Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4605 | 0.4303 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0196 | 0.6 | 0.6134 |
Mycobacterium ulcerans | hypothetical protein | 0.0165 | 0.4675 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0284 | 0.9782 | 1 |
Schistosoma mansoni | inositol transporter | 0.0156 | 0.431 | 0.431 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0163 | 0.4605 | 0.4605 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Schistosoma mansoni | protein kinase | 0.0122 | 0.2851 | 0.2851 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0068 | 0.053 | 0.053 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0196 | 0.6 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0196 | 0.6 | 0.6 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0156 | 0.431 | 0.5346 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0165 | 0.4675 | 0.4585 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0182 | 0.5393 | 0.6877 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0289 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0156 | 0.431 | 0.5346 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.4605 | 0.4605 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0165 | 0.4675 | 0.4585 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.6 | 0.5776 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0196 | 0.6 | 0.5776 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0196 | 0.6 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0196 | 0.6 | 0.6134 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0182 | 0.5393 | 0.4084 |
Echinococcus granulosus | solute carrier family 5 | 0.0156 | 0.431 | 0.3992 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0176 | 0.5137 | 0.5251 |
Schistosoma mansoni | protein kinase | 0.0122 | 0.2851 | 0.2851 |
Schistosoma mansoni | protein kinase | 0.0122 | 0.2851 | 0.2851 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0284 | 0.9782 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0156 | 0.431 | 0.3992 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0107 | 0.2212 | 0.1776 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0196 | 0.6 | 0.6134 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0196 | 0.6 | 0.5 |
Brugia malayi | proprotein convertase 2 | 0.0182 | 0.5393 | 0.4084 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4605 | 0.4303 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0196 | 0.6 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0196 | 0.6 | 0.6134 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0122 | 0.2851 | 0.2451 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0176 | 0.5137 | 0.6515 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0196 | 0.6 | 0.4864 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0126 | 0.2995 | 0.2995 |
Schistosoma mansoni | inositol transporter | 0.0156 | 0.431 | 0.431 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0163 | 0.4605 | 0.3073 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0163 | 0.4605 | 0.4605 |
Mycobacterium leprae | conserved hypothetical protein | 0.0165 | 0.4675 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0163 | 0.4605 | 0.4303 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0122 | 0.2851 | 0.3282 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0196 | 0.6 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0196 | 0.6 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0163 | 0.4605 | 0.4303 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0196 | 0.6 | 0.7735 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0107 | 0.2209 | 0.2258 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0196 | 0.6 | 0.6 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0196 | 0.6 | 0.2595 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0182 | 0.5393 | 0.5135 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0289 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0196 | 0.6 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0163 | 0.4605 | 0.3073 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0156 | 0.431 | 0.3992 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0176 | 0.5137 | 0.4865 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0196 | 0.6 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0165 | 0.4675 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0156 | 0.431 | 0.5346 |
Echinococcus granulosus | furin | 0.0289 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.9782 | 1 |
Brugia malayi | celfurPC protein | 0.0233 | 0.7602 | 0.6921 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0176 | 0.5137 | 0.5251 |
Plasmodium vivax | RNA helicase-1, putative | 0.0196 | 0.6 | 0.5 |
Echinococcus multilocularis | 0.0233 | 0.7602 | 1 | |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0196 | 0.6 | 0.7735 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2465 | 0.2043 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0163 | 0.4605 | 0.5762 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0068 | 0.053 | 0.0542 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0156 | 0.431 | 0.3992 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0196 | 0.6 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0196 | 0.6 | 0.5776 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0163 | 0.4605 | 0.5762 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 13 % | Inhibition of MDR1 overexpressed in MDCK cells at 5 uM relative to LSN335984 | ChEMBL. | 18849167 |
Inhibition (binding) | = 74 % | Inhibition of MDR1 overexpressed in MDCK cells at 25 uM relative to LSN335984 | ChEMBL. | 18849167 |
Kb (binding) | = 5.2 10^4/M | Binding affinity to calf thymus DNA by spectrophotometric titration method | ChEMBL. | 17498962 |
Kb (binding) | = 6.1 10^4/M | Binding affinity to M13mp19 DNA by spectrophotometric titration method | ChEMBL. | 17498962 |
Kb (binding) | = 1.7 10^5/M | Binding affinity to calf thymus DNA by isothermal titration calorimetry | ChEMBL. | 17498962 |
Kb (binding) | = 66 10^6/M | Binding affinity to pUC19 DNA assessed as drug concentration to induce plasmid re-supercoiling by topoisomerase 1 DNA unwinding assay | ChEMBL. | 17498962 |
LogP | = 0.6 | Partition coefficient, log P of the compound by shake flask method | ChEMBL. | 17498962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.