Detailed information for compound 402366

Basic information

Technical information
  • TDR Targets ID: 402366
  • Name: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[( 2S)-2-[[(2S)-1-[(2S)-3-[4-(aminomethyl)cycloh exyl]-2-[[2-[2-[2-[bis(carboxymethyl)amino]et hyl-(carboxymethyl)amino]ethyl-(carboxymethyl )amino]acetyl]amino]propanoyl]pyrrolidine-2-c arbonyl]amino]-2-(1-carbamimidoylpiperidin-4- yl)acetyl]amino]-5-(diaminomethylideneamino)p entanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-h ydroxyphenyl)propanoyl]amino]-3,3-dimethylbut anoyl]amino]-4-methylpentanoic acid
  • MW: 1497.74 | Formula: C69H112N18O19
  • H donors: 16 H acceptors: 19 LogP: -8.98 Rotable bonds: 52
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC1CCC(CC1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCN=C(N)N)C1CCN(CC1)C(=N)N)NC(=O)CN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC(=O)O
  • InChi: 1S/C69H112N18O19/c1-40(2)31-49(66(105)106)79-63(102)58(69(3,4)5)81-59(98)47(32-42-16-18-45(88)19-17-42)78-60(99)50-10-7-23-86(50)64(103)46(9-6-22-75-67(71)72)77-62(101)57(44-20-25-85(26-21-44)68(73)74)80-61(100)51-11-8-24-87(51)65(104)48(33-41-12-14-43(34-70)15-13-41)76-52(89)35-83(37-54(92)93)29-27-82(36-53(90)91)28-30-84(38-55(94)95)39-56(96)97/h16-19,40-41,43-44,46-51,57-58,88H,6-15,20-39,70H2,1-5H3,(H3,73,74)(H,76,89)(H,77,101)(H,78,99)(H,79,102)(H,80,100)(H,81,98)(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H,105,106)(H4,71,72,75)/t41?,43?,46-,47-,48-,49-,50-,51-,57-,58+/m0/s1
  • InChiKey: PZJUWDHWQBVWKR-VSKRWVLPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[4-(aminomethyl)cyclohexyl]-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-2-(1-carbamimidoyl-4-piperidyl)acetyl]amino]-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-3-[4-(aminomethyl)cyclohexyl]-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]-1-oxoethyl]amino]-1-oxopropyl]-2-pyrrolidinyl]-oxomethyl]amino]-2-(1-carbamimidoyl-4-piperidinyl)-1-oxoethyl]amino]-5-guanidino-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3,3-dimethyl-1-oxobutyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-[4-(aminomethyl)cyclohexyl]-2-[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethanoylamino]propanoyl]pyrrolidin-2-yl]carbonylamino]-2-(1-carbamimidoylpiperidin-4-yl)ethanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanoyl]pyrrolidin-2-yl]carbonylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-(1-amidino-4-piperidyl)-2-[[(2S)-1-[(2S)-3-[4-(aminomethyl)cyclohexyl]-2-[[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetyl]amino]propanoyl]prolyl]amino]acetyl]amino]-5-guanidino-pentanoyl]prolyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-methyl-valeric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neurotensin receptor 1 (high affinity) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Alanyl dipeptidyl peptidase 0.0054 0.0489 0.1291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Echinococcus granulosus histone deacetylase 7 0.0157 0.1717 0.1717
Onchocerca volvulus Cathepsin L homolog 0.0097 0.101 0.1706
Echinococcus granulosus acylamino acid releasing enzyme 0.0054 0.0489 0.0489
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 1 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0054 0.0489 0.0827
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Schistosoma mansoni zinc finger protein 0.0021 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0054 0.0489 0.0827
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0133 0.1427 0.1427
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0059 0.0059
Trypanosoma brucei ISWI complex protein 0.0015 0.0032 0.0053
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0093 0.0093
Toxoplasma gondii cathepsin B 0.0332 0.379 0.6402
Mycobacterium tuberculosis Probable peptidase 0.0203 0.2266 0.4018
Echinococcus granulosus cathepsin l cysteine peptidase 0.0424 0.4894 0.4894
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0284 0.058
Leishmania major cathepsin L-like protease 0.0424 0.4894 0.8266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.2584 0.5281
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0059
Trypanosoma cruzi histone deacetylase 1, putative 0.0164 0.1799 0.1799
Trypanosoma brucei prolyl endopeptidase 0.0511 0.592 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0424 0.4894 1
Loa Loa (eye worm) cathepsin B 0.0332 0.379 0.379
Giardia lamblia Cysteine protease 0.0097 0.101 0.2665
