TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.341 | Formula: C17H19F3N2O
H donors: 2 H acceptors: 2 LogP: 5.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCC1(CC)CCNc2c1cc1c(c2)nc(cc1C(F)(F)F)O
InChi: 1S/C17H19F3N2O/c1-3-16(4-2)5-6-21-14-9-13-10(7-12(14)16)11(17(18,19)20)8-15(23)22-13/h7-9,21H,3-6H2,1-2H3,(H,22,23)
InChiKey: CZKZCZAZGXEUOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	androgen receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0402	0.8556	0.8917
Schistosoma mansoni	amine GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	neuropeptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	neuropeptide receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptide receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	bifunctional protein NCOAT	0.0327	0.6816	0.7104
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0402	0.8556	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	opsin-like receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptide Y receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus granulosus	neuropeptide receptor	0.0402	0.8556	0.8917
Brugia malayi	AKH receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus granulosus	TGF beta receptor type 1	0.007	0.0844	0.0879
Echinococcus granulosus	G protein coupled receptor 139	0.0402	0.8556	0.8917
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0402	0.8556	0.8917
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Brugia malayi	RE15519p	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0261	0.5273	0.6163
Echinococcus granulosus	allatostatin A receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	sex peptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0402	0.8556	1
Schistosoma mansoni	neuropeptide receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.034	0.712	0.8322
Onchocerca volvulus		0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	sulfakinin receptor protein	0.0402	0.8556	0.8917
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Echinococcus granulosus	neuropeptide receptor A26	0.0402	0.8556	0.8917
Schistosoma mansoni	opsin-like receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	amine GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0103	0.1609	0.1677
Schistosoma mansoni	hypothetical protein	0.0402	0.8556	0.8917
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0447	0.9594	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0402	0.8556	1
Leishmania major	DNA repair protein, putative	0.0058	0.0585	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0212	0.4156	0.4332
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0246	0.4925	1
Schistosoma mansoni	amine GPCR	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0447	0.9594	1
Brugia malayi	Serotonin receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0304	0.6279	0.6545
Brugia malayi	WGR domain containing protein	0.0246	0.4925	0.5133
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	ORL1-like opioid receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	larval opioid receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	tm gpcr rhodopsin	0.0402	0.8556	0.8917
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0447	0.9594	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0402	0.8556	0.8917
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0402	0.8556	0.8917
Echinococcus granulosus	neuropeptides capa receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus granulosus	hypothetical protein	0.0402	0.8556	0.8917
Echinococcus granulosus	g protein coupled receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2454	0.2868
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0447	0.9594	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus granulosus	neuropeptides capa receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0304	0.6279	0.6545
Onchocerca volvulus		0.0402	0.8556	1
Brugia malayi	WGR domain containing protein	0.0447	0.9594	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0402	0.8556	0.8917
Brugia malayi	Melatonin receptor type 1A	0.0402	0.8556	0.8917
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0069	0.0841	0.0877
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.007	0.0844	0.0879
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Loa Loa (eye worm)	neuropeptide F receptor	0.0402	0.8556	1
Schistosoma mansoni	histamine h1 receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0059	0.0607	0.0709
Echinococcus multilocularis	allatostatin A receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	g protein coupled receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	bifunctional protein NCOAT	0.0327	0.6816	0.7104
Echinococcus granulosus	orexin receptor type 2	0.0402	0.8556	0.8917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0402	0.8556	0.8917
Echinococcus granulosus	neuropeptide FF receptor 2	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Schistosoma mansoni	amine GPCR	0.0402	0.8556	0.8917
Brugia malayi	G-protein coupled receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0402	0.8556	0.8917
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hyaluronidase	0.0327	0.6816	0.7967
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Echinococcus granulosus	7tm_1 domain containing protein	0.0402	0.8556	0.8917
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	serotonin receptor	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0069	0.0841	0.0877
Echinococcus granulosus	neuropeptide Y receptor	0.0402	0.8556	0.8917
Brugia malayi	G protein-coupled receptor F59B2.13	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0402	0.8556	0.8917
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0402	0.8556	0.8917
Schistosoma mansoni	Hyaluronidase	0.0327	0.6816	0.7104
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0402	0.8556	0.8917
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0402	0.8556	1
Schistosoma mansoni	adenoreceptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Brugia malayi	putative neuropeptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0246	0.4925	0.5756
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0402	0.8556	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	myosin xvIII	0.0402	0.8556	0.8917
Schistosoma mansoni	neuropeptide F-like receptor	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptide s receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	tyrosine kinase	0.0299	0.6156	0.6416
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0073	0.0933	0.0972
Echinococcus multilocularis	dro:myosuppressin receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	neuropeptides capa receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	neuropeptide f receptor 76f	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Schistosoma mansoni	neuropeptide receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine receptor	0.0402	0.8556	0.8917
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0246	0.4925	1
Echinococcus granulosus	neuropeptide Y receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	TGF beta receptor type 1	0.007	0.0844	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Schistosoma mansoni	hypothetical protein	0.0402	0.8556	0.8917
Leishmania major	hypothetical protein, conserved	0.0058	0.0585	0.5
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0139	0.245	0.2554
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0402	0.8556	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Loa Loa (eye worm)	TYRA-2 protein	0.0402	0.8556	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0073	0.0933	0.109
Loa Loa (eye worm)	neuropeptide F receptor	0.0402	0.8556	1
Entamoeba histolytica	hypothetical protein	0.0069	0.0841	0.0877
Onchocerca volvulus		0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0176	0.3315	0.3875
Brugia malayi	Dopamine receptor protein 1	0.0402	0.8556	0.8917
Echinococcus granulosus	tm gpcr rhodopsin	0.0402	0.8556	0.8917
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0246	0.4925	0.5133
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0402	0.8556	0.8917
Onchocerca volvulus	DNA ligase 3 homolog	0.0058	0.0585	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	Protein kinase domain containing protein	0.0261	0.5273	0.5496
Echinococcus multilocularis	somatostatin receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus granulosus	g protein coupled receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	orexin receptor type 2	0.0402	0.8556	0.8917
Brugia malayi	G protein-coupled receptor	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	hypothetical protein	0.0402	0.8556	0.8917
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Brugia malayi	Dopamine receptor protein 2	0.0402	0.8556	0.8917
Echinococcus granulosus	g protein coupled receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus granulosus	poly adp ribose polymerase 2	0.0246	0.4925	0.5133
Onchocerca volvulus		0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus granulosus	biogenic amine 5HT receptor	0.0402	0.8556	0.8917
Brugia malayi	GnHR receptor homolog	0.0402	0.8556	0.8917
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0069	0.0841	0.0877
Echinococcus multilocularis	neuropeptides capa receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Brugia malayi	Dopamine receptor	0.0402	0.8556	0.8917
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0402	0.8556	0.8917
Brugia malayi	follicle stimulating hormone receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	protein kinase	0.007	0.0844	0.0879
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0402	0.8556	0.8917
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0246	0.4925	1
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0327	0.6816	0.7104
Echinococcus granulosus	TGF-beta receptor type-1	0.007	0.0844	0.0879
Brugia malayi	neuropeptide F receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	neuropeptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	fmrfamide receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	biogenic amine receptor	0.0402	0.8556	0.8917
Brugia malayi	G-protein coupled receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Brugia malayi	neuropeptide F receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0246	0.4925	0.5133
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	biogenic amine 5HT receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Onchocerca volvulus		0.0402	0.8556	1
Schistosoma mansoni	protein kinase	0.0073	0.0933	0.0972
Echinococcus multilocularis	g-protein coupled receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	serotonin receptor	0.0402	0.8556	0.8917
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0402	0.8556	0.8917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0402	0.8556	0.8917
Echinococcus granulosus	g-protein coupled receptor	0.0402	0.8556	0.8917
Brugia malayi	protein C17H12.11	0.0059	0.0607	0.0632
Echinococcus granulosus	neuropeptide s receptor	0.0402	0.8556	0.8917
Brugia malayi	hypothetical protein	0.0059	0.0607	0.0632
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus granulosus	activin receptor type	0.0073	0.0933	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	sex peptide receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	fmrfamide receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0402	0.8556	0.8917
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	activin receptor type	0.0073	0.0933	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0402	0.8556	0.8917
Loa Loa (eye worm)	G-protein coupled receptor	0.0402	0.8556	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Schistosoma mansoni	amine GPCR	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0402	0.8556	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0402	0.8556	0.8917
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	serotonin receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0607	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	G-protein coupled receptor	0.0402	0.8556	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0585	0.0683
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Brugia malayi	Hyaluronidase family protein	0.0327	0.6816	0.7104
Echinococcus granulosus	WGR domain containing protein	0.0139	0.245	0.2554
Echinococcus granulosus	rhodopsin orphan GPCR	0.0402	0.8556	0.8917
Echinococcus multilocularis	g protein coupled receptor	0.0402	0.8556	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0402	0.8556	1
Brugia malayi	Serotonin receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0402	0.8556	0.8917
Echinococcus granulosus	somatostatin receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus multilocularis	fmrfamide receptor	0.0402	0.8556	0.8917
Onchocerca volvulus		0.0402	0.8556	1
Echinococcus multilocularis	g protein coupled receptor	0.0402	0.8556	0.8917
Schistosoma mansoni	hypothetical protein	0.0402	0.8556	0.8917

