Detailed information for compound 346701

Basic information

Technical information
  • TDR Targets ID: 346701
  • Name: 4-bromo-N-[1-(cyanomethylcarbamoyl)cyclohexyl ]benzamide
  • MW: 364.237 | Formula: C16H18BrN3O2
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C1(CCCCC1)NC(=O)c1ccc(cc1)Br
  • InChi: 1S/C16H18BrN3O2/c17-13-6-4-12(5-7-13)14(21)20-16(8-2-1-3-9-16)15(22)19-11-10-18/h4-7H,1-3,8-9,11H2,(H,19,22)(H,20,21)
  • InChiKey: AGJGTOPQVLECER-UHFFFAOYSA-N  


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Synonyms

  • 4-bromo-N-[1-[(cyanomethylamino)-oxomethyl]cyclohexyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Oryctolagus cuniculus Cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus cathepsin L cysteine protease Cathepsin K   329 aa 328 aa 47.9 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin K   329 aa 269 aa 27.1 %
Plasmodium berghei berghepain-1 Cathepsin K   329 aa 345 aa 31.6 %
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Cathepsin K   329 aa 270 aa 26.7 %
Onchocerca volvulus Cathepsin K   329 aa 310 aa 40.6 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 354 aa 37.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 279 aa 28.0 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin K   329 aa 308 aa 32.1 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 299 aa 24.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 326 aa 25.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Babesia bovis papain family cysteine protease containing protein Cathepsin K   329 aa 331 aa 32.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 362 aa 25.1 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 338 aa 34.9 %
Echinococcus granulosus cysteine protease Cathepsin K   329 aa 328 aa 46.6 %
Plasmodium yoelii cathepsin c precursor Cathepsin K   329 aa 292 aa 23.3 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin K   329 aa 290 aa 30.0 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin K   329 aa 305 aa 36.4 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 356 aa 37.4 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 290 aa 31.4 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 316 aa 32.0 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin K   329 aa 318 aa 31.1 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin K   329 aa 302 aa 35.4 %
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Cathepsin K   329 aa 265 aa 26.0 %
Onchocerca volvulus Cathepsin K   329 aa 298 aa 31.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Neospora caninum hypothetical protein Cathepsin K   329 aa 381 aa 24.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 310 aa 24.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 296 aa 24.7 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 274 aa 27.7 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 316 aa 31.3 %
Toxoplasma gondii cathepsin CPC1 Cathepsin K   329 aa 351 aa 23.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 380 aa 23.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Onchocerca volvulus Cathepsin K   329 aa 324 aa 40.7 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 331 aa 26.9 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin K   329 aa 342 aa 36.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 351 aa 24.8 %
Toxoplasma gondii cathepsin B Cathepsin K   329 aa 290 aa 26.6 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.2 %
Trypanosoma cruzi cysteine protease, putative Cathepsin K   329 aa 318 aa 31.4 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin K   329 aa 309 aa 34.6 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 349 aa 33.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.8 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin K   329 aa 277 aa 25.3 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin K   329 aa 322 aa 41.9 %
Plasmodium knowlesi knowpain-1 Cathepsin K   329 aa 353 aa 28.6 %
Leishmania donovani cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 25.9 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 28.5 %
Onchocerca volvulus Cathepsin K   329 aa 311 aa 37.3 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.4 %
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 264 aa 29.9 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin K   329 aa 345 aa 29.9 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 27.7 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 317 aa 26.5 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.8 %
Trypanosoma brucei cysteine peptidase C (CPC) Cathepsin K   329 aa 270 aa 26.7 %
Babesia bovis cysteine protease 2 Cathepsin K   329 aa 343 aa 30.3 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin K   329 aa 319 aa 37.9 %
Loa Loa (eye worm) hypothetical protein Cathepsin K   329 aa 277 aa 27.4 %
Echinococcus granulosus cathepsin b Cathepsin K   329 aa 268 aa 24.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 299 aa 27.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 291 aa 33.7 %
Babesia bovis cathepsin C precursor, putative Cathepsin K   329 aa 269 aa 25.3 %
Onchocerca volvulus Cathepsin K   329 aa 272 aa 29.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 369 aa 24.7 %
Plasmodium vivax vivapain-3 Cathepsin K   329 aa 327 aa 35.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin K   329 aa 319 aa 44.5 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 278 aa 28.8 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin K   329 aa 375 aa 24.3 %
Onchocerca volvulus Cathepsin L homolog Cathepsin K   329 aa 316 aa 45.3 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 32.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin K   329 aa 348 aa 32.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 276 aa 26.4 %
Onchocerca volvulus Cathepsin K   329 aa 319 aa 41.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0086 0.3558 0.4035
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0275 0.0275
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0125 0.5645 0.5645
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0022 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Brugia malayi Dopamine receptor 0.0125 0.5645 0.6505
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Echinococcus granulosus sex peptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus Glutaredoxin protein 5 0.0022 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.1758 0.3592
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.3558 0.41
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei rac serine-threonine kinase, putative 0.0036 0.0894 0.2059
Loa Loa (eye worm) ctsf protein 0.0086 0.3558 0.4035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus multilocularis cathepsin b 0.0181 0.8677 0.8677
