Detailed information for compound 39726

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.215 | Formula: C11H14BrN3O5S
  • H donors: 3 H acceptors: 4 LogP: -0.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1(CO)SCC(O1)n1cc(Br)c(nc1=O)NC(=O)C
  • InChi: 1S/C11H14BrN3O5S/c1-6(18)13-9-7(12)2-15(10(19)14-9)8-3-21-11(4-16,5-17)20-8/h2,8,16-17H,3-5H2,1H3,(H,13,14,18,19)
  • InChiKey: OVMYDBPLSFMXPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0079 0.0263 0.0295
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0119 0.0097
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0263 0.0295
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0052 0.0111 0.0088
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0152 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0224 0.0201
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1204 0.1349
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1204 0.1285
Giardia lamblia Cytidine deaminase 0.0052 0.0111 0.004
Echinococcus multilocularis lamin 0.0055 0.0129 0.0137
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0023 0.0134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0152 0.0892
Toxoplasma gondii thymidylate kinase 0.0152 0.0684 1
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0174 0.0812 0.2366
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0112 0.0089
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0224 0.0201
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.0684 0.0663
Schistosoma mansoni phosphoglucomutase 0.0045 0.0071 0.0079
Echinococcus multilocularis transfer RNA-Ile 0.1584 0.8927 0.9527
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Onchocerca volvulus 0.0049 0.0095 0.0429
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0617 0.336 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0104 0.0409 0.2404
Mycobacterium ulcerans cytidine deaminase 0.0052 0.0111 0.0264
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0263 0.3633
Plasmodium falciparum thymidylate kinase 0.0152 0.0684 1
Schistosoma mansoni thymidine kinase 0.1584 0.8927 1
Trypanosoma cruzi thymidine kinase, putative 0.177 1 1
Echinococcus granulosus glycogen phosphorylase 0.0329 0.1702 0.1907
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0052 0.0111 0.0264
Echinococcus granulosus thymidine kinase 0.1584 0.8927 1
Echinococcus multilocularis lamin dm0 0.0055 0.0129 0.0137
Echinococcus multilocularis solute carrier family 28 0.0334 0.1733 0.185
Brugia malayi hypothetical protein 0.0242 0.1204 0.7076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0152 0.195
Schistosoma mansoni ap endonuclease 0.0059 0.0152 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.009 0.0096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0023 0.0024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0263 0.072
Onchocerca volvulus 0.0055 0.0129 0.0629
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0182 0.016
Echinococcus granulosus ribonuclease H1 0.0045 0.0071 0.0079
Leishmania major cytidine deaminase-like protein 0.0052 0.0111 0.0088
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0334 0.1733 0.185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Schistosoma mansoni lipoxygenase 0.0057 0.0136 0.0152
Brugia malayi intermediate filament protein 0.0055 0.0129 0.0755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0101
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0023 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0152 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0101
Schistosoma mansoni thymidylate kinase 0.0152 0.0684 0.0766
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0334 0.1733 0.1941
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0263 0.3136
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0182 0.0204
Echinococcus granulosus lamin dm0 0.0055 0.0129 0.0144
Schistosoma mansoni inositol monophosphatase 0.0079 0.0263 0.0295
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0702
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0052 0.0111 0.1331
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0129 0.0755
Giardia lamblia Glycogen phosphorylase 0.0329 0.1702 0.1643
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0182 0.0204
Trichomonas vaginalis ribonuclease H1, putative 0.0045 0.0071 0.0048
Schistosoma mansoni survival motor neuron protein 0.0049 0.0095 0.0106
Entamoeba histolytica glycogen phosphorylase, putative 0.0329 0.1702 0.1683
Loa Loa (eye worm) inositol-1 0.0079 0.0263 0.1546
Echinococcus granulosus thymidylate kinase 0.0152 0.0684 0.0766
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0023 0.0026
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0216 0.2442
Onchocerca volvulus 0.0052 0.0111 0.0524
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0023 0.0024
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0153 0.0131
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Schistosoma mansoni hypothetical protein 0.0152 0.0684 0.0766
Mycobacterium ulcerans thymidine phosphorylase 0.0617 0.336 1
Leishmania major hypothetical protein, conserved 0.0054 0.0119 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0152 0.0892
Giardia lamblia Hypothetical protein 0.0072 0.0224 0.0154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.009 0.053
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0142 0.0628 0.1815
Entamoeba histolytica glycogen phosphorylase, putative 0.0142 0.0628 0.0607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.009 0.053
Echinococcus multilocularis musashi 0.0055 0.0129 0.0137
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0023 0.0025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1166 0.3427
Schistosoma mansoni lamin 0.0055 0.0129 0.0144
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.0684 0.0663
Brugia malayi beta-lactamase family protein 0.0037 0.0023 0.0134
Echinococcus multilocularis glycogen phosphorylase 0.0329 0.1702 0.1817
