Detailed information for compound 369222

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.275 | Formula: C17H12O4
  • H donors: 0 H acceptors: 1 LogP: 3.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(c3c1cccc3)oc(=O)c1c2occ1C
  • InChi: 1S/C17H12O4/c1-9-8-20-16-12-7-13(19-2)10-5-3-4-6-11(10)15(12)21-17(18)14(9)16/h3-8H,1-2H3
  • InChiKey: BUPNQLSSOQMMJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi major cysteine proteinase, putative 0.0161 0.1075 0.1067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0424 0.0615
Brugia malayi N-terminal motif family protein 0.0179 0.1213 0.1213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0974 0.0974
Loa Loa (eye worm) fibroinase 0.0709 0.517 0.517
Trypanosoma cruzi major cysteine proteinase, putative 0.0206 0.1416 0.1408
Echinococcus granulosus lamin 0.0028 0.0081 0.0081
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0074 0.0074
Plasmodium vivax serine-repeat antigen (SERA) 0.0161 0.1075 0.195
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0225 0.1551 0.1551
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0139 0.5
Schistosoma mansoni cathepsin s 0.0222 0.1533 0.1533
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0161 0.1075 0.195
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0383 0.2735 0.2729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0424 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0555 0.0555
Giardia lamblia Cathepsin B precursor 0.053 0.3835 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0974 0.0974
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0144 0.0144
Onchocerca volvulus 0.0709 0.517 1
Echinococcus multilocularis cysteine protease 0.0709 0.517 0.517
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0025 0.0025
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0139 0.0139
Mycobacterium ulcerans beta-lactamase 0.0074 0.0424 0.3553
Leishmania major cysteine peptidase A (CPA) 0.0709 0.517 0.9381
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0974 0.0974
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0299 0.0427
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0139 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.1533 0.1525
Echinococcus multilocularis cathepsin b 0.1355 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0083 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0081 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Onchocerca volvulus Huntingtin homolog 0.0128 0.083 0.1472
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2735 0.5253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0974 0.0974
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2735 0.5253
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0222 0.1533 0.1533
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0193 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0114 0.0114
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0424 0.3553
Echinococcus granulosus cathepsin L cysteine protease 0.0383 0.2735 0.2735
Brugia malayi Cathepsin L-like cysteine proteinase 0.0487 0.351 0.351
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0424 0.0952
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0114 0.0114
Brugia malayi intermediate filament protein 0.0028 0.0081 0.0081
Brugia malayi Cathepsin L-like precursor 0.0487 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0709 0.517 0.517
Echinococcus granulosus geminin 0.0164 0.1096 0.1096
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0299 0.0299
Brugia malayi Inositol-1 0.0036 0.0139 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0974 0.0974
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0114 0.0114
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0161 0.1075 0.1075
Echinococcus multilocularis pyruvate kinase 0.0032 0.0113 0.0113
Leishmania major cathepsin L-like protease 0.0709 0.517 0.9381
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Brugia malayi mbt repeat family protein 0.0057 0.0299 0.0299
Toxoplasma gondii preprocathepsin c precursor, putative 0.0161 0.1075 0.195
Mycobacterium tuberculosis Conserved protein 0.0074 0.0424 0.0952
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0424 0.0615
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0424 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0161 0.1075 0.1902
Giardia lamblia Encystation-specific protease 0.0161 0.1075 0.2644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus peregrin 0.0031 0.0104 0.0104
Brugia malayi TAR-binding protein 0.0067 0.0373 0.0373
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0113 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Plasmodium vivax unspecified product 0.0383 0.2735 0.5214
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0424 0.0416
Loa Loa (eye worm) hypothetical protein 0.0128 0.083 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus lamin dm0 0.0028 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0114 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0373 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0083 0.0083
Entamoeba histolytica cysteine protease, putative 0.0709 0.517 1
Giardia lamblia Cysteine protease 0.0161 0.1075 0.2644
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0161 0.1075 0.1075
Schistosoma mansoni jumonji domain containing protein 0.0073 0.042 0.042
Echinococcus multilocularis cathepsin b 0.1355 1 1
Giardia lamblia Cathepsin L-like protease 0.0161 0.1075 0.2644
Schistosoma mansoni cathepsin B (C01 family) 0.0161 0.1075 0.1075
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0161 0.1075 0.195
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0988 1
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1075 0.1902
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Brugia malayi nuclear hormone receptor 0.0032 0.0114 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0424 0.3568
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0161 0.1075 0.195
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0161 0.1075 0.1902
