Detailed information for compound 338281

Basic information

Technical information
  • TDR Targets ID: 338281
  • Name: ethyl 2-[5-[12-[4-(2-ethoxy-2-oxoethyl)-3-met hyl-1,3-thiazol-3-ium-5-yl]dodecyl]-3-methyl- 1,3-thiazol-3-ium-4-yl]acetate diiodide
  • MW: 792.615 | Formula: C28H46I2N2O4S2
  • H donors: 0 H acceptors: 2 LogP: 9.68 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)Cc1[n+](C)csc1CCCCCCCCCCCCc1sc[n+](c1CC(=O)OCC)C.[I-].[I-]
  • InChi: 1S/C28H46N2O4S2.2HI/c1-5-33-27(31)19-23-25(35-21-29(23)3)17-15-13-11-9-7-8-10-12-14-16-18-26-24(30(4)22-36-26)20-28(32)34-6-2;;/h21-22H,5-20H2,1-4H3;2*1H/q+2;;/p-2
  • InChiKey: NMRBLXUHBWUBCY-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[5-[12-[4-(2-ethoxy-2-oxo-ethyl)-3-methyl-thiazol-3-ium-5-yl]dodecyl]-3-methyl-thiazol-3-ium-4-yl]acetate diiodide
  • 2-[5-[12-[4-(2-ethoxy-2-oxoethyl)-3-methyl-5-thiazol-3-iumyl]dodecyl]-3-methyl-4-thiazol-3-iumyl]acetic acid ethyl ester diiodide
  • ethyl 2-[5-[12-[4-(2-ethoxy-2-oxo-ethyl)-3-methyl-1,3-thiazol-3-ium-5-yl]dodecyl]-3-methyl-1,3-thiazol-3-ium-4-yl]ethanoate diiodide
  • 2-[5-[12-[4-(2-ethoxy-2-keto-ethyl)-3-methyl-thiazol-3-ium-5-yl]dodecyl]-3-methyl-thiazol-3-ium-4-yl]acetic acid ethyl ester diiodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Brugia malayi calpain family protein 1 0.0097 0.0375 0.0375
Onchocerca volvulus 0.0271 0.146 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.0307
Brugia malayi cathepsin L precursor 0.0089 0.0328 0.0328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0271 0.146 0.146
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.0171 0.0171
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0161 0.0776 0.3794
Trypanosoma cruzi oligopeptidase b 0.0064 0.0171 0.0171
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0278 0.1509 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0271 0.146 0.146
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Plasmodium falciparum cysteine proteinase falcipain 1 0.0163 0.0787 0.3886
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0278 0.1509 1
Loa Loa (eye worm) cysteine protease 0.0271 0.146 0.146
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0215 0.0215
Schistosoma mansoni cathepsin s 0.0074 0.0232 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Echinococcus multilocularis cathepsin L 0.0089 0.0328 0.0328
Brugia malayi cathepsin F-like cysteine proteinase 0.0089 0.0328 0.0328
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0629
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0787 0.1534
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Plasmodium vivax serine-repeat antigen (SERA) 0.0089 0.0328 0.2173
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0089 0.0328 0.0328
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0064 0.0171 0.5
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0064 0.0171 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0097 0.0375 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Brugia malayi Ets-domain containing protein 0.0071 0.0215 0.0215
Onchocerca volvulus 0.0271 0.146 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Toxoplasma gondii preprocathepsin c precursor, putative 0.0278 0.1509 0.4179
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0787 0.0787
Echinococcus granulosus cathepsin l1 0.0271 0.146 0.146
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0209 0.0209
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0089 0.0328 0.2173
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0182 0.0906 0.5777
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Trypanosoma cruzi oligopeptidase b 0.0064 0.0171 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Onchocerca volvulus 0.0271 0.146 1
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0787 0.237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine proteinase 2 0.0163 0.0787 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0089 0.0328 0.0328
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.0171 0.0516
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.1001 0.5946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0271 0.146 0.146
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.0776 0.1498
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Onchocerca volvulus Cathepsin F homolog 0.0271 0.146 1
Echinococcus multilocularis calpain A 0.0101 0.0403 0.0403
Onchocerca volvulus 0.0197 0.1001 0.6502
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0163 0.0787 0.0787
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Entamoeba histolytica cysteine protease, putative 0.0271 0.146 1
Onchocerca volvulus 0.0271 0.146 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0291 0.0291
Onchocerca volvulus 0.0271 0.146 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0089 0.0328 0.0328
Trypanosoma cruzi cruzipain precursor, putative 0.0271 0.146 0.146
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0089 0.0328 0.2173
Echinococcus granulosus cysteine protease 0.0163 0.0787 0.0787
Brugia malayi hypothetical protein 0.0043 0.0042 0.0042
Echinococcus granulosus prolyl endopeptidase 0.0141 0.0649 0.0649
Echinococcus multilocularis prolyl endopeptidase 0.0141 0.0649 0.0649
Trypanosoma brucei prolyl endopeptidase 0.0141 0.0649 0.1956
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0569 0.3319 0.3319
Brugia malayi Peptidase family M1 containing protein 0.0118 0.0507 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.1001 0.225
