Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adenylate cyclase type IX | 0.084 | 0.1533 | 0.1533 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0442 | 0.0717 | 0.0717 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.4967 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.0767 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1398 | 0.2678 | 0.2678 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1398 | 0.2678 | 0.2678 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0442 | 0.0717 | 0.0717 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0556 | 0.095 | 0.095 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.4967 | 1 | 1 |
Giardia lamblia | GTOR | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.1202 | 0.2275 | 0.2275 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0442 | 0.0717 | 0.0717 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0485 | 0.0804 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0312 | 0.045 | 0.045 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0956 | 0.177 | 0.177 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | Adenylyl cyclase protein | 0.0556 | 0.095 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.095 | 0.095 |
Echinococcus granulosus | GPCR family 2 | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0956 | 0.177 | 0.177 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.4967 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0312 | 0.045 | 0.045 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | adenylate cyclase type IX | 0.084 | 0.1533 | 0.1533 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1231 | 0.2334 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0312 | 0.045 | 0.045 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.1335 | 0.2549 | 0.2549 |
Onchocerca volvulus | 0.0527 | 0.089 | 0.2337 | |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4967 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.1306 | 0.2488 | 0.2488 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0442 | 0.0717 | 0.0717 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0442 | 0.0717 | 0.0717 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0556 | 0.095 | 0.2651 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1398 | 0.2678 | 0.2678 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0442 | 0.0717 | 0.0717 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0312 | 0.045 | 0.045 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0556 | 0.095 | 0.2651 |
Schistosoma mansoni | hypothetical protein | 0.0956 | 0.177 | 0.177 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0865 | 0.1583 | 0.1583 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0556 | 0.095 | 0.095 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | kinase | 0.0312 | 0.045 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0442 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4967 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0093 | 0 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0093 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1398 | 0.2678 | 0.2678 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0865 | 0.1583 | 0.1583 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.1335 | 0.2549 | 0.2549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus epidermidis ATCC12228 | ChEMBL. | 2521516 |
MIC (functional) | = 2 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pyogenes C203 | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pnemoniae UC41 | ChEMBL. | 2521516 |
MIC (functional) | = 4 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus faecalis AACC7080 | ChEMBL. | 2521516 |
MIC (functional) | = 8 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour in an inoculum of 10e6 cfu/mL | ChEMBL. | 2521516 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour determined in iso-sensitest broth with an inoculum of 10e4 cfu/mL | ChEMBL. | 2521516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.