Detailed information for compound 337047

Basic information

Technical information
  • TDR Targets ID: 337047
  • Name: 2-[4-(furan-2-yl)-8-morpholin-4-ylsulfonyl-1, 3-dioxopyrrolo[3,4-c]quinolin-2-yl]ethyl acet ate
  • MW: 499.493 | Formula: C23H21N3O8S
  • H donors: 0 H acceptors: 6 LogP: 0.59 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCCN1C(=O)c2c(C1=O)c1cc(ccc1nc2c1ccco1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C23H21N3O8S/c1-14(27)33-12-8-26-22(28)19-16-13-15(35(30,31)25-6-10-32-11-7-25)4-5-17(16)24-21(20(19)23(26)29)18-3-2-9-34-18/h2-5,9,13H,6-8,10-12H2,1H3
  • InChiKey: NQKDMUZXDTVKOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(2-furyl)-8-morpholinosulfonyl-1,3-dioxo-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
  • acetic acid 2-[4-(2-furyl)-8-morpholinosulfonyl-1,3-dioxo-2-pyrrolo[3,4-c]quinolinyl]ethyl ester
  • 2-[4-(furan-2-yl)-8-morpholin-4-ylsulfonyl-1,3-dioxo-pyrrolo[3,4-c]quinolin-2-yl]ethyl ethanoate
  • acetic acid 2-[4-(2-furyl)-1,3-diketo-8-morpholinosulfonyl-pyrrolo[3,4-c]quinolin-2-yl]ethyl ester
  • 2-(4-furan-2-yl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
  • 2-(4-furan-2-yl-8-morpholin-4-ylsulfonyl-1,3-dioxo-pyrrolo[3,4-c]quinolin-2-yl)ethyl ethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L 0.0181 0.0877 0.0875
Echinococcus multilocularis cysteine protease 0.0422 0.2295 0.2293
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0584 0.0754
Echinococcus multilocularis cathepsin L 0.0129 0.0575 0.0573
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.0489 0.0631
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Trypanosoma brucei Polypeptide deformylase 1 0.0171 0.0818 0.2403
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Giardia lamblia Cysteine protease 0.0129 0.0575 0.1992
Echinococcus granulosus TGF beta signal transducer SmadC 0.0057 0.0151 0.0149
Brugia malayi Papain family cysteine protease containing protein 0.0422 0.2295 0.2961
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0065 0.0063
Echinococcus multilocularis geminin 0.1731 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0115 0.0489 0.0487
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0575 0.2346
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0129 0.0575 0.2346
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0012 0.0015
Brugia malayi MH1 domain containing protein 0.0057 0.0151 0.0194
Trichomonas vaginalis ran, putative 0.0042 0.0059 0.0204
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0054 0.0052
Giardia lamblia Cathepsin B precursor 0.0129 0.0575 0.1992
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0181 0.0877 0.2579
Echinococcus granulosus cathepsin L 0.0181 0.0877 0.0875
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0054 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0575 0.2467
Loa Loa (eye worm) hypothetical protein 0.037 0.1993 0.2571
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.0877 0.0875
Echinococcus granulosus cathepsin L 0.0129 0.0575 0.0573
Leishmania major DNA damage repair protein, putative 0.0036 0.0023 0.0062
Echinococcus granulosus caspase 2 0.0063 0.0186 0.0183
Entamoeba histolytica cysteine proteinase 1, putative 0.0181 0.0877 0.379
Mycobacterium tuberculosis Conserved hypothetical protein 0.0115 0.0489 0.1718
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0497 0.1752
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0023 0.0062
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0519 0.0517
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0012 0.0035
Trypanosoma brucei trypanothione reductase 0.0046 0.0083 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0489 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0575 0.0742
Schistosoma mansoni importin beta-1 0.0057 0.0147 0.0145
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0019 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0057 0.0151 0.0194
Entamoeba histolytica cysteine protease, putative 0.0422 0.2295 1
Toxoplasma gondii hypothetical protein 0.0447 0.2445 0.8748
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0605 0.3376 0.4356
Plasmodium falciparum serine repeat antigen 3 0.0129 0.0575 0.2346
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0054 0.0052
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0519 0.0517
Echinococcus granulosus cathepsin b 0.1349 0.775 0.775
Echinococcus granulosus histone deacetylase 6 0.0043 0.0065 0.0063
Echinococcus granulosus histone deacetylase 6 0.0043 0.0065 0.0063
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1195 0.1193
Schistosoma mansoni terminal deoxycytidyl transferase 0.0115 0.0489 0.0487
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.0489 0.196
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0519 0.0517
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Trypanosoma cruzi cysteine peptidase, putative 0.0609 0.3395 0.4378
Plasmodium falciparum serine repeat antigen 6 0.0129 0.0575 0.2346
Trypanosoma cruzi cysteine proteinase, putative 0.0181 0.0877 0.1129
Trypanosoma brucei unspecified product 0.0115 0.0489 0.1435
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0147 0.052
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1349 0.775 0.775