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0097 0.101 0.2064
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.101 0.2064
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0387 0.0387
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0284 0.048
Plasmodium vivax vivapain-1 0.023 0.2584 0.5281
Plasmodium vivax vivapain-2 0.0424 0.4894 1
Trypanosoma cruzi prolyl endopeptidase 0.0511 0.592 0.592
Trypanosoma brucei calpain-like protein, putative 0.002 0.0093 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Echinococcus granulosus calpain A 0.0056 0.0517 0.0517
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0489 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0157
Brugia malayi Bromodomain containing protein 0.0038 0.03 0.03
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Echinococcus granulosus histone deacetylase 8 0.0073 0.0716 0.0716
Loa Loa (eye worm) histone deacetylase 11 0.0073 0.0716 0.0716
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Trypanosoma cruzi histone deacetylase, putative 0.0157 0.1717 0.1717
Trypanosoma cruzi histone deacetylase, putative 0.0157 0.1717 0.1717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0489 0.1
Schistosoma mansoni histone deacetylase 4 5 0.0157 0.1717 0.1717
Loa Loa (eye worm) ctsf protein 0.0424 0.4894 0.4894
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.023 0.2584 0.2584
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0097 0.101 0.2064
Giardia lamblia Cathepsin B precursor 0.0097 0.101 0.2665
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0097 0.101 0.101
Echinococcus granulosus histone deacetylase 1 0.0164 0.1799 0.1799
Brugia malayi cathepsin F-like cysteine proteinase 0.0097 0.101 0.101
Giardia lamblia Cathepsin L-like protease 0.0097 0.101 0.2665
Trypanosoma cruzi kinesin, putative 0.0014 0.0021 0.0021
Plasmodium falciparum serine repeat antigen 5 0.0097 0.101 0.2064
Plasmodium falciparum histone deacetylase, putative 0.0157 0.1717 0.3509
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0387
Echinococcus granulosus calpain 0.002 0.0093 0.0093
Plasmodium falciparum serine repeat antigen 6 0.0097 0.101 0.2064
Giardia lamblia Cysteine protease 0.0097 0.101 0.2665
Giardia lamblia Cathepsin B precursor 0.0332 0.379 1
Plasmodium vivax histone deacetylase, putative 0.0157 0.1717 0.3509
Schistosoma mansoni cpg binding protein 0.0028 0.0184 0.0184
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0054 0.0489 0.0489
Loa Loa (eye worm) histone deacetylase 7A 0.0157 0.1717 0.1717
Entamoeba histolytica cysteine proteinase 2 0.023 0.2584 0.5281
Onchocerca volvulus 0.0292 0.3319 0.5606
Echinococcus granulosus calpain 5 0.002 0.0093 0.0093
Brugia malayi histone deacetylase 11 0.0073 0.0716 0.0716
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.004 0.0328 0.0328
Giardia lamblia Cysteine protease 0.0097 0.101 0.2665
Echinococcus multilocularis calpain 0.002 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0338 0.3868 0.3868
Onchocerca volvulus Histone deacetylase 10 homolog 0.0073 0.0716 0.1209
Brugia malayi calpain 5 0.0014 0.0021 0.0021
Echinococcus granulosus prolyl endopeptidase 0.0511 0.592 0.592
Loa Loa (eye worm) hypothetical protein 0.0054 0.0489 0.0489
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0093 0.0157
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.101 0.101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0332 0.379 0.379
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Echinococcus multilocularis hypothetical protein 0.002 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.101 0.2064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0093 0.0093
Echinococcus granulosus histone deacetylase 3 0.0164 0.1799 0.1799
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.0032
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0054 0.0489 0.1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0164 0.1799 0.3677
Toxoplasma gondii histone deacetylase HDAC2 0.0164 0.1799 0.3039
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0094 0.0094
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0097 0.101 0.2665
Trypanosoma cruzi cysteine peptidase, putative 0.0471 0.5442 0.5442
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0554 0.0554
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0054 0.0489 0.0489
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0054 0.0489 0.0489
