TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.329 | Formula: C22H23Cl2NO3
H donors: 2 H acceptors: 3 LogP: 6.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@H](NC(=O)c1ccc(c(c1)c1ccc(cc1)Cl)Cl)CC1CCCCC1
InChi: 1S/C22H23Cl2NO3/c23-17-9-6-15(7-10-17)18-13-16(8-11-19(18)24)21(26)25-20(22(27)28)12-14-4-2-1-3-5-14/h6-11,13-14,20H,1-5,12H2,(H,25,26)(H,27,28)/t20-/m1/s1
InChiKey: XUCFUHUVLHILOK-HXUWFJFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0863	0.0856
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0791	0.3852	0.3828
Loa Loa (eye worm)	hypothetical protein	0.199	1	1
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0282	0.1238	0.1204
Onchocerca volvulus		0.0223	0.0936	0.0888
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0057	0.0535
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0302	0.0302
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0052	0.0057	0.0051
Echinococcus multilocularis	cathepsin L	0.0121	0.0414	0.0406
Brugia malayi	ecdysteroid receptor	0.0163	0.0626	0.0619
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.047	0.2201	0.2201
Trypanosoma brucei	prolyl endopeptidase	0.199	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0863	0.0856
Leishmania major	C-8 sterol isomerase-like protein	0.0381	0.1747	0.1715
Echinococcus granulosus	expressed conserved protein	0.0092	0.0264	0.0256
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.0863	0.0856
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0282	0.1238	0.1204
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0414	0.4054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0269	0.0269
Onchocerca volvulus		0.0223	0.0936	0.0888
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0143	0.0135
Brugia malayi	Cathepsin L-like precursor	0.0154	0.058	0.0573
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0218	0.0909	0.0909
Brugia malayi	aspartic protease BmAsp-2, identical	0.0051	0.0053	0.0045
Schistosoma mansoni	cathepsin s	0.0069	0.0149	0.0149
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Trypanosoma cruzi	cruzipain precursor, putative	0.0223	0.0936	0.0901
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0209	0.0863	0.9211
Onchocerca volvulus		0.0223	0.0936	0.0888
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0223	0.0936	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Trypanosoma cruzi	Emopamil binding protein, putative	0.0282	0.1238	0.1204
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0154	0.058	0.0573
Trypanosoma cruzi	Emopamil binding protein, putative	0.0282	0.1238	0.1204
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0052	0.0057	0.0004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.0057	0.005
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0209	0.0863	0.0814
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.058	0.058
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0181	0.072	0.7675
Plasmodium falciparum	serine repeat antigen 4	0.0052	0.0057	0.0051
Onchocerca volvulus		0.0282	0.1238	0.1191
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0052	0.0057	0.005
Brugia malayi	Hint module family protein	0.0054	0.0068	0.006
Plasmodium vivax	vivapain-3	0.0121	0.0414	0.4084
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.0863	0.0856
Loa Loa (eye worm)	hypothetical protein	0.047	0.2201	0.2195
Echinococcus granulosus	Desert hedgehog protein	0.0198	0.0807	0.08
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.0057	0.0535
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0051	0.0053	0.0045
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0048	0.0039	0.0039
Echinococcus granulosus	cathepsin l1	0.0154	0.058	0.0573
Onchocerca volvulus		0.0052	0.0057	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0414	0.4372
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0149	0.011
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.047	0.2201	0.2201
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0143	0.0135
Onchocerca volvulus	Cathepsin L homolog	0.0223	0.0936	0.0888
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0269	0.0262
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.047	0.2201	0.2201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0057	0.0057
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0057	0.0019
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0863	0.0856
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0069	0.0149	0.0141
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.0863	0.0856
Echinococcus multilocularis	geminin	0.0183	0.073	0.0723
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0121	0.0414	0.0414
Trypanosoma brucei	oligopeptidase b	0.0791	0.3852	0.3828
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.058	0.5946
Schistosoma mansoni	cathepsin F (C01 family)	0.0223	0.0936	0.0936
Brugia malayi	Papain family cysteine protease containing protein	0.0052	0.0057	0.005
Giardia lamblia	Cathepsin B precursor	0.0181	0.072	0.8229
Echinococcus granulosus	cathepsin b	0.047	0.2201	0.2195
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0209	0.0863	0.0828
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0307	0.03
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0068	0.006
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0149	0.0141
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0038	0.003
Schistosoma mansoni	memapsin-2 (A01 family)	0.1266	0.6283	0.6283
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0052	0.0057	0.0051
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0057	0.0057
Trypanosoma cruzi	cysteine proteinase, putative	0.0121	0.0414	0.0377
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0863	0.0856
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0052	0.0057	0.0535
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.0863	0.0814
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0791	0.3852	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0209	0.0863	0.0828
Brugia malayi	TAR-binding protein	0.0068	0.0143	0.0135
Plasmodium vivax	serine-repeat antigen (SERA)	0.0052	0.0057	0.0051
Trypanosoma cruzi	cysteine proteinase, putative	0.0121	0.0414	0.0377
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Plasmodium vivax	unspecified product	0.0121	0.0414	0.4084
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0057	0.0535
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0269	0.0262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0121	0.0414	0.4084
