TDR Targets

Basic information

Technical information

TDR Targets ID: 417289
Name: 4,5,6,7-tetrabromo-N,N,1-trimethylbenzimidazo l-2-amine
MW: 490.815 | Formula: C10H9Br4N3
H donors: 0 H acceptors: 1 LogP: 4.66 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1c(Br)c(Br)c(c2c1nc(n2C)N(C)C)Br
InChi: 1S/C10H9Br4N3/c1-16(2)10-15-8-6(13)4(11)5(12)7(14)9(8)17(10)3/h1-3H3
InChiKey: WFQHVWNFYYLZHM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4,5,6,7-tetrabromo-N,N,1-trimethyl-benzimidazol-2-amine
4,5,6,7-tetrabromo-N,N,1-trimethyl-2-benzimidazolamine
dimethyl-(4,5,6,7-tetrabromo-1-methyl-benzimidazol-2-yl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, alpha prime polypeptide		References
Homo sapiens	casein kinase 2, beta polypeptide	Starlite/ChEMBL	References
Homo sapiens	casein kinase 2, alpha 1 polypeptide		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei gambiense	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania braziliensis	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania braziliensis	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Theileria parva	casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium vivax	unspecified product	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania major	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	casein kinase ii regulatory subunit protein	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania major	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium knowlesi	casein kinase 2, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	hypothetical protein	Get druggable targets OG5_126901	All targets in OG5_126901
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Candida albicans	likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma brucei	Casein kinase II	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania mexicana	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus multilocularis	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Echinococcus granulosus	casein kinase ii subunit alpha	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative casein kinase II regulatory subunit; besthit Pf 23508244	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126901	All targets in OG5_126901
Schistosoma japonicum	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium yoelii	Protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	casein kinase II beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II, alpha chain (CK II)	Get druggable targets OG5_126901	All targets in OG5_126901
Babesia bovis	protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania donovani	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II alpha' subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Neospora caninum	YOR039Wp-like protein, related	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium parvum	casein kinase II, alpha subunit, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Cryptosporidium hominis	protein kinase domain	Get druggable targets OG5_126901	All targets in OG5_126901
Loa Loa (eye worm)	CMGC/CK2 protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	casein kinase ii beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	CMGC kinase, CK2 family	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania infantum	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei gambiense	casein kinase II, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Brugia malayi	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Kinase, CMGC CK2	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II beta 4 subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	ck2 beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	protein kinase	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania mexicana	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Casein kinase II, alpha chain	Get druggable targets OG5_126901	All targets in OG5_126901
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03097 casein kinase 2, alpha polypeptide, putative	Get druggable targets OG5_126901	All targets in OG5_126901
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase 2, alpha subunit	Get druggable targets OG5_126901	All targets in OG5_126901
Leishmania donovani	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha prime polypeptide	350 aa	319 aa	50.2 %
Trypanosoma cruzi	casein kinase II, alpha chain, putative	casein kinase 2, alpha 1 polypeptide	391 aa	316 aa	51.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Echinococcus multilocularis	cathepsin b	0.0735	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0735	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0091	0.0647	0.3831
Leishmania major	cathepsin L-like protease	0.021	0.2382	0.5257
Onchocerca volvulus		0.0156	0.1595	1
Entamoeba histolytica	cysteine protease, putative	0.0156	0.1595	0.9449
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.0647	0.3831
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.0647	0.3831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.0647	0.2091
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0259	0.3093	0.3093
Echinococcus granulosus	cathepsin l1	0.0111	0.0948	0.0948
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Echinococcus granulosus	cathepsin L cysteine protease	0.0091	0.0647	0.0647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Trypanosoma cruzi	cysteine peptidase, putative	0.0156	0.1595	0.1595
Echinococcus multilocularis	cathepsin L cysteine protease	0.0156	0.1595	0.1595
Brugia malayi	Casein kinase II, alpha chain	0.0162	0.1688	0.1688
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0259	0.3093	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0166	0.1736	0.1736
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0156	0.1595	0.9449
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0259	0.3093	1
Plasmodium vivax	vivapain-2	0.0156	0.1595	0.9449
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0948	0.0948
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Trypanosoma cruzi	cysteine peptidase, putative	0.021	0.2382	0.2382
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine proteinase 2	0.0091	0.0647	0.3831
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0948	0.0948
Echinococcus granulosus	casein kinase ii subunit alpha	0.0162	0.1688	0.1688
Trypanosoma cruzi	casein kinase II, putative	0.0162	0.1688	0.1688
Onchocerca volvulus		0.0156	0.1595	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Trypanosoma cruzi	cysteine peptidase, putative	0.021	0.2382	0.2382
Onchocerca volvulus		0.0156	0.1595	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0735	1	1
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0162	0.1688	0.1688
Entamoeba histolytica	casein kinase, putative	0.0162	0.1688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0948	0.3067
Onchocerca volvulus		0.0156	0.1595	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0259	0.3093	0.3093
Giardia lamblia	Cathepsin B precursor	0.0259	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0948	0.0948
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Trypanosoma cruzi	cysteine proteinase, putative	0.0091	0.0647	0.0647
