Detailed information for compound 403140

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1562.21 | Formula: C80H101ClN16O15
  • H donors: 15 H acceptors: 16 LogP: 4.48 Rotable bonds: 53
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N)C)CCCCNC(C)C)CC(C)C)Cc1ccc(cc1)NC(=O)C)Cc1ccc(cc1)NC(=O)C)NC(=O)[C@H](NC(=O)c1cccnc1)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc2c(c1)cccc2)NC(=O)C)Cc1ccc(cc1)Cl
  • InChi: 1S/C80H101ClN16O15/c1-45(2)37-62(72(104)89-61(18-11-12-35-84-46(3)4)80(112)97-36-14-19-68(97)78(110)85-47(5)69(82)102)90-74(106)64(40-52-23-30-59(31-24-52)86-48(6)99)91-75(107)65(41-53-25-32-60(33-26-53)87-49(7)100)93-77(109)67(44-98)94-79(111)70(95-71(103)57-17-13-34-83-43-57)96-76(108)66(39-51-21-28-58(81)29-22-51)92-73(105)63(88-50(8)101)42-54-20-27-55-15-9-10-16-56(55)38-54/h9-10,13,15-17,20-34,38,43,45-47,61-68,70,84,98H,11-12,14,18-19,35-37,39-42,44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,106)(H,91,107)(H,92,105)(H,93,109)(H,94,111)(H,95,103)(H,96,108)/t47-,61+,62+,63-,64-,65+,66-,67+,68-,70-/m1/s1
  • InChiKey: IMVHFVNUAUEHCR-SBRZTDQMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 271 aa 20.7 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 20.8 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 292 aa 19.5 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 19.0 %
Schistosoma mansoni peptide (allatostatin)-like receptor Gonadotropin-releasing hormone receptor   327 aa 272 aa 23.2 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Gonadotropin-releasing hormone receptor   327 aa 273 aa 19.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Gonadotropin-releasing hormone receptor   327 aa 263 aa 23.2 %
Echinococcus granulosus tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 19.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Gonadotropin-releasing hormone receptor   327 aa 343 aa 21.6 %
Brugia malayi ORL1-like opioid receptor Gonadotropin-releasing hormone receptor   327 aa 293 aa 20.8 %
Echinococcus multilocularis neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 20.9 %
Echinococcus granulosus tm gpcr rhodopsin Gonadotropin-releasing hormone receptor   327 aa 299 aa 23.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 24.3 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Gonadotropin-releasing hormone receptor   327 aa 290 aa 19.7 %
Echinococcus multilocularis tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 20.1 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 284 aa 19.4 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 27.8 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Gonadotropin-releasing hormone receptor   327 aa 305 aa 24.9 %
Echinococcus granulosus allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 284 aa 22.9 %
Schistosoma mansoni neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Gonadotropin-releasing hormone receptor   327 aa 334 aa 21.6 %
Echinococcus multilocularis allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 279 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ctsf protein 0.0681 0.4906 0.4906
Schistosoma mansoni biogenic amine receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.1345 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis neuropeptide Y receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0096 0.0096
Echinococcus multilocularis sex peptide receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) melatonin receptor type 1A 0.0167 0.0962 0.0962
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0681 0.4906 0.4906
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Plasmodium vivax vivapain-2 0.0681 0.4906 1
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Echinococcus multilocularis NCK adaptor protein 0.0055 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Schistosoma mansoni tyrosine kinase 0.0284 0.1855 0.1855
Brugia malayi larval opioid receptor 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Echinococcus multilocularis neuropeptide s receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0167 0.0962 0.0962
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0055 0.01 0.01
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0167 0.0962 0.0962
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0167 0.0962 0.0962
Echinococcus granulosus cysteine protease 0.0369 0.2509 0.2509
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0096 0.0115
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0156 0.0874 0.1692
Entamoeba histolytica cysteine protease, putative 0.0681 0.4906 1
Loa Loa (eye worm) G-protein coupled receptor 0.0167 0.0962 0.0962
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0167 0.0962 0.1246
