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2945 1 1
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0078
Brugia malayi Papain family cysteine protease containing protein 0.0766 0.2549 0.2549
Echinococcus multilocularis caspase 3 0.0088 0.0228 0.0228
Giardia lamblia Cathepsin B precursor 0.0327 0.1045 0.2733
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0078
Toxoplasma gondii target of rapamycin (TOR), putative 0.0043 0.0074 0.0149
Leishmania major importin beta-1 subunit, putative 0.0024 0.0011 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Echinococcus granulosus cysteine protease 0.0766 0.2549 0.2549
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0038 0.0038
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0078
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0101 0.0274 0.0274
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0048 0.0048
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0766 0.2549 0.2549
Trypanosoma cruzi oligopeptidase b 0.0051 0.0103 0.0103
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0058 0.0058
Schistosoma mansoni importin beta-1 0.003 0.003 0.003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0133 0.0397
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0011 0.0022
Giardia lamblia Cathepsin B precursor 0.1137 0.3814 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1045 0.2197
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Brugia malayi Importin beta-1 subunit 0.003 0.003 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.044 0.1432 0.1432
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Onchocerca volvulus 0.1412 0.4755 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0133 0.0274
Mycobacterium tuberculosis Conserved protein 0.0108 0.0296 0.1126
Entamoeba histolytica hypothetical protein 0.0095 0.0252 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0219 0.0678 0.0678
Leishmania major GTP-binding protein, putative 0.0022 0.0003 0.0006
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0054 0.0108
Giardia lamblia Cathepsin B precursor 0.1137 0.3814 1
Brugia malayi cathepsin L precursor 0.0327 0.1045 0.1045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0089 0.0187
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.1015 0.1015
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.3251 0.6835
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0194 0.0194
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1045 0.2192
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0296 0.1126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.0332 0.0332
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0056 0.012 0.012
Plasmodium vivax glutathione reductase, putative 0.0047 0.0089 0.0181
Loa Loa (eye worm) hypothetical protein 0.1412 0.4755 0.4755
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0048 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0244 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1045 0.2197
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0103 0.2017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0046 0.0097
Leishmania major cysteine peptidase A (CPA) 0.1412 0.4755 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0089 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Trypanosoma cruzi cysteine proteinase, putative 0.0766 0.2549 0.2549
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0972 0.3251 0.3251
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0071 0.0149
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2945 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0054 0.0108
Brugia malayi beta-lactamase 0.0108 0.0296 0.0296
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1045 0.1045
Trypanosoma brucei metacaspase MCA2 0.0032 0.0038 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0122
Plasmodium falciparum serine repeat antigen 3 0.0327 0.1045 0.2192
Brugia malayi cathepsin L-like cysteine proteinase 0.0327 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1045 0.2197
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.2614 0.2614
Schistosoma mansoni hypothetical protein 0.0675 0.2236 0.2236
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0011 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0056 0.012 0.012
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.003
Brugia malayi MH2 domain containing protein 0.0241 0.0752 0.0752
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0338 0.0338
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0295 0.1122
Schistosoma mansoni ran 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2945 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.0122
Onchocerca volvulus 0.1412 0.4755 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0011 0.0018
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1045 0.2192
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0133 0.3258
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Schistosoma mansoni cathepsin s 0.044 0.1432 0.1432
Brugia malayi fibroinase precursor 0.0327 0.1045 0.1045
Onchocerca volvulus Cathepsin L homolog 0.1412 0.4755 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0054 0.0054
Echinococcus granulosus cathepsin L 0.0327 0.1045 0.1045
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.044 0.1432 0.1432
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0054 0.0054
Giardia lamblia Cathepsin B precursor 0.0327 0.1045 0.2733
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0048 0.01
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0296 0.0623
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0322 0.1242
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0327 0.1045 0.2197
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0133 0.0133
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0048 0.01
Onchocerca volvulus 0.1412 0.4755 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0041 0.0041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Trypanosoma brucei metacaspase MCA3 0.0032 0.0038 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0296 0.0623
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0089 0.0089
Giardia lamblia Cathepsin B precursor 0.0327 0.1045 0.2733
Mycobacterium tuberculosis Probable reductase 0.0107 0.0295 0.1122
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0295 0.1122
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0071 0.0149
Plasmodium falciparum serine repeat antigen 2 0.0327 0.1045 0.2192
Plasmodium vivax unspecified product 0.0766 0.2549 0.5357