Plasmodium falciparum serine repeat antigen 4 0.0161 0.1075 0.195
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0161 0.1075 0.195
Plasmodium falciparum serine repeat antigen 7 0.0161 0.1075 0.195
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1075 0.1953
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1075 0.1075
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Schistosoma mansoni cellular tumor antigen P53 0.011 0.0697 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0114 0.0114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0025 0.0025
Onchocerca volvulus Cathepsin F homolog 0.0709 0.517 1
Entamoeba histolytica cysteine proteinase, putative 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0357 0.0357
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0161 0.1075 0.195
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.053 0.3835 0.6955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Mycobacterium ulcerans lipase LipD 0.0074 0.0424 0.3553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0114 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Echinococcus multilocularis musashi 0.0028 0.0081 0.0081
Schistosoma mansoni pyruvate kinase 0.0032 0.0113 0.0113
Brugia malayi cathepsin Z-like cysteine proteinase 0.0161 0.1075 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0114 0.0114
Echinococcus multilocularis cathepsin L cysteine protease 0.0709 0.517 0.517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0114 0.0114
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2735 0.5185
Schistosoma mansoni inositol monophosphatase 0.0036 0.0139 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0161 0.1075 0.195
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0299 0.0299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1075 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0222 0.1533 0.1533
Onchocerca volvulus 0.0032 0.0114 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Trypanosoma cruzi cysteine peptidase, putative 0.0383 0.2735 0.2729
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Loa Loa (eye worm) hypothetical protein 0.0487 0.351 0.351
Brugia malayi nuclear receptor NHR-88 0.0032 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0373 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0083 0.0004
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0114 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0114 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0114 0.0114
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0161 0.1075 0.195
Plasmodium vivax unspecified product 0.0161 0.1075 0.195
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0114 0.0114
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.004
Brugia malayi ecdysteroid receptor 0.0032 0.0114 0.0114
Plasmodium falciparum serine repeat antigen 8 0.0161 0.1075 0.195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0232 0.0232
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0161 0.1075 0.195
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0081 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0253 0.0253
Loa Loa (eye worm) MBCTL1 0.0065 0.0357 0.0357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0424 0.0424
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Brugia malayi Bromodomain containing protein 0.009 0.0542 0.0542
Giardia lamblia Cathepsin B precursor 0.0161 0.1075 0.2644
Schistosoma mansoni lamin 0.0028 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0025 0.0025
Echinococcus multilocularis pyruvate kinase 0.0032 0.0113 0.0113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0562 0.0562
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0113 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0114 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Giardia lamblia Cathepsin B precursor 0.0161 0.1075 0.2644
Onchocerca volvulus 0.0709 0.517 1
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1075 0.1075
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0113 0.0104
Echinococcus granulosus cathepsin l1 0.0487 0.351 0.351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Plasmodium vivax vivapain-2 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.1075 0.1902
Plasmodium falciparum serine repeat antigen 9 0.0161 0.1075 0.195
Schistosoma mansoni hypothetical protein 0.0025 0.0057 0.0057
Brugia malayi cathepsin L-like cysteine proteinase 0.0161 0.1075 0.1075
Echinococcus multilocularis cathepsin L cysteine protease 0.0709 0.517 0.517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus multilocularis lamin dm0 0.0028 0.0081 0.0081
Giardia lamblia Cathepsin L-like protease 0.0161 0.1075 0.2644
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0114 0.0114
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0113 0.0063
Giardia lamblia Hypothetical protein 0.0161 0.1075 0.2644
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Plasmodium falciparum serine repeat antigen 5 0.0161 0.1075 0.195
Leishmania major pyruvate kinase 0.0032 0.0113 0.0189
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Leishmania major cathepsin L-like protease 0.0754 0.5511 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0114 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Trypanosoma cruzi cysteine peptidase, putative 0.0754 0.5511 0.5507
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0709 0.517 0.517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0383 0.2735 0.5185
Schistosoma mansoni cathepsin C 0.0161 0.1075 0.1075
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0161 0.1075 0.1075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0114 0.0114
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0114 0.0114
Brugia malayi jmjC domain containing protein 0.0036 0.0144 0.0144
Brugia malayi hypothetical protein 0.0128 0.083 0.083
