Detailed information for compound 403619

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2196.37 | Formula: C90H142N26O34S2
  • H donors: 31 H acceptors: 34 LogP: -11.17 Rotable bonds: 93
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)CCC(=O)O)CCC(=O)O)CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)N)CC(C)C)CCC(=O)O)CCCN=C(N)N)CCC(=O)O)CSCNC(=O)C)CC(C)C)CCC(=O)O)CCC(=O)O)CSCNC(=O)C
  • InChi: 1S/C90H142N26O34S2/c1-43(2)34-58(110-73(134)49(91)37-65(92)120)81(142)107-54(21-27-68(125)126)77(138)102-50(16-11-31-97-89(93)94)75(136)106-56(23-29-70(129)130)80(141)114-62(39-151-41-99-46(6)118)84(145)111-59(35-44(3)4)82(143)108-55(22-28-69(127)128)79(140)109-57(24-30-71(131)132)87(148)116-33-13-18-64(116)86(147)115-63(40-152-42-100-47(7)119)85(146)113-61(38-117)83(144)103-51(17-12-32-98-90(95)96)76(137)105-53(20-26-67(123)124)78(139)104-52(19-25-66(121)122)74(135)101-45(5)72(133)112-60(88(149)150)36-48-14-9-8-10-15-48/h8-10,14-15,43-45,49-64,117H,11-13,16-42,91H2,1-7H3,(H2,92,120)(H,99,118)(H,100,119)(H,101,135)(H,102,138)(H,103,144)(H,104,139)(H,105,137)(H,106,136)(H,107,142)(H,108,143)(H,109,140)(H,110,134)(H,111,145)(H,112,133)(H,113,146)(H,114,141)(H,115,147)(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,149,150)(H4,93,94,97)(H4,95,96,98)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
  • InChiKey: BFZWZVQUPFQPMU-RQXNMVFJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0179 0.1789 0.1789
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.031 0.3386 1
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0089 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0853 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Onchocerca volvulus Cathepsin L homolog 0.0067 0.0424 0.1103
Onchocerca volvulus 0.0067 0.0424 0.1103
Echinococcus multilocularis cathepsin b 0.0853 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.1789 0.1789
Loa Loa (eye worm) fibroinase 0.0179 0.1789 0.1789
Echinococcus granulosus cysteine protease 0.0067 0.0424 0.0424
Brugia malayi cathepsin L-like cysteine proteinase 0.0067 0.0424 0.0424
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.031 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0179 0.1789 0.1789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0424 0.1253
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0179 0.1789 0.1789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0424 0.0424
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0424 0.0424
Onchocerca volvulus Cathepsin F homolog 0.0179 0.1789 1
Brugia malayi cathepsin L-like precursor 0.0179 0.1789 0.1789
Brugia malayi calpain family protein 1 0.0085 0.0646 0.0646
Echinococcus granulosus cathepsin L cysteine proteinase 0.0179 0.1789 0.1789
Onchocerca volvulus 0.0179 0.1789 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0067 0.0424 0.2371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1789 1
Schistosoma mansoni cathepsin F (C01 family) 0.0179 0.1789 0.1789
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0179 0.1789 1
Toxoplasma gondii cathepsin B 0.031 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0255 0.0255
Plasmodium vivax unspecified product 0.0067 0.0424 0.2371
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Entamoeba histolytica cysteine protease, putative 0.0179 0.1789 1
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Loa Loa (eye worm) hypothetical protein 0.0179 0.1789 0.1789
Echinococcus granulosus cathepsin b 0.0853 1 1
Echinococcus multilocularis cathepsin b 0.0853 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0424 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Brugia malayi Papain family cysteine protease containing protein 0.0179 0.1789 0.1789
Onchocerca volvulus Cathepsin L homolog 0.0179 0.1789 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0424 0.1253
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0067 0.0424 0.0424
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Plasmodium vivax vivapain-2 0.0179 0.1789 1
Plasmodium vivax vivapain-1 0.0067 0.0424 0.2371
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Loa Loa (eye worm) ctsf protein 0.0179 0.1789 0.1789
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0424 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Brugia malayi calpain family protein 1 0.0085 0.0646 0.0646
Trypanosoma brucei cysteine peptidase C (CPC) 0.031 0.3386 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0179 0.1789 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Toxoplasma gondii cathepsin CPL 0.0179 0.1789 0.461
Plasmodium vivax unspecified product 0.0067 0.0424 0.2371
Brugia malayi fibroinase precursor 0.0067 0.0424 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0089 0.0694 0.0694
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0085 0.0646 0.0646
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0179 0.1789 0.461
Schistosoma mansoni cathepsin B (C01 family) 0.0067 0.0424 0.0424
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0067 0.0424 0.2371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Leishmania major cysteine peptidase A (CPA) 0.0179 0.1789 0.5285
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0067 0.0424 0.2371
Onchocerca volvulus 0.0179 0.1789 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0067 0.0424 0.0424
Loa Loa (eye worm) cysteine protease 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.1789 0.1789
Schistosoma mansoni cathepsin F (C01 family) 0.0179 0.1789 0.1789
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Trypanosoma cruzi cysteine proteinase, putative 0.0067 0.0424 0.0424
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1789 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0853 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0067 0.0424 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Onchocerca volvulus 0.0179 0.1789 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Brugia malayi Cathepsin L-like cysteine proteinase 0.0179 0.1789 0.1789
Brugia malayi cathepsin L precursor 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0179 0.1789 0.1789
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0179 0.1789 0.1789
