Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ribonucleotide reductase M1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0121 | 0.3989 | 1 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0102 | 0.3049 | 0.5 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0121 | 0.3989 | 0.3989 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.0121 | 0.3989 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0102 | 0.3049 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.017 | 0.6387 | 0.6387 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0121 | 0.3989 | 0.3989 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0121 | 0.3989 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0102 | 0.3049 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0121 | 0.3989 | 0.5 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0102 | 0.3049 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0121 | 0.3989 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0121 | 0.3989 | 0.5 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0121 | 0.3989 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0243 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0121 | 0.3989 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0243 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0121 | 0.3989 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0041 | 0 | 0.5 |
Onchocerca volvulus | 0.0041 | 0 | 0.5 | |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0121 | 0.3989 | 0.3989 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0121 | 0.3989 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0102 | 0.3049 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | Inhibition of mammalian ribonucleotide reductase in a standard dTTP-dependent GDP reductase assay | ChEMBL. | 15454215 |
IC50 (binding) | = 2.4 uM | Inhibition of mammalian ribonucleotide reductase in a standard dTTP-dependent GDP reductase assay | ChEMBL. | 15454215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.