TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1057.03 | Formula: C48H67Cl2N13O10
H donors: 12 H acceptors: 11 LogP: 0.22 Rotable bonds: 34
Rule of 5 violations (Lipinski): 4
SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)C(C)C)Cc1cc(Cl)c(c(c1)Cl)O)C(C)C)CCCN=C(N)N
InChi: 1S/C48H67Cl2N13O10/c1-25(2)38(61-41(66)32(57-37(64)23-53-5)13-9-15-55-48(51)52)44(69)58-33(20-28-17-30(49)40(65)31(50)18-28)42(67)62-39(26(3)4)45(70)59-34(21-29-22-54-24-56-29)46(71)63-16-10-14-36(63)43(68)60-35(47(72)73)19-27-11-7-6-8-12-27/h6-8,11-12,17-18,22,24-26,32-36,38-39,53,65H,9-10,13-16,19-21,23H2,1-5H3,(H,54,56)(H,57,64)(H,58,69)(H,59,70)(H,60,68)(H,61,66)(H,62,67)(H,72,73)(H4,51,52,55)/t32-,33-,34-,35-,36+,38-,39-/m0/s1
InChiKey: ILJDUPJOUFEANE-UAPUBHJXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0325	0.0158
Brugia malayi	neuropeptide F receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	serotonin receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	ctsf protein	0.0026	0.0325	0.0325
Brugia malayi	RE15519p	0.0207	0.8546	0.8546
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.017	0.017
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0026	0.0325	0.0335
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Echinococcus granulosus	somatostatin receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0022	0.017	0.017
Brugia malayi	G protein-coupled receptor	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Loa Loa (eye worm)	G-protein coupled receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptide receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Schistosoma mansoni	neuropeptide receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0325	0.0325
Echinococcus granulosus	neuropeptide receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	neuropeptide F-like receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0207	0.8546	0.8521
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0077	0.2643	0.2643
Echinococcus granulosus	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	neuropeptide receptor	0.0207	0.8546	0.8546
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	g-protein coupled receptor	0.0207	0.8546	0.8546
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Plasmodium vivax	vivapain-2	0.0026	0.0325	0.5
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0026	0.0325	0.0335
Schistosoma mansoni	ceramide glucosyltransferase	0.0232	0.9686	0.9686
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Brugia malayi	Serotonin receptor	0.0207	0.8546	0.8546
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.3384	0.6282
Echinococcus granulosus	cathepsin b	0.0137	0.5387	0.5387
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0325	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0207	0.8546	0.8546
Schistosoma mansoni	hypothetical protein	0.0207	0.8546	0.8546
Brugia malayi	cathepsin B-like cysteine proteinase	0.0137	0.5387	0.5387
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptide receptor	0.0207	0.8546	0.8521
Echinococcus multilocularis	cysteine protease	0.0026	0.0325	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0325	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Echinococcus granulosus	g protein coupled receptor	0.0207	0.8546	0.8546
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0325	0.0335
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0207	0.8546	0.8521
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	g protein coupled receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0239	1	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0207	0.8546	0.8521
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0022	0.017	0.017
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0137	0.5387	0.5387
Echinococcus granulosus	cathepsin b	0.0137	0.5387	0.5387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	growth hormone secretagogue receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0239	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptides capa receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	ceramide glucosyltransferase	0.0232	0.9686	0.9686
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0207	0.8546	0.8521
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0325	0.0325
Echinococcus granulosus	g protein coupled receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0207	0.8546	0.8546
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Echinococcus multilocularis	orexin receptor type 2	0.0207	0.8546	0.8521
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0207	0.8546	0.8546
Echinococcus multilocularis	somatostatin receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	orexin receptor type 2	0.0207	0.8546	0.8546
Echinococcus multilocularis	cysteine protease	0.0026	0.0325	0.0158
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0207	0.8546	0.8823
Loa Loa (eye worm)	melatonin receptor type 1A	0.0207	0.8546	0.8546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	voltage-gated potassium channel	0.0022	0.017	0.017
Echinococcus multilocularis	neuropeptide Y receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	hypothetical protein	0.0207	0.8546	0.8546
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0048	0.1337	0.2482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus multilocularis	serotonin receptor	0.0207	0.8546	0.8521
Brugia malayi	Dopamine receptor protein 1	0.0207	0.8546	0.8546
Schistosoma mansoni	opsin-like receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	biogenic amine 5HT receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0207	0.8546	0.8521
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptide s receptor	0.0207	0.8546	0.8521
Onchocerca volvulus		0.0026	0.0325	0.0335
Onchocerca volvulus		0.0207	0.8546	0.8823
Echinococcus multilocularis	cathepsin b	0.0137	0.5387	0.5308
Brugia malayi	AKH receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0207	0.8546	0.8521