Plasmodium falciparum serine repeat antigen 2 0.0156 0.0874 0.1692
Echinococcus granulosus 7TM GPCR rhodopsin 0.0167 0.0962 0.0962
Leishmania major cysteine peptidase A (CPA) 0.0681 0.4906 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Brugia malayi G protein-coupled receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0874 0.2253
Entamoeba histolytica cysteine proteinase, putative 0.0369 0.2509 0.5114
Giardia lamblia Cathepsin B precursor 0.0156 0.0874 0.2253
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0681 0.4906 0.6354
Brugia malayi G-protein coupled receptor 0.0167 0.0962 0.0962
Schistosoma mansoni nephrin 0.0086 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0369 0.2509 0.506
Trypanosoma brucei cysteine peptidase C (CPC) 0.0524 0.3697 0.7508
Brugia malayi SRC-1 0.0284 0.1855 0.1855
Schistosoma mansoni cathepsin F (C01 family) 0.0468 0.3272 0.3272
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0369 0.2509 0.2469
Trypanosoma cruzi cysteine peptidase, putative 0.0681 0.4906 0.4879
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus alpha 1A adrenergic receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis g-protein coupled receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0284 0.1855 0.1855
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0055 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase Abl 0.0069 0.0207 0.0207
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0681 0.4906 0.4906
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Brugia malayi Variant SH3 domain containing protein 0.0055 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0096 0.0096
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0156 0.0874 0.1692
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0284 0.1855 0.1855
Brugia malayi protein-tyrosine kinase 0.0257 0.1648 0.1648
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Trypanosoma cruzi cruzipain precursor, putative 0.0213 0.1314 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0243 0.154 0.154
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Loa Loa (eye worm) TK protein kinase 0.0257 0.1648 0.1648
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Echinococcus granulosus hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.0874 0.0874
Echinococcus granulosus tyrosine protein kinase Src64B 0.0284 0.1855 0.1855
Echinococcus multilocularis Immunoglobulin 0.0069 0.0206 0.0206
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1345 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0069 0.0207 0.0207
Plasmodium vivax vivapain-1 0.0369 0.2509 0.506
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin B precursor 0.0524 0.3697 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0874 0.1692
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0096 0.0087
Echinococcus multilocularis G-protein coupled receptor, putative 0.0167 0.0962 0.0962
Plasmodium vivax serine-repeat antigen (SERA) 0.0156 0.0874 0.1692
Schistosoma mansoni neuropeptide receptor 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni amine GPCR 0.0167 0.0962 0.0962
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0091 0.0377 0.0377
Plasmodium falciparum serine repeat antigen 4 0.0156 0.0874 0.1692
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis neuropeptides capa receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Echinococcus granulosus cathepsin l cysteine peptidase 0.0681 0.4906 0.4906
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0874 0.1692
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus granulosus biogenic amine 5HT receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis G protein coupled receptor 139 0.0167 0.0962 0.0962
Echinococcus multilocularis g protein coupled receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus multilocularis tyrosine protein kinase Blk 0.0257 0.1648 0.1648
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0468 0.3272 0.3236
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus cathepsin L 0.0156 0.0874 0.0874
Plasmodium vivax unspecified product 0.0369 0.2509 0.506
Schistosoma mansoni neuropeptide F-like receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0069 0.0207 0.0207
Brugia malayi cathepsin L-like precursor 0.0468 0.3272 0.3272
Schistosoma mansoni cathepsin F (C01 family) 0.0681 0.4906 0.4906
Echinococcus multilocularis tyrosine protein kinase HCK 0.0229 0.1435 0.1435
Brugia malayi hypothetical protein 0.0069 0.0206 0.0206
Schistosoma mansoni cathepsin F (C01 family) 0.0681 0.4906 0.4906
Schistosoma mansoni cathepsin B (C01 family) 0.0156 0.0874 0.0874
Schistosoma mansoni neuropeptide f receptor 76f 0.0167 0.0962 0.0962
