Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 10 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.1108 | 0.3671 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0102 | 0.1228 | 0.4068 |
Loa Loa (eye worm) | disintegrin family protein | 0.0074 | 0.0591 | 0.1361 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.3019 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0477 | 0.9831 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.0209 | 0.0692 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0209 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0209 | 0.0692 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.3019 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1085 | 0.3593 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0102 | 0.1228 | 0.4068 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.3019 | 1 |
Echinococcus multilocularis | 0.0056 | 0.0168 | 0.0555 | |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0068 | 0.0446 | 0.1478 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0485 | 1 | 1 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0485 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.3019 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1108 | 0.3671 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0446 | 0.0844 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0209 | 0.0692 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.3019 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.1108 | 0.3671 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0102 | 0.1228 | 0.4068 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0485 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1085 | 0.3593 |
Brugia malayi | Disintegrin family protein | 0.0102 | 0.1228 | 0.4068 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.0209 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0209 | 0.0692 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.1085 | 0.3593 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0209 | 0.0692 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0068 | 0.0446 | 0.1478 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1108 | 0.3671 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.1108 | 0.3671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 480 nM | Inhibition of ADAM10 | ChEMBL. | 17256836 |
IC50 (binding) | = 480 nM | Inhibition of ADAM10 | ChEMBL. | 17256836 |
IC50 (functional) | = 560 nM | Inhibition of Her2 sheddase activity in BT474 cell line | ChEMBL. | 17256836 |
IC50 (functional) | = 560 nM | Inhibition of Her2 sheddase activity in BT474 cell line | ChEMBL. | 17256836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.