Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.0389 | 0.0389 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.032 | 0.3438 | 0.3438 |
Schistosoma mansoni | hypothetical protein | 0.0899 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.032 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0484 | 0.0484 |
Entamoeba histolytica | hypothetical protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.032 | 0.3438 | 0.3438 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.0484 | 0.0484 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0899 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.032 | 0.3438 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0899 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0899 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0051 | 0.0389 | 0.0389 |
Echinococcus multilocularis | tar DNA binding protein | 0.0051 | 0.0389 | 0.0389 |
Leishmania major | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | ring and YY1 binding protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.0484 | 0.0484 |
Entamoeba histolytica | hypothetical protein | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.032 | 0.3438 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0899 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.0484 | 0.0484 |
Onchocerca volvulus | 0.032 | 0.3438 | 0.3438 | |
Brugia malayi | hypothetical protein | 0.0103 | 0.0985 | 0.0985 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Kinase | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.0484 | 0.0484 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.032 | 0.3438 | 0.3438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0899 | 1 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.032 | 0.3438 | 0.3438 |
Leishmania major | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0899 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0899 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | TAR-binding protein | 0.0051 | 0.0389 | 0.0389 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.032 | 0.3438 | 1 |
Schistosoma mansoni | fusion | 0.032 | 0.3438 | 0.3438 |
Brugia malayi | brahma associated protein 60 kDa | 0.0899 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.032 | 0.3438 | 1 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0899 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0899 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.0389 | 0.0389 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.032 | 0.3438 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.1785 | 0.1785 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.032 | 0.3438 | 0.3438 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.032 | 0.3438 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0103 | 0.0985 | 0.0985 |
Schistosoma mansoni | RNA binding protein | 0.032 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.032 | 0.3438 | 0.3438 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.1785 | 0.1785 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0.0484 | 0.0484 |
Leishmania major | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0051 | 0.0389 | 0.0389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.0389 | 0.0389 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.0484 | 0.0484 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0899 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0899 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0899 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.0389 | 0.0389 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.032 | 0.3438 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Kinase, NEK | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.032 | 0.3438 | 0.3438 | |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0899 | 1 | 1 |
Entamoeba histolytica | SPRY domain protein | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0059 | 0.0484 | 0.0484 |
Brugia malayi | TAR-binding protein | 0.0051 | 0.0389 | 0.0389 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.0484 | 0.0484 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.0899 | 1 | 1 | |
Giardia lamblia | Kinase, NEK | 0.0016 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0051 | 0.0389 | 0.0389 |
Giardia lamblia | Ser/Thr protein kinase | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0899 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0899 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | ran binding protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Zinc finger domain | 0.0016 | 0 | 0.5 |
Giardia lamblia | Ribonuclease | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.032 | 0.3438 | 0.3438 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0899 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0059 | 0.0484 | 0.0484 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.032 | 0.3438 | 0.3438 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0899 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0051 | 0.0389 | 0.0389 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0.0484 | 0.0484 |
Echinococcus granulosus | tar DNA binding protein | 0.0051 | 0.0389 | 0.0389 |
Schistosoma mansoni | brg-1 associated factor | 0.0899 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.032 | 0.3438 | 0.3438 |
Leishmania major | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0899 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0899 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.0484 | 0.0484 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.032 | 0.3438 | 0.3438 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.0484 | 0.0484 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.032 | 0.3438 | 0.3438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.0389 | 0.0389 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.032 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3438 | 0.3438 |
Schistosoma mansoni | zinc finger protein | 0.032 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0899 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0103 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0985 | 0.0985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Onchocerca volvulus | 0.032 | 0.3438 | 0.3438 | |
Giardia lamblia | Hypothetical protein | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | zinc finger domain containing protein | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.032 | 0.3438 | 1 |
Giardia lamblia | Zinc finger domain | 0.0016 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 nM | Inhibitory activity against human plasma renin | ChEMBL. | 3302256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.