Plasmodium vivax histone deacetylase, putative 0.0043 0.0065 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1349 0.775 0.775
Echinococcus granulosus caspase 0.012 0.0519 0.0517
Plasmodium falciparum cysteine proteinase falcipain 1 0.0181 0.0877 0.3582
Plasmodium vivax glutathione reductase, putative 0.0046 0.0083 0.0331
Giardia lamblia Cysteine protease 0.0129 0.0575 0.1992
Schistosoma mansoni ran 0.0042 0.0059 0.0057
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Echinococcus multilocularis cathepsin b 0.1349 0.775 0.775
Brugia malayi cathepsin L-like precursor 0.037 0.1993 0.2571
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0584 0.0582
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0575 0.1992
Loa Loa (eye worm) fibroinase 0.0422 0.2295 0.2961
Entamoeba histolytica cysteine proteinase 2 0.0181 0.0877 0.379
Echinococcus multilocularis histone deacetylase 0.0043 0.0065 0.0063
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Echinococcus multilocularis caspase 3 0.0088 0.033 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0575 0.2052
Giardia lamblia Cysteine protease 0.0129 0.0575 0.1992
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0584 0.0582
Leishmania major cathepsin L-like protease 0.0609 0.3395 1
Brugia malayi Cathepsin L-like precursor 0.037 0.1993 0.2571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1195 0.1193
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0023 0.0021
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0012 0.0029
Echinococcus granulosus aminopeptidase N 0.0034 0.0012 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0489 0.1435
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0447 0.2445 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1195 0.1193
Schistosoma mansoni hypothetical protein 0.0035 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.037 0.1993 0.2571
Leishmania major cysteine peptidase A (CPA) 0.0422 0.2295 0.6758
Brugia malayi glutathione reductase 0.0046 0.0083 0.0107
Trypanosoma cruzi Peptide deformylase 2, putative 0.0171 0.0818 0.1052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1349 0.775 0.775
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0186 0.0183
Schistosoma mansoni smad 0.0057 0.0151 0.0149
Leishmania major histone deacetylase, putative 0.0043 0.0065 0.0185
Schistosoma mansoni DNA polymerase eta 0.0115 0.0489 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0147 0.0428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Entamoeba histolytica cysteine proteinase, putative 0.037 0.1993 0.8677
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Giardia lamblia Cathepsin B precursor 0.0129 0.0575 0.1992
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Loa Loa (eye worm) hypothetical protein 0.0051 0.0116 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Leishmania major cathepsin L-like protease 0.0422 0.2295 0.6758
Brugia malayi Cell death protein 3 precursor 0.0063 0.0186 0.0239
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0575 0.2346
Leishmania major cathepsin L-like protease 0.0422 0.2295 0.6758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0575 0.2052
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0575 0.0742
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0059 0.0057
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0023 0.0027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0428 0.1461
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0129 0.0575 0.2346
Plasmodium falciparum glutathione reductase 0.0046 0.0083 0.0331
Echinococcus multilocularis Smad4 0.0057 0.0151 0.0149
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1349 0.775 1
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.0489 0.0631
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.007
Brugia malayi prolyl oligopeptidase family protein 0.0346 0.185 0.2387
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0181 0.0877 0.1129
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0083 0.0081
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0065 0.0063
Echinococcus multilocularis cathepsin L cysteine protease 0.0422 0.2295 0.2293
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0084
Schistosoma mansoni smad1 5 8 and 0.0057 0.0151 0.0149
Plasmodium vivax peptide deformylase, putative 0.0447 0.2445 1
Trypanosoma cruzi cysteine peptidase, putative 0.0609 0.3395 0.4378
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0023 0.0086
Trypanosoma cruzi Peptide deformylase 2, putative 0.0171 0.0818 0.1052
Echinococcus multilocularis caspase 2 0.0063 0.0186 0.0183
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0422 0.2295 0.2293
Loa Loa (eye worm) cathepsin B 0.0507 0.2794 0.3605
Leishmania major cathepsin L-like protease 0.0609 0.3395 1
Plasmodium falciparum histone deacetylase 2 0.0043 0.0065 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0489 0.1435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0575 0.2052
Loa Loa (eye worm) prolyl oligopeptidase 0.0346 0.185 0.2387
Toxoplasma gondii cathepsin CPC2 0.0129 0.0575 0.2052
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0065 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0609 0.3395 0.4378
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0129 0.0575 0.2052
