Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0081 | 0.0032 | 0.0032 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0362 | 0.0163 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0362 | 0.0163 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | lipase LipU | 0.0362 | 0.0163 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.1396 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0362 | 0.0163 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0081 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0362 | 0.0163 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 2.1396 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0362 | 0.0163 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0362 | 0.0163 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.1396 | 1 | 1 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0362 | 0.0163 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0362 | 0.0163 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0362 | 0.0163 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0362 | 0.0163 | 1 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0362 | 0.0163 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0362 | 0.0163 | 0.0163 |
Mycobacterium ulcerans | esterase LipC | 0.0362 | 0.0163 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0362 | 0.0163 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0081 | 0.0032 | 0.0032 |
Brugia malayi | Carboxylesterase family protein | 0.0081 | 0.0032 | 0.1937 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0362 | 0.0163 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0081 | 0.0032 | 0.0032 |
Trichomonas vaginalis | Esterase, putative | 0.0362 | 0.0163 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0362 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0362 | 0.0163 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0081 | 0.0032 | 0.0032 |
Trichomonas vaginalis | Esterase, putative | 0.0362 | 0.0163 | 1 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0362 | 0.0163 | 1 |
Mycobacterium ulcerans | lipase LipI | 0.0362 | 0.0163 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0081 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0032 | 0.0032 |
Echinococcus multilocularis | acetylcholinesterase | 0.0081 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | esterase/lipase | 0.0362 | 0.0163 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0362 | 0.0163 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0081 | 0.0032 | 0.1937 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0362 | 0.0163 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0362 | 0.0163 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.0362 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0362 | 0.0163 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0362 | 0.0163 | 0.5 |
Leishmania major | ecotin, putative | 0.0362 | 0.0163 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0362 | 0.0163 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0362 | 0.0163 | 0.0163 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0362 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0362 | 0.0163 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0081 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0362 | 0.0163 | 1 |
Onchocerca volvulus | 0.0362 | 0.0163 | 1 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 2.1396 | 1 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0362 | 0.0163 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0362 | 0.0163 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0081 | 0.0032 | 0.0032 |
Mycobacterium ulcerans | esterase LipW | 0.0362 | 0.0163 | 1 |
Loa Loa (eye worm) | hypothetical protein | 2.1396 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0362 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0362 | 0.0163 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0362 | 0.0163 | 0.0163 |
Mycobacterium ulcerans | esterase LipO | 0.0362 | 0.0163 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0362 | 0.0163 | 1 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0362 | 0.0163 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1200 nM | Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells | ChEMBL. | 12657272 |
EC50 (functional) | = 1200 nM | Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cells | ChEMBL. | 12657272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.