Schistosoma mansoni	myosin xvIII	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	neuropeptide Y receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	gamma secretase subunit aph 1	0.0239	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0077	0.2643	0.2516
Echinococcus multilocularis	G protein coupled receptor 139	0.0207	0.8546	0.8521
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0026	0.0325	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0239	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0207	0.8546	0.8521
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	neuropeptides capa receptor	0.0207	0.8546	0.8546
Brugia malayi	G-protein coupled receptor	0.0207	0.8546	0.8546
Brugia malayi	Dopamine receptor	0.0207	0.8546	0.8546
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0325	0.0325
Echinococcus granulosus	allatostatin A receptor	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Plasmodium vivax	vivapain-2	0.0026	0.0325	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0207	0.8546	0.8546
Brugia malayi	putative neuropeptide receptor	0.0207	0.8546	0.8546
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0325	0.0603
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Echinococcus multilocularis	neuropeptides capa receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Echinococcus granulosus	tm gpcr rhodopsin	0.0207	0.8546	0.8546
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0325	0.0158
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0207	0.8546	0.8546
Echinococcus granulosus	biogenic amine 5HT receptor	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Brugia malayi	Serotonin receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	sex peptide receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0207	0.8546	0.8521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Echinococcus granulosus	7tm_1 domain containing protein	0.0207	0.8546	0.8546
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0207	0.8546	0.8823
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	serotonin receptor	0.0207	0.8546	0.8521
Brugia malayi	larval opioid receptor	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0207	0.8546	0.8546
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0207	0.8546	0.8546
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0207	0.8546	0.8546
Trypanosoma brucei	Aph-1 protein, putative	0.0093	0.3384	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.1337	0.554
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0207	0.8546	0.8521
Schistosoma mansoni	amine GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0325	0.0603
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0325	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0207	0.8546	0.8521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0325	0.1346
Schistosoma mansoni	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Loa Loa (eye worm)	neuropeptide F receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	cathepsin B	0.0048	0.1337	0.1337
Schistosoma mansoni	amine GPCR	0.0207	0.8546	0.8546
Trypanosoma cruzi	Aph-1 protein, putative	0.0093	0.3384	0.6282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Schistosoma mansoni	opsin-like receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine receptor	0.0207	0.8546	0.8546
Brugia malayi	follicle stimulating hormone receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Onchocerca volvulus		0.0026	0.0325	0.0335
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0207	0.8546	0.8546
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0325	0.5
Echinococcus granulosus	fmrfamide receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	amine GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.5387	0.5387
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0048	0.1337	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.2963	0.2963
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	fibroinase	0.0026	0.0325	0.0325
Schistosoma mansoni	neuropeptide receptor	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0325	0.0325
Brugia malayi	sulfakinin receptor protein	0.0207	0.8546	0.8546
Giardia lamblia	Ceramide glucosyltransferase	0.0105	0.3932	1
Echinococcus granulosus	neuropeptide receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0077	0.2643	0.2643
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Echinococcus granulosus	ceramide glucosyltransferase	0.0232	0.9686	0.9686
Schistosoma mansoni	opsin-like receptor	0.0207	0.8546	0.8546
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0022	0.017	0.017
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0325	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.2414	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Brugia malayi	Dopamine receptor protein 2	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0325	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0325	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0325	0.0325
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0207	0.8546	0.8521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.5387	0.5387
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0325	0.0603
Brugia malayi	neuropeptide F receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Loa Loa (eye worm)	neuropeptide F receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	sex peptide receptor	0.0207	0.8546	0.8521
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Onchocerca volvulus		0.0207	0.8546	0.8823
Echinococcus granulosus	tm gpcr rhodopsin	0.0207	0.8546	0.8546
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0325	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0207	0.8546	0.8546
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0325	0.0335
Brugia malayi	G-protein coupled receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0207	0.8546	0.8521