Schistosoma mansoni hypothetical protein 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine proteinase 2 0.0369 0.2509 0.5114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0167 0.0962 0.0962
Brugia malayi Melatonin receptor type 1A 0.0167 0.0962 0.0962
Echinococcus granulosus 7tm_1 domain containing protein 0.0167 0.0962 0.0962
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0284 0.1855 0.1855
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0053 0.0053
Echinococcus multilocularis cathepsin b 0.1345 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0167 0.0962 0.0962
Brugia malayi Tyrosine-protein kinase abl-1 0.0069 0.0207 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0213 0.1314 0.1268
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0468 0.3272 0.3272
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0874 0.2253
Echinococcus granulosus neuropeptide Y receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0681 0.4906 0.4906
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Schistosoma mansoni nck2/grb4 0.0055 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis cysteine protease 0.0681 0.4906 0.4906
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0167 0.0962 0.0962
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Brugia malayi Dopamine receptor protein 2 0.0167 0.0962 0.0962
Schistosoma mansoni adapter molecule crk 0.0055 0.01 0.01
Brugia malayi Immunoglobulin I-set domain containing protein 0.0069 0.0206 0.0206
Brugia malayi RE15519p 0.0167 0.0962 0.0962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Plasmodium falciparum serine repeat antigen 1 0.0156 0.0874 0.1692
Brugia malayi cathepsin F-like cysteine proteinase 0.0156 0.0874 0.0874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0468 0.3272 0.4237
Toxoplasma gondii cathepsin CPC1 0.0156 0.0874 0.1692
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0681 0.4906 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0681 0.4906 1
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.0874 0.0874
Trypanosoma cruzi major cysteine proteinase, putative 0.0156 0.0874 0.0825
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0167 0.0962 0.0962
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0874 0.0874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0369 0.2509 0.506
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Onchocerca volvulus 0.0681 0.4906 0.6354
Schistosoma mansoni cathepsin C 0.0156 0.0874 0.0874
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0284 0.1855 0.1855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Onchocerca volvulus 0.1017 0.748 0.9687
Entamoeba histolytica protein kinase, putative 0.0229 0.1435 0.2925
Echinococcus granulosus growth factor receptor bound protein 2 0.0055 0.01 0.01
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0096 0.0115
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi G protein-coupled receptor F59B2.13 0.0167 0.0962 0.0962
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase Srms 0.0257 0.1648 0.1648
Giardia lamblia Cathepsin B precursor 0.0156 0.0874 0.2253
Loa Loa (eye worm) fibroinase 0.0681 0.4906 0.4906
Entamoeba histolytica cysteine proteinase, putative 0.0369 0.2509 0.5114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0167 0.0962 0.0962
Brugia malayi Protein kinase domain containing protein 0.0049 0.0053 0.0053
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0156 0.0874 0.2253
Loa Loa (eye worm) neuropeptide F receptor 0.0167 0.0962 0.0962
Schistosoma mansoni adenoreceptor 0.0167 0.0962 0.0962
Plasmodium falciparum serine repeat antigen 3 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0096 0.0087
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0156 0.0874 0.1782
Echinococcus granulosus sex peptide receptor 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0369 0.2509 0.506
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0167 0.0962 0.0962
Trypanosoma cruzi cruzipain precursor, putative 0.0681 0.4906 0.4879
Onchocerca volvulus 0.0167 0.0962 0.1246
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Brugia malayi Dopamine receptor 0.0167 0.0962 0.0962
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0284 0.1855 0.1855
Trypanosoma cruzi cysteine proteinase, putative 0.0369 0.2509 0.2469
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0156 0.0874 0.1692
Giardia lamblia Encystation-specific protease 0.0156 0.0874 0.2253
Entamoeba histolytica cysteine proteinase, putative 0.0369 0.2509 0.5114
Onchocerca volvulus 0.0167 0.0962 0.1246
Echinococcus granulosus somatostatin receptor 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0156 0.0874 0.1692
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Giardia lamblia Cathepsin B precursor 0.0524 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Plasmodium falciparum serine repeat antigen 6 0.0156 0.0874 0.1692