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0332 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Entamoeba histolytica cysteine proteinase, putative 0.1412 0.4755 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0054 0.0114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0336 1
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0045 0.0083 0.0175
Brugia malayi Inositol-1 0.0038 0.0058 0.0058
Plasmodium falciparum serine repeat antigen 1 0.0327 0.1045 0.2192
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0111 0.0309 0.0644
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1045 0.1045
Brugia malayi POT family protein 0.0042 0.0072 0.0072
Echinococcus granulosus cathepsin b 0.2945 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2945 1 1
Leishmania major oligopeptidase b 0.0051 0.0103 0.0217
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0295 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0338 0.0338
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0296 0.0623
Giardia lamblia Cysteine protease 0.0327 0.1045 0.2733
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0093 0.0093
Echinococcus granulosus prolyl endopeptidase 0.0129 0.0368 0.0368
Echinococcus multilocularis snurportin 1 0.0318 0.1015 0.1015
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0327 0.1045 0.1045
Giardia lamblia Hypothetical protein 0.0327 0.1045 0.2733
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0054 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0244 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1045 0.2192
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1045 0.1045
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1045 0.2197
Loa Loa (eye worm) cysteine protease 0.1412 0.4755 0.4755
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0011 0.0011
Loa Loa (eye worm) POT family protein 0.0042 0.0072 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0296 0.0623
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0332 0.0332
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1412 0.4755 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0336 0.1305
Trypanosoma cruzi metacaspase, putative 0.0032 0.0038 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0133 0.3258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Loa Loa (eye worm) hypothetical protein 0.044 0.1432 0.1432
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0327 0.1045 0.2197
Brugia malayi hypothetical protein 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0091 0.024 0.0429
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2945 1 1
Giardia lamblia Encystation-specific protease 0.0327 0.1045 0.2733
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0327 0.1045 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Echinococcus granulosus cathepsin l1 0.1412 0.4755 0.4755
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1045 0.1045
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0752 0.0752
Schistosoma mansoni cathepsin F (C01 family) 0.1412 0.4755 0.4755
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.0122
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1045 0.2192
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.0071 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0048 0.0048
Giardia lamblia GTOR 0.0056 0.012 0.0307
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0219 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0766 0.2549 0.536
Loa Loa (eye worm) fibroinase 0.1412 0.4755 0.4755
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0089 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0766 0.2549 0.536
Onchocerca volvulus Cathepsin L homolog 0.0327 0.1045 0.2135
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1412 0.4755 1
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Echinococcus multilocularis caspase 2 0.0032 0.0038 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1045 0.1045
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0056 0.012 0.012
Echinococcus multilocularis cathepsin L cysteine protease 0.1412 0.4755 0.4755
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0056 0.012 0.012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1412 0.4755 0.4755
Loa Loa (eye worm) hypothetical protein 0.044 0.1432 0.1432
Loa Loa (eye worm) cathepsin B 0.1137 0.3814 0.3814
Plasmodium vivax vivapain-1 0.0766 0.2549 0.5357
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0048 0.01
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0048 0.0048
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0296 0.8626
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0054 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0083 0.0174
Loa Loa (eye worm) hypothetical protein 0.0972 0.3251 0.3251
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0296 0.0296
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0368 0.0368
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0467 0.0467
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0295 0.1122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0244 0.0244
Echinococcus multilocularis caspase 0.012 0.0338 0.0338
Trichomonas vaginalis ran, putative 0.0022 0.0003 0.0006
Brugia malayi Cell death protein 3 precursor 0.0032 0.0038 0.0038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1412 0.4755 0.4755
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.003 0.0031 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1045 0.2197
Entamoeba histolytica hypothetical protein 0.0327 0.1045 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0083 0.0174
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0056 0.012 0.0246
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0336 0.1305
Trypanosoma cruzi cysteine proteinase, putative 0.0766 0.2549 0.2549
Mycobacterium ulcerans beta-lactamase 0.0108 0.0296 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Echinococcus multilocularis cathepsin b 0.2945 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1412 0.4755 0.4755
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1045 0.2192
Mycobacterium leprae Probable lipase LipE 0.0108 0.0296 0.8626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0196 0.0598 0.0598
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0003 0.0003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1045 0.1045
Trypanosoma cruzi cruzipain precursor, putative 0.1412 0.4755 0.4755
Echinococcus granulosus caspase 0.012 0.0338 0.0338
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0011 0.0018
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.0368 0.0368
