TDR Targets

Basic information

Technical information

TDR Targets ID: 420599
Name: (5Z)-5-[(4-fluorophenyl)methylidene]-2-sulfan ylidene-1,3-thiazolidin-4-one
MW: 239.289 | Formula: C10H6FNOS2
H donors: 1 H acceptors: 1 LogP: 2.9 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=S)S/C/1=C\c1ccc(cc1)F
InChi: 1S/C10H6FNOS2/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5-
InChiKey: BQOQSIQMDZUHKF-YVMONPNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(4-fluorophenyl)methylene]-2-thioxo-thiazolidin-4-one
(5Z)-5-[(4-fluorophenyl)methylene]-2-thioxo-4-thiazolidinone
(5Z)-5-(4-fluorobenzylidene)-2-thioxo-thiazolidin-4-one
5-[(4-fluorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
5-[(4-fluorophenyl)methylene]-2-thioxo-thiazolidin-4-one
5-[(4-fluorophenyl)methylene]-2-thioxo-4-thiazolidinone
5-(4-fluorobenzylidene)-2-thioxo-thiazolidin-4-one
402-93-7
ZINC00977257
BRN 0171047
NSC 32121
Rhodanine, 5-(p-fluorobenzylidene)- (8CI)
STOCK2S-88393
STK281842
5-(4-Fluorobenzylidene)rhodanine
NSC32121
Rhodanine, 5-(4-fluorobenzylidene)-
Rhodanine, 5-(p-fluorobenzylidene)-

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	N-acetyltransferase 1 (arylamine N-acetyltransferase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	Get druggable targets OG5_131280	All targets in OG5_131280
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	Get druggable targets OG5_131280	All targets in OG5_131280

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.1876	1	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.1876	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.0141	1
Brugia malayi	protein-tyrosine kinase	0.0033	0.0074	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Brugia malayi	SRC-1	0.0037	0.0093	0.0083
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0763	0.4005	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0033	0.0074	0.0063
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0033	0.0074	0.0063
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.1876	1	1
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.1876	1	0.5
Brugia malayi	nuclear receptor RXR	0.0024	0.0025	0.0014
Loa Loa (eye worm)	TK protein kinase	0.0033	0.0074	0.0063
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0307	0.0296
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0093	0.0083
Brugia malayi	ecdysteroid receptor	0.0046	0.0141	0.013
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0558	0.0547
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0025	0.0014
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.0141	0.013
Brugia malayi	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.0141	0.013
Echinococcus multilocularis	dual specificity	0.0123	0.0558	0.0547
Giardia lamblia	Aurora kinase	0.1876	1	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0037	0.0093	0.0083
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.1876	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0141	0.013
Echinococcus granulosus	dual specificity	0.0123	0.0558	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0037	0.0093	0.0083
Schistosoma mansoni	tyrosine kinase	0.0037	0.0093	0.0083
Entamoeba histolytica	protein kinase domain containing protein	0.0123	0.0558	0.0558
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0033	0.0074	0.0063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.0141	0.013
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.0141	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.0141	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.1876	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.0141	0.013
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.0141	0.013
Brugia malayi	steroid hormone receptor	0.0046	0.0141	0.013
Echinococcus multilocularis	aurora kinase A	0.1876	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0307	0.0296
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.0123	0.0558	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.0558	0.0547
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0307	0.0296
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0033	0.0074	0.0063
Loa Loa (eye worm)	SRC-1	0.0037	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.1876	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.0141	0.013
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.0141	0.013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Entamoeba histolytica	hypothetical protein	0.0123	0.0558	0.0558
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	serine/threonine kinase 12	0.1876	1	1
Brugia malayi	hypothetical protein	0.0024	0.0025	0.0014
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0037	0.0093	0.0083
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.0141	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.0141	0.013
Schistosoma mansoni	coup transcription factor	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0033	0.0074	0.0063
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.0141	0.013
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0763	0.4005	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0025	0.0014
Trypanosoma brucei	aurora B kinase	0.1876	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.0141	0.013
Onchocerca volvulus		0.0046	0.0141	1
Toxoplasma gondii	aurora kinase	0.1876	1	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0037	0.0093	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0472	0.0462
Brugia malayi	TAR-binding protein	0.0076	0.0307	0.0296
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase HCK	0.003	0.0054	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.0141	0.013
Brugia malayi	serine/threonine-protein kinase 6	0.1876	1	1
Entamoeba histolytica	protein kinase, putative	0.1876	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0037	0.0093	0.0083
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.0141	0.013
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.003	0.0054	0.0054
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0025	0.0014
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.0141	0.013
Brugia malayi	nuclear hormone receptor	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0025	0.0014
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine kinase	0.0033	0.0074	0.0063
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0307	0.0296
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.0141	0.013
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase HCK	0.003	0.0054	0.0043
Schistosoma mansoni	retinoic acid receptor RXR	0.0046	0.0141	0.013
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Trypanosoma cruzi	aurora B kinase, putative	0.1876	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0025	0.0014
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0123	0.0558	0.0547
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0141	0.013
Trichomonas vaginalis	AGC family protein kinase	0.1876	1	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.0141	0.013
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0053	0.0179	0.0168
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0037	0.0093	0.0083
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0037	0.0093	0.0083
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0141	0.013
Entamoeba histolytica	protein kinase, putative	0.0123	0.0558	0.0558
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.0141	0.013
Leishmania major	protein kinase, putative	0.1876	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Loa Loa (eye worm)	AUR protein kinase	0.1876	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.0141	0.013
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0307	0.0296
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.0141	0.013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0141	0.013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0472	0.0462
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.1876	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1876	1	1
Entamoeba histolytica	protein kinase , putative	0.1876	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.0141	0.013
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0032	0.0068	0.0058
Schistosoma mansoni	tyrosine kinase	0.0037	0.0093	0.0083
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.0141	0.013
Schistosoma mansoni	protein kinase	0.1876	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0014
Echinococcus granulosus	aurora kinase A	0.1876	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.0141	0.013
Brugia malayi	RNA binding protein	0.0076	0.0307	0.0296
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.1876	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0046	0.0141	0.013
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0307	0.0296
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0141	0.013
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0093	0.0083
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.0141	0.013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0032	0.0068	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.0141	0.013
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.0141	0.013
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0046	0.0141	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0141	0.013
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0037	0.0093	0.0083
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0093	0.0083
Loa Loa (eye worm)	TK protein kinase	0.003	0.0054	0.0043