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0161 0.1075 0.1075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1355 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Brugia malayi Bromodomain containing protein 0.0046 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0504 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Schistosoma mansoni hypothetical protein 0.0038 0.0154 0.0154
Brugia malayi cathepsin L precursor 0.0161 0.1075 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0114 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1075 0.1075
Mycobacterium ulcerans hypothetical protein 0.0074 0.0424 0.3553
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1075 0.1902
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0161 0.1075 0.195
Onchocerca volvulus Cathepsin L homolog 0.0709 0.517 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0307 0.0307
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0424 0.0671
Schistosoma mansoni hypothetical protein 0.0028 0.0083 0.0083
Plasmodium falciparum serine repeat antigen 3 0.0161 0.1075 0.195
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0709 0.517 1
Brugia malayi RNA binding protein 0.0067 0.0373 0.0373
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1355 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0114 0.0114
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Schistosoma mansoni cathepsin F (C01 family) 0.0487 0.351 0.351
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0114 0.0114
Echinococcus granulosus pyruvate kinase 0.0032 0.0113 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0114 0.0114
Giardia lamblia Cathepsin B precursor 0.0161 0.1075 0.2644
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0299 0.0299
Onchocerca volvulus 0.0709 0.517 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0113 0.0113
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0113 0.0006
Trypanosoma cruzi cysteine proteinase, putative 0.0383 0.2735 0.2729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2735 0.4955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Brugia malayi Papain family cysteine protease containing protein 0.0709 0.517 0.517
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0225 0.1551 0.1551
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0139 0.0236
Echinococcus multilocularis tumor protein p63 0.0754 0.5505 0.5505
Loa Loa (eye worm) hypothetical protein 0.0027 0.0077 0.0077
Echinococcus multilocularis geminin 0.0164 0.1096 0.1096
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0025 0.0025
Plasmodium falciparum pyruvate kinase 0.0032 0.0113 0.006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0139 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0555 0.0555
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0555 0.1002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0114 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0487 0.351 0.6764
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0988 0.2669
Leishmania major cathepsin L-like protease 0.0709 0.517 0.9381
Leishmania major cathepsin L-like protease 0.0709 0.517 0.9381
Brugia malayi steroid hormone receptor 0.0032 0.0114 0.0114
Leishmania major cathepsin L-like protease 0.0754 0.5511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Entamoeba histolytica hypothetical protein 0.0038 0.0154 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0232 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0114 0.0114
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0424 0.0755
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0383 0.2735 0.2735
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1075 0.1075
Schistosoma mansoni pyruvate kinase 0.0032 0.0113 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0038 0.0154 0.0221
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0424 0.0424
Mycobacterium leprae Probable lipase LipE 0.0074 0.0424 0.3568
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0299 0.0299
Giardia lamblia Hypothetical protein 0.0161 0.1075 0.2644
Loa Loa (eye worm) ctsf protein 0.0709 0.517 0.517
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0161 0.1075 0.2017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0424 0.0424
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0222 0.1533 0.1533
Trypanosoma brucei polo-like protein kinase 0.0091 0.0555 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0032 0.0113 0.0113
Plasmodium falciparum cysteine proteinase falcipain 1 0.0383 0.2735 0.5214
Plasmodium vivax vivapain-2 0.0709 0.517 1
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Toxoplasma gondii ABC1 family protein 0.0074 0.0424 0.0671
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.1075 0.2644
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0114 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0114 0.0114
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0165 0.0165
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0161 0.1075 0.195
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.2157 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.053 0.3835 0.736
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0487 0.351 0.6717
Leishmania major hypothetical protein, conserved 0.0074 0.0424 0.0755
Schistosoma mansoni cathepsin S (C01 family) 0.0161 0.1075 0.1075
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0113 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0383 0.2735 0.2735
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0236 0.0236
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.1075 0.2644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0144 0.0144
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1075 0.1075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0114 0.0114
Brugia malayi beta-lactamase family protein 0.0074 0.0424 0.0424
Toxoplasma gondii cathepsin B 0.053 0.3835 0.7376
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0114 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0424 0.0424
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0154 0.0154
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0406 0.0406
Entamoeba histolytica cysteine proteinase 2 0.0383 0.2735 0.5253