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Plasmodium falciparum	serine repeat antigen 2	0.0052	0.0057	0.0051
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0143	0.0135
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0209	0.0863	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0051	0.0053	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0053	0.0045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0057	0.0057
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0052	0.0057	0.0051
Brugia malayi	Cathepsin L-like precursor	0.0154	0.058	0.0573
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0209	0.0863	0.0856
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0269	0.0269
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0121	0.0414	0.0414
Echinococcus granulosus	cathepsin L cysteine protease	0.0121	0.0414	0.0406
Echinococcus granulosus	cathepsin b	0.047	0.2201	0.2195
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0209	0.0863	0.0856
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.0863	0.9211
Brugia malayi	S-adenosyl-methionine cycloartenol-C24-methyltransferase	0.0303	0.1348	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0154	0.058	0.0573
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0052	0.0057	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.0936	0.0901
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0143	0.0143
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0209	0.0863	0.0828
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Brugia malayi	Hint module family protein	0.0054	0.0068	0.006
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0414	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0223	0.0936	1
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.0863	0.0863
Plasmodium falciparum	serine repeat antigen 1	0.0052	0.0057	0.0051
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0209	0.0863	0.9166
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0414	0.0377
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0121	0.0414	0.0377
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0057	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.058	0.6163
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0269	0.0262
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.047	0.2201	0.217
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0791	0.3852	0.3828
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.0057	0.0535
Plasmodium falciparum	serine repeat antigen 6	0.0052	0.0057	0.0051
Echinococcus multilocularis	hedgehog	0.0198	0.0807	0.08
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0181	0.072	0.0684
Schistosoma mansoni	cathepsin D (A01 family)	0.0051	0.0053	0.0053
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0051	0.0053	0.0045
Schistosoma mansoni	cathepsin B (C01 family)	0.0052	0.0057	0.0057
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0863	0.0856
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0223	0.0936	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0052	0.0057	0.005
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0282	0.1238	0.1204
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0414	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0181	0.072	0.0684
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0414	0.0406
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0223	0.0936	0.0929
Entamoeba histolytica	cysteine proteinase, putative	0.0121	0.0414	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0143	0.0135
Plasmodium falciparum	serine repeat antigen 5	0.0052	0.0057	0.0051
Trypanosoma cruzi	oligopeptidase b	0.0791	0.3852	0.3828
Echinococcus multilocularis	cathepsin L cysteine protease	0.0223	0.0936	0.0929
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0121	0.0414	0.4372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0052	0.0057	0.0051
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0143	0.0135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0121	0.0414	0.0377
Echinococcus multilocularis	cathepsin b	0.047	0.2201	0.2195
Loa Loa (eye worm)	hypothetical protein	0.0467	0.2189	0.2183
Schistosoma mansoni	cathepsin C	0.0052	0.0057	0.0057
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0209	0.0863	0.0863
Entamoeba histolytica	hypothetical protein, conserved	0.0209	0.0863	0.9166
Onchocerca volvulus		0.0223	0.0936	0.0888
Loa Loa (eye worm)	aspartyl protease 6	0.0051	0.0053	0.0045
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0209	0.0863	0.9211
Echinococcus multilocularis	cathepsin L cysteine protease	0.0223	0.0936	0.0929
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0294	0.0287
Brugia malayi	Papain family cysteine protease containing protein	0.0223	0.0936	0.0929
Toxoplasma gondii	prolyl endopeptidase	0.199	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0143	0.0143
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0223	0.0936	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.072	0.072
Loa Loa (eye worm)	hypothetical protein	0.01	0.0307	0.03
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0149	0.0141
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0057	0.0535
Toxoplasma gondii	cathepsin B	0.0181	0.072	0.0671
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Brugia malayi	cathepsin L precursor	0.0052	0.0057	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0038	0.003
Echinococcus multilocularis	cathepsin b	0.047	0.2201	0.2195
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0223	0.0936	1
Trypanosoma cruzi	prolyl endopeptidase	0.199	1	1
Echinococcus granulosus	acylamino acid releasing enzyme	0.0209	0.0863	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0068	0.006
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0121	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0626	0.0619
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0052	0.0057	0.005
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0056	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Echinococcus granulosus	cysteine protease	0.0121	0.0414	0.0406
Brugia malayi	Papain family cysteine protease containing protein	0.0052	0.0057	0.005
Plasmodium vivax	serine-repeat antigen (SERA)	0.0052	0.0057	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0053	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.072	0.0684
Loa Loa (eye worm)	hypothetical protein	0.047	0.2205	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0223	0.0936	0.0929
