Detailed information for compound 337807

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.379 | Formula: C21H17N3O2
  • H donors: 2 H acceptors: 3 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)Nc1ccc(cc1)C(=O)/C=C/c1ccccn1
  • InChi: 1S/C21H17N3O2/c25-20(14-13-17-6-4-5-15-22-17)16-9-11-19(12-10-16)24-21(26)23-18-7-2-1-3-8-18/h1-15H,(H2,23,24,26)/b14-13+
  • InChiKey: JFNGAUFZLKYYQT-BUHFOSPRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit beta 0.007 0.1278 0.1278
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0356 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Schistosoma mansoni intermediate filament proteins 0.0041 0.0481 0.0481
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 1
Loa Loa (eye worm) polyprenyl synthetase 0.0257 0.6456 0.6456
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Brugia malayi Cation transporter family protein 0.007 0.1278 0.1278
Brugia malayi Polyprenyl synthetase family protein 0.0128 0.288 0.288
Brugia malayi Cation transporter family protein 0.007 0.1278 0.1278
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.007 0.1278 0.1278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0143 0.0143
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.007 0.1278 0.1278
Brugia malayi Polyprenyl synthetase family protein 0.0257 0.6456 0.6456
Entamoeba histolytica hexokinase 2 0.0125 0.2812 0.975
Loa Loa (eye worm) hypothetical protein 0.0088 0.1786 0.1786
Brugia malayi Hexokinase family protein 0.0079 0.1525 0.1525
Loa Loa (eye worm) hypothetical protein 0.0118 0.2613 0.2613
Echinococcus multilocularis muscleblind protein 0.0118 0.2613 0.2613
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Loa Loa (eye worm) ACC-1 protein 0.007 0.1278 0.1278
Onchocerca volvulus Huntingtin homolog 0.0088 0.1786 0.6301
Loa Loa (eye worm) hypothetical protein 0.004 0.0457 0.0457
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0356 0.0356
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0126 0.2835 0.2835
Onchocerca volvulus 0.007 0.1278 0.4507
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0128 0.288 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Onchocerca volvulus Hexokinase homolog 0.0079 0.1525 0.538
Loa Loa (eye worm) GABA receptor subunit 0.0056 0.0914 0.0914
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0041 0.0481 0.0481
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0257 0.6456 1
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0386 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0126 0.2835 0.2835
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis glycine receptor subunit beta 0.007 0.1278 0.1278
Brugia malayi hypothetical protein 0.0088 0.1786 0.1786
Echinococcus granulosus survival motor neuron protein 1 0.017 0.4044 0.4044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Brugia malayi MH2 domain containing protein 0.0086 0.1725 0.1725
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0128 0.288 1
Brugia malayi hypothetical protein 0.0028 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.007 0.1278 0.1278
Onchocerca volvulus 0.0056 0.0914 0.3225
Echinococcus multilocularis musashi 0.0041 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Schistosoma mansoni glutathione synthetase 0.0128 0.288 0.288
Schistosoma mansoni lamin 0.0041 0.0481 0.0481
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.004 0.0457 0.0457
Loa Loa (eye worm) hexokinase 0.0039 0.0428 0.0428
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0056 0.0914 0.0914
Echinococcus multilocularis glycine receptor subunit beta 0.007 0.1278 0.1278
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0128 0.288 0.288
Echinococcus granulosus nAChR subunit 0.0056 0.0914 0.0914
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0094 0.1957 0.1957
Brugia malayi Intermediate filament tail domain containing protein 0.0041 0.0481 0.0481
Schistosoma mansoni survival motor neuron protein 0.0035 0.0315 0.0315
Echinococcus multilocularis hexokinase type 2 0.0125 0.2812 0.2812
Giardia lamblia Farnesyl diphosphate synthase 0.0257 0.6456 0.5
Loa Loa (eye worm) hexokinase 0.0125 0.2812 0.2812
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0056 0.0914 0.0914
Onchocerca volvulus 0.0125 0.2812 0.9917
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis lamin dm0 0.0041 0.0481 0.0481
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0257 0.6456 1
Onchocerca volvulus 0.0079 0.1525 0.538
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0257 0.6456 0.507
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0257 0.6456 0.507
Loa Loa (eye worm) hypothetical protein 0.0088 0.1786 0.1786
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Trypanosoma cruzi polyprenyl synthase, putative 0.0386 1 1
Schistosoma mansoni trans-prenyltransferase 0.0128 0.288 0.288
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.007 0.1278 0.1278
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0257 0.6456 1
Onchocerca volvulus 0.007 0.1278 0.4507
Loa Loa (eye worm) hypothetical protein 0.0118 0.2613 0.2613
Onchocerca volvulus 0.0041 0.0481 0.1697
Onchocerca volvulus 0.0035 0.0315 0.1111
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.007 0.1278 0.1278
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0386 1 1
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0128 0.288 0.288
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Entamoeba histolytica hypothetical protein 0.0056 0.0914 0.2817
Schistosoma mansoni hypothetical protein 0.0028 0.0143 0.0143
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0094 0.1957 0.1957
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0386 1 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0128 0.288 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Loa Loa (eye worm) hexokinase 0.0125 0.2812 0.2812
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Onchocerca volvulus 0.0126 0.2835 1
Loa Loa (eye worm) intermediate filament protein 0.0041 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0085 0.1714 0.1714
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.004 0.0461 0.0461
Onchocerca volvulus 0.0041 0.0481 0.1697
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Onchocerca volvulus 0.0126 0.2835 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hexokinase type II 0.0125 0.2812 0.2812
Brugia malayi hexokinase 0.0125 0.2812 0.2812
Onchocerca volvulus 0.0126 0.2835 1
Brugia malayi Cation transporter family protein 0.0126 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 0.5
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0914 0.0914
Leishmania major farnesyl pyrophosphate synthase 0.0257 0.6456 0.507
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.007 0.1278 0.1278