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0135 0.0135
Leishmania major histone deacetylase, putative 0.0157 0.1717 0.29
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Brugia malayi calpain family protein 1 0.0054 0.0489 0.0489
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.101 0.101
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0157
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0332 0.379 0.7746
Brugia malayi calpain 7 0.002 0.0093 0.0093
Schistosoma mansoni cathepsin s 0.0133 0.1427 0.1427
Loa Loa (eye worm) hypothetical protein 0.0133 0.1427 0.1427
Onchocerca volvulus 0.0424 0.4894 0.8266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2584 0.4365
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.101 0.2064
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0424 0.4894 0.4894
Echinococcus multilocularis histone deacetylase 6 0.0157 0.1717 0.1717
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0015 0.0032 0.0032
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0133 0.1427 0.1427
Onchocerca volvulus 0.0028 0.0184 0.031
Brugia malayi Histone deacetylase family protein 0.0157 0.1717 0.1717
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0093
Leishmania major cathepsin L-like protease 0.0471 0.5442 0.9192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.101 0.2064
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.023 0.2584 0.2584
Echinococcus granulosus cathepsin L cysteine proteinase 0.0424 0.4894 0.4894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0387
Leishmania major cathepsin L-like protease 0.0424 0.4894 0.8266
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0854 1 1
Giardia lamblia Cathepsin B precursor 0.0097 0.101 0.2665
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.101 0.101
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0284 0.058
Entamoeba histolytica cysteine proteinase, putative 0.0424 0.4894 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0014 0.0021 0.0042
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0517 0.0517
Giardia lamblia Encystation-specific protease 0.0097 0.101 0.2665
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0301 0.0301
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.1427 0.1427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Schistosoma mansoni cathepsin F (C01 family) 0.0424 0.4894 0.4894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.101 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Trypanosoma brucei oligopeptidase b 0.0203 0.2266 0.3827
Loa Loa (eye worm) hypothetical protein 0.0054 0.0489 0.0489
Brugia malayi histone deacetylase 1 (HD1) 0.0164 0.1799 0.1799
Echinococcus multilocularis cathepsin b 0.0854 1 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0054 0.0489 0.0827
Echinococcus multilocularis histone deacetylase 7 0.0157 0.1717 0.1717
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni cathepsin F (C01 family) 0.0424 0.4894 0.4894
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Giardia lamblia Cathepsin B precursor 0.0097 0.101 0.2665
Plasmodium falciparum serine repeat antigen 3 0.0097 0.101 0.2064
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0321 0.0321
Plasmodium falciparum histone deacetylase 2 0.0157 0.1717 0.3509
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Plasmodium falciparum serine repeat antigen 8 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0097 0.101 0.2064
Brugia malayi Histone deacetylase family protein 0.0157 0.1717 0.1717
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0517 0.0517
Schistosoma mansoni hypothetical protein 0.002 0.0094 0.0094
Onchocerca volvulus 0.0424 0.4894 0.8266
Echinococcus multilocularis cathepsin L 0.0097 0.101 0.101
Onchocerca volvulus 0.0097 0.101 0.1706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0097 0.101 0.2064
Echinococcus granulosus histone deacetylase 6 0.0157 0.1717 0.1717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Echinococcus multilocularis zinc finger protein 0.0021 0.01 0.01
Schistosoma mansoni cathepsin S (C01 family) 0.0097 0.101 0.101
Brugia malayi cathepsin L-like cysteine proteinase 0.0097 0.101 0.101
Entamoeba histolytica cysteine proteinase, putative 0.023 0.2584 0.5281
Echinococcus granulosus cathepsin L cysteine protease 0.023 0.2584 0.2584
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0097 0.101 0.2064
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0054 0.0489 0.0827