Loa Loa (eye worm)	hypothetical protein	0.0137	0.5387	0.5387
Loa Loa (eye worm)	TYRA-2 protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0325	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	g-protein coupled receptor	0.0207	0.8546	0.8521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Schistosoma mansoni	neuropeptide F-like receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0207	0.8546	0.8521
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0207	0.8546	0.8521
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Echinococcus multilocularis	fmrfamide receptor	0.0207	0.8546	0.8521
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0325	0.0325
Schistosoma mansoni	amine GPCR	0.0207	0.8546	0.8546
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0207	0.8546	0.8546
Toxoplasma gondii	cathepsin B	0.0048	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Echinococcus multilocularis	dro:myosuppressin receptor	0.0207	0.8546	0.8521
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.5387	0.5387
Brugia malayi	ORL1-like opioid receptor	0.0207	0.8546	0.8546
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0048	0.1337	1
Echinococcus multilocularis	cathepsin b	0.0137	0.5387	0.5308
Schistosoma mansoni	biogenic amine receptor	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	allatostatin A receptor	0.0207	0.8546	0.8521
Echinococcus granulosus	neuropeptide Y receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0137	0.5387	1
Echinococcus granulosus	neuropeptides capa receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	amine GPCR	0.0207	0.8546	0.8546
Schistosoma mansoni	biogenic amine receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0067	0.2183	0.2183
Echinococcus multilocularis	neuropeptide Y receptor	0.0207	0.8546	0.8521
Onchocerca volvulus		0.0207	0.8546	0.8823
Schistosoma mansoni	adenoreceptor	0.0207	0.8546	0.8546
Brugia malayi	Ceramide glucosyltransferase	0.0232	0.9686	0.9686
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0207	0.8546	0.8521
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	neuropeptide receptor A26	0.0207	0.8546	0.8521
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0207	0.8546	0.8546
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0207	0.8546	0.8521
Echinococcus granulosus	voltage gated potassium channel	0.0022	0.017	0.017
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0325	0.0325
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0077	0.2643	0.2643
Onchocerca volvulus		0.0207	0.8546	0.8823
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.2414	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0207	0.8546	0.8546
Brugia malayi	G protein-coupled receptor F59B2.13	0.0207	0.8546	0.8546
Echinococcus granulosus	G protein coupled receptor 139	0.0207	0.8546	0.8546
Echinococcus multilocularis	g protein coupled receptor	0.0207	0.8546	0.8521
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0325	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0325	0.0325
Brugia malayi	Melatonin receptor type 1A	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0026	0.0325	0.0335
Schistosoma mansoni	histamine h1 receptor	0.0207	0.8546	0.8546
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0325	0.0335
Brugia malayi	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	g protein coupled receptor	0.0207	0.8546	0.8546
Schistosoma mansoni	neuropeptide receptor	0.0207	0.8546	0.8546
Echinococcus granulosus	neuropeptide receptor A26	0.0207	0.8546	0.8546
Loa Loa (eye worm)	cysteine protease	0.0026	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0325	0.1346
Schistosoma mansoni	neuropeptide f receptor 76f	0.0207	0.8546	0.8546
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0207	0.8546	0.8521
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0232	0.9686	0.9686
Onchocerca volvulus		0.0207	0.8546	0.8823
Echinococcus granulosus	dro:myosuppressin receptor	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0232	0.9686	1
Onchocerca volvulus		0.0207	0.8546	0.8823
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0207	0.8546	0.8546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0207	0.8546	0.8521
Onchocerca volvulus		0.0207	0.8546	0.8823
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus multilocularis	ceramide glucosyltransferase	0.0232	0.9686	0.9681
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Echinococcus granulosus	cathepsin l1	0.0026	0.0325	0.0325
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0207	0.8546	0.8546
Echinococcus granulosus	tm gpcr rhodopsin	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0207	0.8546	0.8823
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Loa Loa (eye worm)	hypothetical protein	0.0207	0.8546	0.8546
Onchocerca volvulus		0.0026	0.0325	0.0335
Brugia malayi	GnHR receptor homolog	0.0207	0.8546	0.8546
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0325	0.0158
Echinococcus multilocularis	fmrfamide receptor	0.0207	0.8546	0.8521
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0207	0.8546	0.8546
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.2963	0.2963
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0207	0.8546	0.8546
Echinococcus granulosus	7TM GPCR rhodopsin	0.0207	0.8546	0.8546

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 19 %	In vivo biological activity on the blood pressure of the anesthetized rat.	ChEMBL.	6699877
Activity (functional)	= 22 %	In vitro biological activity on rabbit aorta strip.	ChEMBL.	6699877
Activity (binding)	= 28 %	Displacement of [3H]-AT from angiotensin II receptor in bovine adrenocortical membranes	ChEMBL.	6699877
Activity (binding)	= 28 %	Displacement of [3H]-AT from angiotensin II receptor in bovine adrenocortical membranes	ChEMBL.	6699877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL413906

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 401865