Trypanosoma cruzi	oligopeptidase b	0.0791	0.3852	0.3828
Plasmodium vivax	hypothetical protein, conserved	0.0209	0.0863	0.9171
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0052	0.0057	0.0051
Trypanosoma brucei	Emopamil binding protein, putative	0.0282	0.1238	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0936	0.0929
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0052	0.0057	0.0051
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Onchocerca volvulus		0.0223	0.0936	0.0888
Brugia malayi	hypothetical protein	0.0051	0.0053	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0052	0.0057	0.0535
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0057	0.0535
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.051	0.0503
Toxoplasma gondii	cathepsin CPC2	0.0052	0.0057	0.0004
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Brugia malayi	fibroinase precursor	0.0052	0.0057	0.005
Giardia lamblia	Cathepsin B precursor	0.0181	0.072	0.8229
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.0936	0.0901
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0209	0.0863	0.9166
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.199	1	1
Echinococcus granulosus	prolyl endopeptidase	0.199	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0209	0.0863	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1348	0.1342
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.0936	0.0901
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0143	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0052	0.0057	0.0051
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.051	0.0503
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0381	0.1747	0.1741
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0209	0.0863	0.9166
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0209	0.0863	0.0828
Schistosoma mansoni	cathepsin S (C01 family)	0.0052	0.0057	0.0057
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0209	0.0863	0.9166
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0052	0.0057	0.0535
Entamoeba histolytica	cysteine proteinase 1, putative	0.0121	0.0414	0.4054
Echinococcus multilocularis	lamin b receptor	0.0048	0.0039	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.0936	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.199	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0269	0.0262
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0223	0.0936	0.0929
Plasmodium vivax	vivapain-2	0.0223	0.0936	1
Brugia malayi	Pepsin A precursor	0.0051	0.0053	0.0045
Onchocerca volvulus		0.0223	0.0936	0.0888
Onchocerca volvulus		0.0154	0.058	0.053
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0154	0.058	0.0573
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Loa Loa (eye worm)	fibroinase	0.0223	0.0936	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.0057	0.0535
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0143	0.0143
Onchocerca volvulus	Cathepsin L homolog	0.0052	0.0057	0.0004
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.0936	1
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Onchocerca volvulus	Bile acid receptor homolog	0.0163	0.0626	0.0576
Brugia malayi	aspartic protease BmAsp-1, identical	0.0051	0.0053	0.0045
Schistosoma mansoni	patched 1	0.0042	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0052	0.0057	0.0535
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0057	0.0057
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0069	0.0149	0.0141
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0144	0.0137
Schistosoma mansoni	hypothetical protein	0.0144	0.0532	0.0532
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.058	0.6163
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Plasmodium falciparum	serine repeat antigen 7	0.0052	0.0057	0.0051
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0294	0.2697
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0143	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.0057	0.005
Leishmania major	oligopeptidase b	0.0791	0.3852	0.3828
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0791	0.3852	0.3828
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0381	0.1747	0.1715
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.0863	0.0856
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0223	0.0936	0.0936
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0294	0.0287
Leishmania major	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Leishmania major	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Leishmania major	hypothetical protein, conserved	0.0282	0.1238	0.1204
Loa Loa (eye worm)	ctsf protein	0.0223	0.0936	0.0929
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0052	0.0057	0.0535
Entamoeba histolytica	cysteine protease, putative	0.0223	0.0936	1
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.1782	0.8929	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0052	0.0057	0.005
Plasmodium falciparum	peptidase, putative	0.0209	0.0863	0.9171
Schistosoma mansoni	cathepsin D (A01 family)	0.0051	0.0053	0.0053
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0223	0.0936	0.0929
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.199	1	1
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0209	0.0863	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1088	0.1081
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0052	0.0057	0.0051
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0052	0.0057	0.0057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0052	0.0057	0.0535
Echinococcus granulosus	cathepsin l1	0.0223	0.0936	0.0929
Schistosoma mansoni	hypothetical protein	0.0069	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Echinococcus multilocularis	cysteine protease	0.0223	0.0936	0.0929
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Brugia malayi	cathepsin L-like precursor	0.0154	0.058	0.0573
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0149	0.011
Entamoeba histolytica	cysteine proteinase 2	0.0121	0.0414	0.4054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0307	0.03
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0381	0.1747	0.1715
Echinococcus multilocularis	prolyl endopeptidase	0.199	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0223	0.0936	0.0901
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0143	0.0135
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0209	0.0863	1
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0209	0.0863	0.0863