Schistosoma mansoni cathepsin S (C01 family) 0.0067 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Echinococcus multilocularis calpain A 0.0089 0.0694 0.0694
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0089 0.0694 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Trypanosoma cruzi cysteine proteinase, putative 0.0067 0.0424 0.0424
Plasmodium vivax serine-repeat antigen (SERA) 0.0067 0.0424 0.2371
Echinococcus granulosus cathepsin b 0.0853 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0067 0.0424 0.0424
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0067 0.0424 0.0424
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0853 1 1
Echinococcus multilocularis calpain family protein 1, d 0.0063 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Brugia malayi cathepsin F-like cysteine proteinase 0.0067 0.0424 0.0424
Brugia malayi cathepsin Z-like cysteine proteinase 0.0067 0.0424 0.0424
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0067 0.0424 0.2371
Onchocerca volvulus 0.0179 0.1789 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0067 0.0424 0.0424
Echinococcus granulosus cathepsin L 0.0067 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0067 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0076 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0179 0.1789 0.461
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0067 0.0424 0.2371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0067 0.0424 0.0424
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.1789 0.1789
Giardia lamblia Cathepsin B precursor 0.031 0.3386 1
Onchocerca volvulus 0.0179 0.1789 1
Giardia lamblia Cathepsin B precursor 0.031 0.3386 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1789 0.5285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Trypanosoma cruzi major cysteine proteinase, putative 0.0067 0.0424 0.0424
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0067 0.0424 0.2371
Echinococcus granulosus cathepsin L 0.0067 0.0424 0.0424
Echinococcus granulosus cathepsin L cysteine protease 0.0067 0.0424 0.0424
Loa Loa (eye worm) calpain family protein 1 0.0085 0.0646 0.0646
Giardia lamblia Cathepsin B precursor 0.031 0.3386 1
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0373 0.0373
Trypanosoma cruzi cysteine protease, putative 0.0067 0.0424 0.0424
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0067 0.0424 0.2371
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.031 0.3386 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.031 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0085 0.0646 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Onchocerca volvulus 0.0179 0.1789 1
Schistosoma mansoni cathepsin C 0.0067 0.0424 0.0424
Echinococcus multilocularis cathepsin L 0.0067 0.0424 0.0424
Plasmodium vivax vivapain-2 0.0179 0.1789 1
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Leishmania major cathepsin L-like protease 0.0179 0.1789 0.5285
Echinococcus granulosus cathepsin l1 0.0179 0.1789 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0067 0.0424 0.2371
Echinococcus granulosus cathepsin l1 0.0179 0.1789 0.1789
Echinococcus multilocularis cathepsin L 0.0067 0.0424 0.0424
Onchocerca volvulus 0.0179 0.1789 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0067 0.0424 0.2371
Echinococcus granulosus cathepsin l cysteine peptidase 0.0179 0.1789 0.1789
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1789 1
Trypanosoma cruzi cruzipain precursor, putative 0.0179 0.1789 0.1789
Brugia malayi Cathepsin L-like precursor 0.0179 0.1789 0.1789
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0067 0.0424 0.0424
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0853 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0179 0.1789 0.1789
Echinococcus multilocularis cysteine protease 0.0179 0.1789 0.1789
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.1789 0.1789
Onchocerca volvulus 0.0179 0.1789 1
Loa Loa (eye worm) cathepsin B 0.031 0.3386 0.3386
Echinococcus multilocularis cysteine protease 0.0179 0.1789 0.1789
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0067 0.0424 0.2371
Plasmodium falciparum cysteine proteinase falcipain 3 0.0179 0.1789 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0067 0.0424 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0067 0.0424 0.0424
Echinococcus multilocularis cathepsin L cysteine protease 0.0179 0.1789 0.1789
Plasmodium vivax vivapain-3 0.0067 0.0424 0.2371
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0089 0.0694 0.0694
Echinococcus granulosus calpain A 0.0089 0.0694 0.0694
Onchocerca volvulus Cathepsin L homolog 0.0179 0.1789 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0424 0.0424
Brugia malayi cathepsin Z-like cysteine proteinase 0.0067 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.1789 0.461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1789 0.461
Loa Loa (eye worm) hypothetical protein 0.0067 0.0424 0.0424
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0853 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0067 0.0424 0.2371
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.1789 0.1789
Echinococcus multilocularis cathepsin L cysteine protease 0.0179 0.1789 0.1789
Brugia malayi Papain family cysteine protease containing protein 0.0067 0.0424 0.0424
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0853 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 480 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.0625 mM ChEMBL. 3806626
Activity (binding) = 920 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.125 mM ChEMBL. 3806626
Activity (binding) = 2380 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.25 mM ChEMBL. 3806626
Activity (binding) = 480 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.0625 mM ChEMBL. 3806626
Activity (binding) = 920 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.125 mM ChEMBL. 3806626
Activity (binding) = 2380 Substrate activity was determined for the rat liver microsomal vitamin K dependent carboxylase by dpm incorporation at 0.25 mM ChEMBL. 3806626

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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