Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; alpha-1/beta-2/gamma-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0211 | 0.6745 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.6491 | 0.9625 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | caspase 3 | 0.0072 | 0.1658 | 0.635 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0117 | 0.3311 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0183 | 0.5737 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | metacaspase 1 | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.03 | 1 | 1 |
Leishmania major | metacaspase, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.03 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0098 | 0.2611 | 0.7886 |
Trypanosoma brucei | metacaspase | 0.0026 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0117 | 0.3311 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0183 | 0.5737 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Plasmodium vivax | metacaspase 1, putative | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | caspase | 0.0098 | 0.2611 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0098 | 0.2611 | 1 |
Echinococcus granulosus | caspase | 0.0098 | 0.2611 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0098 | 0.2611 | 0.7886 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.6745 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | metacaspase-like protein | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0183 | 0.5737 | 0.3627 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0098 | 0.2611 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0026 | 0 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0183 | 0.5737 | 0.3627 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.03 | 1 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0072 | 0.1658 | 0.635 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0117 | 0.3311 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity against pentylenetetrazole-induced seizures in non-Swiss Albino mouse at 50 mg/kg, ip | ChEMBL. | 17571865 | |
Activity (functional) | 0 | Anticonvulsant activity against pentylenetetrazole-induced seizures in non-Swiss Albino mouse at 50 mg/kg, ip | ChEMBL. | 17571865 |
IC50 (binding) | = 7.1 | Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptor | ChEMBL. | 20684859 |
IC50 (binding) | = 80 nM | Displacement of [35S]TBPS from GABAA receptor in Sprague-Dawley rat cortex membrane | ChEMBL. | 17571865 |
Imax (binding) | = 86 % | Displacement of [35S]TBPS from GABAA receptor in Sprague-Dawley rat cortex membrane | ChEMBL. | 17571865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.