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0023 0.0075
Echinococcus multilocularis smad 0.0057 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0051 0.0116 0.0149
Plasmodium falciparum thioredoxin reductase 0.0046 0.0083 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Loa Loa (eye worm) ctsf protein 0.0422 0.2295 0.2961
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0023 0.0062
Echinococcus multilocularis snurportin 1 0.0605 0.3376 0.3374
Brugia malayi cathepsin B-like cysteine proteinase 0.1349 0.775 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0115 0.0489 0.0487
Toxoplasma gondii thioredoxin reductase 0.0046 0.0083 0.0289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1195 0.1193
Echinococcus granulosus cathepsin l1 0.0422 0.2295 0.2293
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0116 0.0149
Trichomonas vaginalis DNA polymerase eta, putative 0.0115 0.0489 0.1743
Brugia malayi Papain family cysteine protease containing protein 0.0181 0.0877 0.1132
Schistosoma mansoni Smad4 0.0057 0.0151 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.0877 0.379
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.0489 0.1435
Echinococcus granulosus cysteine protease 0.0181 0.0877 0.0875
Brugia malayi Cathepsin L-like precursor 0.0051 0.0116 0.0149
Echinococcus granulosus cathepsin l1 0.037 0.1993 0.1991
Brugia malayi MH2 domain containing protein 0.0841 0.4761 0.6143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.0877 0.0875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0116 0.0498 0.1777
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0116 0.0498 0.064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0129 0.0575 0.2346
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0065 0.0063
Plasmodium falciparum peptide deformylase 0.0447 0.2445 1
Giardia lamblia Cathepsin L-like protease 0.0129 0.0575 0.1992
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.0877 0.379
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0181 0.0877 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0575 0.2052
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0497 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.037 0.1993 0.713
Schistosoma mansoni cathepsin s 0.0051 0.0116 0.0113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0116 0.0149
Entamoeba histolytica hypothetical protein 0.0035 0.0019 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2295 1
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0447 0.2445 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0147 0.019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0059 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0575 0.0742
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Entamoeba histolytica deoxycytidyl transferase, putative 0.0115 0.0489 0.2089
Giardia lamblia Cysteine protease 0.0129 0.0575 0.1992
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Toxoplasma gondii cathepsin B 0.0507 0.2794 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0129 0.0575 0.2346
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Leishmania major GTP-binding protein, putative 0.0042 0.0059 0.0168
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0116 0.0498 0.1462
Plasmodium falciparum cysteine proteinase falcipain 3 0.0422 0.2295 0.9386
Plasmodium falciparum serine repeat antigen 2 0.0129 0.0575 0.2346
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0584 0.0582
Loa Loa (eye worm) MH1 domain-containing protein 0.0057 0.0151 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0083 0.0107
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0497 0.1752
Echinococcus multilocularis cysteine protease 0.0422 0.2295 0.2293
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Toxoplasma gondii preprocathepsin c precursor, putative 0.0129 0.0575 0.2052
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Brugia malayi MH2 domain containing protein 0.0057 0.0151 0.0194
Echinococcus multilocularis cathepsin b 0.1349 0.775 0.775
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0057 0.0151 0.0149
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0083 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0279 0.0817
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0023 0.0075
Plasmodium falciparum serine repeat antigen 8 0.0129 0.0575 0.2346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Echinococcus granulosus histone deacetylase 7 0.0043 0.0065 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Echinococcus multilocularis dna polymerase eta 0.0115 0.0489 0.0487
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.007
Trypanosoma brucei unspecified product 0.0079 0.0279 0.0817
Onchocerca volvulus 0.0422 0.2295 1
Trypanosoma brucei unspecified product 0.0079 0.0279 0.0817
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0129 0.0575 0.2346
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.1195 0.1193
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0003
Loa Loa (eye worm) glutathione reductase 0.0046 0.0083 0.0107
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0428 0.1461
Loa Loa (eye worm) RNA binding protein 0.0131 0.0584 0.0754
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Echinococcus multilocularis aminopeptidase N 0.0034 0.0012 0.001
