Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | polyprenyl synthetase | 0.1639 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0494 | 0.29 | 1 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0494 | 0.29 | 0.264 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0494 | 0.29 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 0.5 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0329 | 0.1874 | 0.1577 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1639 | 1 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0494 | 0.29 | 0.264 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1639 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0494 | 0.29 | 0.29 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0494 | 0.29 | 0.264 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0826 | 0.4955 | 0.4955 |
Loa Loa (eye worm) | hexokinase | 0.0052 | 0.016 | 0.016 |
Brugia malayi | Hexokinase family protein | 0.0083 | 0.0353 | 0.0353 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Schistosoma mansoni | glutathione synthetase | 0.0494 | 0.29 | 0.264 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0329 | 0.1874 | 0.1577 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 0.5 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1639 | 1 | 0.5 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1639 | 1 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0826 | 0.4955 | 1 |
Brugia malayi | Hexokinase family protein | 0.0052 | 0.016 | 0.016 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1639 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0494 | 0.29 | 0.5 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0329 | 0.1874 | 0.1577 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1639 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0826 | 0.4955 | 0.4771 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0494 | 0.29 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0329 | 0.1874 | 0.1577 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0494 | 0.29 | 0.29 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0329 | 0.1874 | 0.1577 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Loa Loa (eye worm) | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0494 | 0.29 | 0.264 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0329 | 0.1874 | 0.1577 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0329 | 0.1874 | 0.1577 |
Brugia malayi | hexokinase | 0.0083 | 0.0353 | 0.0353 |
Onchocerca volvulus | 0.0083 | 0.0353 | 1 | |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0188 | 0.0188 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Leishmania major | polyprenyl synthase, putative | 0.0826 | 0.4955 | 0.4771 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0494 | 0.29 | 0.264 |
Loa Loa (eye worm) | hexokinase type II | 0.0083 | 0.0353 | 0.0353 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0826 | 0.4955 | 0.4955 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1639 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0494 | 0.29 | 0.264 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0329 | 0.1874 | 0.1577 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0494 | 0.29 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.