TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.978 | Formula: C25H33ClO7
H donors: 1 H acceptors: 2 LogP: 5.06 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCC(c1ccc(cc1)Cl)O[C@H]1O[C@@H]2OC3(C)CC[C@@H]4C2(C([C@H]1C)CC[C@H]4C)OO3
InChi: 1S/C25H33ClO7/c1-14-4-9-19-15(2)22(29-20(10-11-21(27)28)16-5-7-17(26)8-6-16)30-23-25(19)18(14)12-13-24(3,31-23)32-33-25/h5-8,14-15,18-20,22-23H,4,9-13H2,1-3H3,(H,27,28)/t14-,15-,18+,19?,20?,22+,23-,24?,25?/m1/s1
InChiKey: CASWDFLWXWLZCX-FYKLBHLISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G protein-coupled receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	biogenic amine receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0345912	0.620697	0.620697
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0302952	0.525875	0.787724
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0364244	0.66116	0.66116
Brugia malayi	ORL1-like opioid receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	Melatonin receptor type 1A	0.0364244	0.66116	0.66116
Echinococcus granulosus	neuropeptides capa receptor	0.0364244	0.66116	0.66116
Trypanosoma brucei	adenosine transporter 2	0.00762287	0.0254397	0.0254397
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0517756	1	1
Trypanosoma brucei	adenosine transporter 2, putative	0.00762287	0.0254397	0.0254397
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	neuropeptide receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0150601	0.189597	0.189597
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0517756	1	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0367156	0.667587	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0364244	0.66116	0.66116
Schistosoma mansoni	growth hormone secretagogue receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	opsin-like receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	neuropeptide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	tm gpcr rhodopsin	0.0364244	0.66116	0.66116
Trypanosoma brucei	adenosine transporter, putative	0.00762287	0.0254397	0.0254397
Trypanosoma cruzi	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Schistosoma mansoni	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0364244	0.66116	0.66116
Schistosoma mansoni	histamine h1 receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0364244	0.66116	0.66116
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0345912	0.620697	0.620697
Loa Loa (eye worm)	hypothetical protein	0.00762287	0.0254397	0.0381069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Trypanosoma brucei	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	hypothetical protein	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trypanosoma cruzi	nucleobase transporter, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus multilocularis	neuropeptide receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Trypanosoma brucei	unspecified product	0.00762287	0.0254397	0.0254397
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0322445	0.5689	0.5689
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0517756	1	1
Echinococcus granulosus	hypothetical protein	0.0364244	0.66116	0.66116
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	equilibrative nucleoside transporter	0.0302952	0.525875	0.525875
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0302952	0.525875	0.795382
Entamoeba histolytica	nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0517756	1	1
Leishmania major	nucleobase transporter	0.00762287	0.0254397	0.0254397
Onchocerca volvulus		0.0364244	0.66116	1
Leishmania major	nucleobase transporter	0.00762287	0.0254397	0.0254397
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0150601	0.189597	0.189597
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0302952	0.525875	0.795382
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	g protein coupled receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0322445	0.5689	0.5689
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0517756	1	1
Trypanosoma brucei	purine nucleoside transporter	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Brugia malayi	AKH receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Leishmania major	inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040	0.00762287	0.0254397	0.0254397
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Echinococcus multilocularis	orexin receptor type 2	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0364244	0.66116	0.66116
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0517756	1	0.5
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0517756	1	1
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0302952	0.525875	0.525875
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	g protein coupled receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	g-protein coupled receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Brugia malayi	GnHR receptor homolog	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0345912	0.620697	0.929762
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Brugia malayi	hypothetical protein	0.0302952	0.525875	0.525875
Brugia malayi	putative neuropeptide receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	neuropeptide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0364244	0.66116	0.66116
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0364244	0.66116	1
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus multilocularis	neuropeptide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0364244	0.66116	0.66116
Brugia malayi	larval opioid receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	amine GPCR	0.0364244	0.66116	0.66116
Echinococcus multilocularis	G protein coupled receptor 139	0.0364244	0.66116	0.66116
Echinococcus multilocularis	serotonin receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0517756	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	amine GPCR	0.0364244	0.66116	0.66116
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0364244	0.66116	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0364244	0.66116	0.990372
Trypanosoma cruzi	nucleoside transporter-like, putative	0.00762287	0.0254397	0.0254397
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0302952	0.525875	0.525875
Schistosoma mansoni	amine GPCR	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0364244	0.66116	0.66116