Echinococcus multilocularis cysteine protease 0.0424 0.4894 0.4894
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0489 0.0489
Brugia malayi Papain family cysteine protease containing protein 0.0424 0.4894 0.4894
Brugia malayi Papain family cysteine protease containing protein 0.023 0.2584 0.2584
Leishmania major cathepsin L-like protease 0.0424 0.4894 0.8266
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Trypanosoma cruzi kinesin, putative 0.0014 0.0021 0.0021
Plasmodium falciparum serine repeat antigen 9 0.0097 0.101 0.2064
Toxoplasma gondii cathepsin CPL 0.0424 0.4894 0.8266
Schistosoma mansoni calpain (C02 family) 0.002 0.0093 0.0093
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0097 0.101 0.2665
Echinococcus granulosus calpain A 0.002 0.0093 0.0093
Plasmodium falciparum peptidase, putative 0.0054 0.0489 0.1
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Echinococcus granulosus histone deacetylase 0.0157 0.1717 0.1717
Entamoeba histolytica cysteine proteinase 1, putative 0.023 0.2584 0.5281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0424 0.4894 0.4894
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0284 0.048
Loa Loa (eye worm) hypothetical protein 0.0292 0.3319 0.3319
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0203 0.2266 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0511 0.592 1
Entamoeba histolytica cysteine protease, putative 0.0424 0.4894 1
Leishmania major histone deacetylase, putative 0.0164 0.1799 0.3039
Plasmodium falciparum serine repeat antigen 1 0.0097 0.101 0.2064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Giardia lamblia Hypothetical protein 0.0097 0.101 0.2665
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0164 0.1799 0.3677
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.101 0.101
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0511 0.592 1
Echinococcus granulosus cathepsin l1 0.0292 0.3319 0.3319
Plasmodium vivax histone deacetylase 1, putative 0.0164 0.1799 0.3677
Echinococcus multilocularis histone deacetylase 1 0.0164 0.1799 0.1799
Echinococcus multilocularis cpg binding protein 0.0031 0.0225 0.0225
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0203 0.2266 0.3827
Echinococcus multilocularis calpain 5 0.002 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0284 0.058
Plasmodium vivax unspecified product 0.0097 0.101 0.2064
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.101 0.101
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0097 0.101 0.2064
Echinococcus multilocularis cysteine protease 0.0424 0.4894 0.4894
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0568 0.0568
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0517 0.0517
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.101 0.101
Onchocerca volvulus 0.0424 0.4894 0.8266
Toxoplasma gondii histone deacetylase HDAC5 0.0073 0.0716 0.1209
Schistosoma mansoni cpg binding protein 0.0031 0.0225 0.0225
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Trypanosoma brucei prolyl oligopeptidase, putative 0.0203 0.2266 0.3827
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0272 0.0272
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0489 0.1
Schistosoma mansoni cathepsin C 0.0097 0.101 0.101
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0097 0.101 0.2064
Echinococcus multilocularis cathepsin b 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0489 0.0489
Plasmodium vivax vivapain-3 0.023 0.2584 0.5281
Brugia malayi cathepsin L-like precursor 0.0292 0.3319 0.3319
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0568 0.0568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0387 0.0387
Brugia malayi Cathepsin L-like precursor 0.0292 0.3319 0.3319
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0052 0.0052
Echinococcus granulosus histone deacetylase 6 0.0169 0.1864 0.1864
Plasmodium vivax serine-repeat antigen (SERA) 0.0097 0.101 0.2064
Entamoeba histolytica cysteine proteinase, putative 0.023 0.2584 0.5281
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0332 0.379 0.379
Schistosoma mansoni histone deacetylase 0.0164 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.0424 0.4894 0.4894
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0093 0.0093
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0097 0.101 0.101
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0284 0.0284
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0054 0.0489 0.0489
