Detailed information for compound 409673

Basic information

Technical information
  • TDR Targets ID: 409673
  • Name: (2S)-2-amino-3-(4-cyanophenyl)-N-hydroxypropa namide
  • MW: 205.213 | Formula: C10H11N3O2
  • H donors: 3 H acceptors: 3 LogP: -0.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@H](Cc1ccc(cc1)C#N)N
  • InChi: 1S/C10H11N3O2/c11-6-8-3-1-7(2-4-8)5-9(12)10(14)13-15/h1-4,9,15H,5,12H2,(H,13,14)/t9-/m0/s1
  • InChiKey: LBUVBAXZCRTNMC-VIFPVBQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-3-(4-cyanophenyl)propanehydroxamic acid
  • (2S)-2-azanyl-3-(4-cyanophenyl)-N-hydroxy-propanamide
  • (2S)-2-amino-3-(4-cyanophenyl)-N-hydroxy-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0231 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1096 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus g-protein coupled receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.1096 1
Brugia malayi follicle stimulating hormone receptor 0.0046 0.1096 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.0346 1 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1096 1
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.0346 1 0.5
Echinococcus multilocularis somatostatin receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.1096 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.0346 1 0.5
Schistosoma mansoni amine GPCR 0.0046 0.1096 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1096 1
Echinococcus granulosus allatostatin A receptor 0.0046 0.1096 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.1096 1
Echinococcus granulosus g protein coupled receptor 0.0046 0.1096 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.1096 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Brugia malayi G protein-coupled receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.1096 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1096 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1096 1
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0574
Onchocerca volvulus 0.0046 0.1096 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1096 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.1096 0.5
Mycobacterium ulcerans hypothetical protein 0.0346 1 1
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1096 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.076 0.6929
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1096 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.1096 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.1096 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.1096 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.103 0.9354
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0568 0.5184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Brugia malayi putative neuropeptide receptor 0.0046 0.1096 1
Brugia malayi sulfakinin receptor protein 0.0046 0.1096 1
Brugia malayi larval opioid receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Brugia malayi G-protein coupled receptor 0.0046 0.1096 1
Schistosoma mansoni myosin xvIII 0.0046 0.1096 1
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1096 1
Echinococcus multilocularis serotonin receptor 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.084 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1096 1
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.1096 1
Echinococcus granulosus neuropeptide receptor 0.0046 0.1096 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1096 1
Brugia malayi neuropeptide F receptor 0.0046 0.1096 1
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1096 1
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1096 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1096 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0919 0.8282
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Brugia malayi ORL1-like opioid receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.1096 1
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0231 0.2109
Onchocerca volvulus 0.0046 0.1096 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Mycobacterium ulcerans putative regulatory protein 0.0346 1 1
Brugia malayi AKH receptor 0.0046 0.1096 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0231 0.2109
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Brugia malayi Dopamine receptor protein 2 0.0046 0.1096 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0231 0.1629
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.1096 1
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.1096 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0919 0.8282
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.1096 1
Schistosoma mansoni amine GPCR 0.0046 0.1096 1
Brugia malayi Dopamine receptor protein 1 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.1096 1
Schistosoma mansoni biogenic amine receptor 0.0046 0.1096 1
Echinococcus granulosus orexin receptor type 2 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0231 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.1096 1
Echinococcus granulosus somatostatin receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.1096 1
Echinococcus multilocularis sex peptide receptor 0.0046 0.1096 1
Echinococcus multilocularis serotonin receptor 0.0046 0.1096 1
Schistosoma mansoni hypothetical protein 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Brugia malayi RE15519p 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0231 0.5
Brugia malayi hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.1096 1
Echinococcus granulosus sex peptide receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Schistosoma mansoni histamine h1 receptor 0.0046 0.1096 1
Brugia malayi Melatonin receptor type 1A 0.0046 0.1096 1
Echinococcus granulosus g protein coupled receptor 0.0046 0.1096 1
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.1096 1
Echinococcus multilocularis allatostatin A receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1096 1
Schistosoma mansoni amine GPCR 0.0046 0.1096 1
Schistosoma mansoni hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni amine GPCR 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.1096 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Brugia malayi neuropeptide F receptor 0.0046 0.1096 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.1096 1
Echinococcus granulosus neuropeptide s receptor 0.0046 0.1096 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1096 1
Brugia malayi G-protein coupled receptor 0.0046 0.1096 1
Brugia malayi GnHR receptor homolog 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Mycobacterium ulcerans two component transcriptional regulator 0.0346 1 1
Onchocerca volvulus 0.0046 0.1096 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0919 0.8282
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0346 1 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.1096 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0231 0.2109
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Brugia malayi Serotonin receptor 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.1096 1
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1096 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1096 1
Echinococcus granulosus neuropeptide receptor 0.0046 0.1096 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.1096 1
Brugia malayi Serotonin receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.1096 1
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1096 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.1096 1
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus g protein coupled receptor 0.0046 0.1096 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.1096 1
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1096 1
Schistosoma mansoni opsin-like receptor 0.0046 0.1096 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis orexin receptor type 2 0.0046 0.1096 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1096 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.1096 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1096 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1096 1
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.0346 1 0.5
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0346 1 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.1096 1
Brugia malayi Cytochrome P450 family protein 0.0029 0.0568 0.4891
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.103 0.9354
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1096 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.1096 1
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0346 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.1096 1
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus fmrfamide receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.1096 1
Schistosoma mansoni opsin-like receptor 0.0046 0.1096 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0919 0.8381
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.1096 0.5
Brugia malayi hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus serotonin receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.1096 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.1096 1
Leishmania major cytochrome p450-like protein 0.0017 0.0231 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.084 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0346 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.1096 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0231 0.1629
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.1096 1
Schistosoma mansoni biogenic amine receptor 0.0046 0.1096 1
Schistosoma mansoni amine GPCR 0.0046 0.1096 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Brugia malayi hypothetical protein 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Schistosoma mansoni biogenic amine receptor 0.0046 0.1096 1
Schistosoma mansoni adenoreceptor 0.0046 0.1096 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1096 1
Onchocerca volvulus 0.0046 0.1096 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1096 1
Schistosoma mansoni hypothetical protein 0.0046 0.1096 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1096 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.1096 1
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1096 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1096 1
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.1096 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.1096 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.1096 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1096 1
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1096 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.1096 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.1096 1
Brugia malayi Dopamine receptor 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1096 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.1096 1
Schistosoma mansoni opsin-like receptor 0.0046 0.1096 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 28 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882
IC50 (functional) = 28 uM Inhibition of CSK measured as poly-E4Y phosphorylation by acid precipitation assay in presence of 0.2 mM CoCl2 ChEMBL. 17149882

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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