Detailed information for compound 36297

Basic information

Technical information
  • TDR Targets ID: 36297
  • Name: 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1 -yl]-5-(pyridin-4-ylmethyl)pyrimido[5,4-b]ind ole-9-carboxamide
  • MW: 527.568 | Formula: C29H27F2N7O
  • H donors: 1 H acceptors: 4 LogP: 3.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)c1cccc2c1c1ncnc(c1n2Cc1ccncc1)N1CCN(CC1)CCc1ccc(c(c1)F)F
  • InChi: 1S/C29H27F2N7O/c30-22-5-4-19(16-23(22)31)8-11-36-12-14-37(15-13-36)29-27-26(34-18-35-29)25-21(28(32)39)2-1-3-24(25)38(27)17-20-6-9-33-10-7-20/h1-7,9-10,16,18H,8,11-15,17H2,(H2,32,39)
  • InChiKey: BLIMNWSQDQYNMP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5-(4-pyridylmethyl)pyrimido[5,4-b]indole-9-carboxamide
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]-1-piperazinyl]-5-(4-pyridylmethyl)-9-pyrimido[5,4-b]indolecarboxamide
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazino]-5-(4-pyridylmethyl)pyrimido[5,4-b]indole-9-carboxamide
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5-(pyridin-4-ylmethyl)pyrimido[5,6-b]indole-9-carboxamide
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5-(4-pyridylmethyl)pyrimido[5,6-b]indole-9-carboxamide
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]-1-piperazinyl]-5-(4-pyridylmethyl)-9-pyrimido[5,6-b]indolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1A Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0099 0.1272 0.1225
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0119 0.0119
Schistosoma mansoni cathepsin S (C01 family) 0.0099 0.1272 0.1225
Echinococcus multilocularis cathepsin b 0.0685 1 1
Schistosoma mansoni cathepsin s 0.0144 0.195 0.1907
Echinococcus multilocularis cysteine protease 0.043 0.6204 0.6204
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0099 0.1272 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.028 0.3971 0.637
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0017 0.0053 0.5
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0017 0.0053 0.0045
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0119 0.0119
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0099 0.1272 0.1982
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Leishmania major pentamidine resistance protein 1 0.0021 0.0119 0.0152
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0017 0.0053 0.0049
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0099 0.1272 0.1982
Plasmodium falciparum cysteine proteinase falcipain 3 0.043 0.6204 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0099 0.1272 0.1982
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0119 0.0119
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Giardia lamblia Cathepsin B precursor 0.0099 0.1272 0.3
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0053 0.0053
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0053 0.0053
Plasmodium vivax vivapain-1 0.0243 0.3418 0.5471
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.043 0.6204 1
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.6204 0.6204
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0286 0.4058 0.6511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Loa Loa (eye worm) hypothetical protein 0.0685 1 1
Plasmodium falciparum serine repeat antigen 9 0.0099 0.1272 0.1982
Brugia malayi cathepsin F-like cysteine proteinase 0.0099 0.1272 0.125
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0099 0.1272 0.1982
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Giardia lamblia ABC transporter, putative 0.0021 0.0119 0.0011
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0099 0.1272 0.3
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0119 0.0119
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.3418 0.3383
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Brugia malayi fibroinase precursor 0.0099 0.1272 0.125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3971 0.3939
Giardia lamblia Encystation-specific protease 0.0099 0.1272 0.3
Onchocerca volvulus Cathepsin F homolog 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Brugia malayi cathepsin L-like precursor 0.0286 0.4058 0.4043
Plasmodium falciparum serine repeat antigen 4 0.0099 0.1272 0.1982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1272 0.1225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0115
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.3418 0.3401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Leishmania major ABC-thiol transporter 0.0021 0.0119 0.0152
Plasmodium vivax serine-repeat antigen (SERA) 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0053 0.0053
Entamoeba histolytica cysteine proteinase 1, putative 0.0243 0.3418 0.5471
Entamoeba histolytica cysteine proteinase, putative 0.043 0.6204 1
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Onchocerca volvulus 0.0099 0.1272 0.1982
Brugia malayi Cathepsin L-like precursor 0.0286 0.4058 0.4043
Loa Loa (eye worm) hypothetical protein 0.0144 0.195 0.1947
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Onchocerca volvulus Cathepsin L homolog 0.043 0.6204 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0119 0.0152
Onchocerca volvulus 0.043 0.6204 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0119 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Onchocerca volvulus 0.0286 0.4058 0.6511
