Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | vivapain-2 | 0.0027 | 0.086 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0027 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0027 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0027 | 0.086 | 0.0603 |
Entamoeba histolytica | cysteine protease, putative | 0.0027 | 0.086 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0027 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Echinococcus granulosus | cathepsin b | 0.0143 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.005 | 0.2688 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0027 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.086 | 0.0603 |
Onchocerca volvulus | Cathepsin L homolog | 0.0027 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0027 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0027 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin b | 0.0143 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0143 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0027 | 0.086 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cysteine protease | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0143 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.005 | 0.2688 | 0.2482 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0027 | 0.086 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0027 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.005 | 0.2688 | 0.2688 |
Plasmodium vivax | vivapain-2 | 0.0027 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0143 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0274 | 0.0274 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0019 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | ctsf protein | 0.0027 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.005 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.005 | 0.2688 | 1 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0027 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0027 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0027 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0274 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.005 | 0.2688 | 1 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.005 | 0.2688 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0143 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0143 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | 0 mmHg | The compound was tested for antihypertensive effect in spontaneously hypertensive rat (SHR), expressed as fall in blood pressure (BP) at 50 mg/kg dose given orally; Inactive | ChEMBL. | 7452695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.