Giardia lamblia Cathepsin B precursor 0.0097 0.101 0.2665
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0054 0.0489 0.0489
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Echinococcus multilocularis cathepsin L cysteine protease 0.0424 0.4894 0.4894
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0093 0.0093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0093 0.0093
Toxoplasma gondii preprocathepsin c precursor, putative 0.0097 0.101 0.1706
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0489 0.1
Trypanosoma cruzi histone deacetylase, putative 0.0073 0.0716 0.0716
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2584 0.2584
Loa Loa (eye worm) histone deacetylase 1 0.0164 0.1799 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.101 0.2064
Plasmodium vivax vivapain-2 0.0424 0.4894 1
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Trypanosoma cruzi cysteine proteinase, putative 0.023 0.2584 0.2584
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0457 0.5284 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0093
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0054 0.0489 0.0827
Plasmodium falciparum cysteine proteinase falcipain 1 0.023 0.2584 0.5281
Trypanosoma cruzi cysteine peptidase, putative 0.0424 0.4894 0.4894
Loa Loa (eye worm) hypothetical protein 0.0084 0.0854 0.0854
Trypanosoma cruzi cysteine peptidase, putative 0.0471 0.5442 0.5442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.3319 0.6783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Echinococcus multilocularis calpain A 0.0056 0.0517 0.0517
Loa Loa (eye worm) calpain 5 0.0014 0.0021 0.0021
Trypanosoma cruzi cysteine protease, putative 0.023 0.2584 0.2584
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0054 0.0489 0.0827
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0093 0.0093
Echinococcus granulosus Dipeptidyl peptidase 9 0.0054 0.0489 0.0489
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0424 0.4894 0.4894
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0284 0.0284
Schistosoma mansoni histone deacetylase 0.0164 0.1799 0.1799
Echinococcus multilocularis prolyl endopeptidase 0.0511 0.592 0.592
Trypanosoma brucei histone deacetylase 1 0.0164 0.1799 0.3039
Echinococcus multilocularis histone deacetylase 3 0.0164 0.1799 0.1799
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0424 0.4894 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.101 0.101
Trypanosoma cruzi cysteine proteinase, putative 0.023 0.2584 0.2584
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0854 1 1
Leishmania major cathepsin L-like protease 0.0471 0.5442 0.9192
Brugia malayi histone deacetylase 3 (HD3) 0.0164 0.1799 0.1799
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Loa Loa (eye worm) prolyl oligopeptidase 0.0054 0.0489 0.0489
Trypanosoma cruzi histone deacetylase, putative 0.0157 0.1717 0.1717
Trypanosoma cruzi major cysteine proteinase, putative 0.0144 0.1559 0.1559
Brugia malayi CXXC zinc finger family protein 0.0028 0.0184 0.0184
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0097 0.101 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0054 0.0489 0.0827
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0284 0.048
Plasmodium falciparum cysteine proteinase falcipain 3 0.0424 0.4894 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0052 0.0052
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0054 0.0489 0.0489
Trypanosoma cruzi histone deacetylase 1, putative 0.0164 0.1799 0.1799
Loa Loa (eye worm) prolyl oligopeptidase 0.0054 0.0489 0.0489
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0424 0.4894 0.4894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0387 0.0387
Schistosoma mansoni cpg binding protein 0.0031 0.0225 0.0225
Entamoeba histolytica protein kinase, putative 0.0014 0.0021 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0284 0.0284
Giardia lamblia Histone deacetylase 0.0164 0.1799 0.4747
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.023 0.2584 0.2584
Giardia lamblia Cathepsin B precursor 0.0332 0.379 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0135 0.0135
Echinococcus granulosus cathepsin b 0.0854 1 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0052 0.0052
Plasmodium falciparum serine repeat antigen 4 0.0097 0.101 0.2064
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0203 0.2266 0.4018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.2584 0.5281