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.007 0.1278 0.1278
Echinococcus multilocularis muscleblind protein 1 0.0118 0.2613 0.2613
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Onchocerca volvulus 0.007 0.1278 0.4507
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Brugia malayi Zinc finger, C2H2 type family protein 0.0244 0.6096 0.6096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0356 0.0356
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0257 0.6456 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Leishmania major solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0095
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Leishmania major polyprenyl synthase, putative 0.0386 1 1
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0128 0.288 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Echinococcus granulosus glycine receptor subunit beta 0.007 0.1278 0.1278
Brugia malayi Hexokinase family protein 0.0039 0.0428 0.0428
Loa Loa (eye worm) polyprenyl synthetase 0.0128 0.288 0.288
Onchocerca volvulus Huntingtin homolog 0.0088 0.1786 0.6301
Schistosoma mansoni nAChR subunit 0.007 0.1278 0.1278
Onchocerca volvulus Putative nachr subunit 0.0094 0.1957 0.6903
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0128 0.288 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0914 0.0914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Echinococcus multilocularis nAChR subunit 0.007 0.1278 0.1278
Trypanosoma cruzi polyprenyl synthase, putative 0.0386 1 1
Brugia malayi hexokinase type II 0.004 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0113 0.2472 0.2472
Loa Loa (eye worm) hypothetical protein 0.017 0.4044 0.4044
Loa Loa (eye worm) zinc finger protein 0.0244 0.6096 0.6096
Echinococcus granulosus lamin dm0 0.0041 0.0481 0.0481
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0356 0.0356
Echinococcus multilocularis glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0128 0.288 1
Echinococcus multilocularis lamin 0.0041 0.0481 0.0481
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0094 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0126 0.2835 0.2835
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0126 0.2835 0.2835
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0257 0.6456 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0094 0.1957 0.1957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0356 0.0356
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0315 0.0315
Echinococcus granulosus intermediate filament protein 0.0041 0.0481 0.0481
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0128 0.288 0.288
Loa Loa (eye worm) transcription factor SMAD2 0.0086 0.1725 0.1725
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0094 0.1957 0.1957
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.007 0.1278 0.1278
Echinococcus granulosus zinc finger transcription factor gli2 0.0244 0.6096 0.6096
Echinococcus granulosus muscleblind protein 0.0118 0.2613 0.2613
Onchocerca volvulus 0.0125 0.2812 0.9917
Brugia malayi Hexokinase family protein 0.0125 0.2812 0.2812
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0128 0.288 0.0188
Echinococcus multilocularis survival motor neuron protein 1 0.017 0.4044 0.4044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0056 0.0914 0.0914
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.007 0.1278 0.1278
Onchocerca volvulus 0.0056 0.0914 0.3225
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0128 0.288 0.0095
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.007 0.1278 0.1278
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.007 0.1278 0.1278
Echinococcus granulosus lamin 0.0041 0.0481 0.0481
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.007 0.1278 0.1278
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0386 1 1
Entamoeba histolytica hexokinase 1 0.0125 0.2812 0.975
Echinococcus granulosus hexokinase 0.0125 0.2812 0.2812
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.007 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0143 0.0143
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.007 0.1278 0.1278
Loa Loa (eye worm) hexokinase 0.0079 0.1525 0.1525
Schistosoma mansoni lamin 0.0041 0.0481 0.0481
Loa Loa (eye worm) LGC-31 protein 0.007 0.1278 0.1278
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.007 0.1278 0.1278
Echinococcus granulosus nAChR subunit 0.007 0.1278 0.1278
Treponema pallidum octaprenyl-diphosphate synthase 0.0386 1 1
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0128 0.288 0.288
Brugia malayi hypothetical protein 0.017 0.4044 0.4044
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0094 0.1957 0.1957
Schistosoma mansoni hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) MH2 domain-containing protein 0.0086 0.1725 0.1725
Echinococcus granulosus glycine receptor subunit alpha 1 0.007 0.1278 0.1278
Echinococcus multilocularis hexokinase 0.0125 0.2812 0.2812
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0041 0.0481 0.0481
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0143 0.0143
Echinococcus multilocularis zinc finger transcription factor gli2 0.0244 0.6096 0.6096
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.007 0.1278 0.1278
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.007 0.1278 0.1278
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0094 0.1957 0.1957
Onchocerca volvulus 0.0125 0.2812 0.9917
Brugia malayi excitatory GABA receptor EXP-1A 0.007 0.1278 0.1278
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0257 0.6456 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0315 0.0315
Brugia malayi Muscleblind-like protein 0.0118 0.2613 0.2613
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.007 0.1278 0.1278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0356 0.0356
Echinococcus granulosus hexokinase type 2 0.0125 0.2812 0.2812
Loa Loa (eye worm) hypothetical protein 0.0056 0.0914 0.0914
Brugia malayi intermediate filament protein 0.0041 0.0481 0.0481
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0056 0.0914 0.0914
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0257 0.6456 0.6456
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0914 0.0914
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0128 0.288 0.0188
Loa Loa (eye worm) ACC-1 protein 0.007 0.1278 0.1278
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0128 0.288 0.0188
Echinococcus multilocularis nAChR subunit 0.0056 0.0914 0.0914

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM Inhibitory concentration of compound against Plasmodium falciparum ChEMBL. 15887974

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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