Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.1462 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.0393 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0139 | 0.1637 | 0.1295 |
Echinococcus multilocularis | cathepsin b | 0.0594 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0196 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0196 | 0.2688 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0594 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0189 | 0.2551 | 0.2551 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | calpain | 0.0071 | 0.0393 | 0.0393 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0594 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0196 | 0.2688 | 0.2688 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1244 | 0.1244 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0196 | 0.2688 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.0393 |
Echinococcus multilocularis | cathepsin b | 0.0594 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0196 | 0.2688 | 0.2389 |
Giardia lamblia | Cathepsin B precursor | 0.0196 | 0.2688 | 0.5 |
Trypanosoma brucei | calpain-like protein, putative | 0.0071 | 0.0393 | 0.1462 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0196 | 0.2688 | 0.5 |
Echinococcus granulosus | calpain A | 0.0197 | 0.2708 | 0.2409 |
Entamoeba histolytica | calpain large subunit domain III containing protein | 0.005 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0189 | 0.2551 | 0.2246 |
Echinococcus granulosus | cathepsin b | 0.0594 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0594 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0594 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0189 | 0.2551 | 0.2551 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Plasmodium vivax | calpain, putative | 0.0071 | 0.0393 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0594 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0189 | 0.2551 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2551 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2158 | 0.2158 |
Trypanosoma brucei | calpain-like protein, putative | 0.0071 | 0.0393 | 0.1462 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0594 | 1 | 1 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.1462 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0197 | 0.2708 | 0.2409 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0197 | 0.2708 | 0.2409 |
Trypanosoma brucei | calpain-like protein, putative | 0.0071 | 0.0393 | 0.1462 |
Trypanosoma brucei | calpain-like protein, putative | 0.0071 | 0.0393 | 0.1462 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0139 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1637 | 0.1637 |
Toxoplasma gondii | cathepsin B | 0.0196 | 0.2688 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0196 | 0.2688 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.0393 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0197 | 0.2708 | 0.2409 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Echinococcus multilocularis | calpain A | 0.0197 | 0.2708 | 0.2409 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.1462 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0071 | 0.0393 | 0.1462 |
Brugia malayi | calpain 7 | 0.0071 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | cathepsin B | 0.0196 | 0.2688 | 0.2688 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0071 | 0.0393 | 0.1462 |
Onchocerca volvulus | 0.0117 | 0.1244 | 0.5 | |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0071 | 0.0393 | 0.0393 |
Trypanosoma brucei | antigen, putative | 0.0071 | 0.0393 | 0.1462 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0197 | 0.2708 | 0.2409 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 200 uM | Cytotoxicity against mouse L1210/0 cells after 48 hrs | ChEMBL. | 17341060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.