Giardia lamblia Alanyl dipeptidyl peptidase 0.0054 0.0489 0.1291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.101 0.101
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0517 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0097 0.101 0.2064
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0093
Leishmania major cathepsin L-like protease 0.0424 0.4894 0.8266
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0097 0.101 0.101
Onchocerca volvulus Cathepsin L homolog 0.0424 0.4894 0.8266
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0292 0.3319 0.3319
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Toxoplasma gondii histone deacetylase HDAC4 0.0073 0.0716 0.1209
Plasmodium vivax unspecified product 0.023 0.2584 0.5281
Loa Loa (eye worm) hypothetical protein 0.0292 0.3319 0.3319
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0157
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0203 0.2266 1
Trypanosoma cruzi oligopeptidase b 0.0203 0.2266 0.2266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0059 0.0059
Plasmodium falciparum histone deacetylase 1 0.0164 0.1799 0.3677
Brugia malayi Cathepsin L-like precursor 0.0133 0.1427 0.1427
Trypanosoma brucei kinesin, putative 0.0014 0.0021 0.0035
Plasmodium falciparum serine repeat antigen 2 0.0097 0.101 0.2064
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0097 0.101 0.2064
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0097 0.101 0.2064
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0164 0.1799 0.1799
Trypanosoma brucei histone deacetylase, putative 0.0157 0.1717 0.29
Entamoeba histolytica histone deacetylase, putative 0.0164 0.1799 0.3677
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0093 0.0093
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0097 0.101 0.2064
Loa Loa (eye worm) hypothetical protein 0.0133 0.1427 0.1427
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0097 0.101 0.2064
Leishmania major histone deacetylase, putative 0.0164 0.1799 0.3039
Brugia malayi Cathepsin L-like precursor 0.0292 0.3319 0.3319
Entamoeba histolytica cysteine proteinase, putative 0.023 0.2584 0.5281
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0489 0.1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0157
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0097 0.101 0.2665
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0097 0.101 0.2064
Schistosoma mansoni bromodomain containing protein 0.0064 0.061 0.061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni calpain C (C02 family) 0.002 0.0093 0.0093
Toxoplasma gondii histone deacetylase HDAC1 0.0157 0.1717 0.29
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0054 0.0489 0.1
Trypanosoma cruzi cruzipain precursor, putative 0.0133 0.1427 0.1427
Trypanosoma brucei histone deacetylase 2 0.0073 0.0716 0.1209
Schistosoma mansoni histone deacetylase hda2 0.0073 0.0716 0.0716
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0135 0.0135
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.101 0.2064
Brugia malayi prolyl oligopeptidase family protein 0.0511 0.592 0.592
Echinococcus granulosus cpg binding protein 0.0031 0.0225 0.0225
Echinococcus granulosus cathepsin l1 0.0424 0.4894 0.4894
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0471 0.5442 0.5442
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.101 0.101
Schistosoma mansoni inositol monophosphatase 0.0036 0.0284 0.0284
Trypanosoma brucei antigen, putative 0.002 0.0093 0.0157
Giardia lamblia Hypothetical protein 0.0097 0.101 0.2665
Echinococcus multilocularis histone deacetylase 6 0.0169 0.1864 0.1864
Brugia malayi fibroinase precursor 0.0097 0.101 0.101
Echinococcus granulosus zinc finger protein 0.0021 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0854 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0417 0.0417
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0164 0.1799 0.3677
Loa Loa (eye worm) hypothetical protein 0.0069 0.0678 0.0678
Echinococcus granulosus cathepsin b 0.0854 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0133 0.1427 0.1427
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0097 0.101 0.101
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0097 0.101 0.2064
Leishmania major cathepsin L-like protease 0.0471 0.5442 0.9192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0054 0.0489 0.1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0054 0.0489 0.0489