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0112 0.0089
Brugia malayi Inositol-1 0.0079 0.0263 0.1546
Trypanosoma brucei thymidine kinase 0.177 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0129 0.0755
Toxoplasma gondii exonuclease III APE 0.0059 0.0152 0.195
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0224 0.0201
Entamoeba histolytica glycogen phosphorylase, putative 0.0329 0.1702 0.1683
Schistosoma mansoni glycogen phosphorylase 0.0329 0.1702 0.1907
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Giardia lamblia Hypothetical protein 0.0072 0.0224 0.0154
Echinococcus granulosus Glycosyl transferase family 35 0.0329 0.1702 0.1907
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0263 0.0241
Brugia malayi cytidine deaminase, identical 0.0052 0.0111 0.0651
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0052 0.0112 0.0089
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0182 0.0204
Schistosoma mansoni thyroid hormone receptor 0.015 0.0674 0.0755
Loa Loa (eye worm) thymidylate kinase 0.0152 0.0684 0.4019
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0174 0.0812 0.2366
Brugia malayi RNase H family protein 0.0045 0.0071 0.0416
Echinococcus multilocularis thymidine kinase 0.1584 0.8927 0.9527
Loa Loa (eye worm) beta-lactamase 0.0037 0.0023 0.0134
Echinococcus granulosus lamin 0.0055 0.0129 0.0144
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0263 0.0281
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0334 0.1733 0.1941
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0218 0.1065 0.1136
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.061 0.0684
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Entamoeba histolytica Thymidylate kinase, putative 0.0152 0.0684 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0224 0.0201
Echinococcus granulosus intermediate filament protein 0.0055 0.0129 0.0144
Entamoeba histolytica glycogen phosphorylase, putative 0.0142 0.0628 0.0607
Brugia malayi RNase H family protein 0.0045 0.0071 0.0416
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Schistosoma mansoni hypothetical protein 0.0139 0.061 0.0684
Schistosoma mansoni glycogen phosphorylase 0.0329 0.1702 0.1907
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0023 0.0025
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.061 0.0651
Schistosoma mansoni hypothetical protein 0.0049 0.0095 0.0106
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0152 0.0129
Giardia lamblia CDC8 0.0152 0.0684 0.0618
Trypanosoma brucei ribonuclease H1 0.0045 0.0071 0.0048
Schistosoma mansoni glycogen phosphorylase 0.0142 0.0628 0.0704
Schistosoma mansoni hypothetical protein 0.0316 0.163 0.1825
Brugia malayi hypothetical protein 0.0054 0.0119 0.0702
Trypanosoma brucei RNA helicase, putative 0.0316 0.163 0.161
Leishmania major ribonuclease H1, putative 0.0045 0.0071 0.0048
Echinococcus multilocularis thymidylate kinase 0.0152 0.0684 0.073
Leishmania major hypothetical protein, conserved 0.006 0.0153 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0182 0.0478
Schistosoma mansoni hypothetical protein 0.0037 0.0023 0.0025
Echinococcus multilocularis ribonuclease H1 0.0045 0.0071 0.0076
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0119 0.146
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0119 0.146
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0152 0.0129
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0072 0.0224 0.0154
Loa Loa (eye worm) hypothetical protein 0.0242 0.1204 0.7076
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0263 0.0241
Leishmania major thymidylate kinase-like protein 0.0152 0.0684 0.0663
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0152 0.0684 0.8375
Echinococcus multilocularis Glycosyl transferase, family 35 0.0329 0.1702 0.1817
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0119 0.0097
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0152 0.1321
Brugia malayi beta-lactamase family protein 0.0037 0.0023 0.0134
Schistosoma mansoni hypothetical protein 0.011 0.0444 0.0497
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0152 0.0082
Echinococcus granulosus glycogen phosphorylase 0.0329 0.1702 0.1907
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0224 0.0201
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0152 0.0684 0.1982
Schistosoma mansoni intermediate filament proteins 0.0055 0.0129 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0152 0.0129
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0119 0.0097
Trypanosoma brucei cytidine deaminase 0.0052 0.0111 0.0088
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0263 0.0241
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0182 0.2413
Schistosoma mansoni thyroid hormone receptor 0.015 0.0674 0.0755
Schistosoma mansoni thymidylate kinase 0.0152 0.0684 0.0766
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0182 0.0195
Plasmodium vivax thymidylate kinase, putative 0.0152 0.0684 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.009 0.0096
Loa Loa (eye worm) deoxynucleoside kinase 0.0072 0.0224 0.1313
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.0684 0.0663
Trypanosoma brucei thymidylate kinase, putative 0.0152 0.0684 0.0663
Brugia malayi carbohydrate phosphorylase 0.0329 0.1702 1
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0152 0.0129
Loa Loa (eye worm) glycogen phosphorylase 0.0329 0.1702 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0152 0.0386
Brugia malayi thymidylate kinase 0.0152 0.0684 0.4019
Trichomonas vaginalis cytidine deaminase, putative 0.0052 0.0111 0.0088
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0052 0.0111 0.1115
Trichomonas vaginalis thymidine kinase, putative 0.177 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0152 0.0129
Trichomonas vaginalis cytidine deaminase, putative 0.0052 0.0111 0.0088
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0072 0.0224 0.0239
Entamoeba histolytica cytidine deaminase, putative 0.0052 0.0111 0.0088