Trypanosoma brucei Metacaspase-4 0.0032 0.0038 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Entamoeba histolytica cysteine proteinase, putative 0.0766 0.2549 0.5357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1045 0.1045
Brugia malayi beta-lactamase family protein 0.0108 0.0296 0.0296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0244 0.0244
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0296 0.1126
Loa Loa (eye worm) hypothetical protein 0.044 0.1432 0.1432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1045 0.2197
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0327 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0038
Entamoeba histolytica cysteine protease, putative 0.1412 0.4755 1
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0296 0.1126
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0058 0.0122
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0133 0.028
Plasmodium vivax vivapain-3 0.0766 0.2549 0.5357
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0244 0.0244
Echinococcus granulosus cathepsin L 0.0766 0.2549 0.2549
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0295 0.1122
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0103 0.2011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0048 0.01
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.0368 0.0774
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Echinococcus granulosus cathepsin l1 0.0972 0.3251 0.3251
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0038 0.0038
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0054 0.0054
Trypanosoma brucei prolyl endopeptidase 0.0129 0.0368 0.0774
Brugia malayi glutathione reductase 0.0047 0.0089 0.0089
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0056 0.012 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.012 0.0252
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0467 0.0467
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0766 0.2549 0.2549
Schistosoma mansoni ap endonuclease 0.0037 0.0054 0.0054
Onchocerca volvulus Cathepsin F homolog 0.1412 0.4755 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0327 0.1045 0.1045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0054 0.0054
Toxoplasma gondii preprocathepsin c precursor, putative 0.0327 0.1045 0.2192
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0045 0.0083 0.0175
Onchocerca volvulus 0.1412 0.4755 1
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Entamoeba histolytica cysteine proteinase, putative 0.0766 0.2549 0.5357
Schistosoma mansoni ap endonuclease 0.0037 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0079
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Giardia lamblia Cathepsin B precursor 0.1137 0.3814 1
Loa Loa (eye worm) hypothetical protein 0.0972 0.3251 0.3251
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0037 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0083 0.0174
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0054 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0047 0.0099
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0103 0.0263
Brugia malayi Thioredoxin reductase 0.0047 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0766 0.2549 0.2549
Onchocerca volvulus 0.1412 0.4755 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.012 0.0252
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0327 0.1045 0.2192
Plasmodium vivax vivapain-2 0.1412 0.4755 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1045 0.1045
Echinococcus multilocularis importin subunit beta 1 0.003 0.003 0.003
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0327 0.1045 0.1045
Trypanosoma brucei metacaspase 0.0032 0.0038 0.0079
Echinococcus multilocularis cathepsin b 0.2945 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0133 0.3258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Echinococcus granulosus snurportin 1 0.0318 0.1015 0.1015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0003 0.0003
Toxoplasma gondii cathepsin CPL 0.1412 0.4755 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0071 0.0071
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0327 0.1045 0.2192
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0056 0.012 0.0252
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1045 0.1045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0054 0.0114
Schistosoma mansoni alpha glucosidase 0.0035 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.006 0.0127
Brugia malayi Cathepsin L-like precursor 0.0972 0.3251 0.3251
Brugia malayi Cathepsin L-like precursor 0.044 0.1432 0.1432
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0014 0.003
Trypanosoma brucei cysteine peptidase C (CPC) 0.1137 0.3814 0.8022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0093 0.0093
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0058 0.0116
Mycobacterium tuberculosis Conserved protein 0.0108 0.0296 0.1126
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0327 0.1045 0.2192
Brugia malayi Cathepsin L-like precursor 0.0972 0.3251 0.3251
Giardia lamblia Cysteine protease 0.0327 0.1045 0.2733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1045 0.2733
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0103 0.0217
Echinococcus granulosus caspase 2 0.0032 0.0038 0.0038
Trypanosoma cruzi cysteine protease, putative 0.0766 0.2549 0.2549
Entamoeba histolytica cysteine proteinase 2 0.0766 0.2549 0.5357
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0071 0.0143
Echinococcus granulosus caspase 3 0.0088 0.0228 0.0228
Onchocerca volvulus 0.0108 0.0296 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.0197
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0467 0.0467
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0058 0.0153
Brugia malayi cathepsin L-like precursor 0.0972 0.3251 0.3251
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0048 0.01
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0296 0.0617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0244 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0244 0.0244
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0058 0.0122
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0219 0.0678 0.0678
Plasmodium falciparum glutathione reductase 0.0047 0.0089 0.0181
Leishmania major hypothetical protein, conserved 0.0024 0.0011 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0296 0.1126
Entamoeba histolytica cysteine proteinase, putative 0.0766 0.2549 0.5357
Loa Loa (eye worm) papain family cysteine protease containing protein 0.044 0.1432 0.1432
Onchocerca volvulus 0.0108 0.0296 0.0548