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 10000 nM	Agonist activity to the human androgen receptor (hAR) in CV-1 cells	ChEMBL.	10340624
EC50 (functional)	> 10000 nM	Agonist activity to the human androgen receptor (hAR) in CV-1 cells	ChEMBL.	10340624
Efficacy (functional)	< 10 %	Agonism of human androgen receptor (hAR) in CV-1 cells compared to that of dihydrotestosterone (100%)	ChEMBL.	10340624
Efficacy (functional)	< 10 %	Agonism of human androgen receptor (hAR) in CV-1 cells compared to that of dihydrotestosterone (100%)	ChEMBL.	10340624
Efficacy (functional)	= 73 %	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells was determined as a function of maximal inhibition of dihydrotestosterone using cotransfection assay	ChEMBL.	10340624
Efficacy (functional)	= 73 %	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells was determined as a function of maximal inhibition of dihydrotestosterone using cotransfection assay	ChEMBL.	10340624
IC50 (functional)	= 73 nM	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay	ChEMBL.	10340624
IC50 (functional)	= 73 nM	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay	ChEMBL.	10340624
Ki (binding)	= 58 nM	Binding affinity to the human androgen receptor (hAR), using [3H]-DHT as radioligand in a competitive binding assay	ChEMBL.	10340624
Ki (binding)	= 58 nM	Binding affinity to the human androgen receptor (hAR), using [3H]-DHT as radioligand in a competitive binding assay	ChEMBL.	10340624

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL282866

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 34457