Giardia lamblia Cathepsin B precursor 0.0129 0.0575 0.1992
Echinococcus granulosus Smad4 0.0057 0.0151 0.0149
Onchocerca volvulus Cathepsin L homolog 0.0422 0.2295 1
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Plasmodium falciparum serine repeat antigen 7 0.0129 0.0575 0.2346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0019 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Echinococcus granulosus cathepsin L cysteine protease 0.0181 0.0877 0.0875
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0422 0.2295 0.2961
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0575 0.0573
Brugia malayi Cathepsin L-like precursor 0.037 0.1993 0.2571
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0115 0.0489 0.1743
Leishmania major polypeptide deformylase-like protein, putative 0.0171 0.0818 0.2403
Leishmania major cathepsin L-like protease 0.0422 0.2295 0.6758
Loa Loa (eye worm) hypothetical protein 0.0182 0.0883 0.114
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0012 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Schistosoma mansoni cathepsin F (C01 family) 0.0422 0.2295 0.2293
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0065 0.0185
Entamoeba histolytica Ran family GTPase 0.0042 0.0059 0.0207
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0129 0.0575 0.0742
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0023 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0279 0.0817
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0065 0.0081
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0012 0.0035
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0116 0.0498 0.0496
Plasmodium vivax vivapain-2 0.0422 0.2295 0.9386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0575 0.0573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0084 0.0294
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0023 0.0027
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0422 0.2295 0.2961
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0507 0.2794 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0346 0.185 0.8051
Loa Loa (eye worm) hypothetical protein 0.0115 0.0489 0.0631
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Trypanosoma cruzi cruzipain precursor, putative 0.0609 0.3395 0.4378
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0147 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0422 0.2295 0.8211
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0002 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0422 0.2295 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0116 0.0498 0.1462
Brugia malayi MH2 domain containing protein 0.0057 0.0151 0.0194
Trypanosoma brucei histone deacetylase 4 0.0043 0.0065 0.0185
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.0489 0.1435
Plasmodium vivax vivapain-1 0.0181 0.0877 0.3582
Plasmodium vivax importin-beta 2, putative 0.0057 0.0147 0.0594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0575 0.2052
Plasmodium vivax unspecified product 0.0181 0.0877 0.3582
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Giardia lamblia Hypothetical protein 0.0129 0.0575 0.1992
Entamoeba histolytica hypothetical protein 0.0035 0.0019 0.0029
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0171 0.0818 0.1052
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0233
Onchocerca volvulus 0.0422 0.2295 1
Brugia malayi Histone deacetylase family protein 0.0043 0.0065 0.0084
Schistosoma mansoni cathepsin B (C01 family) 0.0129 0.0575 0.0573
Leishmania major DNA polymerase eta, putative 0.0036 0.0023 0.0062
Echinococcus granulosus caspase 3 0.0088 0.033 0.0328
Toxoplasma gondii cathepsin CPC1 0.0129 0.0575 0.2052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0422 0.2295 0.8211
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0497 0.1752
Loa Loa (eye worm) cysteine protease 0.0422 0.2295 0.2961
Echinococcus granulosus histone deacetylase 0.0043 0.0065 0.0063
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.0168
Onchocerca volvulus 0.037 0.1993 0.8677
Trypanosoma cruzi major cysteine proteinase, putative 0.0129 0.0575 0.0739
Loa Loa (eye worm) MH2 domain-containing protein 0.0841 0.4761 0.6143
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0279 0.0817
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.0074
Brugia malayi hypothetical protein 0.0034 0.0012 0.0015
Leishmania major cathepsin L-like protease 0.0609 0.3395 1
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0575 0.0742
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0171 0.0818 0.1052
Trypanosoma brucei Peptide deformylase 2 0.0171 0.0818 0.2403
Echinococcus granulosus importin subunit beta 1 0.0057 0.0147 0.0145
Leishmania major DNA polymerase kappa, putative 0.0036 0.0023 0.0062
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0065 0.0224
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0584 0.0582
Entamoeba histolytica hypothetical protein 0.0035 0.0019 0.0029
Echinococcus granulosus cathepsin L cysteine proteinase 0.0422 0.2295 0.2293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0129 0.0575 0.2052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.037 0.1993 0.713
Onchocerca volvulus 0.0041 0.0054 0.0186
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0012 0.0015