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12.9 uM	Inhibition of human recombinant NAT1 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method	ChEMBL.	19059786
Inhibition (binding)	< 40 %	Inhibition of Pseudomonas aeruginosa recombinant NAT using isoniazid as substrate at 30 uM	ChEMBL.	19059786
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida parapsilosis C124-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida lusitanae C131-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida colliculosa C122-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida tropicalis C131-1997 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	31.2 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida kefyr C123-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	31.2 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 51.6 ug ml-1	Antifungal activity against Candida glabrata C115-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida krusei C117-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MFC (functional)	= 62.5 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C140 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C139 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C137 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C136 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C135 after 48 hrs	ChEMBL.	17049255
MIC (functional)	0	Antifungal activity against Trichophyton rubrum C110 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 0.97 ug ml-1	Antifungal activity against Trichophyton mentagrophytes C943 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 0.97 ug ml-1	Antifungal activity against Trichophyton mentagrophytes C364 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 1.95 ug ml-1	Antifungal activity against Trichophyton mentagrophytes C738 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 1.95 ug ml-1	Antifungal activity against Trichophyton mentagrophytes C539 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 1.95 ug ml-1	Antifungal activity against Trichophyton mentagrophytes C108 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans ATCC 10231 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Cryptococcus neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Trichophyton mentagrophytes ATCC 9972 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida glabrata C115-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida parapsilosis C124-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida lusitanae C131-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida colliculosa C122-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida tropicalis C131-1997 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans ATCC 10231 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Cryptococcus neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Microsporum gypseum C115 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 15.6 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida krusei C117-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida kefyr C123-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 31.2 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 32 ug ml-1	Antifungal activity against Trichophyton rubrum C113 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 250 ug ml-1	Antifungal activity against Aspergillus niger ATCC 9029 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 250 ug ml-1	Antifungal activity against Aspergillus fumigatus ATCC 26934 after 48 hrs	ChEMBL.	17049255
MIC (functional)	= 250 ug ml-1	Antifungal activity against Aspergillus flavus ATCC 9170 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	3.9 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida glabrata C115-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida lusitanae C131-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida colliculosa C122-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida krusei C117-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida kefyr C123-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida tropicalis C131-1997 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	3.9 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida parapsilosis C124-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC50 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 983040 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 00319 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 972751 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 1.9 ug ml-1	Antifungal activity against Candida neoformans IM 052470 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida glabrata C115-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida parapsilosis C124-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida lusitanae C131-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida colliculosa C122-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 042074 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 031631 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 3.9 ug ml-1	Antifungal activity against Candida neoformans IM 031706 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida krusei C117-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida kefyr C123-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida tropicalis C131-1997 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C125-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C129-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida albicans C130-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans ATCC 32264 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 972724 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 983036 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 7.8 ug ml-1	Antifungal activity against Candida neoformans IM 961951 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C126-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C127-2000 after 48 hrs	ChEMBL.	17049255
MIC80 (functional)	= 15.6 ug ml-1	Antifungal activity against Candida albicans C128-2000 after 48 hrs	ChEMBL.	17049255

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL387624
PubChem: 1207359

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 420599