Echinococcus granulosus tm gpcr rhodopsin 0.0167 0.0962 0.0962
Brugia malayi Tachykinin-like peptides receptor 99D 0.0167 0.0962 0.0962
Brugia malayi sulfakinin receptor protein 0.0167 0.0962 0.0962
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.0874 0.0874
Echinococcus granulosus tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Trypanosoma brucei protein kinase, putative 0.0054 0.0096 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0167 0.0962 0.0962
Toxoplasma gondii cathepsin B 0.0524 0.3697 0.7508
Echinococcus granulosus peptide allatostatin:somatostatin 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin B precursor 0.0524 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni amine GPCR 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin L-like protease 0.0156 0.0874 0.2253
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0156 0.0874 0.1692
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0874 0.2253
Echinococcus granulosus neuroglian 0.0086 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine proteinase, putative 0.0681 0.4906 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0096 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Plasmodium vivax unspecified product 0.0213 0.1314 0.2598
Echinococcus granulosus allatostatin A receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0213 0.1314 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0369 0.2509 0.506
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0874 0.1132
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0524 0.3697 0.3663
Brugia malayi putative neuropeptide receptor 0.0167 0.0962 0.0962
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0167 0.0962 0.0962
Brugia malayi GnHR receptor homolog 0.0723 0.5224 0.5224
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus c src tyrosine kinase 0.0069 0.0207 0.0207
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0053 0.0109
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0156 0.0874 0.1692
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0167 0.0962 0.0962
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0156 0.0874 0.0874
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0167 0.0962 0.0962
Schistosoma mansoni cell adhesion molecule 0.0091 0.0377 0.0377
Plasmodium falciparum serine repeat antigen 8 0.0156 0.0874 0.1692
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0053 0.0053
Onchocerca volvulus 0.0167 0.0962 0.1246
Onchocerca volvulus 0.0167 0.0962 0.1246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0285 0.1863 0.1863
Echinococcus granulosus cathepsin l1 0.0468 0.3272 0.3272
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0874 0.1692
Schistosoma mansoni cathepsin s 0.0213 0.1314 0.1314
Brugia malayi cathepsin L precursor 0.0156 0.0874 0.0874
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.01 0.01
Echinococcus granulosus g protein coupled receptor 0.0167 0.0962 0.0962
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0284 0.1855 0.1855
Brugia malayi putative neuropeptide receptor NPR1 0.0167 0.0962 0.0962
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0096 0.0087
Schistosoma mansoni opsin-like receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis orexin receptor type 2 0.0167 0.0962 0.0962
Echinococcus multilocularis Immunoglobulin 0.0069 0.0206 0.0206
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0096 0.0087
Echinococcus granulosus Immunoglobulin 0.0069 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0213 0.1314 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0096 0.0096
Plasmodium vivax unspecified product 0.0156 0.0874 0.1692
Giardia lamblia Cathepsin L-like protease 0.0156 0.0874 0.2253
Echinococcus multilocularis neuropeptide receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus multilocularis fmrfamide receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Echinococcus granulosus cathepsin l1 0.0681 0.4906 0.4906
Echinococcus multilocularis fmrfamide receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.01 0.01
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0167 0.0962 0.0962
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Onchocerca volvulus 0.0167 0.0962 0.1246
Schistosoma mansoni tyrosine kinase 0.0054 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0108 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Giardia lamblia Cysteine protease 0.0156 0.0874 0.2253
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Giardia lamblia Cysteine protease 0.0156 0.0874 0.2253
Loa Loa (eye worm) cysteine protease 0.0681 0.4906 0.4906
