Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0062 | 0.066 | 0.567 |
Schistosoma mansoni | cpg binding protein | 0.0053 | 0.0299 | 0.0258 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0072 | 0.1083 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0059 | 0.0543 | 0.0582 |
Schistosoma mansoni | porphobilinogen synthase | 0.0226 | 0.7619 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0053 | 0.0299 | 0.0363 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.066 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | delta-aminolevulinic acid dehydratase | 0.0226 | 0.7619 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0138 | 0.3889 | 0.269 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0053 | 0.0299 | 0.0209 |
Echinococcus multilocularis | cpg binding protein | 0.0059 | 0.0543 | 0.0582 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0084 | 0.1612 | 0.2005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Plasmodium falciparum | porphobilinogen synthase | 0.0226 | 0.7619 | 1 |
Mycobacterium leprae | PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) | 0.0226 | 0.7619 | 1 |
Echinococcus granulosus | delta aminolevulinic acid dehydratase | 0.0226 | 0.7619 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.9357 | 1 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0075 | 0.124 | 0.1628 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0049 | 0.0106 | 0.007 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0056 | 0.0434 | 0.5946 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.015 | 0.4421 | 0.5743 |
Brugia malayi | jmjC domain containing protein | 0.0068 | 0.0932 | 0.1551 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0128 | 0.3487 | 0.45 |
Toxoplasma gondii | parasite porphobilinogen synthase PBGS | 0.0226 | 0.7619 | 1 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0049 | 0.0106 | 0.0139 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.02 | 0.651 | 0.7027 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.066 | 0.567 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.0791 | 0.1286 |
Brugia malayi | jmjC domain containing protein | 0.0084 | 0.1612 | 0.2827 |
Schistosoma mansoni | cpg binding protein | 0.0059 | 0.0543 | 0.0582 |
Echinococcus multilocularis | delta aminolevulinic acid dehydratase | 0.0226 | 0.7619 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0068 | 0.0932 | 0.11 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.015 | 0.4421 | 0.5743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.066 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 1 | 0.5 |
Plasmodium vivax | delta-aminolevulinic acid dehydratase, putative | 0.0226 | 0.7619 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.066 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0123 | 0.3243 | 0.4175 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0084 | 0.1612 | 0.2005 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1612 | 0.1628 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.02 | 0.651 | 0.8303 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0128 | 0.3487 | 0.45 |
Mycobacterium ulcerans | delta-aminolevulinic acid dehydratase | 0.0226 | 0.7619 | 1 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.02 | 0.651 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.066 | 0.567 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0138 | 0.3889 | 0.4292 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0072 | 0.1083 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Schistosoma mansoni | porphobilinogen synthase | 0.0226 | 0.7619 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0174 | 0.5435 | 0.576 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0084 | 0.1612 | 0.2005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.066 | 0.567 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2845 | 0.296 |
Schistosoma mansoni | cpg binding protein | 0.0059 | 0.0543 | 0.0582 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0068 | 0.0932 | 0.11 |
Brugia malayi | jmjC domain containing protein | 0.0065 | 0.0791 | 0.1286 |
Schistosoma mansoni | jumonji domain containing protein | 0.0068 | 0.0932 | 0.11 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0128 | 0.3487 | 0.45 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.066 | 1 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0049 | 0.0106 | 0.007 |
Brugia malayi | jmjC domain containing protein | 0.0174 | 0.5435 | 1 |
Onchocerca volvulus | 0.0053 | 0.0299 | 0.5 | |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Chlamydia trachomatis | delta-aminolevulinic acid dehydratase | 0.0226 | 0.7619 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | mM | Competitive inhibition constant of the compound was tested against trypsin using the reporter substrate Ac-R-pNa; No inhibition | ChEMBL. | 10866385 |
Ki (binding) | 0 mM | Competitive inhibition constant of the compound was tested against trypsin using the reporter substrate Ac-R-pNa; No inhibition | ChEMBL. | 10866385 |
Ki (binding) | = 0.027 mM | Competitive inhibition constant of the compound was tested against Human neutrophil elastase using the reporter substrate MeO-AAPV-pNa | ChEMBL. | 10866385 |
Ki (binding) | = 0.027 mM | Competitive inhibition constant of the compound was tested against Human neutrophil elastase using the reporter substrate MeO-AAPV-pNa | ChEMBL. | 10866385 |
Ki (binding) | = 0.1 mM | Peptide was tested for inhibition constant for competitive inhibition using Suc-AAPA-pNa and Pancreatic elastase | ChEMBL. | 10866385 |
Ki (binding) | = 0.1 mM | Peptide was tested for inhibition constant for competitive inhibition using Suc-AAPA-pNa and Pancreatic elastase | ChEMBL. | 10866385 |
Ki (binding) | = 0.16 mM | Competitive inhibition constant of the compound was tested against Chymotrypsinogen using the reporter substrate Suc-AAPA-pNa | ChEMBL. | 10866385 |
Ki (binding) | = 0.16 mM | Competitive inhibition constant of the compound was tested against Chymotrypsinogen using the reporter substrate Suc-AAPA-pNa | ChEMBL. | 10866385 |
Ki' (binding) | = 0.34 mM | Inhibition constant for uncompetitive inhibition of Suc-AAPA and Pancreatic elastase | ChEMBL. | 10866385 |
Ki' (binding) | = 0.34 mM | Inhibition constant for uncompetitive inhibition of Suc-AAPA and Pancreatic elastase | ChEMBL. | 10866385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.