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0487 0.351 0.351
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0424 0.0952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0113 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0144 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.021 0.0191
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0074 0.0074
Onchocerca volvulus 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.1533 0.1533
Schistosoma mansoni hypothetical protein 0.0347 0.2463 0.2463
Onchocerca volvulus 0.0074 0.0424 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0114 0.0114
Onchocerca volvulus 0.0709 0.517 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0193 0.0193
Onchocerca volvulus 0.0057 0.0299 0.0427
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1213 0.2225
Brugia malayi beta-lactamase 0.0074 0.0424 0.0424
Onchocerca volvulus 0.0074 0.0424 0.0674
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0139 0.0295
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0988 1
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0161 0.1075 0.195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3398 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0114 0.0114
Echinococcus granulosus tumor protein p63 0.0754 0.5505 0.5505
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0114 0.0114
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Schistosoma mansoni zinc finger protein 0.0018 0.0009 0.0009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0357 0.0357
Brugia malayi MH2 domain containing protein 0.0231 0.1597 0.1597
Schistosoma mansoni cathepsin F (C01 family) 0.0709 0.517 0.517
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.021 0.0191
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0161 0.1075 0.2644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.0974 0.0974
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.1075 0.1902
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0114 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1075 0.1075
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0161 0.1075 0.1075
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0424 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0114 0.0114
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0555 0.0555
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0383 0.2735 0.4955
Entamoeba histolytica hypothetical protein 0.0038 0.0154 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.1533 0.1533
Plasmodium falciparum cysteine proteinase falcipain 3 0.0709 0.517 1
Giardia lamblia Cysteine protease 0.0161 0.1075 0.2644
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.1597 0.1597
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0555 0.093
Echinococcus granulosus cysteine protease 0.0383 0.2735 0.2735
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0119
Brugia malayi jmjC domain containing protein 0.0092 0.0562 0.0562
Brugia malayi Papain family cysteine protease containing protein 0.0383 0.2735 0.2735
Schistosoma mansoni cathepsin F (C01 family) 0.0709 0.517 0.517
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0161 0.1075 0.1902
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0424 0.0952
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0373 0.0373
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0113 0.0024
Echinococcus granulosus tar DNA binding protein 0.0067 0.0373 0.0373
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.053 0.3835 0.383
Brugia malayi beta-lactamase family protein 0.0074 0.0424 0.0424
Echinococcus granulosus intermediate filament protein 0.0028 0.0081 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0154 0.0154
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0114 0.0114
Plasmodium vivax serine-repeat antigen (SERA) 0.0161 0.1075 0.195
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.2157 0.5527
Echinococcus granulosus zinc finger protein 0.0023 0.0047 0.0047
Trypanosoma cruzi cruzipain precursor, putative 0.0222 0.1533 0.1525
Plasmodium falciparum serine repeat antigen 6 0.0161 0.1075 0.195
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2735 0.5253
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0025 0.0025
Brugia malayi fibroinase precursor 0.0161 0.1075 0.1075
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Brugia malayi mbt repeat family protein 0.0057 0.0299 0.0299
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1355 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0299 0.0299
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Schistosoma mansoni kinase 0.0046 0.0219 0.0219
Entamoeba histolytica hypothetical protein 0.0038 0.0154 0.0221
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.0546
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0114 0.0064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0424 0.0952
Giardia lamblia Cysteine protease 0.0161 0.1075 0.2644
Loa Loa (eye worm) hypothetical protein 0.0487 0.351 0.351
Onchocerca volvulus 0.011 0.0697 0.121
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0383 0.2735 0.2735
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0555 0.0991
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0709 0.517 1
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Echinococcus granulosus pyruvate kinase 0.0032 0.0113 0.0113
Plasmodium falciparum serine repeat antigen 1 0.0161 0.1075 0.195
Toxoplasma gondii cathepsin CPL 0.0709 0.517 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0127 0.0127
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0139 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0373 0.0373
Brugia malayi PHD-finger family protein 0.0028 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0709 0.517 1
Plasmodium falciparum serine repeat antigen 2 0.0161 0.1075 0.195
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0161 0.1075 0.1075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0114 0.0114
