Detailed information for compound 415428

Basic information

Technical information
  • TDR Targets ID: 415428
  • Name: 8-[[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1- yl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7,9- dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6), 2,4-triene-3-carbaldehyde
  • MW: 420.31 | Formula: C18H17N2O8P
  • H donors: 1 H acceptors: 4 LogP: -0.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc2c(c1)COP(=O)(O2)OC[C@@H]1C=C[C@@H](O1)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C18H17N2O8P/c1-11-7-20(18(23)19-17(11)22)16-5-3-14(27-16)10-26-29(24)25-9-13-6-12(8-21)2-4-15(13)28-29/h2-8,14,16H,9-10H2,1H3,(H,19,22,23)/t14-,16+,29?/m0/s1
  • InChiKey: UJAJPOYOPQQARS-CCWRPAJNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-triene-3-carbaldehyde
  • 8-[[(2S,5R)-5-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-triene-3-carboxaldehyde
  • 8-[[(2S,5R)-5-(2,4-diketo-5-methyl-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]-8-keto-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-triene-3-carbaldehyde
  • 4H-1,3,2-Benzodioxaphosphorin-6-carboxaldehyde, 2-[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]-, 2-oxide
  • AIDS-354423
  • AIDS354423

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis methionine aminopeptidase 0.0256 0 0.5
Trypanosoma brucei methionine aminopeptidase 2, putative 0.2065 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2065 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2065 1 1
Echinococcus granulosus methionyl aminopeptidase 2 0.2065 1 1
Schistosoma mansoni hypothetical protein 0.0349 0.051 0.051
Plasmodium vivax methionine aminopeptidase 2, putative 0.2065 1 1
Treponema pallidum aminopeptidase P 0.0256 0 0.5
Giardia lamblia Methionine aminopeptidase 0.2065 1 1
Leishmania major methionine aminopeptidase 2, putative 0.2065 1 1
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0256 0 0.5
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0256 0 0.5
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0256 0 0.5
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.2065 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.2065 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.2065 1 1
Mycobacterium ulcerans dipeptidase PepE 0.0256 0 0.5
Mycobacterium ulcerans methionine aminopeptidase 0.0256 0 0.5
Treponema pallidum methionine aminopeptidase (map) 0.0256 0 0.5
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0256 0 0.5
Mycobacterium tuberculosis Dipeptidase PepE 0.0256 0 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2065 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0256 0 0.5
Chlamydia trachomatis aminopeptidase P 0.0256 0 0.5
Toxoplasma gondii methionine aminopeptidase 2, putative 0.2065 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0256 0 0.5
Echinococcus multilocularis methionyl aminopeptidase 2 0.2065 1 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0256 0 0.5
Plasmodium falciparum methionine aminopeptidase 2 0.2065 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2065 1 1
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0256 0 0.5
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0256 0 0.5
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.2065 1 1
Mycobacterium ulcerans aminopeptidase 0.0256 0 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0256 0 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.2065 1 1
Mycobacterium ulcerans dipeptidase 0.0256 0 0.5
Entamoeba histolytica methionine aminopeptidase, putative 0.2065 1 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.2065 1 1
Trypanosoma brucei RNA helicase, putative 0.0349 0.051 0.051

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) 0 Hydrolysis half life in CEM cell extracts at pH 6.9 ChEMBL. 17335187
Activity (ADMET) 0 Hydrolysis half life in RPMI-1650/FCS medium at pH 7.6 ChEMBL. 17335187
Activity (ADMET) 0 Hydrolysis half life in human serum at pH 6.8 ChEMBL. 17335187
EC50 (functional) = 0.15 uM Antiviral activity against HIV2 ROD in CEM/0 cells ChEMBL. 17335187
EC50 (functional) = 0.41 uM Antiviral activity against HIV1 in CEM/0 cells ChEMBL. 17335187
EC50 (functional) = 5 uM Antiviral activity against HIV2 ROD in CEM/TK- cells ChEMBL. 17335187
t1/2 = 0.18 hr Chemical stability in phosphate buffer at pH 7.3 ChEMBL. 17335187

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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