TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.47 | Formula: C25H24N2O2
H donors: 1 H acceptors: 2 LogP: 4.58 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)c1cccc(c1)C(=O)C)Nc1ccc2c(c1)N(C)CCC2
InChi: 1S/C25H24N2O2/c1-17(28)21-5-3-6-22(15-21)18-8-10-20(11-9-18)25(29)26-23-13-12-19-7-4-14-27(2)24(19)16-23/h3,5-6,8-13,15-16H,4,7,14H2,1-2H3,(H,26,29)
InChiKey: FXBAKEKMXDSFRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Plasmodium vivax	unspecified product	0.0192	0.1167	0.2249
Onchocerca volvulus	Cathepsin F homolog	0.0616	0.4538	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0616	0.4538	0.4538
Schistosoma mansoni	amine oxidase	0.0069	0.0189	0.0189
Schistosoma mansoni	cathepsin S (C01 family)	0.0143	0.0779	0.0779
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Toxoplasma gondii	cathepsin B	0.0502	0.3631	0.7914
Toxoplasma gondii	cathepsin CPC1	0.0143	0.0779	0.1357
Echinococcus granulosus	cysteine protease	0.0335	0.2303	0.2303
Onchocerca volvulus	Cathepsin L homolog	0.0616	0.4538	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0143	0.0779	0.1357
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0335	0.2303	0.4054
Echinococcus granulosus	geminin	0.0165	0.0957	0.0957
Loa Loa (eye worm)	cathepsin B	0.0502	0.3631	0.3631
Plasmodium falciparum	serine repeat antigen 2	0.0143	0.0779	0.1357
Echinococcus multilocularis	cathepsin L	0.0335	0.2303	0.2303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0616	0.4538	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0502	0.3631	0.7914
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0143	0.0779	0.0779
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Brugia malayi	cathepsin F-like cysteine proteinase	0.0192	0.1167	0.1167
Onchocerca volvulus		0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0502	0.3631	0.3508
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0335	0.2303	0.2155
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0502	0.3631	0.7587
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Echinococcus multilocularis	cathepsin L cysteine protease	0.0616	0.4538	0.4538
Echinococcus granulosus	cathepsin L	0.0335	0.2303	0.2303
Loa Loa (eye worm)	hypothetical protein	0.1304	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.1487	0.1487
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin C	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0143	0.0779	0.1357
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.003	0.003
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0616	0.4538	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0143	0.0779	0.1357
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0143	0.0779	0.1357
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Onchocerca volvulus		0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Echinococcus granulosus	cathepsin l1	0.0616	0.4538	0.4538
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0616	0.4538	0.4538
Schistosoma mansoni	cathepsin s	0.0192	0.1167	0.1167
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0143	0.0779	0.1357
Plasmodium falciparum	serine repeat antigen 3	0.0143	0.0779	0.1357
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0192	0.1167	0.1167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0143	0.0779	0.0779
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0069	0.0189	0.5
Plasmodium vivax	unspecified product	0.0335	0.2303	0.4861
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0176	0.1045	0.1045
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Schistosoma mansoni	hypothetical protein	0.0165	0.0957	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Plasmodium falciparum	serine repeat antigen 4	0.0143	0.0779	0.1357
Brugia malayi	Papain family cysteine protease containing protein	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0192	0.1167	0.1167
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1135	0.1135
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	hypothetical protein	0.0232	0.1487	0.1487
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.003	0.003
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0424	0.3014	0.288
Echinococcus granulosus	cathepsin L cysteine protease	0.0335	0.2303	0.2303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Plasmodium vivax	vivapain-3	0.0335	0.2303	0.4861
Onchocerca volvulus		0.0188	0.1135	0.247
Brugia malayi	Papain family cysteine protease containing protein	0.0335	0.2303	0.2303
Schistosoma mansoni	hypothetical protein	0.0165	0.0957	0.0957
Echinococcus multilocularis	cysteine protease	0.0616	0.4538	0.4538
Trypanosoma cruzi	major cysteine proteinase, putative	0.0143	0.0779	0.0602
Plasmodium vivax	vivapain-2	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0189	0.0189
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0616	0.4538	1
Onchocerca volvulus	Cathepsin L homolog	0.0616	0.4538	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0019	0.0019
Plasmodium vivax	vivapain-1	0.0335	0.2303	0.4861
Trypanosoma cruzi	cysteine proteinase, putative	0.0335	0.2303	0.2155
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0502	0.3631	0.5942
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0143	0.0779	0.0779
Onchocerca volvulus		0.0424	0.3014	0.6628
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1045	0.1045
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1304	1	1
Loa Loa (eye worm)	cysteine protease	0.0616	0.4538	0.4538
Brugia malayi	Papain family cysteine protease containing protein	0.0335	0.2303	0.2303
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	ctsf protein	0.0616	0.4538	0.4538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0424	0.3014	0.3014
Entamoeba histolytica	cysteine proteinase, putative	0.0616	0.4538	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0143	0.0779	0.1357
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1487	0.1487
Plasmodium falciparum	serine repeat antigen 7	0.0143	0.0779	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine proteinase 2	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0176	0.1045	0.1045
Plasmodium vivax	serine-repeat antigen (SERA)	0.0143	0.0779	0.1357
Trypanosoma cruzi	cruzipain precursor, putative	0.0192	0.1167	0.0997
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0502	0.3631	0.3631
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0192	0.1167	0.1167