Trypanosoma cruzi	cysteine peptidase, putative	0.021	0.2382	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0735	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Trypanosoma cruzi	cysteine protease, putative	0.0091	0.0647	0.0647
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0156	0.1595	0.1595
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0735	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0259	0.3093	1
Leishmania major	casein kinase II, putative	0.0162	0.1688	0.0621
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Giardia lamblia	Kinase, CMGC CK2	0.0162	0.1688	0.5458
Brugia malayi	Papain family cysteine protease containing protein	0.0156	0.1595	0.1595
Onchocerca volvulus		0.0111	0.0948	0.5946
Trypanosoma brucei	Casein kinase II	0.0162	0.1688	0.4258
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0091	0.0647	0.0647
Plasmodium vivax	vivapain-1	0.0091	0.0647	0.3831
Trypanosoma cruzi	cysteine peptidase, putative	0.0091	0.0647	0.0647
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0162	0.1688	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Echinococcus multilocularis	cysteine protease	0.0156	0.1595	0.1595
Toxoplasma gondii	cathepsin B	0.0259	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0091	0.0647	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0156	0.1595	0.5158
Trypanosoma cruzi	major cysteine proteinase, putative	0.01	0.0787	0.0787
Leishmania major	cathepsin L-like protease	0.021	0.2382	0.5257
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1595	0.1595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Onchocerca volvulus	Cathepsin L homolog	0.0156	0.1595	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0948	0.3067
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0111	0.0948	0.0948
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0735	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Giardia lamblia	Cathepsin B precursor	0.0259	0.3093	1
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Echinococcus granulosus	cathepsin b	0.0735	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0156	0.1595	0.5158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Brugia malayi	Papain family cysteine protease containing protein	0.0091	0.0647	0.0647
Entamoeba histolytica	cysteine proteinase 1, putative	0.0091	0.0647	0.3831
Giardia lamblia	Cathepsin B precursor	0.0259	0.3093	1
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Loa Loa (eye worm)	fibroinase	0.0156	0.1595	0.1595
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Schistosoma mansoni	protein kinase	0.0162	0.1688	0.1688
Plasmodium vivax	vivapain-2	0.0156	0.1595	0.9449
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0156	0.1595	0.1595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Echinococcus granulosus	cathepsin b	0.0735	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0735	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Loa Loa (eye worm)	ctsf protein	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.0647	0.3831
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0948	0.0948
Plasmodium vivax	unspecified product	0.0162	0.1688	1
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Toxoplasma gondii	CMGC kinase, CK2 family	0.0162	0.1688	0.5458
Leishmania major	cathepsin L-like protease	0.021	0.2382	0.5257
Trypanosoma cruzi	cruzipain precursor, putative	0.021	0.2382	0.2382
Loa Loa (eye worm)	cathepsin B	0.0259	0.3093	0.3093
Toxoplasma gondii	cathepsin CPL	0.0156	0.1595	0.5158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Onchocerca volvulus		0.0156	0.1595	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0091	0.0647	0.2091
Schistosoma mansoni	cathepsin F (C01 family)	0.0156	0.1595	0.1595
Echinococcus granulosus	cathepsin l1	0.0156	0.1595	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0948	0.0948
Trypanosoma cruzi	cysteine proteinase, putative	0.0091	0.0647	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Brugia malayi	cathepsin L-like precursor	0.0111	0.0948	0.0948
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.0948	0.0948
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0156	0.1595	0.9449
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Echinococcus multilocularis	cysteine protease	0.0156	0.1595	0.1595
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0162	0.1688	1
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1595	0.9449
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Brugia malayi	Cathepsin L-like precursor	0.0156	0.1595	0.1595
Entamoeba histolytica	cysteine proteinase, putative	0.0156	0.1595	0.9449
Echinococcus granulosus	cysteine protease	0.0091	0.0647	0.0647
Onchocerca volvulus		0.0156	0.1595	1
Echinococcus granulosus	cathepsin L	0.0091	0.0647	0.0647
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0948	0.5618
Schistosoma mansoni	cathepsin F (C01 family)	0.0156	0.1595	0.1595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Plasmodium vivax	vivapain-3	0.0091	0.0647	0.3831
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Onchocerca volvulus		0.0156	0.1595	1
Echinococcus multilocularis	cathepsin b	0.0735	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0091	0.0647	0.0647
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0162	0.1688	0.1688
Brugia malayi	Papain family cysteine protease containing protein	0.0091	0.0647	0.0647
Entamoeba histolytica	cysteine proteinase, putative	0.0091	0.0647	0.3831
Echinococcus multilocularis	cathepsin L cysteine protease	0.0156	0.1595	0.1595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.1688	1
Entamoeba histolytica	cysteine protease, putative	0.0091	0.0647	0.3831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0156	0.1595	0.5158
Plasmodium vivax	unspecified product	0.0091	0.0647	0.3831
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Onchocerca volvulus	Cathepsin F homolog	0.0156	0.1595	1
Trichomonas vaginalis	CMGC family protein kinase	0.0162	0.1688	0.5458
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0156	0.1595	0.9449
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0091	0.0647	0.0647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0156	0.1595	0.5158
Loa Loa (eye worm)	cysteine protease	0.0156	0.1595	0.1595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.021	0.2382	0.7096
Echinococcus multilocularis	cathepsin L	0.0091	0.0647	0.0647
Onchocerca volvulus	Cathepsin L homolog	0.0156	0.1595	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.13 uM	Inhibition of CK2	ChEMBL.	15566294
IC50 (binding)	= 0.13 uM	Inhibition of CK2	ChEMBL.	15566294
Ki (binding)	= 35 nM	Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD substrate after 15 mins by scintillation counting	ChEMBL.	22115617
Ki (binding)	= 109 nM	Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate after 15 mins by scintillation counting	ChEMBL.	22115617
Ki (binding)	= 154 nM	Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD substrate after 15 mins by scintillation counting	ChEMBL.	22115617
Ki (binding)	= 212 nM	Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate after 15 mins by scintillation counting	ChEMBL.	22115617
Ki (binding)	= 0.2 uM	Inhibition of CK2	ChEMBL.	15566294
Ki (binding)	= 0.2 uM	Inhibition of CK2	ChEMBL.	15566294

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL375230
PubChem: 11352337

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 417289