Brugia malayi	neuropeptide F receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0517756	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Brugia malayi	Serotonin receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	neuropeptide FF receptor 2	0.0364244	0.66116	0.66116
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0517756	1	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0517756	1	1
Schistosoma mansoni	hypothetical protein	0.0364244	0.66116	0.66116
Trypanosoma brucei	adenosine transporter 2, putative	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0302952	0.525875	0.525875
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	putative neuropeptide receptor NPR1	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Trypanosoma brucei	adenosine transporter 2, putative	0.00762287	0.0254397	0.0254397
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0322445	0.5689	0.0907472
Brugia malayi	G protein-coupled receptor F59B2.13	0.0364244	0.66116	0.66116
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0345912	0.620697	0.620697
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0364244	0.66116	0.66116
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	Serotonin receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0367156	0.667587	1
Trypanosoma brucei	adenosine transporter, putative	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	TYRA-2 protein	0.0364244	0.66116	0.990372
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0517756	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0364244	0.66116	0.990372
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0517756	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0364244	0.66116	0.66116
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0150601	0.189597	0.189597
Echinococcus granulosus	sex peptide receptor	0.0364244	0.66116	0.66116
Brugia malayi	follicle stimulating hormone receptor	0.0364244	0.66116	0.66116
Entamoeba histolytica	nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Onchocerca volvulus		0.0364244	0.66116	1
Trypanosoma brucei	unspecified product	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0364244	0.66116	0.66116
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0517756	1	0.5
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0517756	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	fmrfamide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0302952	0.525875	0.787724
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Leishmania major	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	neuropeptides capa receptor	0.0364244	0.66116	0.66116
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0517756	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	neuropeptide F receptor	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	G-protein coupled receptor	0.0364244	0.66116	0.990372
Echinococcus granulosus	biogenic amine 5HT receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Onchocerca volvulus		0.0364244	0.66116	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0364244	0.66116	0.990372
Brugia malayi	sulfakinin receptor protein	0.0364244	0.66116	0.66116
Trypanosoma brucei	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0517756	1	1
Trypanosoma brucei	adenosine transporter 2, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	biogenic amine receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0364244	0.66116	0.66116
Echinococcus granulosus	neuropeptide Y receptor	0.0364244	0.66116	0.66116
Brugia malayi	Dopamine receptor protein 2	0.0364244	0.66116	0.66116
Schistosoma mansoni	protein kinase	0.00762287	0.0254397	0.0254397
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	orexin receptor type 2	0.0364244	0.66116	0.66116
Schistosoma mansoni	equilibrative nucleoside transporter	0.00762287	0.0254397	0.0254397
Brugia malayi	hypothetical protein	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	neuropeptide f receptor 76f	0.0364244	0.66116	0.66116
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0517756	1	1
Trypanosoma cruzi	nucleoside transporter-like, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	biogenic amine receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0364244	0.66116	0.66116
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0364244	0.66116	0.66116
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trypanosoma cruzi	nucleobase transporter, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus multilocularis	g protein coupled receptor	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0302952	0.525875	0.525875
Echinococcus multilocularis	g protein coupled receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0171844	0.236487	0.236487
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0364244	0.66116	0.66116
Echinococcus granulosus	dro:myosuppressin receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0364244	0.66116	0.66116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0364244	0.66116	0.66116
Leishmania major	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Echinococcus granulosus	somatostatin receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0364244	0.66116	0.66116
Schistosoma mansoni	amine GPCR	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0364244	0.66116	0.990372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0364244	0.66116	0.66116
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0302952	0.525875	0.525875
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	7TM GPCR rhodopsin	0.0364244	0.66116	0.66116
Echinococcus granulosus	neuropeptide receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0322445	0.5689	0.5689
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Trypanosoma brucei	adenosine transporter 2, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0364244	0.66116	0.66116
Toxoplasma gondii	nucleoside transporter protein	0.00762287	0.0254397	0.0254397
Echinococcus granulosus	neuropeptide receptor A26	0.0364244	0.66116	0.66116
Echinococcus granulosus	neuropeptides capa receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	amine GPCR	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Schistosoma mansoni	myosin xvIII	0.0364244	0.66116	0.66116
Echinococcus granulosus	g-protein coupled receptor	0.0364244	0.66116	0.66116
Brugia malayi	Dopamine receptor protein 1	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	g protein coupled receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0226724	0.357619	0.357619
Toxoplasma gondii	nucleoside transporter protein	0.00762287	0.0254397	0.0254397
