Detailed information for compound 40116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.507 | Formula: C28H26FNO7
  • H donors: 2 H acceptors: 2 LogP: 3.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)NCc1ccc(cc1)F
  • InChi: 1S/C28H26FNO7/c1-33-22-7-15(8-23(34-2)27(22)31)24-17-9-20-21(37-13-36-20)10-18(17)26(19-12-35-28(32)25(19)24)30-11-14-3-5-16(29)6-4-14/h3-10,19,24-26,30-31H,11-13H2,1-2H3/t19-,24+,25-,26+/m0/s1
  • InChiKey: KPTPAZOGVODZMU-QNMIOERPSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0013 0.006 0.0532
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Onchocerca volvulus 0.0013 0.006 0.0532
Giardia lamblia Hypothetical protein 0.0119 0.113 0.5
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0119 0.113 0.113
Brugia malayi Cytochrome P450 family protein 0.0014 0.0075 0.0075
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.006 0.006
Onchocerca volvulus 0.0013 0.006 0.0532
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.006 0.006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.006 0.006
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.006 0.006
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.006 0.006
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0119 0.113 0.113
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0997 1 1
Entamoeba histolytica translation initiation factor 4e, putative 0.0119 0.113 0.113
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0119 0.113 0.1063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.006 0.006
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0997 1 1
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0119 0.113 0.5
Brugia malayi Cation transporter family protein 0.0013 0.006 0.006
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.006 0.006
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0119 0.113 0.1063
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0119 0.113 0.5
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0997 1 1
Entamoeba histolytica hypothetical protein 0.0119 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0119 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Onchocerca volvulus 0.0013 0.006 0.0532
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0119 0.113 0.1063
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.006 0.006
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.006 0.006
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.006 0.006
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0119 0.113 0.1063
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0119 0.113 0.113
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.006 0.006
Giardia lamblia Hypothetical protein 0.0119 0.113 0.5
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.006 0.006
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0119 0.113 0.1063
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.006 0.006
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0119 0.113 0.1063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.006 0.006
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.006 0.006
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.006 0.006
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.006 0.006
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.006 0.006
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.006 0.006
Plasmodium vivax translation initiation factor 4E, putative 0.0119 0.113 0.5
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0119 0.113 0.113
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.006 0.006
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.006 0.006
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0119 0.113 0.113
Loa Loa (eye worm) ACC-1 protein 0.0013 0.006 0.006
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.006 0.006
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.006 0.006
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0119 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0119 0.113 0.1063
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0119 0.113 0.1063
Leishmania major eukaryotic translation initiation factor-like 0.0997 1 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Plasmodium vivax hypothetical protein, conserved 0.0119 0.113 0.5
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0997 1 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.006 0.006
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0119 0.113 0.1063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Loa Loa (eye worm) translation initiation factor 4E 0.0997 1 1
Brugia malayi Cation transporter family protein 0.0013 0.006 0.006
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.006 0.006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.006 0.006
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.006 0.006
Onchocerca volvulus 0.0013 0.006 0.0532
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.006 0.006
Brugia malayi Cytochrome P450 family protein 0.0014 0.0075 0.0075
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.006 0.006
Leishmania major eukaryotic translation initiation factor, putative 0.0119 0.113 0.1063
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0997 1 1
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0119 0.113 0.113
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.006 0.006
Giardia lamblia Translation elongation factor 0.0119 0.113 0.5
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0997 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0119 0.113 1
Schistosoma mansoni nAChR subunit 0.0013 0.006 0.006
Echinococcus granulosus nAChR subunit 0.0013 0.006 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0075 0.0075
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0119 0.113 0.1063
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0075 0.0075
Giardia lamblia hypothetical protein 0.0119 0.113 0.5
Onchocerca volvulus Putative nachr subunit 0.0013 0.006 0.0532
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0119 0.113 0.1063
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.006 0.006
Echinococcus multilocularis nAChR subunit 0.0013 0.006 0.006
Leishmania major eukaryotic translation initiation factor-like protein 0.0997 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.006 0.006
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0119 0.113 0.113
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0119 0.113 0.113
Leishmania major hypothetical protein, conserved 0.0119 0.113 0.1063
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0075 0.0075
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0997 1 1
Loa Loa (eye worm) ACC-1 protein 0.0013 0.006 0.006
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.006 0.006
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0119 0.113 0.113
Brugia malayi Cation transporter family protein 0.0013 0.006 0.006
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0119 0.113 0.1063
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0997 1 1
Leishmania major hypothetical protein, conserved 0.0119 0.113 0.1063
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0997 1 1
Onchocerca volvulus 0.0013 0.006 0.0532
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.006 0.006
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0075 0.5
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.006 0.006
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0033
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.006 0.006
Loa Loa (eye worm) LGC-31 protein 0.0013 0.006 0.006
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
Complex formation (functional) = 169 % % complex formation of cellular protein -DNA complex at a concentration of 10 microM. ChEMBL. 1662724
Complex formation (binding) = 169 % Percentage of intracellular covalent DNA-topoisomerase II complexes formed ChEMBL. 12014968
Complex formation (binding) = 169 % Percentage of intracellular covalent DNA-topoisomerase II complexes formed ChEMBL. 12014968
ID50 (functional) > 4 uM 50% reduction in KB cell number after a 3-day incubation. ChEMBL. 1662724
ID50 (binding) = 50 uM Inhibition of human DNA topoisomerase II ChEMBL. 1662724
ID50 (binding) = 50 uM Inhibition of human DNA topoisomerase II ChEMBL. 1662724
Protein-DNA complex formation (functional) = 169 % Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. ChEMBL. 8691468
Protein-DNA complex formation (functional) = 169 % Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. ChEMBL. 8691468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

3 literature references were collected for this gene.

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