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0167 0.0962 0.0962
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1345 1 1
Onchocerca volvulus Cathepsin F homolog 0.0681 0.4906 0.6354
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi G-protein coupled receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi Serotonin receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Loa Loa (eye worm) G-protein coupled receptor 0.0167 0.0962 0.0962
Echinococcus granulosus twitchin 0.0087 0.0348 0.0348
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0874 0.0874
Plasmodium falciparum serine repeat antigen 7 0.0156 0.0874 0.1692
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine proteinase, putative 0.0681 0.4906 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0369 0.2509 0.5114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0167 0.0962 0.0962
Brugia malayi Dopamine receptor protein 1 0.0167 0.0962 0.0962
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0156 0.0874 0.1782
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0069 0.0206 0.0206
Echinococcus multilocularis neuroglian 0.0086 0.034 0.034
Echinococcus multilocularis growth factor receptor bound protein 2 0.0055 0.01 0.01
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0167 0.0962 0.0962
Schistosoma mansoni tyrosine kinase 0.0284 0.1855 0.1855
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trypanosoma cruzi cysteine protease, putative 0.0369 0.2509 0.2469
Brugia malayi intracellular kinase 0.0054 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0874 0.1692
Schistosoma mansoni neuropeptide receptor 0.0167 0.0962 0.0962
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Onchocerca volvulus Cathepsin L homolog 0.0681 0.4906 0.6354
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0167 0.0962 0.0962
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0156 0.0874 0.1692
Trypanosoma cruzi cysteine peptidase, putative 0.0681 0.4906 0.4879
Toxoplasma gondii cathepsin CPC2 0.0156 0.0874 0.1692
Echinococcus multilocularis cathepsin L 0.0156 0.0874 0.0874
Brugia malayi Sex muscle abnormal protein 5 0.0055 0.01 0.01
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Onchocerca volvulus 0.0167 0.0962 0.1246
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0096 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.0167 0.0962 0.0962
Echinococcus granulosus cathepsin b 0.1345 1 1
Schistosoma mansoni histamine h1 receptor 0.0167 0.0962 0.0962
Echinococcus granulosus neuropeptide receptor 0.0167 0.0962 0.0962
Brugia malayi Papain family cysteine protease containing protein 0.0369 0.2509 0.2509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0874 0.0874
Echinococcus granulosus tachykinin peptides receptor 99D 0.0167 0.0962 0.0962
Brugia malayi Cathepsin L-like cysteine proteinase 0.0468 0.3272 0.3272
Brugia malayi neuropeptide F receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0167 0.0962 0.0962
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0874 0.0874
Schistosoma mansoni biogenic amine (5HT) receptor 0.0167 0.0962 0.0962
Echinococcus granulosus fmrfamide receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine proteinase, putative 0.0468 0.3272 0.6668
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) cathepsin B 0.0524 0.3697 0.3697
Echinococcus multilocularis allatostatin A receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Onchocerca volvulus 0.0681 0.4906 0.6354
Echinococcus granulosus cathepsin L cysteine proteinase 0.0681 0.4906 0.4906
Echinococcus granulosus neuropeptides capa receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus granulosus biogenic amine 5HT receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Echinococcus multilocularis g protein coupled receptor 0.0167 0.0962 0.0962
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0681 0.4906 0.4906
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0524 0.3697 0.7508
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Onchocerca volvulus 0.0167 0.0962 0.1246
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0096 0.0087
Loa Loa (eye worm) hypothetical protein 0.0108 0.0511 0.0511
Schistosoma mansoni amine GPCR 0.0167 0.0962 0.0962
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.01 0.01
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0874 0.1692
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0156 0.0874 0.0874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Entamoeba histolytica hypothetical protein 0.0156 0.0874 0.1782
Schistosoma mansoni neuropeptide receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0213 0.1314 0.1314
Echinococcus granulosus g protein coupled receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus multilocularis cathepsin L 0.0369 0.2509 0.2509
