Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Giardia lamblia | Hypothetical protein | 0.0119 | 0.113 | 0.5 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0119 | 0.113 | 0.113 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0119 | 0.113 | 0.113 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0997 | 1 | 1 |
Entamoeba histolytica | translation initiation factor 4e, putative | 0.0119 | 0.113 | 0.113 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0997 | 1 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0119 | 0.113 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0013 | 0.006 | 0.006 |
Giardia lamblia | Hypothetical protein | 0.0119 | 0.113 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0013 | 0.006 | 0.006 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.5 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0119 | 0.113 | 0.113 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | ACC-1 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | hypothetical protein | 0.0119 | 0.113 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0119 | 0.113 | 0.1063 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0119 | 0.113 | 0.1063 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0997 | 1 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Plasmodium vivax | hypothetical protein, conserved | 0.0119 | 0.113 | 0.5 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0997 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0119 | 0.113 | 0.1063 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0997 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Giardia lamblia | Translation elongation factor | 0.0119 | 0.113 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0997 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0119 | 0.113 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0075 | 0.0075 |
Giardia lamblia | hypothetical protein | 0.0119 | 0.113 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0013 | 0.006 | 0.0532 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0119 | 0.113 | 0.1063 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | nAChR subunit | 0.0013 | 0.006 | 0.006 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0997 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0119 | 0.113 | 0.113 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0119 | 0.113 | 0.113 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.113 | 0.1063 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0075 | 0.0075 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0997 | 1 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0013 | 0.006 | 0.006 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0119 | 0.113 | 0.113 |
Brugia malayi | Cation transporter family protein | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0119 | 0.113 | 0.1063 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0997 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.113 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0997 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0.006 | 0.0532 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0013 | 0.006 | 0.006 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0075 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0013 | 0.006 | 0.006 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0033 | 0.0033 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.006 | 0.006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0013 | 0.006 | 0.006 |
Loa Loa (eye worm) | LGC-31 protein | 0.0013 | 0.006 | 0.006 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0013 | 0.006 | 0.006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Complex formation (functional) | = 169 % | % complex formation of cellular protein -DNA complex at a concentration of 10 microM. | ChEMBL. | 1662724 |
Complex formation (binding) | = 169 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
Complex formation (binding) | = 169 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
ID50 (functional) | > 4 uM | 50% reduction in KB cell number after a 3-day incubation. | ChEMBL. | 1662724 |
ID50 (binding) | = 50 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
ID50 (binding) | = 50 uM | Inhibition of human DNA topoisomerase II | ChEMBL. | 1662724 |
Protein-DNA complex formation (functional) | = 169 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Protein-DNA complex formation (functional) | = 169 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.