Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) | Isocitrate lyase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Mycobacterium leprae | Isocitrate lyase | Isocitrate lyase | 547 aa | 536 aa | 35.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0627 | 0.8223 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0226 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0226 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.5371 | 0.5371 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 0.8223 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0488 | 0.5371 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0627 | 0.8223 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0226 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0714 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0226 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 0.8223 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0627 | 0.8223 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0488 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0714 | 1 | 1 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.0627 | 0.8223 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0226 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0226 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0714 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Reduction of appressorium formation in wild type Magnaporthe grisea Guy 11 after 14 hrs | ChEMBL. | 17317180 |
IC50 (binding) | Inhibition of His-tagged human platelet 12-lipoxygenase | ChEMBL. | 12608855 | |
IC50 (binding) | = 0.5 uM | Inhibition of His-tagged human reticulocyte 15-lipoxygenase | ChEMBL. | 12608855 |
IC50 (binding) | = 15 uM | Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase | ChEMBL. | 17317180 |
IC50 (binding) | = 15 uM | Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase | ChEMBL. | 17317180 |
IC50 (binding) | = 273.6 uM | Inhibition of Magnaporthe grisea Guy 11 malate synthase | ChEMBL. | 17317180 |
MIC (functional) | = 105.4 uM | Growth inhibition of Magnaporthe grisea Guy 11 in presence of sodium acetate after 6 days | ChEMBL. | 17317180 |
MIC (functional) | = 842.8 uM | Growth inhibition of Magnaporthe grisea Guy 11 in presence of glucose after 6 days | ChEMBL. | 17317180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.