Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0013 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0051 | 0.2688 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0051 | 0.2708 | 0.2409 |
Loa Loa (eye worm) | cathepsin B | 0.0051 | 0.2688 | 0.2688 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0393 | 0.1462 |
Toxoplasma gondii | cathepsin B | 0.0051 | 0.2688 | 0.5 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.0013 | 0 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.0049 | 0.2551 | 0.2551 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1244 | 0.1244 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0051 | 0.2708 | 0.2409 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.0393 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0155 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0051 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0051 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2551 | 0.2551 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.0393 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | calpain | 0.0019 | 0.0393 | 0.0393 |
Giardia lamblia | Cathepsin B precursor | 0.0051 | 0.2688 | 0.5 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0036 | 0.1637 | 0.1637 |
Echinococcus granulosus | cathepsin b | 0.0155 | 1 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.1462 |
Echinococcus granulosus | calpain A | 0.0051 | 0.2708 | 0.2409 |
Brugia malayi | calpain 7 | 0.0019 | 0.0393 | 0.0393 |
Onchocerca volvulus | 0.0031 | 0.1244 | 0.5 | |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Trypanosoma brucei | antigen, putative | 0.0019 | 0.0393 | 0.1462 |
Giardia lamblia | Cathepsin B precursor | 0.0051 | 0.2688 | 0.5 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0393 | 0.1462 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0393 | 0.1462 |
Echinococcus multilocularis | calpain A | 0.0051 | 0.2708 | 0.2409 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1637 | 0.1637 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0036 | 0.1637 | 0.1295 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0051 | 0.2708 | 0.2409 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.0393 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0051 | 0.2688 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0051 | 0.2708 | 0.2409 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.1462 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2158 | 0.2158 |
Brugia malayi | calpain family protein 1 | 0.0049 | 0.2551 | 0.2551 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0049 | 0.2551 | 0.2246 |
Echinococcus granulosus | cathepsin b | 0.0155 | 1 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.0019 | 0.0393 | 0.1462 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0051 | 0.2688 | 0.2389 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0019 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0051 | 0.2688 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0155 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0155 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0019 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0049 | 0.2551 | 0.2551 |
Plasmodium vivax | calpain, putative | 0.0019 | 0.0393 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.9 | Reduction in log CFU of Mycobacterium tuberculosis Kurono infected in mouse lung at 50 mg/kg, po relative to control | ChEMBL. | 17181168 |
MIC (functional) | = 0.39 ug ml-1 | Antituberculosis activity against INH resistant Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
MIC (functional) | = 0.39 ug ml-1 | Antituberculosis activity against rifampicin resistant Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
MIC (functional) | = 0.39 ug ml-1 | Antituberculosis activity against INH resistant Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
MIC (functional) | = 0.39 ug ml-1 | Antituberculosis activity against rifampicin resistant Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
MIC (functional) | = 0.78 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
MIC (functional) | = 0.78 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 17181168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.