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0616	0.4538	0.4538
Echinococcus granulosus	cathepsin l1	0.0424	0.3014	0.3014
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0335	0.2303	0.4054
Schistosoma mansoni	hypothetical protein	0.0047	0.0019	0.0019
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Trypanosoma cruzi	cysteine protease, putative	0.0335	0.2303	0.2155
Brugia malayi	Cathepsin L-like precursor	0.0424	0.3014	0.3014
Trypanosoma cruzi	cruzipain precursor, putative	0.0616	0.4538	0.4433
Echinococcus multilocularis		0.0069	0.0189	0.0189
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0192	0.1167	0.0997
Leishmania major	cysteine peptidase A (CPA)	0.0616	0.4538	1
Onchocerca volvulus		0.0616	0.4538	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0143	0.0779	0.1357
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Toxoplasma gondii	cathepsin CPL	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0335	0.2303	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0143	0.0779	0.0779
Plasmodium falciparum	serine repeat antigen 1	0.0143	0.0779	0.1357
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0616	0.4538	0.4538
Brugia malayi	cathepsin F-like cysteine proteinase	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0424	0.3014	0.5946
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0143	0.0779	0.1357
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Echinococcus multilocularis	cathepsin b	0.1304	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.003	0.003
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Plasmodium falciparum	serine repeat antigen 6	0.0143	0.0779	0.1357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1045	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0189	0.0189
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Plasmodium falciparum	serine repeat antigen 5	0.0143	0.0779	0.1357
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0612	0.4509	1
Echinococcus granulosus	cathepsin L	0.0143	0.0779	0.0779
Brugia malayi	Cathepsin L-like precursor	0.0424	0.3014	0.3014
Plasmodium vivax	serine-repeat antigen (SERA)	0.0143	0.0779	0.1357
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0143	0.0779	0.0779
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Onchocerca volvulus		0.0616	0.4538	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0143	0.0779	0.1357
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0019	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0335	0.2303	0.2155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0335	0.2303	0.4861
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Echinococcus multilocularis	cysteine protease	0.0616	0.4538	0.4538
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1304	1	1
Plasmodium falciparum	serine repeat antigen 9	0.0143	0.0779	0.1357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0069	0.0189	0.0189
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0544	0.3964	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	cathepsin L-like precursor	0.0424	0.3014	0.3014
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0069	0.0189	0.5
Plasmodium falciparum	serine repeat antigen 8	0.0143	0.0779	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0612	0.4509	1
Echinococcus granulosus	cathepsin b	0.1304	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0069	0.0189	0.0189
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Plasmodium vivax	unspecified product	0.0143	0.0779	0.1357
Plasmodium vivax	vivapain-2	0.0616	0.4538	1
Loa Loa (eye worm)	fibroinase	0.0616	0.4538	0.4538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0335	0.2303	0.2155
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0069	0.0189	0.0189
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0616	0.4538	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine proteinase, putative	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	hypothetical protein	0.0069	0.0189	0.0189
Onchocerca volvulus	Cathepsin L homolog	0.0143	0.0779	0.1682
Echinococcus multilocularis	geminin	0.0165	0.0957	0.0957
Echinococcus granulosus	cathepsin b	0.1304	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0616	0.4538	0.4538
Toxoplasma gondii	cathepsin CPC2	0.0143	0.0779	0.1357
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0143	0.0779	0.1357
Echinococcus multilocularis	cathepsin L	0.0143	0.0779	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Schistosoma mansoni	amine oxidase	0.0069	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0049	0.003	0.003
Trypanosoma cruzi	major cysteine proteinase, putative	0.0143	0.0779	0.0602
Brugia malayi	cathepsin L precursor	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0424	0.3014	0.5946
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.1487	0.1487
Schistosoma mansoni	cathepsin F (C01 family)	0.0424	0.3014	0.3014
Echinococcus multilocularis	cathepsin b	0.1304	1	1
Onchocerca volvulus		0.0143	0.0779	0.1682
Onchocerca volvulus		0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.028	0.028
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0143	0.0779	0.1357
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0143	0.0779	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0616	0.4538	0.4538
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0143	0.0779	0.1357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Entamoeba histolytica	cysteine proteinase, putative	0.0424	0.3014	0.5946
Onchocerca volvulus		0.0616	0.4538	1
Onchocerca volvulus		0.0616	0.4538	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.008	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Brugia malayi	SWIRM domain containing protein	0.0188	0.1135	0.1135
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0176	0.1045	0.1045
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0143	0.0779	0.1357
Brugia malayi	fibroinase precursor	0.0143	0.0779	0.0779
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Brugia malayi	cathepsin L-like cysteine proteinase	0.0143	0.0779	0.0779
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779

Activities

Activity type	Activity value	Assay description	Source	Reference
pKb (functional)	= 7	Antagonist activity against human TRPV1 assessed as inhibition of capsaicin-induced calcium influx by FLIPR assay	ChEMBL.	16806913

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 368987