Detailed information for compound 426286

Basic information

Technical information
  • TDR Targets ID: 426286
  • Name: (5R)-3-[3-fluoro-4-(4-thiophen-2-ylsulfonylpi perazin-1-yl)phenyl]-5-(triazol-1-ylmethyl)-1 ,3-oxazolidin-2-one
  • MW: 492.547 | Formula: C20H21FN6O4S2
  • H donors: 0 H acceptors: 5 LogP: 1.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[C@H](CN1c1ccc(c(c1)F)N1CCN(CC1)S(=O)(=O)c1cccs1)Cn1nncc1
  • InChi: 1S/C20H21FN6O4S2/c21-17-12-15(27-14-16(31-20(27)28)13-25-6-5-22-23-25)3-4-18(17)24-7-9-26(10-8-24)33(29,30)19-2-1-11-32-19/h1-6,11-12,16H,7-10,13-14H2/t16-/m0/s1
  • InChiKey: IFQWVBGDXZAILU-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)piperazin-1-yl]phenyl]-5-(triazol-1-ylmethyl)oxazolidin-2-one
  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)-1-piperazinyl]phenyl]-5-(1-triazolylmethyl)-2-oxazolidinone
  • (5R)-3-[3-fluoro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)phenyl]-5-(1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one
  • (5R)-3-[3-fluoro-4-[4-(2-thienylsulfonyl)piperazino]phenyl]-5-(triazol-1-ylmethyl)oxazolidin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0167 0.0191
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Echinococcus granulosus calpain 5 0.0058 0.0382 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Schistosoma mansoni calpain (C02 family) 0.0058 0.0382 0.0382
Toxoplasma gondii PAN domain-containing protein 0.0338 0.3972 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Onchocerca volvulus 0.006 0.0412 0.362
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Brugia malayi Kringle domain containing protein 0.0083 0.0703 0.0703
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Plasmodium vivax calpain, putative 0.0058 0.0382 0.5437
Schistosoma mansoni furin-1 (S08 family) 0.0089 0.0779 0.0779
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0106 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.1106 0.4098
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0106 0.0266
Onchocerca volvulus 0.006 0.0412 0.362
Toxoplasma gondii PAN/Apple domain-containing protein 0.0049 0.0271 0.0683
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Toxoplasma gondii cathepsin B 0.0238 0.27 0.6796
Onchocerca volvulus 0.0031 0.0035 0.0312
Plasmodium falciparum cysteine proteinase falcipain 1 0.0041 0.0167 0.2374
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Echinococcus granulosus cathepsin L cysteine protease 0.0041 0.0167 0.0191
Plasmodium vivax subtilisin-like protease 1 0.0031 0.0035 0.0504
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trypanosoma cruzi cysteine protease, putative 0.0041 0.0167 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0035 0.0041
Schistosoma mansoni site-1 peptidase (S08 family) 0.0031 0.0035 0.0035
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Brugia malayi endoprotease bli-4 precursor 0.0172 0.185 0.185
Loa Loa (eye worm) hypothetical protein 0.0083 0.0703 0.0703
Toxoplasma gondii subtilisin SUB2 0.0031 0.0035 0.0089
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Toxoplasma gondii subtilisin SUB9 0.0031 0.0035 0.0089
Loa Loa (eye worm) hypothetical protein 0.0136 0.1388 0.1388
Giardia lamblia High cysteine membrane protein Group 2 0.0055 0.0341 0.1263
Echinococcus granulosus cathepsin L cysteine proteinase 0.006 0.0412 0.0471
Trypanosoma cruzi kinesin, putative 0.0041 0.0158 0.0181
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Onchocerca volvulus 0.0083 0.0703 0.6181
Echinococcus multilocularis neuroendocrine convertase 2 0.0117 0.1145 0.1312
Toxoplasma gondii microneme protein MIC4 0.0049 0.0271 0.0683
Brugia malayi calpain 5 0.0041 0.0158 0.0158
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0167 0.0191
Brugia malayi Cathepsin L-like precursor 0.0047 0.0245 0.0245
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0412 0.0412
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0245 0.0906
Echinococcus granulosus Furin 1 0.006 0.0402 0.0461
Echinococcus granulosus cathepsin l1 0.006 0.0412 0.0471
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0114 0.1106 0.1267
Loa Loa (eye worm) ctsf protein 0.006 0.0412 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2b 0.006 0.0412 0.5856
Entamoeba histolytica calpain large subunit domain III containing protein 0.0041 0.0158 0.3841
Echinococcus multilocularis cysteine protease 0.006 0.0412 0.0471
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Onchocerca volvulus 0.0096 0.0867 0.7628
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.1137 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.1301
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0412 0.0412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Plasmodium vivax vivapain-2 0.006 0.0412 0.5856
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Brugia malayi calpain family protein 1 0.0154 0.1612 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Echinococcus granulosus calpain A 0.0164 0.1747 0.2001
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0412 0.0412
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0121
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Toxoplasma gondii subtilisin SUB8 0.0031 0.0035 0.0089
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0031 0.0035 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Toxoplasma gondii kringle domain-containing protein 0.0083 0.0703 0.1769
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Toxoplasma gondii PAN domain-containing protein 0.0338 0.3972 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0306 0.3568 0.4087
