Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0294 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0294 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.7374 | 1 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Mycobacterium ulcerans | lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0294 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0294 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0294 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0294 | 0 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0294 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0294 | 0 | 0.5 |
Onchocerca volvulus | 0.0294 | 0 | 0.5 | |
Brugia malayi | aryl-acylamidase | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.7374 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0294 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.7374 | 1 | 1 |
Leishmania major | ecotin, putative | 0.0294 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0294 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0294 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 97 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 97 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 25 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 108 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 108 % | Percentage change in median survival time of P388 (leukaemia) inoculated female mice following 100 mg/kg i.p. | ChEMBL. | 7452684 |
T/C (functional) | = 111 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 12.5 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 111 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 12.5 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 114 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
T/C (functional) | = 114 % | Antitumor activity against P-388 Leukemia in female BDF1 mice expressed as percent T/C at dose 50 mg/kg | ChEMBL. | 7452684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.