TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 343.382 | Formula: C20H17N5O
H donors: 1 H acceptors: 4 LogP: 3.79 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(cc(c1/C=C/c1cncc(c1)c1nn[nH]n1)C)c1ccco1
InChi: 1S/C20H17N5O/c1-13-8-16(19-4-3-7-26-19)9-14(2)18(13)6-5-15-10-17(12-21-11-15)20-22-24-25-23-20/h3-12H,1-2H3,(H,22,23,24,25)/b6-5+
InChiKey: XFBUODNVNPFENG-AATRIKPKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	TK protein kinase	0.0036	0.7539	0.7539
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine kinase	0.0041	0.8785	0.8785
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	1	1
Echinococcus multilocularis	steroid dehydrogenase	0.0021	0.3321	0.3321
Leishmania major	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.035	0.035
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.3321
Leishmania major	dehydrogenase-like protein	0.0021	0.3321	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	1	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.8435	0.8435
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0021	0.3321	0.3321
Brugia malayi	hypothetical protein	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0021	0.3321	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Brugia malayi	Dehydrogenases, short chain protein 2	0.0021	0.3321	0.3321
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Echinococcus multilocularis	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.035	0.035
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Giardia lamblia	Reductase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Echinococcus multilocularis	steroid dehydrogenase	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0021	0.3321	0.3321
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Leishmania major	oxidoreductase-like protein	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Onchocerca volvulus		0.0021	0.3321	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0021	0.3321	0.3321
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.8785	0.8785
Onchocerca volvulus		0.0021	0.3321	0.5
Echinococcus granulosus	hypothetical protein	0.0021	0.3321	0.3321
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0021	0.3321	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0021	0.3321	0.3321
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	1	1
Onchocerca volvulus		0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Leishmania major	pteridine reductase 1	0.0021	0.3321	0.5
Brugia malayi	protein-tyrosine kinase	0.0041	0.8785	0.8785
Loa Loa (eye worm)	dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	dehydrogenases, short chain protein 2	0.0021	0.3321	0.3321
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.8785	0.8785
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.8785	0.8785
Echinococcus multilocularis	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0021	0.3321	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.035	0.035
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	1	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0021	0.3321	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	tyrosine kinase	0.0045	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0021	0.3321	0.3321
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0021	0.3321	0.3321
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	1	1
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.8785	0.8785
Schistosoma mansoni	tyrosine kinase	0.001	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.035	0.035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.7539	0.7539
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.035	0.035
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Leishmania major	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	hypothetical protein	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0021	0.3321	0.3321
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.7539	0.7539
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0021	0.3321	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0021	0.3321	0.5
Leishmania major	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Giardia lamblia	Hypothetical protein	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0021	0.3321	0.3321
Echinococcus granulosus	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Brugia malayi	hypothetical protein	0.0021	0.3321	0.3321
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	1	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0021	0.3321	0.3321
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0021	0.3321	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.3321	0.3321
Toxoplasma gondii	oxidoreductase, putative	0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.8435	0.8435
Echinococcus granulosus	steroid dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.8785	0.8785
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0021	0.3321	0.3321
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	1	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0021	0.3321	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0021	0.3321	0.5
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0021	0.3321	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Entamoeba histolytica	protein kinase, putative	0.0036	0.7539	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	ketoacyl reductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Brugia malayi	Retinol dehydrogenase 12	0.0021	0.3321	0.3321
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Echinococcus granulosus	c src tyrosine kinase	0.001	0.035	0.035
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0021	0.3321	0.3321
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Echinococcus granulosus	carbonyl reductase 1	0.0021	0.3321	0.3321
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0021	0.3321	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0021	0.3321	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	1	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0021	0.3321	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.035	0.035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Mycobacterium ulcerans	oxidoreductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Schistosoma mansoni	tyrosine kinase	0.001	0.035	0.035
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0021	0.3321	0.3321
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0021	0.3321	0.3321
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0021	0.3321	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.5
Mycobacterium ulcerans	oxidoreductase	0.0021	0.3321	0.5
Schistosoma mansoni	carbonyl reductase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Echinococcus multilocularis	retinol dehydrogenase 13	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Loa Loa (eye worm)	dehydrogenase	0.0021	0.3321	0.3321
Loa Loa (eye worm)	SRC-1	0.0045	1	1
Schistosoma mansoni	steroid dehydrogenase	0.0021	0.3321	0.3321
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.3321	0.5
Loa Loa (eye worm)	TK protein kinase	0.0041	0.8785	0.8785
Leishmania major	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0021	0.3321	0.5
Mycobacterium ulcerans	dehydrogenase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Schistosoma mansoni	tyrosine kinase	0.0045	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0021	0.3321	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0021	0.3321	0.3321
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.3321	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Loa Loa (eye worm)	oxidoreductase	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.3321	0.3321
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0021	0.3321	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.3321	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0021	0.3321	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Mycobacterium tuberculosis	Probable oxidoreductase	0.0021	0.3321	0.5
Onchocerca volvulus		0.0021	0.3321	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0021	0.3321	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.3321	0.3321
Onchocerca volvulus	Sepiapterin reductase homolog	0.0021	0.3321	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0021	0.3321	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Log IC50 (binding)	= 6.2	Inhibition of c-RAF1/MEK1/ERK2 signalling pathway by SPA	ChEMBL.	16890436

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 408830