Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 1.7374 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Onchocerca volvulus | 0.0294 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0294 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Brugia malayi | aryl-acylamidase | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0294 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0294 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0294 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.7374 | 1 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 25 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 25 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 32 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 32 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 43 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 43 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 58 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 58 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 61 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 61 % | Antitumor activity against MH 134 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 71 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 71 % | Antitumor activity against Meth A cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 110 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 110 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 111 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 111 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 121 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 121 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 121 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 200 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 121 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 128 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 128 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 100 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 136 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 136 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 200 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 151 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 151 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 167 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 300 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 167 % | Antitumor activity against L-1210 cells in female BDF1 mice expressed as percent T/C at dose 300 mg/kg | ChEMBL. | 7452684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.