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0058 0.0382 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0412 0.1524
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Toxoplasma gondii cathepsin CPL 0.006 0.0412 0.1036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.006 0.0412 0.0412
Brugia malayi calpain 7 0.0058 0.0382 0.0382
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Giardia lamblia Furin precursor putative serine protease 0.0029 0.0003 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0029 0.0003 0.0013
Brugia malayi cathepsin B-like cysteine proteinase 0.0708 0.8729 0.8729
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0049 0.0271 0.0683
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Echinococcus multilocularis 0.0144 0.1483 0.1699
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0263
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0154 0.1612 0.1612
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0238 0.27 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Toxoplasma gondii subtilisin SUB4 0.0031 0.0035 0.0089
Leishmania major cysteine peptidase A (CPA) 0.006 0.0412 0.1412
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Echinococcus granulosus cathepsin l1 0.0047 0.0245 0.028
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Onchocerca volvulus 0.0049 0.0271 0.2385
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0083 0.0703 1
Onchocerca volvulus 0.0049 0.0271 0.2385
Plasmodium vivax vivapain-1 0.0041 0.0167 0.2374
Echinococcus multilocularis cathepsin L 0.0041 0.0167 0.0191
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0029 0.0003 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Schistosoma mansoni inositol monophosphatase 0.0036 0.0106 0.0106
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0057 1
Echinococcus multilocularis Furin 1 0.006 0.0402 0.0461
Echinococcus granulosus cathepsin b 0.0708 0.8729 1
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.006 0.0412 0.362
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Onchocerca volvulus 0.0049 0.0271 0.2385
Onchocerca volvulus 0.0049 0.0271 0.2385
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0167 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0167 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Plasmodium falciparum subtilisin-like protease 1 0.0031 0.0035 0.0504
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.1009 0.1156
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus multilocularis hypothetical protein 0.0058 0.0382 0.0438
Plasmodium falciparum subtilisin-like protease 3 0.0031 0.0035 0.0504
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Schistosoma mansoni site-1 peptidase (S08 family) 0.0031 0.0035 0.0035
Onchocerca volvulus 0.006 0.0412 0.362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Onchocerca volvulus 0.0047 0.0245 0.2152
Echinococcus multilocularis calpain family protein 1, d 0.0113 0.1091 0.125
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0238 0.27 0.3093
Schistosoma mansoni hypothetical protein 0.0083 0.0703 0.0703
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Loa Loa (eye worm) hypothetical protein 0.0154 0.1612 0.1612
Echinococcus granulosus cysteine protease 0.0041 0.0167 0.0191
Plasmodium vivax vivapain-2 0.006 0.0412 0.5856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Onchocerca volvulus 0.0049 0.0271 0.2385
Leishmania major cathepsin L-like protease 0.0107 0.1009 0.3653
Trypanosoma cruzi major cysteine proteinase, putative 0.0075 0.0597 0.0684
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Echinococcus multilocularis tissue type plasminogen activator 0.0083 0.0703 0.0805
Onchocerca volvulus 0.006 0.0412 0.362
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Toxoplasma gondii subtilisin SUB5 0.0031 0.0035 0.0089
Onchocerca volvulus Cathepsin F homolog 0.006 0.0412 0.362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Echinococcus granulosus cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Entamoeba histolytica cysteine proteinase 1, putative 0.0041 0.0167 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0306 0.3568 0.4087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0382 0.0382
Echinococcus granulosus calpain A 0.0058 0.0382 0.0438
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0106 0.0391
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.006 0.0402 0.0402
Loa Loa (eye worm) cysteine protease 0.006 0.0412 0.0412
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0117 0.1137 0.1137
Toxoplasma gondii microneme protein MIC17C 0.0049 0.0271 0.0683
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0114 0.1106 0.1267
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0106 0.0263
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Brugia malayi Inositol-1 0.0036 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0035 0.0041
Trypanosoma brucei antigen, putative 0.0058 0.0382 0.1301
Loa Loa (eye worm) calpain 0.0058 0.0382 0.0382
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0172 0.185 0.185
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0535 0.651 0.7458
Plasmodium falciparum cysteine proteinase falcipain 2a 0.006 0.0412 0.5856
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0412 0.0471
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Plasmodium falciparum subtilisin-like protease 2 0.0031 0.0035 0.0504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Toxoplasma gondii hypothetical protein 0.0049 0.0271 0.0683
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Loa Loa (eye worm) fibroinase 0.006 0.0412 0.0412
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0106 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0167 0.0191