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Entamoeba histolytica protein kinase 2, putative 0.0023 0.0153 0.0313
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.0772 0.089
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0125 0.5645 0.5645
Echinococcus granulosus neuropeptide s receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0275 0.0275
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis allatostatin A receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0672 0.1372
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus cathepsin l1 0.0086 0.3558 0.3558
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus somatostatin receptor 0.0125 0.5645 0.5645
Onchocerca volvulus Cathepsin L homolog 0.0086 0.3558 0.6303
Plasmodium vivax unspecified product 0.0027 0.0369 0.1037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0369 0.0418
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Brugia malayi Tachykinin-like peptides receptor 99D 0.0125 0.5645 0.6505
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0125 0.5645 0.6402
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0125 0.5645 0.5645
Echinococcus granulosus orexin receptor type 2 0.0125 0.5645 0.5645
Trypanosoma cruzi Protein kinase B 0.0025 0.0275 0.0317
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0051 0.1668 0.3409
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Echinococcus multilocularis somatostatin receptor 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.3558 0.7269
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0694 0.0787
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1442 0.1662
Plasmodium vivax vivapain-3 0.0047 0.1442 0.4054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0125 0.5645 0.5645
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.1758 0.1758
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.3079 0.6291
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0104 0.4551 0.9299
Leishmania major cysteine peptidase A (CPA) 0.0086 0.3558 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.3558 0.3558
Onchocerca volvulus 0.0086 0.3558 0.6303
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0125 0.5645 0.6505
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0125 0.5645 0.6505
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0059 0.2115 0.3748
Brugia malayi G-protein coupled receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Onchocerca volvulus 0.0086 0.3558 0.6303
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Brugia malayi RE15519p 0.0125 0.5645 0.6505
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2115 0.4322
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.1758 0.1758
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.1758 0.3592
Brugia malayi Cathepsin L-like precursor 0.0059 0.2115 0.2438
Echinococcus granulosus dro:myosuppressin receptor 0.0125 0.5645 0.5645
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.3558 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.1758 0.2315
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.1442 0.2947
Brugia malayi sulfakinin receptor protein 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0825 0.1685
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.2684 0.5483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.5645 0.6402
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Echinococcus granulosus serotonin receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0022 0.014 0.014
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.4895 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Brugia malayi G protein-coupled receptor F59B2.13 0.0125 0.5645 0.6505
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0033 0.0694 0.08
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.5645 0.6402
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.3558 0.3558
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0205 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1442 0.2947
Echinococcus multilocularis serotonin receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0125 0.5645 0.5645
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0369 0.0425
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.1037 0.1195
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Entamoeba histolytica protein kinase, putative 0.0036 0.0894 0.1826
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.0153 0.0431
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0125 0.5645 0.5645
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.8677 0.8677
Echinococcus multilocularis neuropeptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus nervana 2 0.0022 0.014 0.014
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0882 0.1803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.0153 0.0153
Echinococcus multilocularis G-protein coupled receptor, putative 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Onchocerca volvulus 0.0086 0.3558 0.6303
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2487
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.3558 0.3558
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.0153 0.0431
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.5645 0.5645
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Echinococcus multilocularis neuropeptide FF receptor 2 0.0125 0.5645 0.5645
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus multilocularis neuropeptide s receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.1758 0.2026
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0125 0.5645 0.5645
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.1758 0.4635
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.0275 0.0275
Echinococcus multilocularis cathepsin L 0.0047 0.1442 0.1442
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.5645 0.5645
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi Serotonin receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.5645 0.5645
Giardia lamblia GTOR 0.0052 0.1758 0.655
Brugia malayi cathepsin L-like precursor 0.0059 0.2115 0.2438
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0036 0.0894 0.1014
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus multilocularis sex peptide receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.5645 0.5645
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.3558 0.3558
Plasmodium vivax vivapain-2 0.0086 0.3558 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0125 0.5645 0.5645
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Onchocerca volvulus Cathepsin F homolog 0.0086 0.3558 0.6303
Echinococcus multilocularis orexin receptor type 2 0.0125 0.5645 0.5645