Giardia lamblia Deoxynucleoside kinase 0.0487 0.2614 0.2562
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0263 0.0241
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0174 0.0812 1
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0071 0.0048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0095 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0224 0.0201
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0674 0.072
Leishmania major thymidine kinase, putative 0.177 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0136 0.0152
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0136 0.0145
Trichomonas vaginalis thymidylate kinase, putative 0.0152 0.0684 0.0663
Schistosoma mansoni hypothetical protein 0.0518 0.2794 0.313
Trichomonas vaginalis thymidine kinase, putative 0.177 1 1
Mycobacterium ulcerans thymidylate kinase 0.0152 0.0684 0.1982
Onchocerca volvulus Putative thymidylate kinase 0.0152 0.0684 0.3938
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0263 0.0241
Chlamydia trachomatis glycogen phosphorylase 0.0329 0.1702 1
Echinococcus multilocularis thymidine kinase 0.1584 0.8927 0.9527
Schistosoma mansoni phosphoglucomutase 0.0045 0.0071 0.0079
Brugia malayi hypothetical protein 0.0035 0.001 0.0059
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.006 0.0153 0.0131
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0263 0.0241
Toxoplasma gondii ribonuclease HI protein 0.0045 0.0071 0.0724
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0072 0.0224 0.025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0152 0.017
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0142 0.0628 0.1815
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1661 0.937 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.0329 0.1702 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.022 0.1291
Schistosoma mansoni hypothetical protein 0.0071 0.022 0.0246
Giardia lamblia Thymidine kinase 0.177 1 1
Onchocerca volvulus Ribonuclease H1 homolog 0.0045 0.0071 0.0285
Echinococcus multilocularis thymidine phosphorylase 0.0617 0.336 0.3586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.009 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0152 0.0129
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0071 0.0048
Brugia malayi hypothetical protein 0.0037 0.0023 0.0133
Trypanosoma cruzi thymidylate kinase, putative 0.0152 0.0684 0.0663
Echinococcus multilocularis geminin 0.0518 0.2794 0.2982
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0409 0.2404
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0182 0.0478
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0152 0.0386
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.022 0.1291
Schistosoma mansoni hypothetical protein 0.0518 0.2794 0.313
Echinococcus granulosus geminin 0.0518 0.2794 0.313
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0224 0.0201
Onchocerca volvulus 0.0055 0.0129 0.0629
Trypanosoma cruzi cytidine deaminase-like protein 0.0052 0.0111 0.0088
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0216 0.0578
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0263 0.0241
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1584 0.8927 1
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0072 0.0224 0.025
Entamoeba histolytica glycogenphosphorylase, putative 0.0142 0.0628 0.0607
Trypanosoma brucei unspecified product 0.0052 0.0112 0.0089
Echinococcus granulosus cytidine deaminase 0.0052 0.0111 0.0124
Echinococcus granulosus solute carrier family 28 0.0334 0.1733 0.1941
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0263 0.0241
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0129 0.0755
Brugia malayi beta-lactamase 0.0037 0.0023 0.0134
Echinococcus granulosus thymidine kinase 0.1584 0.8927 1
Trichomonas vaginalis thymidine kinase, putative 0.177 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0112 0.0089
Echinococcus granulosus thymidine phosphorylase 0.0617 0.336 0.3764
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0152 0.0684 1
Schistosoma mansoni ap endonuclease 0.0059 0.0152 0.017
Schistosoma mansoni phosphoglucomutase 0.0045 0.0071 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0224 0.0201
Trichomonas vaginalis glycogen phosphorylase, putative 0.0329 0.1702 0.1683
Echinococcus multilocularis glycogen phosphorylase 0.0329 0.1702 0.1817
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0182 0.0478
Schistosoma mansoni lamin 0.0055 0.0129 0.0144
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0152 0.1321
Trichomonas vaginalis glycogen phosphorylase, putative 0.0329 0.1702 0.1683
Loa Loa (eye worm) hypothetical protein 0.0055 0.0129 0.0755
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0152 0.0129
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0072 0.0224 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0409 0.2404
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0023 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0134
Treponema pallidum thymidylate kinase (tmk) 0.0152 0.0684 1
Trypanosoma cruzi thymidine kinase, putative 0.177 1 1
Echinococcus multilocularis cytidine deaminase 0.0052 0.0111 0.0118
Loa Loa (eye worm) hypothetical protein 0.0054 0.0123 0.0721
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0023 0.0026
Onchocerca volvulus 0.0052 0.0111 0.0524
Brugia malayi Deoxynucleoside kinase family protein 0.0072 0.0224 0.1313
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0409 0.2404
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.0201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0182 0.0478
Brugia malayi RNase H family protein 0.0045 0.0071 0.0416

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NI 0 The compound was tested for inhibitory activity against human cytomegalovirus(HCMV) in flow 2002 cells; no inhibition up to 100 ug/ml. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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