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0031 0.0035 0.0035
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0412 0.0471
Loa Loa (eye worm) subtilase 0.0807 1 1
Echinococcus granulosus calpain 7 C02 family 0.0058 0.0382 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Toxoplasma gondii microneme protein MIC17A 0.0049 0.0271 0.0683
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Onchocerca volvulus Cathepsin L homolog 0.006 0.0412 0.362
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0094 0.0842 0.0964
Schistosoma mansoni calpain C (C02 family) 0.0058 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Toxoplasma gondii hypothetical protein 0.0049 0.0271 0.0683
Brugia malayi Cathepsin L-like cysteine proteinase 0.0047 0.0245 0.0245
Echinococcus multilocularis calpain 5 0.0058 0.0382 0.0438
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma cruzi subtilisin peptidase 0.0031 0.0035 0.0041
Plasmodium falciparum cysteine proteinase falcipain 3 0.006 0.0412 0.5856
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Echinococcus granulosus calpain 0.0058 0.0382 0.0438
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0106 0.0121
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0382 0.0438
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0708 0.8729 1
Echinococcus multilocularis cathepsin b 0.0708 0.8729 1
Toxoplasma gondii subtilisin SUB6 0.0031 0.0035 0.0089
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0058 0.0382 0.1301
Echinococcus granulosus furin 0.0172 0.185 0.2119
Loa Loa (eye worm) inositol-1 0.0036 0.0106 0.0106
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) calpain 5 0.0041 0.0158 0.0158
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0057 1
Toxoplasma gondii subtilisin SUB11 0.0031 0.0035 0.0089
Toxoplasma gondii subtilisin SUB10 0.0031 0.0035 0.0089
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0167 0.0618
Onchocerca volvulus 0.0117 0.1137 1
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Entamoeba histolytica cysteine proteinase 2 0.0041 0.0167 0.4054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0117 0.1137 0.1137
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0708 0.8729 0.8729
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0106 0.0391
Onchocerca volvulus 0.0049 0.0271 0.2385
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0245 0.5946
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0106 1
Echinococcus multilocularis calpain A 0.0164 0.1747 0.2001
Brugia malayi proprotein convertase 2 0.0117 0.1145 0.1145
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0167 0.4054
Leishmania major hypothetical protein, conserved 0.0083 0.0703 0.2505
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0412 1
Echinococcus multilocularis cathepsin b 0.0708 0.8729 1
Entamoeba histolytica protein kinase, putative 0.0041 0.0158 0.3841
Brugia malayi calpain family protein 1 0.0154 0.1612 0.1612
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0106 0.0121
Plasmodium vivax vivapain-3 0.0041 0.0167 0.2374
Echinococcus granulosus membrane bound transcription factor site 1 0.0031 0.0035 0.0041
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Onchocerca volvulus 0.0049 0.0271 0.2385
Toxoplasma gondii subtilisin SUB1 0.0031 0.0035 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0703 0.0805
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0164 0.1744 0.1998
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0238 0.27 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0238 0.27 0.27
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0167 0.0493
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0167 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma brucei cysteine peptidase C (CPC) 0.0238 0.27 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.1106 0.4098
Loa Loa (eye worm) hypothetical protein 0.0058 0.038 0.038
Onchocerca volvulus 0.0092 0.0818 0.7195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0167 0.0618
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0807 1 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0058 0.0382 0.0438
Loa Loa (eye worm) hypothetical protein 0.0708 0.8729 0.8729
Toxoplasma gondii microneme protein, putative 0.0049 0.0271 0.0683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) calpain family protein 1 0.0154 0.1612 0.1612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Brugia malayi cathepsin L-like precursor 0.0047 0.0245 0.0245
Brugia malayi celfurPC protein 0.0144 0.1483 0.1483
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.006 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Echinococcus granulosus neuroendocrine convertase 2 0.0117 0.1145 0.1312
Onchocerca volvulus 0.006 0.0412 0.362
Loa Loa (eye worm) endoprotease bli-4 0.0172 0.185 0.185
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Loa Loa (eye worm) calpain family protein 1 0.0113 0.1091 0.1091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Onchocerca volvulus Cathepsin L homolog 0.006 0.0412 0.362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) hypothetical protein 0.0172 0.185 0.185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Leishmania major kinesin, putative 0.0041 0.0158 0.046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Echinococcus multilocularis membrane bound transcription factor site 1 0.0031 0.0035 0.0041
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0031 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Brugia malayi Protein kinase domain containing protein 0.0083 0.0703 0.0703
Loa Loa (eye worm) cathepsin B 0.0238 0.27 0.27