Toxoplasma gondii prolyl endopeptidase 0.0511 0.592 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0097 0.101 0.2064
Loa Loa (eye worm) inositol-1 0.0036 0.0284 0.0284
Plasmodium vivax histone deacetylase 2, putative 0.0157 0.1717 0.3509
Leishmania major cysteine peptidase A (CPA) 0.0424 0.4894 0.8266
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0489 0.0489
Brugia malayi calpain family protein 1 0.0054 0.0489 0.0489
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0716 0.0716
Echinococcus granulosus histone deacetylase 6 0.0157 0.1717 0.1717
Leishmania major oligopeptidase b 0.0203 0.2266 0.3827
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0284 0.0284
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0507 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2584 0.4365
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.101 0.2064
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0203 0.2266 0.3827
Echinococcus granulosus cysteine protease 0.023 0.2584 0.2584
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 1 1
Toxoplasma gondii hypothetical protein 0.0054 0.0489 0.0827
Echinococcus granulosus cathepsin L 0.0097 0.101 0.101
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0489 0.1
Trypanosoma brucei histone deacetylase 3 0.0157 0.1717 0.29
Echinococcus multilocularis histone deacetylase 6 0.0157 0.1717 0.1717
Brugia malayi cathepsin Z-like cysteine proteinase 0.0097 0.101 0.101
Brugia malayi Cathepsin L-like cysteine proteinase 0.0292 0.3319 0.3319
Brugia malayi Histone deacetylase 1 0.0164 0.1799 0.1799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.101 0.101
Trypanosoma brucei cysteine peptidase C (CPC) 0.0332 0.379 0.6402
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.101 0.101
Plasmodium falciparum serine repeat antigen 7 0.0097 0.101 0.2064
Plasmodium vivax calpain, putative 0.002 0.0093 0.019
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0284 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0387 0.0387
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0184 0.0184
Onchocerca volvulus 0.0424 0.4894 0.8266
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.101 0.2064
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.0032
Echinococcus multilocularis histone deacetylase 0.0157 0.1717 0.1717
Onchocerca volvulus Cathepsin L homolog 0.0424 0.4894 0.8266
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0489 0.0489
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0284 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Trypanosoma brucei histone deacetylase 4 0.0157 0.1717 0.29
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Giardia lamblia Cysteine protease 0.0097 0.101 0.2665
Onchocerca volvulus 0.0424 0.4894 0.8266
Toxoplasma gondii cathepsin CPC2 0.0097 0.101 0.1706
Loa Loa (eye worm) hypothetical protein 0.0097 0.101 0.101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0054 0.0489 0.0489
Loa Loa (eye worm) fibroinase 0.0424 0.4894 0.4894
Echinococcus multilocularis histone deacetylase 8 0.0073 0.0716 0.0716
Echinococcus multilocularis cathepsin L 0.023 0.2584 0.2584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Giardia lamblia Cathepsin B precursor 0.0332 0.379 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0203 0.2266 0.2266
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Loa Loa (eye worm) histone deacetylase 0.0157 0.1717 0.1717
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0097 0.101 0.101
Plasmodium vivax unspecified product 0.0133 0.1427 0.2917
Echinococcus multilocularis acylamino acid releasing enzyme 0.0054 0.0489 0.0489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0424 0.4894 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0093 0.0157
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0489 0.1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0093 0.0093
Trypanosoma brucei calpain-like protein, putative 0.002 0.0093 0.0157
Loa Loa (eye worm) cysteine protease 0.0424 0.4894 0.4894
Giardia lamblia Cathepsin B precursor 0.0097 0.101 0.2665
Leishmania major hypothetical protein, conserved 0.0015 0.0032 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0424 0.4894 1
Entamoeba histolytica cysteine proteinase, putative 0.023 0.2584 0.5281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni cathepsin F (C01 family) 0.0292 0.3319 0.3319
Schistosoma mansoni cathepsin B (C01 family) 0.0097 0.101 0.101