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Schistosoma mansoni hypothetical protein 0.0041 0.0054 0.0052
Echinococcus granulosus snurportin 1 0.0605 0.3376 0.3374
Echinococcus granulosus dna polymerase eta 0.0115 0.0489 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Leishmania major importin beta-1 subunit, putative 0.0046 0.0084 0.0242
Giardia lamblia Hypothetical protein 0.0129 0.0575 0.1992
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0575 0.2052
Trypanosoma brucei cysteine peptidase C (CPC) 0.0507 0.2794 0.823
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0084 0.0294
Plasmodium falciparum serine repeat antigen 4 0.0129 0.0575 0.2346
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0023 0.0062
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0575 0.0742
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0012 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1349 0.775 0.775
Toxoplasma gondii cathepsin CPL 0.0422 0.2295 0.8211
Plasmodium vivax unspecified product 0.0051 0.0116 0.0464
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0575 0.0573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Mycobacterium ulcerans peptide deformylase 0.0447 0.2445 1
Onchocerca volvulus 0.0129 0.0575 0.2467
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0447 0.2445 0.5
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Giardia lamblia Cathepsin L-like protease 0.0129 0.0575 0.1992
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0575 0.2346
Giardia lamblia Cathepsin L precursor 0.0129 0.0575 0.1992
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0019 0.0016
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0027
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0041 0.0038
Brugia malayi RNA, U transporter 1 0.0161 0.0763 0.0984
Trypanosoma cruzi cysteine proteinase, putative 0.0181 0.0877 0.1129
Echinococcus granulosus cathepsin b 0.1349 0.775 0.775
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.1907 0.5614
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0041 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0356 0.1907 0.246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.0877 0.379
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0084 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Trypanosoma cruzi major cysteine proteinase, putative 0.0316 0.1675 0.2159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Plasmodium falciparum histone deacetylase, putative 0.0043 0.0065 0.0257
Brugia malayi Importin beta-1 subunit 0.0057 0.0147 0.019
Brugia malayi polk-prov protein 0.0036 0.0023 0.003
Leishmania major trypanothione reductase 0.0046 0.0083 0.0238
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0076
Echinococcus granulosus histone deacetylase 6 0.0043 0.0065 0.0063
Brugia malayi prolyl oligopeptidase family protein 0.0116 0.0498 0.0643
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0116 0.0498 0.1462
Brugia malayi cathepsin F-like cysteine proteinase 0.0129 0.0575 0.0742
Onchocerca volvulus 0.0422 0.2295 1
Leishmania major cathepsin L-like protease 0.0422 0.2295 0.6758
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0428 0.1461
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0575 0.2052
Schistosoma mansoni smad1 5 8 and 0.0057 0.0151 0.0149
Plasmodium vivax unspecified product 0.0129 0.0575 0.2346
Giardia lamblia Cathepsin B precursor 0.0507 0.2794 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0023 0.0086
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0054 0.007
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0575 0.1992
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0422 0.2295 0.9386
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0065 0.0257
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0065 0.0063
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0507 0.2794 0.3604
Brugia malayi Smad1 0.0057 0.0151 0.0194
Giardia lamblia Cathepsin B precursor 0.0129 0.0575 0.1992
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0186 0.076
Schistosoma mansoni hypothetical protein 0.1731 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0575 0.2346
Plasmodium vivax vivapain-2 0.0422 0.2295 0.9386
Brugia malayi TAR-binding protein 0.0131 0.0584 0.0754
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0012 0.0013
Leishmania major cathepsin L-like protease 0.0422 0.2295 0.6758
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0489 0.0628
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0129 0.0575 0.2346
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0065 0.0081
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0116 0.0146
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Brugia malayi RNA binding protein 0.0131 0.0584 0.0754
Onchocerca volvulus 0.0422 0.2295 1
Onchocerca volvulus 0.0422 0.2295 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0023 0.0046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0115 0.0489 0.0487
Loa Loa (eye worm) hypothetical protein 0.0051 0.0116 0.0149
Brugia malayi hypothetical protein 0.0089 0.0337 0.0435
Echinococcus multilocularis dna polymerase kappa 0.0115 0.0489 0.0487
Leishmania major histone deacetylase, putative 0.0043 0.0065 0.0185
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0129 0.0575 0.2346