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0099 0.1272 0.125
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Loa Loa (eye worm) hypothetical protein 0.0286 0.4058 0.4055
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0144 0.195 0.193
Entamoeba histolytica cysteine proteinase, putative 0.0286 0.4058 0.6511
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0099 0.1272 0.1982
Trypanosoma cruzi cysteine proteinase, putative 0.0243 0.3418 0.3418
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.6204 0.6204
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.3418 0.3401
Onchocerca volvulus 0.043 0.6204 1
Entamoeba histolytica ABC transporter, putative 0.0021 0.0119 0.0107
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0119 0.0152
Brugia malayi Cathepsin L-like precursor 0.0286 0.4058 0.4043
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0025 0.0021
Onchocerca volvulus 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Brugia malayi multidrug resistance related protein 1 0.0021 0.0119 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0243 0.3418 0.3418
Plasmodium vivax unspecified product 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Schistosoma mansoni cathepsin B (C01 family) 0.0099 0.1272 0.1225
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.043 0.6204 0.6203
Plasmodium falciparum cysteine proteinase falcipain 2a 0.043 0.6204 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0119 0.0107
Giardia lamblia Cysteine protease 0.0099 0.1272 0.3
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0685 1 1
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0016 0.0049 0.0049
Plasmodium vivax vivapain-3 0.0243 0.3418 0.5471
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0053 0.0053
Toxoplasma gondii cathepsin CPC2 0.0099 0.1272 0.1982
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.6204 0.6204
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0099 0.1272 0.1982
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.3418 0.3383
Loa Loa (eye worm) ctsf protein 0.043 0.6204 0.6203
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.043 0.6204 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.043 0.6204 0.6203
Loa Loa (eye worm) cathepsin B 0.028 0.3971 0.3969
Leishmania major p-glycoprotein e 0.0021 0.0119 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0099 0.1272 0.1982
Onchocerca volvulus 0.043 0.6204 1
Giardia lamblia Cathepsin L-like protease 0.0099 0.1272 0.3
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0119 0.0107
Plasmodium vivax unspecified product 0.0144 0.195 0.3084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Giardia lamblia Cathepsin B precursor 0.0099 0.1272 0.3
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1272 0.1982
Brugia malayi Papain family cysteine protease containing protein 0.043 0.6204 0.6195
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0025 0.0021
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0053 0.0053
Loa Loa (eye worm) fibroinase 0.043 0.6204 0.6203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1272 0.1982
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Giardia lamblia Cathepsin B precursor 0.0099 0.1272 0.3
Trypanosoma cruzi cruzipain precursor, putative 0.0144 0.195 0.195
Entamoeba histolytica cysteine proteinase, putative 0.043 0.6204 1
Giardia lamblia Cathepsin L-like protease 0.0099 0.1272 0.3
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0099 0.1272 0.1982
Onchocerca volvulus Cathepsin L homolog 0.0099 0.1272 0.1982
Schistosoma mansoni cathepsin F (C01 family) 0.043 0.6204 0.6184
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.3418 0.5471
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0053 0.0053
Leishmania major p-glycoprotein 0.0017 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.0144 0.195 0.1947
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0243 0.3418 0.5471
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0119 0.0152
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Echinococcus granulosus cathepsin L 0.0243 0.3418 0.3418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0243 0.3418 0.3418
Giardia lamblia Cysteine protease 0.0099 0.1272 0.3
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Toxoplasma gondii cathepsin B 0.028 0.3971 0.637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.1272 0.1982
Entamoeba histolytica hypothetical protein 0.0021 0.0119 0.0107
Brugia malayi cathepsin L precursor 0.0099 0.1272 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0119 0.0107
Giardia lamblia Cysteine protease 0.0099 0.1272 0.3
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0243 0.3418 0.5491
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0119 0.0119
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1272 0.1225
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0119 0.0152
Brugia malayi cathepsin L-like cysteine proteinase 0.0099 0.1272 0.125
Echinococcus multilocularis cathepsin l cysteine peptidase 0.043 0.6204 0.6204
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.3418 0.5471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Echinococcus granulosus cysteine protease 0.0243 0.3418 0.3418
Plasmodium falciparum cysteine proteinase falcipain 2b 0.043 0.6204 1
Giardia lamblia Cathepsin B precursor 0.0099 0.1272 0.3
Echinococcus multilocularis cysteine protease 0.043 0.6204 0.6204
