Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | flap endonuclease 1, putative | 0.0032 | 0.845 | 0.845 |
Plasmodium vivax | exonuclease I, putative | 0.0011 | 0.1642 | 0.1642 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0036 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0032 | 0.845 | 0.845 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0036 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0032 | 0.845 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0027 | 0.6808 | 0.6181 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0036 | 1 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0032 | 0.845 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0032 | 0.845 | 0.8145 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 1 | 1 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0036 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0032 | 0.845 | 0.8145 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0032 | 0.845 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0032 | 0.845 | 0.8145 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0032 | 0.845 | 0.8145 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0031 | 0.8168 | 0.9587 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0036 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0032 | 0.845 | 1 |
Plasmodium falciparum | exonuclease I, putative | 0.0011 | 0.1642 | 0.1642 |
Echinococcus granulosus | flap endonuclease 1 | 0.0032 | 0.845 | 0.8145 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0036 | 1 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0032 | 0.845 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0032 | 0.845 | 0.8145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1800 nM | Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes | ChEMBL. | 16134949 |
IC50 (binding) | = 1800 nM | Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutes | ChEMBL. | 16134949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.