Toxoplasma gondii histone deacetylase HDAC3 0.0164 0.1799 0.3039
Giardia lamblia Cathepsin L precursor 0.0097 0.101 0.2665
Trypanosoma cruzi cruzipain precursor, putative 0.0471 0.5442 0.5442
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0511 0.592 0.592
Plasmodium vivax histone deacetylase, putative 0.0073 0.0716 0.1463
Leishmania major kinesin, putative 0.0014 0.0021 0.0035
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0332 0.379 0.6402
Brugia malayi Inositol-1 0.0036 0.0284 0.0284
Echinococcus granulosus cathepsin L 0.023 0.2584 0.2584
Onchocerca volvulus Cathepsin F homolog 0.0424 0.4894 0.8266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0387 0.0387
Schistosoma mansoni inositol monophosphatase 0.0036 0.0284 0.0284
Loa Loa (eye worm) calpain 0.002 0.0093 0.0093
Trypanosoma cruzi histone deacetylase, putative 0.0073 0.0716 0.0716
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Loa Loa (eye worm) histone deacetylase 3 0.0164 0.1799 0.1799
Entamoeba histolytica hypothetical protein 0.0097 0.101 0.2064
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0489 0.0489
Trichomonas vaginalis histone deacetylase, putative 0.0164 0.1799 0.3677
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0387 0.0387
Onchocerca volvulus 0.0424 0.4894 0.8266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.101 0.2064
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.023 0.2584 0.2584
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0097 0.101 0.2665
Onchocerca volvulus 0.0033 0.0249 0.042
Schistosoma mansoni histone deacetylase 1 2 3 0.0073 0.0716 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.3319 0.6783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0424 0.4894 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0059 0.0059
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0054 0.0489 0.0489
Leishmania major histone deacetylase, putative 0.0157 0.1717 0.29
Echinococcus granulosus calpain 7 C02 family 0.002 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0471 0.5442 0.9192
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Trypanosoma cruzi oligopeptidase b 0.0203 0.2266 0.2266
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0054 0.0489 0.1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0387 0.0387
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0424 0.4894 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0097 0.101 0.2064
Leishmania major cathepsin L-like protease 0.0424 0.4894 0.8266
Loa Loa (eye worm) hypothetical protein 0.0133 0.1427 0.1427
Echinococcus multilocularis cathepsin L cysteine protease 0.0424 0.4894 0.4894
Brugia malayi Bromodomain containing protein 0.0075 0.0747 0.0747
Giardia lamblia Cathepsin L-like protease 0.0097 0.101 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.101 0.2064
Loa Loa (eye worm) hypothetical protein 0.0097 0.1001 0.1001
Trypanosoma brucei calpain-like protein, putative 0.002 0.0093 0.0157
Toxoplasma gondii cathepsin CPC1 0.0097 0.101 0.1706
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0097 0.101 0.2064
Onchocerca volvulus 0.0424 0.4894 0.8266
Schistosoma mansoni histone deacetylase hda2 0.0169 0.1864 0.1864
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0511 0.592 0.592
Loa Loa (eye worm) hypothetical protein 0.0511 0.592 0.592
Entamoeba histolytica cysteine proteinase, putative 0.0292 0.3319 0.6783
Loa Loa (eye worm) hypothetical protein 0.0039 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0043 0.0369 0.0369
Entamoeba histolytica cysteine protease, putative 0.023 0.2584 0.5281
Brugia malayi cathepsin L precursor 0.0097 0.101 0.101
Schistosoma mansoni histone deacetylase 4 5 0.0157 0.1717 0.1717
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0203 0.2266 0.2266
Brugia malayi Cathepsin L-like precursor 0.0424 0.4894 0.4894
Entamoeba histolytica cysteine protease, putative 0.0097 0.101 0.2064
Brugia malayi Papain family cysteine protease containing protein 0.023 0.2584 0.2584
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0097 0.101 0.2064
Brugia malayi PHD-finger family protein 0.0026 0.0162 0.0162

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.3 nM Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide ChEMBL. 12852770
IC50 (binding) = 0.3 nM Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide ChEMBL. 12852770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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