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0099 0.1272 0.3
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.6204 0.6204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Echinococcus granulosus cathepsin L cysteine protease 0.0243 0.3418 0.3418
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0685 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0099 0.1272 0.1225
Plasmodium falciparum serine repeat antigen 3 0.0099 0.1272 0.1982
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0025 0.0025
Echinococcus multilocularis ATP binding cassette sub family B 0.0016 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Echinococcus granulosus cathepsin L cysteine proteinase 0.043 0.6204 0.6204
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0286 0.4058 0.4058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1272 0.1982
Schistosoma mansoni multidrug resistance protein 0.0021 0.0119 0.0066
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.028 0.3971 0.3971
Onchocerca volvulus 0.043 0.6204 1
Toxoplasma gondii cathepsin CPL 0.043 0.6204 1
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Echinococcus multilocularis cathepsin L 0.0243 0.3418 0.3418
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.3418 0.5471
Echinococcus granulosus cathepsin L 0.0099 0.1272 0.1272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Plasmodium vivax vivapain-2 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.3418 0.5471
Leishmania major cathepsin L-like protease 0.043 0.6204 1
Onchocerca volvulus Cathepsin L homolog 0.043 0.6204 1
Trypanosoma brucei p-glycoprotein 0.0021 0.0119 0.0152
Echinococcus granulosus cathepsin b 0.0685 1 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Giardia lamblia Cathepsin B precursor 0.028 0.3971 1
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Brugia malayi cathepsin Z-like cysteine proteinase 0.0099 0.1272 0.125
Echinococcus granulosus cathepsin l1 0.0286 0.4058 0.4058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Loa Loa (eye worm) hypothetical protein 0.0286 0.4058 0.4055
Brugia malayi Cathepsin L-like precursor 0.0144 0.195 0.193
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0099 0.1272 0.1982
Plasmodium falciparum serine repeat antigen 8 0.0099 0.1272 0.1982
Brugia malayi Cathepsin L-like cysteine proteinase 0.0286 0.4058 0.4043
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0099 0.1272 0.1225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0286 0.4058 0.4055
Trypanosoma cruzi cysteine proteinase, putative 0.0243 0.3418 0.3418
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1272 0.1225
Plasmodium falciparum serine repeat antigen 2 0.0099 0.1272 0.1982
Schistosoma mansoni multidrug resistance protein 0.0021 0.0119 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.1272 0.125
Schistosoma mansoni cathepsin F (C01 family) 0.0286 0.4058 0.4026
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0119 0.0152
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0119 0.0115
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.028 0.3971 0.6386
Onchocerca volvulus 0.043 0.6204 1
Giardia lamblia MRP-like ABC transporter 0.0021 0.0119 0.0011
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0053 0.0053
Echinococcus granulosus cathepsin l cysteine peptidase 0.043 0.6204 0.6204
Entamoeba histolytica cysteine protease, putative 0.0243 0.3418 0.5471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0099 0.1272 0.1225
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1272 0.1225
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0144 0.195 0.193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0119 0.0107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0049
Schistosoma mansoni multidrug resistance protein 0.0021 0.0119 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.3418 0.3383
Plasmodium falciparum serine repeat antigen 1 0.0099 0.1272 0.1982
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.1272 0.1982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0685 1 1
Entamoeba histolytica hypothetical protein 0.0099 0.1272 0.1982
Trypanosoma brucei cysteine peptidase C (CPC) 0.028 0.3971 0.6386
Brugia malayi ABC transporter family protein 0.0017 0.0053 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1272 0.1982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0243 0.3418 0.5491
Brugia malayi cathepsin Z-like cysteine proteinase 0.0099 0.1272 0.125
Entamoeba histolytica cysteine protease, putative 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0099 0.1272 0.1268
Loa Loa (eye worm) hypothetical protein 0.0144 0.195 0.1947
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0099 0.1272 0.1268
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0025 0.0021
Plasmodium vivax unspecified product 0.0243 0.3418 0.5471
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.1272 0.1272
Schistosoma mansoni multidrug resistance protein 0.0021 0.0119 0.0066
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0119 0.0119
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0053 0.0053
Toxoplasma gondii cathepsin CPC1 0.0099 0.1272 0.1982
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0099 0.1272 0.1982
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0099 0.1272 0.1982
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0144 0.195 0.1947