Toxoplasma gondii cathepsin B 0.007 0.2684 0.7543
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0125 0.5645 0.6402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Brugia malayi G-protein coupled receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Onchocerca volvulus 0.0125 0.5645 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.3558 0.7269
Toxoplasma gondii cathepsin CPL 0.0086 0.3558 1
Onchocerca volvulus 0.0086 0.3558 0.6303
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0055 0.1895 0.7063
Echinococcus granulosus 7tm_1 domain containing protein 0.0125 0.5645 0.5645
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.0153 0.0153
Loa Loa (eye worm) cathepsin B 0.007 0.2684 0.3044
Echinococcus multilocularis serotonin receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Onchocerca volvulus Neuropeptide F receptor homolog 0.0125 0.5645 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni histamine h1 receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.5645 0.5645
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2119
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0125 0.5645 0.6505
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Onchocerca volvulus 0.0086 0.3558 0.6303
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.4895 0.5641
Schistosoma mansoni cathepsin s 0.0027 0.0369 0.0369
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0125 0.5645 0.5645
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.3558 0.3558
Brugia malayi Melatonin receptor type 1A 0.0125 0.5645 0.6505
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) phosphatidylinositol 3 0.0183 0.8816 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.1758 0.1994
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.4895 0.5641
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1442 0.1662
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Echinococcus multilocularis G protein coupled receptor 139 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0086 0.3558 0.6303
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0095 0.4032 0.4646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Giardia lamblia Kinase, AGC PKA 0.0023 0.0153 0.0571
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.1758 0.2026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.3558 0.4035
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) cysteine protease 0.0086 0.3558 0.4035
Plasmodium vivax vivapain-2 0.0086 0.3558 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Echinococcus granulosus cathepsin l1 0.0059 0.2115 0.2115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis cathepsin b 0.0181 0.8677 0.8677
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Onchocerca volvulus 0.0125 0.5645 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.8677 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0672 0.1372
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0275 0.0317
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.4895 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Echinococcus multilocularis nervana 2 0.0022 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0181 0.8677 0.9843
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.4895 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2115 0.2438
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0125 0.5645 0.6402
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0039 0.1037 0.2119
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus cathepsin L 0.0047 0.1442 0.1442
Brugia malayi AKH receptor 0.0125 0.5645 0.6505
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.5645 0.5645
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.3558 0.41
Entamoeba histolytica cysteine protease, putative 0.0086 0.3558 0.7269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0125 0.5645 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0022 0.014 0.014
Brugia malayi GnHR receptor homolog 0.0125 0.5645 0.6505
Echinococcus multilocularis neuropeptide receptor A26 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0153 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Brugia malayi ORL1-like opioid receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1442 0.1662
Brugia malayi follicle stimulating hormone receptor 0.0125 0.5645 0.6505
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0125 0.5645 0.5645
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0205 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0454 0.169
Echinococcus granulosus fmrfamide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Echinococcus multilocularis cysteine protease 0.0086 0.3558 0.3558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2115 0.4322
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0369 0.0425
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0125 0.5645 0.5645
Brugia malayi Dopamine receptor protein 1 0.0125 0.5645 0.6505
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0073 0.2852 0.3287
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0356 0.0456
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0111 0.4895 1
Echinococcus multilocularis fmrfamide receptor 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus multilocularis nervana 2 0.0022 0.014 0.014
Echinococcus granulosus cathepsin b 0.0181 0.8677 0.8677
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Onchocerca volvulus 0.0125 0.5645 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0039 0.1037 0.1195
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0125 0.5645 0.5645
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.5645 0.5645
Brugia malayi Protein kinase domain containing protein 0.0036 0.0894 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.1442 0.1662
Schistosoma mansoni neuropeptide f receptor 76f 0.0125 0.5645 0.5645
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.1758 0.4635
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0039 0.1037 0.1037
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Loa Loa (eye worm) TYRA-2 protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.2684 0.7395
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.4895 0.5641
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Echinococcus granulosus cysteine protease 0.0047 0.1442 0.1442
Echinococcus granulosus tachykinin peptides receptor 99D 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.0275 0.0275
Onchocerca volvulus 0.0086 0.3558 0.6303
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.1758 0.2026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0125 0.5645 0.6402
Plasmodium vivax vivapain-1 0.0047 0.1442 0.4054
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0073 0.2852 0.2852