Brugia malayi hypothetical protein 0.0035 0.0019 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.1195 0.1193
Trypanosoma brucei histone deacetylase 3 0.0043 0.0065 0.0185
Brugia malayi Cathepsin L-like cysteine proteinase 0.037 0.1993 0.2571
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0065 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Brugia malayi MH1 domain containing protein 0.0057 0.0151 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0129 0.0575 0.2052
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0129 0.0575 0.2052
Plasmodium falciparum importin beta, putative 0.0057 0.0147 0.0594
Echinococcus granulosus cathepsin l cysteine peptidase 0.0422 0.2295 0.2293
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0129 0.0575 0.0742
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.1907 0.2458
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0083 0.0331
Schistosoma mansoni cathepsin C 0.0129 0.0575 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Mycobacterium tuberculosis Probable reductase 0.0104 0.0428 0.1461
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0023 0.0075
Giardia lamblia Cathepsin B precursor 0.0129 0.0575 0.1992
Leishmania major DNA polymerase eta, putative 0.0115 0.0489 0.1435
Echinococcus multilocularis caspase 0.012 0.0519 0.0517
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0023 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.0877 0.3133
Brugia malayi cathepsin L precursor 0.0129 0.0575 0.0742
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0575 0.0573
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0116 0.0498 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0575 0.2052
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.1907 0.246
Treponema pallidum polypeptide deformylase (def) 0.0447 0.2445 0.5
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0065 0.0084
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0584 0.0754
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0012 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0115 0.0489 0.0628
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0575 0.0573
Leishmania major DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Brugia malayi Thioredoxin reductase 0.0046 0.0083 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Schistosoma mansoni hypothetical protein 0.0605 0.3376 0.3374
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0115 0.0489 0.0631
Echinococcus granulosus Dipeptidyl peptidase 9 0.0116 0.0498 0.0496
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0129 0.0575 0.0573
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0129 0.0575 0.2346
Onchocerca volvulus 0.0422 0.2295 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0041 0.0054 0.0052
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0012 0.0029
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0116 0.0498 0.064
Loa Loa (eye worm) hypothetical protein 0.1349 0.775 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0235 0.1195 0.1542
Plasmodium falciparum serine repeat antigen 5 0.0129 0.0575 0.2346
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Echinococcus granulosus smad 0.0057 0.0151 0.0149
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0083 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0422 0.2295 0.2959
Plasmodium falciparum serine repeat antigen 1 0.0129 0.0575 0.2346
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0012 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0181 0.0877 0.1129
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0489 0.1435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0181 0.0877 0.2579
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0575 0.0573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Loa Loa (eye worm) histone deacetylase 0.0043 0.0065 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0181 0.0877 0.1132
Loa Loa (eye worm) transcription factor SMAD2 0.0841 0.4761 0.6143
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0422 0.2295 0.9386
Trypanosoma cruzi cysteine protease, putative 0.0181 0.0877 0.1129
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0575 0.0742
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0584 0.0754
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.0489 0.196
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0428 0.1461
Echinococcus granulosus dna polymerase kappa 0.0115 0.0489 0.0487
Loa Loa (eye worm) hypothetical protein 0.0063 0.0186 0.0239
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0059 0.0233
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0557 0.3093 0.3989
Schistosoma mansoni cathepsin F (C01 family) 0.037 0.1993 0.1991
Trypanosoma brucei DNA polymerase eta, putative 0.0115 0.0489 0.1435
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0507 0.2794 0.823
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0012 0.001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0059 0.0204
Chlamydia trachomatis peptide deformylase 0.0447 0.2445 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0181 0.0877 0.3133
Echinococcus multilocularis cathepsin L cysteine protease 0.0422 0.2295 0.2293
Plasmodium vivax vivapain-3 0.0181 0.0877 0.3582
