Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0112 | 0.2645 | 0.0457 |
Giardia lamblia | Kinase, CMGC CDK | 0.0101 | 0.2293 | 0.2003 |
Onchocerca volvulus | 0.0112 | 0.2645 | 1 | |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0363 | 0.0363 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0101 | 0.2293 | 0.2003 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus multilocularis | 0.033 | 0.9757 | 0.9748 | |
Schistosoma mansoni | kinase | 0.0057 | 0.0839 | 0.0494 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0101 | 0.2293 | 0.2291 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0363 | 0.0363 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0101 | 0.2293 | 0.2003 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0123 | 0.3013 | 0.2751 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0065 | 0.1122 | 0.0788 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0101 | 0.2293 | 0.2003 |
Echinococcus granulosus | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus granulosus | cyclin dependent kinase | 0.0101 | 0.2293 | 0.2003 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0101 | 0.2293 | 0.2293 |
Brugia malayi | Protein kinase domain containing protein | 0.0301 | 0.8791 | 0.8746 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0057 | 0.0839 | 0.0494 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0123 | 0.3013 | 0.0934 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0338 | 1 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0301 | 0.8791 | 0.8746 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Giardia lamblia | Kinase, CMGC CDK | 0.0101 | 0.2293 | 0.2003 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0123 | 0.3013 | 0.3145 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0101 | 0.2293 | 0.2003 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.8548 | 0.8494 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0112 | 0.2645 | 0.2369 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0112 | 0.2645 | 0.0457 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0112 | 0.2645 | 0.2369 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.2293 | 0.2003 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0301 | 0.8791 | 0.8746 |
Brugia malayi | Protein kinase domain containing protein | 0.0101 | 0.2293 | 0.2003 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0065 | 0.1122 | 0.0788 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0112 | 0.2645 | 0.0457 |
Brugia malayi | cell division control protein 2 homolog | 0.0101 | 0.2293 | 0.2003 |
Trypanosoma brucei | protein kinase, putative | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus granulosus | hypothetical protein | 0.033 | 0.9757 | 0.9748 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0123 | 0.3013 | 0.2751 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0338 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0101 | 0.2293 | 0.2003 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0112 | 0.2645 | 0.2645 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0363 | 0.0363 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0338 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0057 | 0.0839 | 0.0565 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0112 | 0.2645 | 0.2709 |
Leishmania major | protein kinase, putative | 0.0338 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0338 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0338 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0123 | 0.3013 | 0.2751 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.2293 | 0.2003 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0123 | 0.3013 | 0.2751 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3384 | 0.3135 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0338 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0057 | 0.0839 | 0.0494 |
Echinococcus granulosus | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Brugia malayi | hypothetical protein | 0.0135 | 0.3384 | 0.3135 |
Echinococcus granulosus | dual specificity | 0.0301 | 0.8791 | 0.8746 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0301 | 0.8791 | 0.8746 |
Trichomonas vaginalis | cyclin A, putative | 0.0042 | 0.0363 | 0.0363 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0101 | 0.2293 | 0.2293 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.3013 | 0.2751 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0301 | 0.8791 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0101 | 0.2293 | 0.2003 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0338 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3384 | 0.3135 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0282 | 0.8173 | 0.8105 |
Echinococcus multilocularis | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.8173 | 0.8105 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.9757 | 0.9748 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0101 | 0.2293 | 0.2003 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0282 | 0.8173 | 0.8105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0301 | 0.8791 | 0.8746 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0101 | 0.2293 | 0.2003 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0123 | 0.3013 | 0.2751 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0338 | 1 | 1 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0338 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0363 | 0.0363 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0301 | 0.8791 | 0.8746 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0338 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus multilocularis | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0338 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0301 | 0.8791 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0112 | 0.2645 | 0.2369 |
Entamoeba histolytica | protein kinase, putative | 0.0123 | 0.3013 | 0.3145 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0363 | 0.0363 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0363 | 0.0363 |
Echinococcus multilocularis | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0.0839 | 0.0494 |
Entamoeba histolytica | protein kinase, putative | 0.0112 | 0.2645 | 0.2709 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0338 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0123 | 0.3013 | 0.3013 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.8548 | 0.8494 |
Giardia lamblia | Kinase, CMGC CLK | 0.0338 | 1 | 1 |
Brugia malayi | intracellular kinase | 0.0112 | 0.2645 | 0.2369 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.205 | 0.1751 |
Echinococcus multilocularis | protein kinase shaggy | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0338 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0301 | 0.8791 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0112 | 0.2645 | 0.2645 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.8261 | 0.8196 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0101 | 0.2293 | 0.2003 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0057 | 0.0839 | 0.0494 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0301 | 0.8791 | 0.8746 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.011 | 0.2576 | 0.2626 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0123 | 0.3013 | 0.2751 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0363 | 0.0363 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0338 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0301 | 0.8791 | 0.8746 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0112 | 0.2645 | 0.2369 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0282 | 0.8173 | 0.8105 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0101 | 0.2293 | 0.2003 |
Leishmania major | protein kinase, putative | 0.0338 | 1 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0338 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0057 | 0.0839 | 0.0494 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0101 | 0.2293 | 0.2293 |
Entamoeba histolytica | hypothetical protein | 0.0301 | 0.8791 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0112 | 0.2645 | 0.2369 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0112 | 0.2645 | 0.2369 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0112 | 0.2645 | 0.2709 |
Echinococcus granulosus | dual specificity | 0.0123 | 0.3013 | 0.2751 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 40 uM | Inhibition of telomerase by TRAP assay | ChEMBL. | 16913707 |
Inhibition (functional) | = 33 % | Inhibition of human MCF7 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Inhibition (functional) | = 33 % | Inhibition of human MCF7 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Inhibition (functional) | = 94 % | Inhibition of human NCI-H460 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Inhibition (functional) | = 94 % | Inhibition of human NCI-H460 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Inhibition (functional) | = 106 % | Inhibition of human SF268 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Inhibition (functional) | = 106 % | Inhibition of human SF268 cell growth at 100 uM relative to control | ChEMBL. | 16913707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.