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Echinococcus multilocularis g-protein coupled receptor 0.0125 0.5645 0.5645
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.8677 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Loa Loa (eye worm) melatonin receptor type 1A 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0038 0.0969 0.1099
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0369 0.0425
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1442 0.1662
Brugia malayi putative neuropeptide receptor 0.0125 0.5645 0.6505
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.1758 0.1758
Echinococcus granulosus neuropeptide receptor A26 0.0125 0.5645 0.5645
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.2684 0.3093
Entamoeba histolytica protein kinase, putative 0.0034 0.0772 0.1578
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis neuropeptide receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Echinococcus granulosus neuropeptide receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi Serotonin receptor 0.0125 0.5645 0.6505
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Echinococcus granulosus cathepsin b 0.0181 0.8677 0.8677
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Brugia malayi G protein-coupled receptor 0.0125 0.5645 0.6505
Brugia malayi putative neuropeptide receptor NPR1 0.0125 0.5645 0.6505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) fibroinase 0.0086 0.3558 0.4035
Entamoeba histolytica hypothetical protein 0.0089 0.3711 0.7581
Brugia malayi Cathepsin L-like precursor 0.0027 0.0369 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.2684 0.6268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.1216 0.1401
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Toxoplasma gondii AGC kinase 0.0034 0.0772 0.217
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0089 0.3711 0.7581
Schistosoma mansoni myosin xvIII 0.0125 0.5645 0.5645
Brugia malayi larval opioid receptor 0.0125 0.5645 0.6505
Onchocerca volvulus 0.0125 0.5645 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Echinococcus granulosus neuropeptide FF receptor 2 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.1076 0.3025
Echinococcus granulosus hypothetical protein 0.0125 0.5645 0.5645
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.1442 0.1662
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.3079 0.6291
Onchocerca volvulus 0.0125 0.5645 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2115 0.2438
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0369 0.0425
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0039 0.1037 0.2119
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.1216 0.302
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.1037 0.2119
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2115 0.4322
Echinococcus granulosus g-protein coupled receptor 0.0125 0.5645 0.5645
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus neuropeptide receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Brugia malayi neuropeptide F receptor 0.0125 0.5645 0.6505
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.1442 0.1442
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.5645 0.5645
Echinococcus granulosus 7TM GPCR rhodopsin 0.0125 0.5645 0.5645
Brugia malayi Cathepsin L-like precursor 0.0059 0.2115 0.2438
Entamoeba histolytica protein kinase, putative 0.0036 0.0894 0.1826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.2684 0.2684
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Schistosoma mansoni adenoreceptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1442 0.2947
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.3558 0.4035
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0125 0.5645 0.5645
Echinococcus granulosus alpha 1A adrenergic receptor 0.0125 0.5645 0.5645
Brugia malayi Dopamine receptor protein 2 0.0125 0.5645 0.6505
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Loa Loa (eye worm) hypothetical protein 0.0073 0.2852 0.3235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0125 0.5645 0.5645
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Echinococcus granulosus G protein coupled receptor 139 0.0125 0.5645 0.5645
Onchocerca volvulus Cathepsin L homolog 0.0086 0.3558 0.6303
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0275 0.0561
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1442 0.3694
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.5645 0.6402
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.1442 0.4054
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.5645 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus multilocularis cysteine protease 0.0086 0.3558 0.3558
Brugia malayi neuropeptide F receptor 0.0125 0.5645 0.6505
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.1758 0.2315
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Schistosoma mansoni alpha-1 adrenergic receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus nervana 2 0.0022 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1442 0.3694
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2115 0.2115
Trypanosoma cruzi cysteine protease, putative 0.0047 0.1442 0.1662
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Plasmodium vivax unspecified product 0.0047 0.1442 0.4054
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.0772 0.0876
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1369 0.2797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Echinococcus multilocularis fmrfamide receptor 0.0125 0.5645 0.5645
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0275 0.0561
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0073 0.2852 0.2852
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.3558 1
Echinococcus granulosus allatostatin A receptor 0.0125 0.5645 0.5645
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.3558 1
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.5645 0.5645
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Entamoeba histolytica cysteine proteinase 2 0.0047 0.1442 0.2947
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0125 0.5645 0.6505

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.018 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 2.3 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 10 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 17 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 0.018 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 2.3 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 10 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 17 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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