Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0487 | 0.2979 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0048 | 0.0017 | 0.0425 |
Mycobacterium ulcerans | putative regulatory protein | 0.0487 | 0.2979 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0487 | 0.2979 | 0.5 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0105 | 0.0403 | 1 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0487 | 0.2979 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0057 | 0.0079 | 0.1963 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0487 | 0.2979 | 0.5 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0105 | 0.0403 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0048 | 0.0017 | 0.0017 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0368 | 0.2177 | 1 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0487 | 0.2979 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0057 | 0.0079 | 0.1963 |
Loa Loa (eye worm) | TK protein kinase | 0.0114 | 0.0464 | 0.1849 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0406 | 0.2436 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0487 | 0.2979 | 0.5 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.1569 | 0.1569 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0487 | 0.2979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0079 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0079 | 0.0256 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0487 | 0.2979 | 0.5 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0487 | 0.2979 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0105 | 0.0403 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 0.0403 | 0.0403 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0487 | 0.2979 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0406 | 0.2436 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0105 | 0.0403 | 1 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0487 | 0.2979 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.