Plasmodium vivax	vivapain-2	0.0223	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Echinococcus multilocularis	cysteine protease	0.0223	0.0936	0.0929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0052	0.0057	0.0057
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Onchocerca volvulus	Cathepsin L homolog	0.0223	0.0936	0.0888
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0052	0.0057	0.0057
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.199	1	1
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0209	0.0863	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0052	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0149	0.0141
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0051	0.0053	0.0045
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0294	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Trypanosoma brucei	Sterol methyltransferase, putative	0.0623	0.2985	0.2958
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0154	0.058	0.0543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0791	0.3852	0.3828
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0294	0.0287
Brugia malayi	cathepsin L-like cysteine proteinase	0.0052	0.0057	0.005
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0863	0.0856
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0264	0.0256
Brugia malayi	Papain family cysteine protease containing protein	0.0052	0.0057	0.005
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0223	0.0936	0.0929
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0307	0.03
Toxoplasma gondii	cathepsin CPC1	0.0052	0.0057	0.0004
Schistosoma mansoni	hypothetical protein	0.0183	0.073	0.073
Brugia malayi	hypothetical protein	0.0051	0.0053	0.0045
Trypanosoma cruzi	cysteine protease, putative	0.0121	0.0414	0.0377
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0325	0.1457	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0051	0.0053	0.0487
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0209	0.0863	0.9166
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0052	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0053	0.0045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Echinococcus granulosus	cathepsin L	0.0121	0.0414	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0149	0.0141
Loa Loa (eye worm)	cysteine protease	0.0223	0.0936	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Leishmania major	cathepsin L-like protease	0.0223	0.0936	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0381	0.1747	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0791	0.0784
Brugia malayi	cathepsin B-like cysteine proteinase	0.047	0.2201	0.2195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Plasmodium vivax	unspecified product	0.0069	0.0149	0.1082
Brugia malayi	cathepsin F-like cysteine proteinase	0.0069	0.0149	0.0141
Echinococcus granulosus	cathepsin L	0.0052	0.0057	0.005
Brugia malayi	cathepsin F-like cysteine proteinase	0.0052	0.0057	0.005
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0791	0.3852	0.3828
Plasmodium falciparum	serine repeat antigen 9	0.0052	0.0057	0.0051
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.0936	0.0901
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0052	0.0057	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0144	0.0137
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0038	0.003
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0209	0.0863	0.0828
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0052	0.0057	0.0051
Brugia malayi	RNA binding protein	0.0068	0.0143	0.0135
Giardia lamblia	Cathepsin B precursor	0.0181	0.072	0.8229
Loa Loa (eye worm)	hypothetical protein	0.0154	0.058	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0057	0.005
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0439	0.0432
Brugia malayi	Papain family cysteine protease containing protein	0.0121	0.0414	0.0406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0052	0.0057	0.0535
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0623	0.2985	0.2958
Echinococcus granulosus	lamin b receptor	0.0048	0.0039	0.0031
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0597	0.2854	0.2848
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0052	0.0057	0.0051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.0936	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0053	0.0053
Toxoplasma gondii	cathepsin CPL	0.0223	0.0936	0.0888
Entamoeba histolytica	cysteine protease, putative	0.0121	0.0414	0.4054
Echinococcus granulosus	geminin	0.0183	0.073	0.0723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0269	0.0262
Brugia malayi	Cathepsin L-like precursor	0.0223	0.0936	0.0929
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0051	0.0053	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0209	0.0863	0.0814
Schistosoma mansoni	hypothetical protein	0.0183	0.073	0.073
Plasmodium vivax	unspecified product	0.0052	0.0057	0.0051
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0209	0.0863	0.0856
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0269	0.0269
Echinococcus multilocularis	cathepsin L	0.0052	0.0057	0.005
Plasmodium falciparum	serine repeat antigen 3	0.0052	0.0057	0.0051
Onchocerca volvulus	Cathepsin F homolog	0.0223	0.0936	0.0888
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0414	0.0377
Loa Loa (eye worm)	cathepsin B	0.0181	0.072	0.0713
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0269	0.0262
Plasmodium vivax	vivapain-1	0.0121	0.0414	0.4084
Onchocerca volvulus		0.0223	0.0936	0.0888
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0052	0.0057	0.0051
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0791	0.3852	0.5
Plasmodium falciparum	serine repeat antigen 8	0.0052	0.0057	0.0051
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.0936	0.0901
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0223	0.0936	0.0929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.047	0.2201	0.2201
Toxoplasma gondii	hypothetical protein	0.0209	0.0863	0.0814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.0936	1
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0209	0.0863	0.0828

Activities

Activity type	Activity value	Assay description	Source	Reference
IC90 (functional)	= 11 ug ml-1	Antibacterial activity of compound to inhibit the growth of Gram-positive bacteria; Range is 5-11 ug/mL	ChEMBL.	15006375

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 42873