Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0119 | 0.113 | 0.1063 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | ACC-1 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | hypothetical protein | 0.0119 | 0.113 | 0.113 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0119 | 0.113 | 0.113 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.5 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0119 | 0.113 | 0.1063 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0119 | 0.113 | 0.1063 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0013 | 0.006 | 0.006 |
Giardia lamblia | Hypothetical protein | 0.0119 | 0.113 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | hypothetical protein | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0119 | 0.113 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0997 | 1 | 1 |
Entamoeba histolytica | translation initiation factor 4e, putative | 0.0119 | 0.113 | 0.113 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0997 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0119 | 0.113 | 0.113 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Giardia lamblia | Hypothetical protein | 0.0119 | 0.113 | 0.5 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0119 | 0.113 | 0.113 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | LGC-31 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0013 | 0.006 | 0.006 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0075 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0033 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0997 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.113 | 0.1063 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | ACC-1 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0119 | 0.113 | 0.1063 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0997 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0119 | 0.113 | 0.113 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0075 | 0.0075 |
Giardia lamblia | hypothetical protein | 0.0119 | 0.113 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0013 | 0.006 | 0.0532 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0119 | 0.113 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Giardia lamblia | Translation elongation factor | 0.0119 | 0.113 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0997 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0119 | 0.113 | 0.1063 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Plasmodium vivax | hypothetical protein, conserved | 0.0119 | 0.113 | 0.5 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0997 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Complex formation (functional) | = 169 % | % complex formation of cellular protein -DNA complex at a concentration of 10 microM. | ChEMBL. | 1662724 |
Complex formation (binding) | = 169 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
Complex formation (binding) | = 169 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
ID50 (functional) | > 4 uM | 50% reduction in KB cell number after a 3-day incubation. | ChEMBL. | 1662724 |
ID50 (binding) | = 50 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
ID50 (binding) | = 50 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
Protein-DNA complex formation (functional) | = 169 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Protein-DNA complex formation (functional) | = 169 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.