Echinococcus multilocularis roundabout 2 0.0108 0.0511 0.0511
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0524 0.3697 0.3697
Giardia lamblia Cysteine protease 0.0156 0.0874 0.2253
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0069 0.0206 0.0206
Brugia malayi Cathepsin L-like precursor 0.0468 0.3272 0.3272
Echinococcus granulosus tyrosine protein kinase Src42A 0.0284 0.1855 0.1855
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0524 0.3697 0.7508
Echinococcus multilocularis neuropeptide receptor A26 0.0167 0.0962 0.0962
Schistosoma mansoni biogenic amine receptor 0.0167 0.0962 0.0962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0874 0.0874
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0053 0.0109
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0681 0.4906 0.4906
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0257 0.1648 0.1648
Plasmodium falciparum cysteine proteinase falcipain 1 0.0369 0.2509 0.506
Brugia malayi follicle stimulating hormone receptor 0.0167 0.0962 0.0962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0874 0.0874
Echinococcus granulosus tm gpcr rhodopsin 0.0167 0.0962 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0167 0.0962 0.0962
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0257 0.1648 0.1648
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Brugia malayi Papain family cysteine protease containing protein 0.0369 0.2509 0.2509
Giardia lamblia Hypothetical protein 0.0156 0.0874 0.2253
Giardia lamblia Cysteine protease 0.0156 0.0874 0.2253
Schistosoma mansoni growth hormone secretagogue receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Onchocerca volvulus Tyrosine kinase homolog 0.1048 0.7721 1
Brugia malayi Cathepsin L-like precursor 0.0468 0.3272 0.3272
Plasmodium falciparum serine repeat antigen 9 0.0156 0.0874 0.1692
Brugia malayi ORL1-like opioid receptor 0.0167 0.0962 0.0962
Brugia malayi Variant SH3 domain containing protein 0.0055 0.01 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Brugia malayi fibroinase precursor 0.0156 0.0874 0.0874
Onchocerca volvulus 0.0681 0.4906 0.6354
Plasmodium falciparum serine repeat antigen 5 0.0156 0.0874 0.1692
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0167 0.0962 0.0962
Entamoeba histolytica protein kinase, putative 0.0054 0.0096 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Echinococcus multilocularis neuropeptide receptor 0.0167 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0167 0.0962 0.0962
Echinococcus multilocularis cathepsin L cysteine protease 0.0681 0.4906 0.4906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0468 0.3272 0.6632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0167 0.0962 0.0962
Loa Loa (eye worm) TYRA-2 protein 0.0167 0.0962 0.0962
Plasmodium vivax vivapain-2 0.0681 0.4906 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0681 0.4906 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0156 0.0874 0.0874
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis neuropeptide Y receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) neuropeptide F receptor 0.0167 0.0962 0.0962
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0167 0.0962 0.0962
Echinococcus granulosus neuropeptide Y receptor 0.0167 0.0962 0.0962
Brugia malayi Papain family cysteine protease containing protein 0.0681 0.4906 0.4906
Loa Loa (eye worm) SRC-1 0.0284 0.1855 0.1855
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0053 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0681 0.4906 0.6354
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0156 0.0874 0.1692
Echinococcus granulosus serotonin receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0167 0.0962 0.0962
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0369 0.2509 0.2509
Echinococcus granulosus orexin receptor type 2 0.0167 0.0962 0.0962
Schistosoma mansoni neuropeptide receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0874 0.1692
Schistosoma mansoni amine GPCR 0.0167 0.0962 0.0962
Plasmodium vivax vivapain-3 0.0369 0.2509 0.506
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0096 0.0096
Echinococcus multilocularis somatostatin receptor 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0091 0.0377 0.0377
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0167 0.0962 0.0962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0681 0.4906 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0681 0.4906 0.4906
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Onchocerca volvulus 0.0681 0.4906 0.6354
Echinococcus granulosus tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Brugia malayi neuropeptide F receptor 0.0167 0.0962 0.0962
