Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.6 | Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand. | ChEMBL. | 8258822 |
Ki (binding) | = -7.6 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Ki (binding) | = -5.967 | Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand. | ChEMBL. | 8258822 |
Log Ki (binding) | = 5.967 | Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand. | ChEMBL. | 8258822 |
Log Ki (binding) | = 7.6 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Log Ki (binding) | = 7.602 | Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand. | ChEMBL. | 8258822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.