Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0181 | 0.101 | 0.1001 |
Brugia malayi | follicle stimulating hormone receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | AKH receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0105 | 0.0407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | GnHR receptor homolog | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0654 | 0.4759 | 0.4536 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Dopamine receptor protein 2 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Dopamine receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | putative neuropeptide receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | larval opioid receptor | 0.0105 | 0.0407 | 0.0856 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0865 | 0.6424 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Hyaluronidase family protein | 0.0654 | 0.4759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | Hyaluronidase | 0.0654 | 0.4759 | 0.4536 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0654 | 0.4759 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0654 | 0.4759 | 0.7233 |
Brugia malayi | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Echinococcus granulosus | geminin | 0.0181 | 0.101 | 0.1384 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1356 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | ORL1-like opioid receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | sulfakinin receptor protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | G-protein coupled receptor | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.178 | 0.374 |
Brugia malayi | RE15519p | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | Serotonin receptor | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.101 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | 0.0105 | 0.0407 | 0.5 | |
Loa Loa (eye worm) | hyaluronidase | 0.0654 | 0.4759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0105 | 0.0407 | 0.5 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.101 | 0.0628 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0407 | 0.0856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -29 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for the compound at dose 100 mg/kg | ChEMBL. | 6481768 |
Change (functional) | = -25 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for Indomethacin 4.0 mg/kg | ChEMBL. | 6481768 |
Change (functional) | = -3 % | Percentage change in volume of pleural fluid in the 5-h Evans Blue-Carrageenan pleural assay for the compound at dose 4 mg/kg | ChEMBL. | 6481768 |
Efficacy ratio (functional) | = 1.43 | Oral antiinflammatory activity, measured in rats at the dose of 316 mg/kg | ChEMBL. | 6481768 |
Efficacy ratio (functional) | = 1.46 | Oral antiinflammatory activity, measured in rats at the dose of 316 mg/kg | ChEMBL. | 6481768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.