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0517756	1	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0517756	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0364244	0.66116	0.66116
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	G protein coupled receptor 139	0.0364244	0.66116	0.66116
Echinococcus granulosus	fmrfamide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0302952	0.525875	0.787724
Trypanosoma cruzi	nucleoside transporter 1, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0517756	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Brugia malayi	G-protein coupled receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0364244	0.66116	0.66116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0150601	0.189597	0.189597
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0302952	0.525875	0.525875
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0345912	0.620697	0.929762
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trypanosoma brucei	purine nucleoside transporter	0.00762287	0.0254397	0.0254397
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0302952	0.525875	0.525875
Echinococcus multilocularis	neuropeptide Y receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	somatostatin receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	neuropeptide receptor	0.0364244	0.66116	0.66116
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.00762287	0.0254397	0.0254397
Echinococcus granulosus	7tm_1 domain containing protein	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.00762287	0.0254397	0.0254397
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0195311	0.288284	0.5
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus multilocularis	sex peptide receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0150601	0.189597	0.189597
Brugia malayi	G-protein coupled receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	fmrfamide receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	g protein coupled receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	adenoreceptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0364244	0.66116	0.66116
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.00762287	0.0254397	0.0254397
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus multilocularis	serotonin receptor	0.0364244	0.66116	0.66116
Echinococcus multilocularis	allatostatin A receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	hypothetical protein	0.0364244	0.66116	0.66116
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0517756	1	0.5
Entamoeba histolytica	nucleoside transporter, putative	0.0302952	0.525875	0.525875
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.00762287	0.0254397	0.0254397
Brugia malayi	Dopamine receptor	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus granulosus	neuropeptide s receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	biogenic amine 5HT receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	opsin-like receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0345912	0.620697	0.929762
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0171844	0.236487	0.236487
Brugia malayi	RE15519p	0.0364244	0.66116	0.66116
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0322445	0.5689	0.5689
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0364244	0.66116	0.990372
Onchocerca volvulus		0.0364244	0.66116	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0517756	1	1
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0517756	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0364244	0.66116	0.66116
Trypanosoma brucei	adenosine transporter 2	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	opsin-like receptor	0.0364244	0.66116	0.66116
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0364244	0.66116	0.66116
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0364244	0.66116	0.990372
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0517756	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Schistosoma mansoni	neuropeptide receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0345912	0.620697	0.620697
Brugia malayi	neuropeptide F receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	neuropeptide F-like receptor	0.0364244	0.66116	0.66116
Trypanosoma cruzi	nucleobase transporter, putative	0.00762287	0.0254397	0.0254397
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0364244	0.66116	0.990372
Toxoplasma gondii	nucleoside transporter protein	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0517756	1	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0150601	0.189597	0.189597
Echinococcus granulosus	serotonin receptor	0.0364244	0.66116	0.66116
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0364244	0.66116	0.66116
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Echinococcus granulosus	allatostatin A receptor	0.0364244	0.66116	0.66116
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116
Brugia malayi	Nucleoside transporter family protein	0.0302952	0.525875	0.525875
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0195311	0.288284	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0364244	0.66116	0.66116
Onchocerca volvulus		0.0364244	0.66116	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0364244	0.66116	0.66116
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0364244	0.66116	0.66116
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Brugia malayi	hypothetical protein	0.0364244	0.66116	0.66116
Loa Loa (eye worm)	hypothetical protein	0.0364244	0.66116	0.990372
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.00762287	0.0254397	0.0254397
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0364244	0.66116	0.66116

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.261 ng ml-1	In vitro inhibitory concentration against P. falciparum clone CDC Indochina 3 (W-2).	ChEMBL.	9135037
IC50 (functional)	= 1.261 ng ml-1	In vitro inhibitory concentration against P. falciparum clone CDC Indochina 3 (W-2).	ChEMBL.	9135037
IC50 (functional)	= 2.403 ng ml-1	In vitro inhibitory concentration against P. falciparum clone CDC Seirra Leone 1 (D-6).	ChEMBL.	9135037
IC50 (functional)	= 2.403 ng ml-1	In vitro inhibitory concentration against P. falciparum clone CDC Seirra Leone 1 (D-6).	ChEMBL.	9135037

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	9135037

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL30501

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 41202