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0346 0.185 0.1848
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0129 0.0575 0.2346
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0346 0.185 0.1848
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0428 0.1461
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0422 0.2295 0.2293
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.0489 0.1718
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0116 0.0149
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0023 0.0062
Onchocerca volvulus 0.0422 0.2295 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0346 0.185 0.1848
Echinococcus granulosus inhibitor of apoptosis protein 0.0041 0.0054 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0575 0.2052
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0041 0.0054 0.0052
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0575 0.0742
Schistosoma mansoni smad1 5 8 and 0.0057 0.0151 0.0149
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0147 0.0428
Entamoeba histolytica hypothetical protein 0.0046 0.0084 0.0316
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0129 0.0575 0.2346
Onchocerca volvulus Deterin homolog 0.0041 0.0054 0.0186
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0489 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0129 0.0575 0.2346
Onchocerca volvulus Cathepsin L homolog 0.0129 0.0575 0.2467
Brugia malayi cathepsin L-like cysteine proteinase 0.0129 0.0575 0.0742
Brugia malayi fibroinase precursor 0.0129 0.0575 0.0742
Giardia lamblia DINP protein human, muc B family 0.0115 0.0489 0.168
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0116 0.0146
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0575 0.2467
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.1907 0.5614
Plasmodium falciparum serine repeat antigen 9 0.0129 0.0575 0.2346
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0519 0.0517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0422 0.2295 0.8211
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Echinococcus granulosus tar DNA binding protein 0.0131 0.0584 0.0582
Entamoeba histolytica hypothetical protein 0.0129 0.0575 0.2467
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0575 0.1992
Entamoeba histolytica hypothetical protein 0.0035 0.0019 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Echinococcus granulosus mothers against decapentaplegic 5 0.0057 0.0151 0.0149
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0012 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0507 0.2794 0.2793
Schistosoma mansoni cathepsin S (C01 family) 0.0129 0.0575 0.0573
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0129 0.0575 0.0573
Giardia lamblia Cathepsin B precursor 0.0507 0.2794 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0584 0.0582
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0575 0.2052
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0129 0.0575 0.1992
Schistosoma mansoni hypothetical protein 0.1731 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0337 0.0435
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.2295 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0584 0.0582
Brugia malayi Histone deacetylase family protein 0.0043 0.0065 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0023 0.0062
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0012 0.001
Giardia lamblia Encystation-specific protease 0.0129 0.0575 0.1992
Giardia lamblia Cathepsin B precursor 0.0507 0.2794 1
Schistosoma mansoni ran 0.0042 0.0059 0.0057
Entamoeba histolytica cysteine protease, putative 0.0181 0.0877 0.379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0609 0.3395 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0084 0.0106
Onchocerca volvulus Cathepsin F homolog 0.0422 0.2295 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0575 0.0742
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0575 0.0573
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0057 0.0151 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0422 0.2295 0.2293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.1195 0.1193
Loa Loa (eye worm) hypothetical protein 0.0422 0.2295 0.2961
Entamoeba histolytica cysteine proteinase, putative 0.0181 0.0877 0.379
Loa Loa (eye worm) Smad1 0.0057 0.0151 0.0194
Brugia malayi Cathepsin L-like precursor 0.0422 0.2295 0.2961
Echinococcus multilocularis mothers against decapentaplegic 5 0.0057 0.0151 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.2295 0.8211
Loa Loa (eye worm) hypothetical protein 0.037 0.1993 0.2571
Entamoeba histolytica cysteine protease, putative 0.0129 0.0575 0.2467
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0012 0.0029
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0023 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.0489 0.0628
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0235 0.1195 0.1542

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 36 nM In vitro inhibitory concentration against human caspase-3 ChEMBL. 15916416
IC50 (binding) = 36 nM In vitro inhibitory concentration against human caspase-3 ChEMBL. 15916416

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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