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0161 0.0776 0.5143
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Schistosoma mansoni ets-related 0.0216 0.1116 0.1116
Plasmodium vivax vivapain-2 0.0271 0.146 0.9675
Loa Loa (eye worm) cathepsin B 0.0569 0.3319 0.3319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) hypothetical protein 0.006 0.0148 0.0148
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0278 0.1509 0.1509
Trypanosoma cruzi prolyl endopeptidase 0.0141 0.0649 0.0649
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.0649 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus multilocularis cathepsin L cysteine protease 0.0271 0.146 0.146
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.0776 0.1498
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0089 0.0328 0.0328
Toxoplasma gondii cathepsin CPC1 0.0278 0.1509 0.4179
Echinococcus multilocularis cathepsin b 0.164 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Echinococcus multilocularis calpain family protein 1, d 0.0071 0.0216 0.0216
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Onchocerca volvulus Cathepsin L homolog 0.0271 0.146 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine proteinase, putative 0.0271 0.146 1
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0197 0.1001 0.1001
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Trypanosoma cruzi major cysteine proteinase, putative 0.0089 0.0328 0.0328
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0216 0.0216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.1001 0.225
Brugia malayi cathepsin L-like precursor 0.0197 0.1001 0.1001
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0787 0.0787
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0271 0.146 0.146
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Loa Loa (eye worm) hypothetical protein 0.0141 0.0649 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Onchocerca volvulus 0.0118 0.0507 0.2736
Loa Loa (eye worm) fibroinase 0.0271 0.146 0.146
Brugia malayi Fli-1 protein 0.0216 0.1116 0.1116
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0182 0.0906 0.0906
Toxoplasma gondii cathepsin CPL 0.0271 0.146 0.4022
Echinococcus granulosus cathepsin L 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Plasmodium vivax vivapain-2 0.0271 0.146 0.9675
Trypanosoma cruzi cysteine protease, putative 0.0163 0.0787 0.0787
Echinococcus multilocularis cysteine protease 0.0271 0.146 0.146
Plasmodium vivax unspecified product 0.0074 0.0232 0.1534
Giardia lamblia Encystation-specific protease 0.0161 0.0776 0.1498
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0569 0.3319 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0569 0.3319 1
Brugia malayi calpain family protein 1 0.0097 0.0375 0.0375
Plasmodium vivax vivapain-1 0.0163 0.0787 0.5215
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0097 0.0375 0.0375
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.0171 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Trypanosoma brucei cysteine peptidase C (CPC) 0.0569 0.3319 1
Schistosoma mansoni cathepsin F (C01 family) 0.0271 0.146 0.146
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Loa Loa (eye worm) fli-1 protein 0.0216 0.1116 0.1116
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0232 0.0232
Schistosoma mansoni cathepsin C 0.0089 0.0328 0.0328
Echinococcus granulosus cathepsin l cysteine peptidase 0.0271 0.146 0.146
Brugia malayi Cathepsin L-like cysteine proteinase 0.0197 0.1001 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0271 0.146 0.146
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0232 0.0232
Onchocerca volvulus 0.0271 0.146 1
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0182 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi fibroinase precursor 0.0089 0.0328 0.0328
Onchocerca volvulus 0.0089 0.0328 0.1371
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Toxoplasma gondii cathepsin B 0.0569 0.3319 1
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Onchocerca volvulus Cathepsin L homolog 0.0271 0.146 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0141 0.0649 0.3821
Plasmodium vivax unspecified product 0.0163 0.0787 0.5215
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0271 0.146 0.146
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Plasmodium vivax unspecified product 0.0089 0.0328 0.2173
Echinococcus granulosus cathepsin L cysteine protease 0.0163 0.0787 0.0787
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0089 0.0328 0.2173
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.164 1 1
Echinococcus granulosus cathepsin l1 0.0197 0.1001 0.1001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.3319 0.3319
Echinococcus multilocularis aminopeptidase N 0.0118 0.0507 0.0507
Echinococcus granulosus cathepsin L 0.0163 0.0787 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Schistosoma mansoni cathepsin S (C01 family) 0.0089 0.0328 0.0328
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.0649 0.0649
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0278 0.1509 0.3948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0052 0.0052
Loa Loa (eye worm) ctsf protein 0.0271 0.146 0.146
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Entamoeba histolytica cysteine proteinase 1, putative 0.0163 0.0787 0.4054
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0483 1