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Echinococcus multilocularis cysteine protease 0.006 0.0412 0.0471
Toxoplasma gondii subtilisin SUB12 0.008 0.067 0.1686
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0113 0.1091 0.1091
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.1009 0.1156
Toxoplasma gondii microneme protein MIC17B 0.0049 0.0271 0.0683
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Echinococcus granulosus cathepsin b 0.0708 0.8729 1
Echinococcus granulosus tm gpcr rhodopsin 0.0535 0.651 0.7458
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0382 0.0438
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Brugia malayi neuroendocrine convertase 1 precursor 0.0117 0.1145 0.1145
Leishmania major cathepsin L-like protease 0.006 0.0412 0.1412
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Echinococcus multilocularis calpain 0.0058 0.0382 0.0438
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0031 0.0035 0.0035
Trypanosoma brucei kinesin, putative 0.0041 0.0158 0.046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0167 0.0167
Schistosoma mansoni Mername-AA248 (C02 family) 0.0058 0.0382 0.0382
Giardia lamblia Cathepsin B precursor 0.0238 0.27 1
Brugia malayi Trypsin family protein 0.0117 0.1137 0.1137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0106 0.2567
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0382 0.1301
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Brugia malayi Cathepsin L-like precursor 0.0047 0.0245 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0708 0.8729 0.8729
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Trypanosoma cruzi kinesin, putative 0.0041 0.0158 0.0181
Schistosoma mansoni inositol monophosphatase 0.0036 0.0106 0.0106
Brugia malayi Cathepsin L-like precursor 0.006 0.0412 0.0412
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.1744 0.1744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0412 0.0471
Plasmodium vivax subtilisin-like serine protease, putative 0.0031 0.0035 0.0504
Loa Loa (eye worm) hypothetical protein 0.0096 0.0867 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.1009 0.3653
Onchocerca volvulus 0.0049 0.0271 0.2385
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0029 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.0271
Brugia malayi PAN domain containing protein 0.0049 0.0271 0.0271
Entamoeba histolytica cysteine protease, putative 0.0041 0.0167 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0245 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0412 0.0471
Echinococcus granulosus cathepsin L 0.0041 0.0167 0.0191
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0041 0.0167 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0412 1
Trichomonas vaginalis hypothetical protein 0.0029 0.0003 0.0013
Echinococcus granulosus tissue type plasminogen activator 0.0083 0.0703 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0003 0.0013
Toxoplasma gondii subtilisin SUB7 0.0031 0.0035 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Plasmodium vivax subtilisin-like protease 2, putative 0.0031 0.0035 0.0504
Toxoplasma gondii PAN domain-containing protein 0.0049 0.0271 0.0683
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.006 0.0402 0.1489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) PAN domain-containing protein 0.0049 0.0271 0.0271
Onchocerca volvulus 0.006 0.0412 0.362
Loa Loa (eye worm) proprotein convertase 2 0.006 0.0402 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0412 0.1524
Plasmodium vivax unspecified product 0.0041 0.0167 0.2374
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0035 0.0131
Plasmodium falciparum cysteine repeat modular protein 1 0.0083 0.0703 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0035 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0412 0.1524
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0035

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-resistant Staphylococcus aureus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-susceptible coagulase-negative staphylococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against vancomycin-sensitive Enterococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against vancomycin-resistant Enterococcus by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Staphylococcus aureus ATCC 25922 by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antimicrobial activity against Streptococcus pneumoniae by agar dilution method ChEMBL. 17140706
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-susceptible Staphylococcus aureus by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-resistant Staphylococcus aureus by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against methicillin-resistant Staphylococcus epidermidis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against Enterococcus faecalis by microdilution broth method ChEMBL. 17363116
MIC (functional) = 1 ug ml-1 Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by microdilution broth method ChEMBL. 17363116
MIC (functional) > 8 ug ml-1 Antimicrobial activity against Staphylococcus aureus ATCC 25922 in presence of 50% human plasma by agar dilution method ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial avtivity against Haemophilus influenzae ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Moraxella catarrhalis ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 ChEMBL. 17140706
MIC (functional) >= 8 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 ChEMBL. 17140706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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