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0139 0.0051
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.053 0.3835 0.3835
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0114 0.0114
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0025
Schistosoma mansoni zinc finger protein 0.0023 0.0047 0.0047
Leishmania major cathepsin L-like protease 0.0709 0.517 0.9381
Trypanosoma brucei cysteine peptidase C (CPC) 0.053 0.3835 0.6955
Echinococcus multilocularis cathepsin L 0.0161 0.1075 0.1075
Schistosoma mansoni lamin 0.0028 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Trypanosoma cruzi cysteine peptidase, putative 0.0754 0.5511 0.5507
Entamoeba histolytica cysteine proteinase 1, putative 0.0383 0.2735 0.5253
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0424 0.0615
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Loa Loa (eye worm) hypothetical protein 0.0065 0.0357 0.0357
Giardia lamblia Pyruvate kinase 0.0032 0.0113 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Brugia malayi cathepsin L-like precursor 0.0487 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Loa Loa (eye worm) cathepsin B 0.053 0.3835 0.3835
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Toxoplasma gondii cathepsin CPC2 0.0161 0.1075 0.195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.0974 0.0974
Loa Loa (eye worm) cysteine protease 0.0709 0.517 0.517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Chlamydia trachomatis pyruvate kinase 0.0032 0.0113 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0709 0.517 0.517
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0113 0.006
Leishmania major pyruvate kinase 0.0032 0.0113 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0373 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0074 0.0424 0.0952
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0161 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.011 0.0697 0.0697
Echinococcus granulosus cathepsin L 0.0383 0.2735 0.2735
Trypanosoma cruzi cysteine proteinase, putative 0.0383 0.2735 0.2729
Giardia lamblia Cathepsin B precursor 0.053 0.3835 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0113 0.0113
Echinococcus granulosus cathepsin L cysteine proteinase 0.0709 0.517 0.517
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.1075 0.1902
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.2157 0.4126
Plasmodium vivax vivapain-3 0.0383 0.2735 0.5214
Giardia lamblia Cysteine protease 0.0161 0.1075 0.2644
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0164 0.1096 0.1096
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.1597 0.1597
Plasmodium vivax unspecified product 0.0222 0.1533 0.285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0114 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0709 0.517 0.5166
Giardia lamblia Kinase, PLK 0.0091 0.0555 0.1257
Schistosoma mansoni bromodomain containing protein 0.0076 0.0438 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0555 0.0555
Schistosoma mansoni coup transcription factor 0.0032 0.0114 0.0114
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0083 0.0083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0114 0.0114
Onchocerca volvulus 0.0161 0.1075 0.1953
Loa Loa (eye worm) hypothetical protein 0.0179 0.1213 0.1213
Loa Loa (eye worm) RNA binding protein 0.0067 0.0373 0.0373
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Giardia lamblia Cathepsin B precursor 0.0161 0.1075 0.2644
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0114 0.0114
Brugia malayi Bromodomain containing protein 0.0031 0.0104 0.0104
Brugia malayi cathepsin F-like cysteine proteinase 0.0161 0.1075 0.1075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2157 0.4041
Onchocerca volvulus 0.0487 0.351 0.6738
Brugia malayi cathepsin Z-like cysteine proteinase 0.0161 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0074 0.0424 0.0952
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0974 0.0974
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.004 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0114 0.0114
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0299 0.0299
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0081 0.0081
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0357 0.0357
Giardia lamblia Cathepsin B precursor 0.0161 0.1075 0.2644
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0161 0.1075 0.195
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1
Echinococcus granulosus cathepsin b 0.1355 1 1
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.1075 0.2644
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0114 0.0114
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0424 0.3553
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0424 0.0424
Brugia malayi Cathepsin L-like precursor 0.0709 0.517 0.517
Loa Loa (eye worm) hypothetical protein 0.0128 0.083 0.083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0114 0.0114
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0709 0.517 0.517
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0139 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0114 0.0114
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1355 1 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.1533 0.1533
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Giardia lamblia Cathepsin L precursor 0.0161 0.1075 0.2644
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0114 0.0064
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0139 0.0051
Onchocerca volvulus Huntingtin homolog 0.0128 0.083 0.1472
Trypanosoma cruzi cruzipain precursor, putative 0.0754 0.5511 0.5507
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0872
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0161 0.1075 0.2017
Schistosoma mansoni hypothetical protein 0.0164 0.1096 0.1096
Loa Loa (eye worm) beta-lactamase 0.0074 0.0424 0.0424
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0232 0.0232
Echinococcus granulosus cathepsin b 0.1355 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0709 0.517 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1075 0.1902
