Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement component 1, s subcomponent | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.2 | 1 | 1 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0545 | 0.2666 | 0.2666 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0545 | 0.2666 | 0.2666 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0545 | 0.2666 | 0.5 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0711 | 0.3503 | 0.5 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.2 | 1 | 0.5 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0711 | 0.3503 | 0.3503 |
Onchocerca volvulus | Arrow homolog | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0545 | 0.2666 | 0.2666 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0545 | 0.2666 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.2 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0545 | 0.2666 | 0.2666 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0545 | 0.2666 | 0.5 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.2 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0081 | 0.0081 |
Schistosoma mansoni | glutathione synthetase | 0.0545 | 0.2666 | 0.2666 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.2 | 1 | 1 |
Leishmania major | polyprenyl synthase, putative | 0.0711 | 0.3503 | 0.1141 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0545 | 0.2666 | 0.5 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0545 | 0.2666 | 0.5 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0711 | 0.3503 | 0.1141 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0711 | 0.3503 | 0.1141 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0021 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0024 | 0.0024 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0545 | 0.2666 | 0.2666 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.2 | 1 | 0.5 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0711 | 0.3503 | 0.3503 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.2 | 1 | 0.5 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.2 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.2 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0545 | 0.2666 | 0.5 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.2 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0021 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.2 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0545 | 0.2666 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0021 | 0.0024 | 0.0024 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0545 | 0.2666 | 0.2666 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0545 | 0.2666 | 0.2666 |
Echinococcus granulosus | Tolloid protein 1 | 0.0021 | 0.0024 | 0.0024 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0545 | 0.2666 | 0.2666 |
Leishmania major | farnesyl pyrophosphate synthase | 0.2 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0711 | 0.3503 | 0.3503 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.2 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0711 | 0.3503 | 0.3503 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0711 | 0.3503 | 0.3503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.06 uM | In vitro binding affinity towards human Complement C1s subcomponent | ChEMBL. | 15149641 |
Ki (binding) | = 1.06 uM | In vitro binding affinity towards human Complement C1s subcomponent | ChEMBL. | 15149641 |
Ki (binding) | = 470 uM | Inhibitory activity against serine protease urokinase-type plasminogen activator (microPa) | ChEMBL. | 11378359 |
Ki (binding) | = 470 uM | Inhibitory activity against serine protease urokinase-type plasminogen activator (microPa) | ChEMBL. | 11378359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.