Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0023 | 0.0069 | 0.0069 |
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.0833 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0074 | 0.0074 |
Schistosoma mansoni | P2X receptor subunit | 0.0117 | 0.0571 | 0.0501 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0517 | 0.2702 | 0.2702 |
Schistosoma mansoni | P2X receptor subunit | 0.0196 | 0.0994 | 0.0927 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0517 | 0.2702 | 0.2648 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0517 | 0.2702 | 0.2702 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0166 | 0.0833 | 0.0833 |
Schistosoma mansoni | P2X receptor subunit | 0.0196 | 0.0994 | 0.0927 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0517 | 0.2702 | 0.2648 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0686 | 0.3604 | 0.3557 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0686 | 0.3604 | 0.3604 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3604 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3604 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1885 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0517 | 0.2702 | 0.2702 |
Onchocerca volvulus | 0.0189 | 0.0956 | 1 | |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0117 | 0.0571 | 0.0501 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1885 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0517 | 0.2702 | 0.5 |
Leishmania major | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0051 | 0.0218 | 0.0218 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0517 | 0.2702 | 0.2648 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0024 | 0.0074 | 0.0074 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0024 | 0.0074 | 0.0074 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3557 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1885 | 1 | 1 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0517 | 0.2702 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1885 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Schistosoma mansoni | glutathione synthetase | 0.0517 | 0.2702 | 0.2648 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0051 | 0.0218 | 0.0218 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0517 | 0.2702 | 0.5 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0517 | 0.2702 | 0.2702 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1885 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0517 | 0.2702 | 0.2702 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0517 | 0.2702 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0686 | 0.3604 | 0.5 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0024 | 0.0074 | 0.0074 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0517 | 0.2702 | 0.2648 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 33 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Survival (functional) | = 33 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.