Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
SARS coronavirus | SARS coronavirus 3C-like proteinase | Starlite/ChEMBL | References |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 1 | 1 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0017 | 0.4134 | 0.4134 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | MACRO domain containing protein 2 | 0.0017 | 0.4134 | 0.4134 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0.4134 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Plasmodium falciparum | Appr-1-p processing domain protein | 0.0017 | 0.4134 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 1 | 1 |
Toxoplasma gondii | macro domain-containing protein | 0.0017 | 0.4134 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.4134 | 0.4134 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 1 | 1 |
Trypanosoma brucei | Macro domain containing protein, putative | 0.0017 | 0.4134 | 0.0998 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 1 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0017 | 0.4134 | 0.4134 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | MACRO domain containing protein 2 | 0.0017 | 0.4134 | 0.4134 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4134 | 0.4134 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.4134 | 0.4134 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Brugia malayi | Appr-1-p processing enzyme family protein | 0.0017 | 0.4134 | 0.4134 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 uM | Inhibition of SARS coronavirus main protease | ChEMBL. | 16913704 |
IC50 (binding) | = 6 uM | Inhibition of SARS coronavirus main protease | ChEMBL. | 16913704 |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 58.4789 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.