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.01 0.01
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0874 0.0874
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0096 0.0195
Schistosoma mansoni tyrosine kinase 0.0069 0.0207 0.0207
Brugia malayi cathepsin F-like cysteine proteinase 0.0213 0.1314 0.1314
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1122 0.8284 0.8284
Giardia lamblia Cathepsin B precursor 0.0156 0.0874 0.2253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus granulosus cathepsin L cysteine protease 0.0369 0.2509 0.2509
Echinococcus granulosus roundabout 2 0.0108 0.0511 0.0511
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0369 0.2509 0.2509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Schistosoma mansoni opsin-like receptor 0.0167 0.0962 0.0962
Echinococcus granulosus protein kinase shaggy 0.0054 0.0096 0.0096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0874 0.0874
Trypanosoma cruzi cysteine peptidase, putative 0.0369 0.2509 0.2469
Echinococcus multilocularis cysteine protease 0.0681 0.4906 0.4906
Brugia malayi Serotonin receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Echinococcus multilocularis neuropeptide FF receptor 2 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Schistosoma mansoni hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus NCK adaptor protein 0.0055 0.01 0.01
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Echinococcus multilocularis g protein coupled receptor 0.0167 0.0962 0.0962
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0053 0.0053
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0156 0.0874 0.1692
Brugia malayi Fibronectin type III domain containing protein 0.0069 0.0206 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0681 0.4906 0.4879
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis serotonin receptor 0.0167 0.0962 0.0962
Echinococcus granulosus tyrosine kinase 0.0257 0.1648 0.1648
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus granulosus cathepsin b 0.1345 1 1
Echinococcus granulosus defective proboscis extension response 0.0069 0.0206 0.0206
Giardia lamblia Cathepsin B precursor 0.0156 0.0874 0.2253
Onchocerca volvulus 0.0681 0.4906 0.6354
Brugia malayi Cathepsin L-like precursor 0.0681 0.4906 0.4906
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0156 0.0874 0.0874
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Schistosoma mansoni amine GPCR 0.0167 0.0962 0.0962
Brugia malayi Cathepsin L-like precursor 0.0213 0.1314 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus granulosus rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1345 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0468 0.3272 0.6632
Plasmodium vivax serine-repeat antigen (SERA) 0.0156 0.0874 0.1692
Loa Loa (eye worm) hypothetical protein 0.0213 0.1314 0.1314
Brugia malayi cathepsin L-like cysteine proteinase 0.0156 0.0874 0.0874
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0369 0.2509 0.2509
Echinococcus granulosus dro:myosuppressin receptor 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Schistosoma mansoni opsin-like receptor 0.0167 0.0962 0.0962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0156 0.0874 0.1132
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0681 0.4906 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0167 0.0962 0.0962
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Schistosoma mansoni cathepsin S (C01 family) 0.0156 0.0874 0.0874
Schistosoma mansoni tyrosine kinase 0.0069 0.0207 0.0207
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus g-protein coupled receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0468 0.3272 0.3272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.0874 0.0874
Entamoeba histolytica cysteine protease, putative 0.0369 0.2509 0.5114
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0284 0.1855 0.1855
Brugia malayi AKH receptor 0.0167 0.0962 0.0962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Brugia malayi cell division control protein 2 homolog 0.0049 0.0053 0.0053
Onchocerca volvulus 0.0681 0.4906 0.6354
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0167 0.0962 0.0962
Schistosoma mansoni biogenic amine (5HT) receptor 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus neuropeptide s receptor 0.0167 0.0962 0.0962
Schistosoma mansoni vesicular amine transporter 0.0069 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Onchocerca volvulus 0.0167 0.0962 0.1246
Echinococcus granulosus tyrosine protein kinase Src42A 0.0243 0.154 0.154
Schistosoma mansoni hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0284 0.1855 0.1855
Entamoeba histolytica cysteine proteinase, putative 0.0369 0.2509 0.5114
