Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2872 | 0.6365 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0028 | 0.0525 | 0.1827 |
Loa Loa (eye worm) | TK protein kinase | 0.0028 | 0.0525 | 0.1163 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2872 | 0.6365 |
Schistosoma mansoni | nephrin | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0085 | 0.4513 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | neuroglian | 0.0051 | 0.2166 | 0.7541 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | peroxidasin | 0.0031 | 0.0706 | 0.2459 |
Echinococcus granulosus | defective proboscis extension response | 0.0031 | 0.0691 | 0.2406 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | septate junction protein | 0.0031 | 0.0706 | 0.1565 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1397 | 0.3096 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0031 | 0.0691 | 0.2406 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | lachesin | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0041 | 0.1397 | 0.4864 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | peroxidasin | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | lachesin | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | roundabout 2 | 0.0061 | 0.2872 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0028 | 0.0525 | 0.1163 |
Schistosoma mansoni | nephrin | 0.0051 | 0.2166 | 0.48 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0028 | 0.0525 | 0.1163 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | vesicular amine transporter | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | neuroglian | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0028 | 0.0525 | 0.1827 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0028 | 0.0525 | 0.1163 |
Echinococcus granulosus | contactin | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | tyrosine kinase | 0.0038 | 0.1231 | 0.2728 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0085 | 0.4513 | 0.1174 |
Schistosoma mansoni | roundabout | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Schistosoma mansoni | titin | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0085 | 0.4513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.1397 | 0.3096 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus granulosus | neuroglian | 0.0031 | 0.0706 | 0.2459 |
Echinococcus multilocularis | neuroglian | 0.0031 | 0.0706 | 0.2459 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Prion-like- | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0085 | 0.4513 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0048 | 0.1922 | 0.4259 |
Echinococcus granulosus | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0085 | 0.4513 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0031 | 0.0691 | 0.2406 |
Schistosoma mansoni | cell adhesion molecule | 0.0031 | 0.0706 | 0.1565 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0031 | 0.0691 | 0.1531 |
Schistosoma mansoni | septate junction protein | 0.0031 | 0.0706 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Echinococcus multilocularis | neuroglian | 0.0051 | 0.2166 | 0.7541 |
Echinococcus granulosus | roundabout 2 | 0.0061 | 0.2872 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0048 | 0.1922 | 0.4259 |
Brugia malayi | Peroxidasin | 0.0031 | 0.0706 | 0.1565 |
Echinococcus multilocularis | hemicentin 1 | 0.0031 | 0.0706 | 0.2459 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.0706 | 0.1565 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0691 | 0.1531 |
Echinococcus granulosus | roundabout 2 | 0.0031 | 0.0706 | 0.2459 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0085 | 0.4513 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0031 | 0.0691 | 0.1531 |
Echinococcus granulosus | twitchin | 0.0051 | 0.2166 | 0.7541 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0085 | 0.4513 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as survival upto 60 days at 25 mg/kg, po | ChEMBL. | 16913722 |
IC50 (functional) | > 205 uM | Cytotoxicity against rat L6 cells | ChEMBL. | 16913722 |
IC50 (functional) | = 1600 uM | Antiprotozoal activity against Plasmodium falciparum K1 | ChEMBL. | 16913722 |
IC50 (functional) | = 1600 uM | Antiprotozoal activity against Plasmodium falciparum K1 | ChEMBL. | 16913722 |
IC50 (functional) | = 24000 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 16913722 |
IC50 (functional) | = 24000 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 16913722 |
Survival (functional) | = 6.25 day | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 25 mg/kg, po | ChEMBL. | 16913722 |
Survival (functional) | = 6.25 day | Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 25 mg/kg, po | ChEMBL. | 16913722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.