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Onchocerca volvulus 0.1412 0.4755 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.1045 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.012 0.0252
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1045 0.2733
Brugia malayi Cathepsin L-like precursor 0.1412 0.4755 0.4755
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0048 0.01
Schistosoma mansoni alpha-glucosidase 0.0136 0.0392 0.0392
Leishmania major hypothetical protein, conserved 0.0108 0.0296 0.0623
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0338 0.0338
Schistosoma mansoni cathepsin C 0.0327 0.1045 0.1045
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0296 1
Plasmodium falciparum serine repeat antigen 4 0.0327 0.1045 0.2192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0047 0.0099
Brugia malayi beta-lactamase family protein 0.0108 0.0296 0.0296
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0003 0.0003
Plasmodium vivax unspecified product 0.044 0.1432 0.3008
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.003 0.0057
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0295 0.8596
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0133 0.0133
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0114 0.0233
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0071 0.0149
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0028 0.0025 0.0052
Giardia lamblia Cathepsin L-like protease 0.0327 0.1045 0.2733
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0108 0.0296 0.0296
Brugia malayi RNA, U transporter 1 0.0085 0.0218 0.0218
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.0332 0.0699
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0048 0.01
Loa Loa (eye worm) hypothetical protein 0.004 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1045 0.2197
Onchocerca volvulus 0.0972 0.3251 0.6811
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0054 0.0044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1045 0.2733
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0003 0.0003
Giardia lamblia Cysteine protease 0.0327 0.1045 0.2733
Schistosoma mansoni hypothetical protein 0.0675 0.2236 0.2236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Echinococcus granulosus caspase 8 0.0032 0.0038 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0209 0.044
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0058
Loa Loa (eye worm) beta-lactamase 0.0108 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.3251 0.6837
Entamoeba histolytica cysteine protease, putative 0.0766 0.2549 0.5357
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0467 0.0467
Schistosoma mansoni inositol monophosphatase 0.0038 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1412 0.4755 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0368 0.0368
Trypanosoma cruzi metacaspase, putative 0.0032 0.0038 0.0038
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0003 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1045 0.2197
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0048 0.0048
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0038 0.0073
Plasmodium falciparum serine repeat antigen 8 0.0327 0.1045 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0327 0.1045 0.2197
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0058 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.003 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0038 0.0073
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.0368 0.0368
Echinococcus multilocularis cathepsin L 0.0327 0.1045 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0074 0.0155
Toxoplasma gondii exonuclease III APE 0.0037 0.0054 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Echinococcus multilocularis caspase 8 0.0032 0.0038 0.0038
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1045 0.1045
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0327 0.1045 0.2192
Entamoeba histolytica cysteine proteinase, putative 0.0766 0.2549 0.5357
Trypanosoma cruzi cysteine peptidase, putative 0.1412 0.4755 0.4755
Leishmania major cathepsin L-like protease 0.1412 0.4755 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1137 0.3814 0.3814
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0103 0.0263
Echinococcus granulosus cathepsin b 0.2945 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0467 0.0467
Echinococcus granulosus cathepsin L cysteine proteinase 0.1412 0.4755 0.4755
Leishmania major trypanothione reductase 0.0047 0.0089 0.0187
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0336 0.1305
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0048 0.0094
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0038 0.0073
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1045 0.1045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.0252 0.0524
Plasmodium falciparum serine repeat antigen 6 0.0327 0.1045 0.2192
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0048 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.0108 0.0296 0.1126
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0327 0.1045 0.1045
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1412 0.4755 0.4755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Leishmania major metacaspase, putative 0.0032 0.0038 0.0079
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0327 0.1045 0.2192
Plasmodium falciparum serine repeat antigen 9 0.0327 0.1045 0.2192
Toxoplasma gondii cathepsin CPC2 0.0327 0.1045 0.2192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1412 0.4755 1
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733
Entamoeba histolytica hypothetical protein 0.0024 0.0011 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1412 0.4755 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0011 0.0024
Toxoplasma gondii cathepsin CPC1 0.0327 0.1045 0.2192
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0011 0.0011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0048 0.0094
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0048 0.0048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0038 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1045 0.2197
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0318 0.1015 0.1015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0046 0.0097
Giardia lamblia Cathepsin L precursor 0.0327 0.1045 0.2733

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5190 nM In vitro inhibitory concentration against human caspase-3 ChEMBL. 15916416
IC50 (binding) = 5190 nM In vitro inhibitory concentration against human caspase-3 ChEMBL. 15916416

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.