Detailed information for compound 417288

Basic information

Technical information
  • TDR Targets ID: 417288
  • Name: 4,5,6,7-tetrabromo-3-methyl-1H-benzimidazol-2 -one
  • MW: 463.746 | Formula: C8H4Br4N2O
  • H donors: 1 H acceptors: 1 LogP: 3.51 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1c(Br)c(Br)c2c(c1Br)n(C)c(=O)[nH]2
  • InChi: 1S/C8H4Br4N2O/c1-14-7-5(12)3(10)2(9)4(11)6(7)13-8(14)15/h1H3,(H,13,15)
  • InChiKey: NDXTXIGOPTZQRA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, beta polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0602 0.4054
Loa Loa (eye worm) hypothetical protein 0.0205 0.0882 0.0882
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.05 0.3093 1
Onchocerca volvulus 0.0205 0.0882 0.5946
Brugia malayi Papain family cysteine protease containing protein 0.0285 0.1484 0.1484
Onchocerca volvulus 0.0285 0.1484 1
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0602 0.0602
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0167 0.0602 0.0602
Onchocerca volvulus Cathepsin L homolog 0.0285 0.1484 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0259 0.1287 0.1287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0882 0.2853
Loa Loa (eye worm) hypothetical protein 0.0205 0.0882 0.0882
Echinococcus multilocularis cysteine protease 0.0285 0.1484 0.1484
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0602 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0882 0.2853
Loa Loa (eye worm) hypothetical protein 0.0205 0.0882 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Entamoeba histolytica cysteine protease, putative 0.0285 0.1484 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0285 0.1484 0.1484
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.1889 0.1889
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Echinococcus granulosus cathepsin b 0.1425 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.1484 0.1484
Trypanosoma cruzi cysteine protease, putative 0.0167 0.0602 0.0602
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0602 0.0602
Trypanosoma cruzi cruzipain precursor, putative 0.0339 0.1889 0.1889
Brugia malayi Cathepsin L-like precursor 0.0205 0.0882 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0602 0.1945
Trypanosoma cruzi major cysteine proteinase, putative 0.0141 0.0405 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.1484 0.1484
Schistosoma mansoni cathepsin F (C01 family) 0.0205 0.0882 0.0882
Loa Loa (eye worm) fibroinase 0.0285 0.1484 0.1484
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0285 0.1484 0.1484
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.1484 0.1484
Onchocerca volvulus Cathepsin L homolog 0.0285 0.1484 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Plasmodium vivax vivapain-2 0.0285 0.1484 1
Plasmodium vivax vivapain-1 0.0167 0.0602 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0602 0.0602
Brugia malayi Cathepsin L-like cysteine proteinase 0.0205 0.0882 0.0882
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0285 0.1484 0.1484
Giardia lamblia Cathepsin B precursor 0.05 0.3093 1
Echinococcus granulosus cathepsin l1 0.0285 0.1484 0.1484
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Loa Loa (eye worm) cysteine protease 0.0285 0.1484 0.1484
Toxoplasma gondii cathepsin CPL 0.0285 0.1484 0.4799
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.1484 0.1484
Echinococcus granulosus cysteine protease 0.0167 0.0602 0.0602
Entamoeba histolytica cysteine proteinase, putative 0.0205 0.0882 0.5946
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Loa Loa (eye worm) cathepsin B 0.05 0.3093 0.3093
Loa Loa (eye worm) hypothetical protein 0.0285 0.1484 0.1484
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Loa Loa (eye worm) hypothetical protein 0.1425 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0602 0.4054
Echinococcus granulosus cathepsin L cysteine protease 0.0167 0.0602 0.0602
Onchocerca volvulus 0.0285 0.1484 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0602 0.1945
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0285 0.1484 1
Echinococcus multilocularis cathepsin b 0.1425 1 1
Onchocerca volvulus 0.0285 0.1484 1
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0602 0.0602
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.05 0.3093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Onchocerca volvulus 0.0285 0.1484 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0285 0.1484 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1425 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1425 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Onchocerca volvulus 0.0285 0.1484 1
Plasmodium vivax vivapain-2 0.0285 0.1484 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0167 0.0602 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.1889 0.1889
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Echinococcus granulosus cathepsin l cysteine peptidase 0.0285 0.1484 0.1484
Leishmania major cathepsin L-like protease 0.0339 0.1889 0.2517
Onchocerca volvulus 0.0285 0.1484 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.1484 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.1484 0.1484
Echinococcus multilocularis cathepsin b 0.1425 1 1
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0602 0.0602
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0602 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.05 0.3093 0.3093
Giardia lamblia Cathepsin B precursor 0.05 0.3093 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.1484 0.1484
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0602 0.0602
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.1484 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.1889 0.1889
Entamoeba histolytica cysteine proteinase 2 0.0167 0.0602 0.4054
Echinococcus granulosus cathepsin b 0.1425 1 1
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1425 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Toxoplasma gondii cathepsin B 0.05 0.3093 1
Loa Loa (eye worm) ctsf protein 0.0285 0.1484 0.1484
Echinococcus multilocularis cathepsin L 0.0167 0.0602 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Plasmodium vivax unspecified product 0.0167 0.0602 0.4054
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.0602 0.0602
Echinococcus granulosus cathepsin L 0.0167 0.0602 0.0602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1425 1 1
Onchocerca volvulus Cathepsin F homolog 0.0285 0.1484 1
Echinococcus granulosus cathepsin l1 0.0205 0.0882 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1425 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.1484 0.1484
Leishmania major cathepsin L-like protease 0.0339 0.1889 0.2517
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Brugia malayi Cathepsin L-like precursor 0.0205 0.0882 0.0882
Leishmania major cathepsin L-like protease 0.0339 0.1889 0.2517
Onchocerca volvulus 0.0285 0.1484 1
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0602 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.05 0.3093 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Echinococcus multilocularis cysteine protease 0.0285 0.1484 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Brugia malayi Cathepsin L-like precursor 0.0285 0.1484 0.1484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.1484 0.4799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.1889 0.5168
Entamoeba histolytica cysteine protease, putative 0.0167 0.0602 0.4054
Plasmodium vivax vivapain-3 0.0167 0.0602 0.4054
Brugia malayi cathepsin L-like precursor 0.0205 0.0882 0.0882
Entamoeba histolytica cysteine proteinase 1, putative 0.0167 0.0602 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.1484 0.4799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.05 0.3093 0.3093
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0285 0.1484 1
Giardia lamblia Cathepsin B precursor 0.05 0.3093 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.39 uM Inhibition of CK2 ChEMBL. 15566294
IC50 (binding) = 0.39 uM Inhibition of CK2 ChEMBL. 15566294
Ki (binding) = 0.2 uM Inhibition of CK2 ChEMBL. 15566294
Ki (binding) = 0.2 uM Inhibition of CK2 ChEMBL. 15566294

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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