Brugia malayi Cathepsin L-like precursor 0.0074 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.164 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Loa Loa (eye worm) hypothetical protein 0.0061 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi cathepsin L-like cysteine proteinase 0.0089 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Leishmania major oligopeptidase b 0.0064 0.0171 0.0516
Onchocerca volvulus Cathepsin L homolog 0.0089 0.0328 0.1371
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Brugia malayi Cathepsin L-like precursor 0.0197 0.1001 0.1001
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.1061 0.245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0052 0.0052
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.0171 0.0516
Brugia malayi Papain family cysteine protease containing protein 0.0271 0.146 0.146
Schistosoma mansoni cathepsin B (C01 family) 0.0089 0.0328 0.0328
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0271 0.146 0.9585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0787 0.0787
Loa Loa (eye worm) prolyl oligopeptidase 0.0182 0.0906 0.0906
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0209 0.0629
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Plasmodium falciparum cysteine proteinase falcipain 3 0.0271 0.146 0.9585
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Echinococcus granulosus calpain A 0.0101 0.0403 0.0403
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.0649 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0052 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0216 0.0216
Plasmodium vivax vivapain-3 0.0163 0.0787 0.5215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0197 0.1001 0.1001
Brugia malayi prolyl oligopeptidase family protein 0.0182 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0043 0.0042 0.0042
Echinococcus granulosus aminopeptidase N 0.0118 0.0507 0.0507
Brugia malayi cathepsin Z-like cysteine proteinase 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0787 0.0787
Toxoplasma gondii cathepsin CPC2 0.0161 0.0776 0.1823
Trypanosoma brucei oligopeptidase b 0.0064 0.0171 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0106 0.0431 0.0431
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.164 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0089 0.0328 0.2173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0787 0.237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Plasmodium vivax serine-repeat antigen (SERA) 0.0089 0.0328 0.2173
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0089 0.0328 0.2173
Echinococcus multilocularis cathepsin L 0.0163 0.0787 0.0787
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0101 0.0403 0.0403
Trypanosoma cruzi major cysteine proteinase, putative 0.0089 0.0328 0.0328
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0074 0.0232 0.0232
Brugia malayi Cathepsin L-like precursor 0.0197 0.1001 0.1001
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Loa Loa (eye worm) peptidase family M1 containing protein 0.0095 0.0367 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0787 0.1534
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.0232 0.0232
Loa Loa (eye worm) calpain family protein 1 0.0097 0.0375 0.0375
Echinococcus multilocularis cathepsin b 0.164 1 1
Toxoplasma gondii prolyl endopeptidase 0.0141 0.0649 0.1416
Echinococcus granulosus cathepsin b 0.164 1 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0141 0.0649 0.1956
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0089 0.0328 0.2173
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0278 0.1509 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.0171 0.0171
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0089 0.0328 0.2173
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0271 0.146 0.146
Schistosoma mansoni gabp alpha 0.0071 0.0215 0.0215
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0215 0.0215
Brugia malayi cathepsin F-like cysteine proteinase 0.0074 0.0232 0.0232
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0215 0.0215
Echinococcus multilocularis cysteine protease 0.0271 0.146 0.146
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi Ets-domain containing protein 0.0071 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0052 0.0052
Echinococcus granulosus cathepsin b 0.164 1 1
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0209 0.0209
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0271 0.146 0.9585
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0209 0.0209
Entamoeba histolytica cysteine proteinase, putative 0.0271 0.146 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0089 0.0328 0.0328
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0307 0.1689 0.1689
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0089 0.0328 0.0328
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0629
Echinococcus granulosus tachykinin peptides receptor 99D 0.0307 0.1689 0.1689
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0209 0.0209
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0182 0.0906 0.0906
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0278 0.1509 1
Onchocerca volvulus 0.0271 0.146 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 22 nM In vitro inhibitory concentration of the compound against Plasmodium falciparum ChEMBL. 15887971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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