Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | 3-dehydroquinate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2726 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0172 | 0.2726 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0258 | 1 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0258 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0172 | 0.2726 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0172 | 0.2726 | 0.5 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0258 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0172 | 0.2726 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0172 | 0.2726 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0172 | 0.2726 | 0.2726 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0172 | 0.2726 | 0.2726 |
Plasmodium falciparum | adenosine deaminase | 0.0172 | 0.2726 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0172 | 0.2726 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0172 | 0.2726 | 0.2726 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0172 | 0.2726 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0172 | 0.2726 | 0.5 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0258 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0172 | 0.2726 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0172 | 0.2726 | 0.5 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0258 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0172 | 0.2726 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Type of inhibition of 3-dehydroquinate synthase was determined; R - Slowly reversible | ChEMBL. | No reference | |
Inhibition (binding) | R 0 | Type of inhibition of 3-dehydroquinate synthase was determined; R - Slowly reversible | ChEMBL. | No reference |
Ki (binding) | = 0.0000000054 M | Inhibition constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
Ki (binding) | = 0.0000000054 M | Inhibition constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
Koff (binding) | = 0.00075 s-1 | Association rate constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
Kon (binding) | = 140000 M-1 s-1 | Rate constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
k_off (binding) | = 0.00075 s-1 | Association rate constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
k_on (binding) | = 140000 M-1 s-1 | Rate constant of the compound was determined against 3-dehydroquinate synthase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.