Plasmodium falciparum serine repeat antigen 6 0.0099 0.1272 0.1982
Onchocerca volvulus 0.043 0.6204 1
Giardia lamblia Cathepsin B precursor 0.028 0.3971 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0099 0.1272 0.1982
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0685 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Trypanosoma cruzi cysteine peptidase, putative 0.0144 0.195 0.195
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0119 0.0152
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.3418 0.5471
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.3418 0.5471
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Loa Loa (eye worm) multidrug resistance protein 3 0.0017 0.0053 0.0049
Giardia lamblia Cathepsin B precursor 0.028 0.3971 1
Entamoeba histolytica cysteine protease, putative 0.043 0.6204 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0099 0.1272 0.3
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.1272 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0119 0.0107
Giardia lamblia Cysteine protease 0.0099 0.1272 0.3
Echinococcus multilocularis cathepsin l cysteine peptidase 0.043 0.6204 0.6204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.6204 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0017 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0025 0.0025
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0099 0.1272 0.1982
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0119 0.0107
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Schistosoma mansoni cathepsin C 0.0099 0.1272 0.1225
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0099 0.1272 0.1268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0119 0.0094
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0099 0.1272 0.1982
Trypanosoma cruzi cruzipain precursor, putative 0.043 0.6204 0.6204
Leishmania major cysteine peptidase A (CPA) 0.043 0.6204 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0119 0.0011
Entamoeba histolytica cysteine proteinase 2 0.0243 0.3418 0.5471
Giardia lamblia Hypothetical protein 0.0099 0.1272 0.3
Schistosoma mansoni cathepsin F (C01 family) 0.043 0.6204 0.6184
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0053 0.0053
Trypanosoma brucei multidrug resistance protein E 0.0021 0.0119 0.0152
Echinococcus multilocularis cathepsin L cysteine protease 0.043 0.6204 0.6204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0286 0.4058 0.6511
Echinococcus granulosus cathepsin b 0.0685 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.043 0.6204 0.6204
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.1272 0.125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1272 0.1225
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0025 0.5
Echinococcus granulosus cathepsin l1 0.043 0.6204 0.6204
Loa Loa (eye worm) cysteine protease 0.043 0.6204 0.6203
Giardia lamblia Cathepsin L precursor 0.0099 0.1272 0.3
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0099 0.1272 0.1982
Giardia lamblia Cathepsin B precursor 0.0099 0.1272 0.3
Trypanosoma cruzi cysteine protease, putative 0.0243 0.3418 0.3418
Plasmodium vivax vivapain-2 0.043 0.6204 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0099 0.1272 0.1982
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0099 0.1272 0.3
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0053 0.0053
Giardia lamblia Hypothetical protein 0.0099 0.1272 0.3
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.043 0.6204 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.6204 1
Brugia malayi Cathepsin L-like precursor 0.043 0.6204 0.6195
Plasmodium vivax serine-repeat antigen (SERA) 0.0099 0.1272 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0049
Echinococcus multilocularis cathepsin L 0.0099 0.1272 0.1272
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0685 1 1
Plasmodium falciparum serine repeat antigen 7 0.0099 0.1272 0.1982
Loa Loa (eye worm) hypothetical protein 0.043 0.6204 0.6203
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0053 0.0053
Plasmodium falciparum serine repeat antigen 5 0.0099 0.1272 0.1982
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.1272 0.1272
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0115
Brugia malayi multidrug resistance protein 3 0.0017 0.0053 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1272 0.1982
Echinococcus multilocularis cathepsin b 0.0685 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) = 0.02 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (ADMET) = 0.2 uM Inhibitory activity against cytochrome P450 3A4 ChEMBL. 14998324
IC50 (ADMET) = 0.2 uM Inhibitory activity against cytochrome P450 3A4 ChEMBL. 14998324
IC50 (binding) >= 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) >= 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) = 0.27 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) = 0.27 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) = 0.85 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) = 0.85 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) > 40 uM In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay ChEMBL. 14998324
IC50 (binding) > 40 uM In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay ChEMBL. 14998324

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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