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0167 0.0962 0.0962
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0053 0.0053
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Loa Loa (eye worm) TK protein kinase 0.0229 0.1435 0.1435
Onchocerca volvulus Neuropeptide F receptor homolog 0.0167 0.0962 0.1246
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus granulosus tyrosine protein kinase Fyn 0.0284 0.1855 0.1855
Trypanosoma cruzi cysteine peptidase, putative 0.0681 0.4906 0.4879
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0069 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0053 0.0053
Schistosoma mansoni neuropeptide F-like receptor 0.0167 0.0962 0.0962
Giardia lamblia Cathepsin B precursor 0.0156 0.0874 0.2253
Onchocerca volvulus 0.0054 0.0096 0.0124
Loa Loa (eye worm) hypothetical protein 0.0069 0.0206 0.0206
Echinococcus granulosus neuropeptide receptor A26 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0046 0.0046
Schistosoma mansoni myosin xvIII 0.0167 0.0962 0.0962
Echinococcus multilocularis serotonin receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0167 0.0962 0.0962
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0096 0.0087
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1345 1 1
Leishmania major cathepsin L-like protease 0.0681 0.4906 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Echinococcus granulosus g protein coupled receptor 0.0167 0.0962 0.0962
Trypanosoma cruzi major cysteine proteinase, putative 0.0156 0.0874 0.0825
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0167 0.0962 0.0962
Echinococcus multilocularis c src tyrosine kinase 0.0069 0.0207 0.0207
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0213 0.1314 0.1314
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0053 0.0053
Trypanosoma cruzi cysteine proteinase, putative 0.0369 0.2509 0.2469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0468 0.3272 0.3272
Echinococcus granulosus tyrosine protein kinase Blk 0.0257 0.1648 0.1648
Brugia malayi hypothetical protein 0.0167 0.0962 0.0962
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0156 0.0874 0.1692
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1345 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0874 0.1692
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0167 0.0962 0.0962
Giardia lamblia Hypothetical protein 0.0156 0.0874 0.2253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0167 0.0962 0.0962
Echinococcus multilocularis cathepsin b 0.1345 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0229 0.1435 0.1435
Echinococcus granulosus G protein coupled receptor 139 0.0167 0.0962 0.0962
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0167 0.0962 0.0962
Echinococcus granulosus cathepsin L 0.0369 0.2509 0.2509
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0156 0.0874 0.1692
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0167 0.0962 0.0962
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0167 0.0962 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0874 0.1692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0681 0.4906 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0962 0.0962
Toxoplasma gondii cathepsin CPL 0.0681 0.4906 1
Entamoeba histolytica cysteine protease, putative 0.0156 0.0874 0.1782
Brugia malayi Immunoglobulin I-set domain containing protein 0.1122 0.8284 0.8284
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0167 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0156 0.0874 0.0874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0681 0.4906 1
Echinococcus granulosus neuropeptides capa receptor 0.0167 0.0962 0.0962
Onchocerca volvulus 0.0167 0.0962 0.1246
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0069 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0681 0.4906 1
Giardia lamblia Cathepsin L precursor 0.0156 0.0874 0.2253
Echinococcus granulosus neuropeptide receptor 0.0167 0.0962 0.0962
Schistosoma mansoni biogenic amine receptor 0.0167 0.0962 0.0962

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.76 nM Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes ChEMBL. 9371239
IC50 (binding) = 0.76 nM Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes ChEMBL. 9371239
ov. rat/total (functional) 0 Ratio of ovulated rats to total number of rats determined in a anti-ovulatory assay by administering 2.5 microg of compound; 0/7 ChEMBL. 9371239
ov. rat/total (functional) 0 Ratio of ovulated rats to total number of rats determined in a anti-ovulatory assay by administering 1 ug of compound; 3/3 ChEMBL. 9371239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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