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0139 0.0139
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0424 0.0952
Trypanosoma cruzi cysteine peptidase, putative 0.0754 0.5511 0.5507
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0083 0.0083
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0357 0.0357
Echinococcus multilocularis cathepsin L 0.0383 0.2735 0.2735
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0114 0.0114
Onchocerca volvulus 0.0709 0.517 1
Onchocerca volvulus 0.0074 0.0424 0.0674
Echinococcus multilocularis cysteine protease 0.0709 0.517 0.517
Entamoeba histolytica cysteine proteinase, putative 0.0383 0.2735 0.5253
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0113 0.0189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0424 0.0424
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0709 0.517 0.517
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0081
Echinococcus multilocularis peregrin 0.0031 0.0104 0.0104
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0373 0.0373
Echinococcus multilocularis zinc finger protein 0.0023 0.0047 0.0047
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0048 0.0232 0.0232
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0025 0.0025
Echinococcus multilocularis lamin 0.0028 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0161 0.1075 0.1902
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0754 0.5511 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0139 0.0139
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0532 0.3851 0.3845
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Echinococcus granulosus cathepsin l cysteine peptidase 0.0709 0.517 0.517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1075 0.1902
Loa Loa (eye worm) hypothetical protein 0.0222 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.1355 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0383 0.2735 0.2735
Brugia malayi PHD-finger family protein 0.003 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Entamoeba histolytica cysteine protease, putative 0.0161 0.1075 0.2017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0406 0.0406
Trypanosoma cruzi cysteine protease, putative 0.0383 0.2735 0.2729
Echinococcus multilocularis pyruvate kinase 0.0025 0.0063 0.0063
Echinococcus granulosus cathepsin L 0.0161 0.1075 0.1075
Onchocerca volvulus 0.0709 0.517 1
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) inositol-1 0.0036 0.0139 0.0139
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0299 0.0299
Entamoeba histolytica cysteine proteinase, putative 0.0709 0.517 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0562 0.0562
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0113 0.0063
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Leishmania major cathepsin L-like protease 0.0709 0.517 0.9381
Leishmania major cathepsin L-like protease 0.0754 0.5511 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0046 0.0215 0.0215
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0139 0.013
Echinococcus granulosus cathepsin l1 0.0709 0.517 0.517
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0373 0.0373
Toxoplasma gondii cathepsin CPC1 0.0161 0.1075 0.195
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0074 0.0424 0.0424
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1355 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0487 0.351 0.6717
Entamoeba histolytica cysteine protease, putative 0.0383 0.2735 0.5253
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0139 0.011
Loa Loa (eye worm) hypothetical protein 0.0161 0.1075 0.1075
Plasmodium vivax vivapain-1 0.0383 0.2735 0.5214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.2157 0.4126
Trichomonas vaginalis esterase, putative 0.0074 0.0424 0.0615
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0424 0.0952
Onchocerca volvulus Cathepsin L homolog 0.0709 0.517 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0357 0.0357
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.1075 0.1075
Giardia lamblia Cathepsin B precursor 0.053 0.3835 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0113 0.0063
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0161 0.1075 0.195
Schistosoma mansoni intermediate filament proteins 0.0028 0.0081 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0424 0.0615
Entamoeba histolytica hypothetical protein 0.0161 0.1075 0.2017
Brugia malayi Cathepsin L-like precursor 0.0487 0.351 0.351
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0373 0.0373
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0161 0.1075 0.1075
Brugia malayi hypothetical protein 0.0038 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0709 0.517 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5 ug ml-1 Cytotoxicity against human MCF7 cells expressing ER ChEMBL. 16942038
ED50 (functional) = 5 ug ml-1 Cytotoxicity against human MCF7 cells expressing ER ChEMBL. 16942038
ED50 (functional) = 8.6 ug ml-1 Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER ChEMBL. 16942038
ED50 (functional) = 8.6 ug ml-1 Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER ChEMBL. 16942038
ED50 (functional) = 9 ug ml-1 Cytotoxicity against human SW620 cells ChEMBL. 16942038
ED50 (functional) = 9 ug ml-1 Cytotoxicity against human SW620 cells ChEMBL. 16942038
ED50 (functional) = 9.5 ug ml-1 Cytotoxicity against human A431 cells ChEMBL. 16942038
ED50 (functional) = 9.5 ug ml-1 Cytotoxicity against human A431 cells ChEMBL. 16942038
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human ZR-75-1 cells expressing ER ChEMBL. 16942038
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 16942038
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human ZR-75-1 cells expressing ER ChEMBL. 16942038
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 16942038

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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